Cognitive deficits characterization using the CogState Research Battery in first-episode psychosis patients

The computer-based CogState Research Battery (CSRB) proposes a test structure which follows MATRICS recommended cognitive domains but lacks direct comparison to pen and paper batteries in first-episode psychosis (FEP). The aim of this study was to compare performances obtained with the CSRB and a pen and paper battery in a historical cohort of FEP patients. Among patients entering an early intervention program between 2003 and 2014, separate cohorts completed the traditional pen and paper cognitive battery (n = 182) and the CSRB (n = 97). Composite z-scores were derived using normative data of matched controls (n = 64 pen and paper, n = 69 CSRB) and were compared between the two batteries for the 7 cognitive domains. The cohort tested using the CSRB performed better on the domains of processing speed, attention, visual memory, and verbal memory than the cohort tested using the pen and paper battery (all p < 0.001). Performance did not differ between the two types of batteries for the working memory, executive functions, and social cognition domains. Cognitive profiles identified in the two patient cohorts were similar, with verbal memory being the most impaired domain. Better performances on the CSRB may be primarily due to the minimal demand of the computerized tests on graphomotor abilities and reading speed compared to the pen and paper tests. Our investigation offers a better understanding on how the results obtained with computerized batteries may compare to earlier work done with traditional tests.

[1]  Richard F. Beltramini,et al.  Meta-Analysis: Quantitative Methods for Research Synthesis , 1987 .

[2]  M. First,et al.  Structured clinical interview for DSM-IV axis I disorders : SCID-I: clinical version : administration booklet , 1996 .

[3]  Comparison Levine,et al.  Quantitative Applications in the Social Sciences , 2006 .

[4]  S. Woods,et al.  Chlorpromazine equivalent doses for the newer atypical antipsychotics. , 2003, The Journal of clinical psychiatry.

[5]  P. Snyder,et al.  A comparison of the CogState Schizophrenia Battery and the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Battery in assessing cognitive impairment in chronic schizophrenia , 2009, Journal of clinical and experimental neuropsychology.

[6]  J. Stroop.  Studies of interference in serial verbal reactions. , 1992 .

[7]  S. Silverstein,et al.  Please Scroll down for Article Journal of Clinical and Experimental Neuropsychology a Comparative Study of the Matrics and Integneuro Cognitive Assessment Batteries , 2022 .

[8]  F. Wolf.  Meta-Analysis: Quantitative Methods for Research Synthesis , 1987 .

[9]  J. Ridley.  Studies of Interference in Serial Verbal Reactions , 2001 .

[10]  R. Brickenkamp,et al.  D2 Test of Attention , 1998 .

[11]  K. Hashimoto,et al.  Criterion and Construct Validity of the CogState Schizophrenia Battery in Japanese Patients with Schizophrenia , 2011, PloS one.

[12]  N. Andreasen.  Scale for the Assessment of Negative Symptoms (SANS) and Scale for the Assessment of Positive Symptoms (SAPS) 1982 , 2007 .

[13]  J. Sweeney,et al.  A comparison of neuropsychological dysfunction in first-episode psychosis patients with unipolar depression, bipolar disorder, and schizophrenia , 2009, Schizophrenia Research.

[14]  S. Lal,et al.  Cognitive and clinical moderators of recognition memory in schizophrenia: a meta-analysis , 2005, Schizophrenia Research.

[15]  Paul Maruff,et al.  The effects of practice on the cognitive test performance of neurologically normal individuals assessed at brief test-retest intervals. , 2003, Journal of the International Neuropsychological Society : JINS.

[16]  P. Snyder,et al.  Stability of cognitive impairment in chronic schizophrenia over brief and intermediate re‐test intervals , 2009, Human psychopharmacology.

[17]  R. Gur,et al.  Computerized neurocognitive test performance in schizophrenia: a lifespan analysis. , 2012, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[18]  Michael F. Green,et al.  Identification of separable cognitive factors in schizophrenia , 2004, Schizophrenia Research.

[19]  A. Malla,et al.  A Canadian Programme for Early Intervention in Non-Affective Psychotic Disorders , 2003, The Australian and New Zealand journal of psychiatry.

[20]  P. Maruff,et al.  Computerised cognitive assessment of athletes with sports related head injury , 2001, British journal of sports medicine.

[21]  Jelle Jolles,et al.  The Stroop Color-Word Test , 2006, Assessment.

[22]  R. Kahn,et al.  Psychomotor planning is deficient in recent-onset schizophrenia , 2009, Schizophrenia Research.

[23]  August B. Hollingshead,et al.  Two Factor Index of Social Position , 1957 .

[24]  P. Snyder,et al.  Spatial working memory and problem solving in schizophrenia: The effect of symptom stabilization with atypical antipsychotic medication , 2008, Psychiatry Research.

[25]  D. Barch.  Neuropsychological abnormalities in schizophrenia and major mood disorders: Similarities and differences , 2009, Current psychiatry reports.

[26]  P. Williamson,et al.  Three syndrome concept of schizophrenia A factor analytic study , 1993, Schizophrenia Research.

[27]  T. Dwolatzky,et al.  The detection of neurocognitive decline in schizophrenia using the Mindstreams Computerized Cognitive Test Battery , 2006, Schizophrenia Research.

[28]  J. Gold,et al.  Overlooking the obvious: a meta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia. , 2007, Archives of general psychiatry.

[29]  J. J. Ryan,et al.  Wechsler Adult Intelligence Scale-III , 2001 .

[30]  N. Andreasen.  Scale for the Assessment of Negative Symptoms , 2014 .

[31]  Takefumi Kikusui,et al.  A Role for Strain Differences in Waveforms of Ultrasonic Vocalizations during Male–Female Interaction , 2011, PloS one.

[32]  M. Deanna.  Neuropsychological Abnormalities in Schizophrenia and Major Mood Disorders: Similarities and Differences , 2009 .

[33]  C. Clark,et al.  Assessing Cognition in Schizophrenia: A Comparison of Clinician and Computerized Test Administration , 2012, Applied neuropsychology. Adult.

[34]  P. Liddle.  The Symptoms of Chronic Schizophrenia , 1987, British Journal of Psychiatry.

[35]  N. Andreasen.  The Scale for the Assessment of Negative Symptoms (SANS): Conceptual and Theoretical Foundations , 1989, British Journal of Psychiatry.

[36]  F. Ortuño,et al.  Schizophrenia Research: Cognition , 2015 .

[37]  B. Gallhofer,et al.  Cognitive subprocesses and schizophrenia. A. Reaction‐time decomposition , 2001, Acta psychiatrica Scandinavica. Supplementum.

[38]  R. Reitan.  Trail Making Test: Manual for Administration and Scoring , 1992 .

[39]  S. Woods,et al.  Dose equivalents for second-generation antipsychotics: the minimum effective dose method. , 2014, Schizophrenia bulletin.