Material Processing and Design of Biodegradable Metal Matrix Composites for Biomedical Applications

In recent years, biodegradable metallic materials have played an important role in biomedical applications. However, as typical for the metal materials, their structure, general properties, preparation technology and biocompatibility are hard to change. Furthermore, biodegradable metals are susceptible to excessive degradation and subsequent disruption of their mechanical integrity; this phenomenon limits the utility of these biomaterials. Therefore, the use of degradable metals, as the base material to prepare metal matrix composite materials, it is an excellent alternative to solve the problems above described. Biodegradable metals can thus be successfully combined with other materials to form biodegradable metallic matrix composites for biomedical applications and functions. The present article describes the processing methods currently available to design biodegradable metal matrix composites for biomedical applications and provides an overview of the current existing biodegradable metal systems. At the end, the manuscript presents and discusses the challenges and future research directions for development of biodegradable metallic matrix composites for biomedical purposes.

[1]  Changchun Zhou,et al.  Bio-Functional Design, Application and Trends in Metallic Biomaterials , 2017, International journal of molecular sciences.

[2]  Steven R Schmid Kalpakjian,et al.  Manufacturing Engineering and Technology , 1991 .

[3]  M. Cima,et al.  Production of injection molding tooling with conformal cooling channels using the three dimensional printing process , 2000 .

[4]  A. Muñoz,et al.  Mechanical properties and corrosion behavior of Mg-HAP composites. , 2014, Journal of the mechanical behavior of biomedical materials.

[5]  D. Kaplan,et al.  Porosity of 3D biomaterial scaffolds and osteogenesis. , 2005, Biomaterials.

[6]  C. Sfeir,et al.  Porous magnesium/PLGA composite scaffolds for enhanced bone regeneration following tooth extraction. , 2015, Acta biomaterialia.

[7]  L. Ruan,et al.  Biodegradable intestinal stents: A review , 2014 .

[8]  E. Degarmo Materials and Processes in Manufacturing , 1974 .

[9]  M. Mabuchi,et al.  Processing of an open-cellular AZ91 magnesium alloy with a low density of 0.05 g/cm3 , 1999 .

[10]  Z. Fan,et al.  Fabrication of biodegradable nano-sized β-TCP/Mg composite by a novel melt shearing technology , 2012 .

[11]  T. Woodfield,et al.  Synthesis and properties of topologically ordered porous magnesium , 2011 .

[12]  Zhiming Yu,et al.  In vitro corrosion behavior and in vivo biodegradation of biomedical β-Ca3(PO4)2/Mg-Zn composites. , 2012, Acta biomaterialia.

[13]  Wei-jia Tang,et al.  On the corrosion behaviour of newly developed biodegradable Mg-based metal matrix composites produced by in situ reaction , 2012 .

[14]  G. He,et al.  A new approach to the fabrication of porous magnesium with well-controlled 3D pore structure for orthopedic applications. , 2014, Materials science & engineering. C, Materials for biological applications.

[15]  H. Nakajima,et al.  Vibration–damping capacity of lotus-type porous magnesium , 2006 .

[16]  P. Cao,et al.  Degradable porous Fe-35wt.%Mn produced via powder sintering from NH4HCO3 porogen , 2015 .

[17]  P. Scolozzi,et al.  Complex orbito-fronto-temporal reconstruction using computer-designed PEEK implant. , 2007, The Journal of craniofacial surgery.

[18]  Yufeng Zheng,et al.  Microstructure, mechanical property, bio-corrosion and cytotoxicity evaluations of Mg/HA composites , 2010 .

[19]  H. Kaufmann,et al.  Vacuum Foaming of Magnesium Slurries , 2005 .

[20]  Sumin Yun,et al.  Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases. , 2015, ACS nano.

[21]  Shahrouz Zamani Khalajabadi,et al.  Effect of mechanical alloying on the phase evolution, microstructure and bio-corrosion properties of a Mg/HA/TiO2/MgO nanocomposite , 2014 .

[22]  Yufeng Zheng,et al.  A review on in vitro corrosion performance test of biodegradable metallic materials , 2013 .

