Sustained-release interleukin-2 following intramuscular injection in rats

[1]  T. Johnston,et al.  Enhanced stability of two model proteins in an agitated solution environment using poloxamer 407. , 1993, Journal of parenteral science and technology : a publication of the Parenteral Drug Association.

[2]  T. Johnston,et al.  Biological activity of urease formulated in poloxamer 407 after intraperitoneal injection in the rat. , 1992, Journal of pharmaceutical sciences.

[3]  T. Johnston,et al.  KINETICS OF SOL-TO-GEL TRANSITION FOR POLOXAMER POLYOLS , 1991 .

[4]  K. Orita,et al.  Application of an interleukin 2 slow delivery system to the immunotherapy of established murine colon 26 adenocarcinoma liver metastases. , 1990, Cancer research.

[5]  P. Heinrich,et al.  Fate of interleukin-6 in the rat. Involvement of skin in its catabolism. , 1990, European journal of biochemistry.

[6]  Johnston Tp,et al.  Sustained-Release of Urease from a Poloxamer Gel Matrix , 1990 .

[7]  S. Miller,et al.  Inulin disposition following intramuscular administration of an inulin/poloxamer gel matrix. , 1989, Journal of parenteral science and technology : a publication of the Parenteral Drug Association.

[8]  J. Richards,et al.  Therapeutic uses of interleukin-2 and lymphokine-activated killer (LAK) cells. , 1989, Blood reviews.

[9]  C. J. Dunn,et al.  Slow release of interleukin-2 from polymer implants. , 1988, Annals of internal medicine.

[10]  R. Braziel,et al.  The toxicity of recombinant human interleukin-2 in rats following intravenous infusion. , 1987, Journal of the National Medical Association.

[11]  W. Colburn,et al.  Plasma concentration profiles of human recombinant interleukin-2 (HrIL-2) in the rat following administration by various systemic routes. , 1987, Drug metabolism and disposition: the biological fate of chemicals.

[12]  J. Thompson,et al.  Interleukin 2 (IL 2) administered in vivo: influence of IL 2 route and timing on T cell growth. , 1985, Journal of immunology.

[13]  S. Rosenberg,et al.  Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2 , 1985, The Journal of experimental medicine.

[14]  S. Rosenberg,et al.  Successful immunotherapy of natural killer-resistant established pulmonary melanoma metastases by the intravenous adoptive transfer of syngeneic lymphocytes activated in vitro by interleukin 2 , 1984, The Journal of experimental medicine.

[15]  S. Rosenberg,et al.  The fate of interleukin-2 after in vivo administration. , 1983, Journal of immunology.

[16]  C. Henney,et al.  In vivo interleukin 2 administration augments the generation of alloreactive cytolytic T lymphocytes and resident natural killer cells. , 1983, Journal of immunology.

[17]  S. Rosenberg,et al.  Lymphokine-activated killer cell phenomenon. Lysis of natural killer- resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes , 1982, The Journal of experimental medicine.

[18]  P. Greenberg,et al.  Augmentation of the anti-tumor therapeutic efficacy of long-term cultured T lymphocytes by in vivo administration of purified interleukin 2 , 1982, The Journal of experimental medicine.

[19]  Y. S. Choi,et al.  Recovery of the in vivo cytotoxic T-cell response in cyclophosphamide-treated mice by injection of mixed-lymphocyte-culture supernatants. , 1981, Cancer research.

[20]  M. Walker,et al.  Inhibition of cytotoxic T-cell clonal expansion by cyclophosphamide and the recovery of cytotoxic T-lymphocyte precursors by supernatants from mixed-lymphocyte cultures. , 1981, Cancer research.

[21]  E. Rüde,et al.  T cell factor (interleukin 2) allows in vivo induction of T helper cells against heterologous erythrocytes in athymic (nu/nu) mice , 1980, European journal of immunology.

[22]  F. Okada,et al.  Enhancement of therapeutic effects of recombinant interleukin 2 on a transplantable rat fibrosarcoma by the use of a sustained release vehicle, pluronic gel. , 1987, Cancer research.

[23]  T. Waldmann,et al.  The role of the kidney in the metabolism of plasma proteins. , 1974, Nephron.