CO2‐welded venous anastomosis: Enhancement of weld strength with heterologous fibrin glue

The milliwatt CO2 laser was used to perform end‐to‐end anastomoses in canine jugular veins. There was a high disruption rate (50%) in laser‐welded veins (n = 10). Fibrin glue (n = 17), formed from human fresh‐frozen plasma, enhanced the weld strength decreasing the disruption rate (18%), resulting in an 82% patency which nearly equaled the contralateral sutured vein patency (93%). The bursting strength was improved with fibrin glue. Transmural necrosis was present initially in all groups but extended for a longer distance in the vessel wall in laser‐welded anastomoses. Sutured anastomoses exhibited a greater inflammatory response. In laser‐welded anastomoses endothelial cells were not as confluent as in sutured anastomoses by six weeks.

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