[23]  William R. Heineman,et al.  Revolutionizing biodegradable metals , 2009 .

[24]  G. Dias,et al.  Calcium phosphate coatings on magnesium alloys for biomedical applications: a review. , 2012, Acta biomaterialia.

[25]  Mariana Calin,et al.  Review on manufacture by selective laser melting and properties of titanium based materials for biomedical applications , 2016 .

[26]  S. Asadi,et al.  The role of titania on the microstructure, biocorrosion and mechanical properties of Mg/HA-based nanocomposites for potential application in bone repair , 2016 .

[27]  X. Ma,et al.  Microstructure, mechanical property and corrosion behavior of interpenetrating (HA+β-TCP)/MgCa composite fabricated by suction casting. , 2013, Materials science & engineering. C, Materials for biological applications.

[28]  Zhengfang Yi,et al.  A Bifunctional Biomaterial with Photothermal Effect for Tumor Therapy and Bone Regeneration , 2016 .

[29]  A. Habibolahzadeh,et al.  Production of aluminum foam by spherical carbamide space holder technique-processing parameters , 2010 .

[30]  Jing Bai,et al.  Mechanical and degradation properties of biodegradable Mg strengthened poly-lactic acid composite through plastic injection molding. , 2017, Materials science & engineering. C, Materials for biological applications.

[31]  M. Niinomi,et al.  Mechanical and biodegradable properties of porous titanium filled with poly-L-lactic acid by modified in situ polymerization technique. , 2011, Journal of the mechanical behavior of biomedical materials.

[32]  Yong Han,et al.  Preparation, mechanical properties and in vitro biodegradation of porous magnesium scaffolds , 2008 .

[33]  W. Müller,et al.  Antibacterial biodegradable Mg-Ag alloys. , 2013, European cells & materials.

[34]  A M Weinstein,et al.  Interface mechanics of porous titanium implants. , 1981, Journal of biomedical materials research.

[35]  A. K. Jha,et al.  Highly porous open cell Ti-foam using NaCl as temporary space holder through powder metallurgy route , 2013 .

[36]  Mamoru Mabuchi,et al.  Processing of biocompatible porous Ti and Mg , 2001 .

[37]  Alexis M Pietak,et al.  Magnesium and its alloys as orthopedic biomaterials: a review. , 2006, Biomaterials.

[38]  M. Meratian,et al.  Innovative processing of lotus-type porous magnesium through thermal decomposition of wood , 2012 .

[39]  Fuzhai Cui,et al.  Surface Modifications of Magnesium Alloys for Biomedical Applications , 2011, Annals of Biomedical Engineering.

[40]  D. Ando,et al.  A lightweight shape-memory magnesium alloy , 2016, Science.

[41]  J. Schrooten,et al.  Open cellular magnesium alloys for biodegradable orthopaedic implants , 2013 .

[42]  Gladius Lewis,et al.  Properties of open-cell porous metals and alloys for orthopaedic applications , 2013, Journal of Materials Science: Materials in Medicine.

[43]  Xiaogang Wang,et al.  Microstructure, mechanical property and corrosion behaviors of interpenetrating C/Mg-Zn-Mn composite fabricated by suction casting. , 2013, Materials Science and Engineering C: Materials for Biological Applications.

[44]  Mark Taylor,et al.  Free form fabricated features on CoCr implants with and without hydroxyapatite coating in vivo: a comparative study of bone contact and bone growth induction , 2011, Journal of materials science. Materials in medicine.

[45]  Xudong Sun,et al.  Preparation and mechanical property of a novel 3D porous magnesium scaffold for bone tissue engineering. , 2014, Materials science & engineering. C, Materials for biological applications.

[46]  Su-gun Lim,et al.  Characteristics of Mg- x HA Composites Fabricated by Cold Isostatic Pressing Process , 2014 .

[47]  A. Gebhardt,et al.  Custom-made cast titanium implants produced with CAD/CAM for the reconstruction of cranium defects. , 1998, International journal of oral and maxillofacial surgery.

[48]  D. Vojtěch,et al.  Microstructural and mechanical properties of biodegradable iron foam prepared by powder metallurgy , 2015 .

[49]  Li Yanxiang,et al.  Evaluation of porosity in lotus-type porous magnesium fabricated by metal/gas eutectic unidirectional solidification , 2005 .

[50]  W. Haider,et al.  In vitro biodegradation, electrochemical corrosion evaluations and mechanical properties of an Mg/HA/TiO2 nanocomposite for biomedical applications , 2017 .

[51]  Yufeng Zheng,et al.  In vitro Study on Biodegradable AZ31 Magnesium Alloy Fibers Reinforced PLGA Composite , 2013 .

[52]  Yufeng Zheng,et al.  Design of magnesium alloys with controllable degradation for biomedical implants: From bulk to surface. , 2016, Acta biomaterialia.

[53]  R. Singer,et al.  Endogenous Particle Stabilization During Magnesium Integral Foam Production , 2004 .

[54]  Li Li,et al.  Microstructure and characteristics of the metal-ceramic composite (MgCa-HA/TCP) fabricated by liquid metal infiltration. , 2011, Journal of biomedical materials research. Part B, Applied biomaterials.

[55]  M. Mabuchi,et al.  Compressibility of porous magnesium foam: dependency on porosity and pore size , 2004 .

[56]  Boeun Lee,et al.  Novel processing of iron-manganese alloy-based biomaterials by inkjet 3-D printing. , 2013, Acta biomaterialia.

[57]  S. Bhaduri,et al.  In situ measurement of shrinkage and temperature profile in microwave- and conventionally-sintered hydroxyapatite bioceramic , 2015 .

[58]  J. Bai,et al.  Impact behaviors of poly-lactic acid based biocomposite reinforced with unidirectional high-strength magnesium alloy wires , 2014 .

[59]  E. Champion Sintering of calcium phosphate bioceramics. , 2013, Acta biomaterialia.

[60]  Yufeng Zheng,et al.  Fabrication and characterization of Mg/P(LLA-CL)-blended nanofiber scaffold , 2014, Journal of biomaterials science. Polymer edition.

[61]  Yong Zhu,et al.  Mechanical and biological properties of bioglass/magnesium composites prepared via microwave sintering route , 2016 .

[62]  Wei Li,et al.  Characterization of biomedical hydroxyapatite/magnesium composites prepared by powder metallurgy assisted with microwave sintering , 2016 .

[63]  L D Zardiackas,et al.  Structure, metallurgy, and mechanical properties of a porous tantalum foam. , 2001, Journal of biomedical materials research.

[64]  Yufeng Zheng,et al.  Novel Magnesium Alloys Developed for Biomedical Application: A Review , 2013 .

[65]  Dinesh K. Agrawal,et al.  MICROWAVE PROCESSING OF CERAMICS , 1998 .

[66]  Sanjeet Hegde,et al.  Improving the Fontan: Pre-surgical planning using four dimensional (4D) flow, bio-mechanical modeling and three dimensional (3D) printing , 2016 .

[67]  Yufeng Zheng,et al.  Progress of biodegradable metals , 2014 .

[68]  Manoj Gupta,et al.  Selective Laser Melting of Magnesium and Magnesium Alloy Powders: A Review , 2016 .

[69]  E. Aghion,et al.  The Prospects of Carrying and Releasing Drugs Via Biodegradable Magnesium Foam , 2010 .

[70]  F. Beckmann,et al.  The morphology of anisotropic 3D-printed hydroxyapatite scaffolds. , 2008, Biomaterials.

[71]  Li Long-fei,et al.  INFLUENCE OF MICROSTRUCTURES OF EUTECTOIDSTEEL ON ROOM TEMPERATURE WORKHARDENING BEHAVIOR , 2013 .

[72]  Xudong Sun,et al.  Preparation and Mechanical Properties of a Novel Biomedical Magnesium-Based Scaffold , 2013 .

[73]  Hui-ping Tang,et al.  Preparation and compressive behavior of porous titanium prepared by space holder sintering process , 2012 .

[74]  E. Willbold,et al.  Biodegradable magnesium scaffolds: Part 1: appropriate inflammatory response. , 2007, Journal of biomedical materials research. Part A.

[75]  A. A. Bakir,et al.  Porous Biodegradable Metals for Hard Tissue Scaffolds: A Review , 2012, International journal of biomaterials.

[76]  Hyoun‐Ee Kim,et al.  Polyetheretherketone/magnesium composite selectively coated with hydroxyapatite for enhanced in vitro bio-corrosion resistance and biocompatibility , 2014 .

[77]  Savio L-Y Woo,et al.  Revolutionizing orthopaedic biomaterials: The potential of biodegradable and bioresorbable magnesium-based materials for functional tissue engineering. , 2014, Journal of biomechanics.

[78]  Jack G. Zhou,et al.  Microstructure, corrosion, and mechanical properties of compression-molded zinc-nanodiamond composites , 2014, Journal of Materials Science.

[79]  Jie Zhou,et al.  In vitro degradation behavior and bioactivity of magnesium-Bioglass(®) composites for orthopedic applications. , 2012, Journal of biomedical materials research. Part B, Applied biomaterials.

[80]  M. Niinomi,et al.  Development of new metallic alloys for biomedical applications. , 2012, Acta biomaterialia.

[81]  Yufeng Zheng,et al.  Magnesium-calcium/hydroxyapatite (Mg-Ca/HA) composites with enhanced bone differentiation properties for orthopedic applications , 2016 .

[82]  Wei Li,et al.  Processing and mechanical properties of magnesium foams , 2009 .

[83]  A. Nakahira,et al.  New technique for bonding hydroxyapatite ceramics and magnesium alloy by hydrothermal hot-pressing method , 2011 .

[84]  E. Figallo,et al.  A new bi-layered scaffold for osteochondral tissue regeneration: In vitro and in vivo preclinical investigations. , 2017, Materials science & engineering. C, Materials for biological applications.

[85]  G. Lu,et al.  Lattice vibration modes and thermal conductivity of potassium dihydrogen phosphate crystal studying by Raman spectroscopy , 2005 .

[86]  D. Ando,et al.  A Lightweight Shape-Memory Magnesium Alloy. , 2016 .

[87]  Shahrouz Zamani Khalajabadi,et al.  The effect of MgO on the biodegradation, physical properties and biocompatibility of a Mg/HA/MgO nanocomposite manufactured by powder metallurgy method , 2016 .

[88]  Boeun Lee,et al.  Binder-jetting 3D printing and alloy development of new biodegradable Fe-Mn-Ca/Mg alloys. , 2016, Acta biomaterialia.

[89]  A. Manonukul,et al.  Effects of replacing metal powder with powder space holder on metal foam produced by metal injection moulding , 2010 .

[90]  John Banhart,et al.  Porous Metals and Metallic Foams: Current Status and Recent Developments , 2008 .

[91]  D. Mantovani,et al.  Developments in metallic biodegradable stents. , 2010, Acta biomaterialia.

[92]  Lai‐Chang Zhang,et al.  Selective Laser Melting of Titanium Alloys and Titanium Matrix Composites for Biomedical Applications: A Review   , 2016 .

[93]  Jochem Nagels,et al.  Stress shielding and bone resorption in shoulder arthroplasty. , 2003, Journal of shoulder and elbow surgery.

[94]  F. Witte,et al.  Biodegradable Metals , 2018, Biomaterials Science.

[95]  J. Čapek,et al.  Properties of porous magnesium prepared by powder metallurgy. , 2013, Materials science & engineering. C, Materials for biological applications.

[96]  Cato T Laurencin,et al.  Biomedical Applications of Biodegradable Polymers. , 2011, Journal of polymer science. Part B, Polymer physics.

[97]  Kun Yu,et al.  In vivo biocompatibility and biodegradation of a Mg-15%Ca3(PO4)2 composite as an implant material , 2013 .

[98]  Volker Wesling,et al.  Selective Laser Melting of Magnesium and Magnesium Alloys , 2013 .

[99]  Yuanhao Wu,et al.  Revolutionizing Metallic Biomaterials , 2017 .