Clinical and economic outcomes of a multidisciplinary team approach in a lower extremity amputation prevention programme for diabetic foot ulcer care in an Asian population: A case‐control study

Present guidelines recommend a multidisciplinary team (MDT) approach to diabetic foot ulcer (DFU) care, but relevant data from Asia are lacking. We aim to evaluate the clinical and economic outcomes of an MDT approach in a lower extremity amputation prevention programme (LEAPP) for DFU care in an Asian population. We performed a case‐control study of 84 patients with DFU between January 2017 and October 2017 (retrospective control) vs 117 patients with DFU between December 2017 and July 2018 (prospective LEAPP cohort). Comparing the clinical outcomes between the retrospective cohort and the LEAPP cohort, there was a significant decrease in mean time from referral to index clinic visit (38.6 vs 9.5 days, P < .001), increase in outpatient podiatry follow‐up (33% vs 76%, P < .001), decrease in 1‐year minor amputation rate (14% vs 3%, P = .007), and decrease in 1‐year major amputation rate (9% vs 3%, P = .05). Simulation of cost avoidance demonstrated an annualised cost avoidance of USD $1.86m (SGD $2.5m) for patients within the LEAPP cohort. In conclusion, similar to the data from Western societies, an MDT approach in an Asian population, via a LEAPP for patients with DFU, demonstrated a significant reduction in minor and major amputation rates, with annualised cost avoidance of USD $1.86m.

[1]  E. Tai,et al.  Diabetes-related lower extremity complications in a multi-ethnic Asian population: a 10 year observational study in Singapore , 2021, Diabetologia.

[2]  J. Car,et al.  Clinical and economic burden of diabetic foot ulcers: A 5‐year longitudinal multi‐ethnic cohort study from the tropics , 2021, International wound journal.

[3]  D. Armstrong,et al.  Five year mortality and direct costs of care for people with diabetic foot complications are comparable to cancer , 2020, Journal of Foot and Ankle Research.

[4]  L. Cloutier,et al.  Effect of contact with podiatry in a team approach context on diabetic foot ulcer and lower extremity amputation: systematic review and meta-analysis , 2020, Journal of Foot and Ankle Research.

[5]  J. Car,et al.  Clinical and economic burden of wound care in the tropics: a 5‐year institutional population health review , 2020, International wound journal.

[6]  M. Brennan,et al.  A systematic review of multidisciplinary teams to reduce major amputations for patients with diabetic foot ulcers. , 2020, Journal of vascular surgery.

[7]  G. Leese,et al.  Preventing foot ulceration in diabetes: systematic review and meta-analyses of RCT data , 2019, Diabetologia.

[8]  Nicholai Jakosz IWGDF guidelines on the prevention and management of diabetic foot disease [Book Review] , 2019 .

[9]  B. van der Werf,et al.  Multidisciplinary clinics reduce treatment costs and improve patient outcomes in diabetic foot disease. , 2019, Journal of vascular surgery.

[10]  S. Cuschieri The STROBE guidelines , 2019, Saudi journal of anaesthesia.

[11]  Frank B. Hu,et al.  Global aetiology and epidemiology of type 2 diabetes mellitus and its complications , 2018, Nature Reviews Endocrinology.

[12]  D. Armstrong,et al.  Building a scalable diabetic limb preservation program: four steps to success , 2018, Diabetic foot & ankle.

[13]  Marcia Nusgart,et al.  An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds. , 2018, Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research.

[14]  A. Icks,et al.  Incidence of lower extremity amputations in the diabetic compared with the non-diabetic population: A systematic review , 2017, PloS one.

[15]  Sicco A Bus,et al.  Diabetic Foot Ulcers and Their Recurrence. , 2017, The New England journal of medicine.

[16]  Z. Moore,et al.  The impact of the multidisciplinary team in the management of individuals with diabetic foot ulcers: a systematic review. , 2017, Journal of wound care.

[17]  Jennifer M. Cooper,et al.  Diabetic foot ulcer severity predicts mortality among veterans with type 2 diabetes. , 2017, Journal of diabetes and its complications.

[18]  D. Margolis,et al.  Association of diabetic foot ulcer and death in a population‐based cohort from the United Kingdom , 2016, Diabetic medicine : a journal of the British Diabetic Association.

[19]  C. Attinger,et al.  Building a Multidisciplinary Hospital-Based Wound Care Center: Nuts and Bolts , 2016, Plastic and reconstructive surgery.

[20]  B. Luo,et al.  Reducing major lower extremity amputations after the introduction of a multidisciplinary team in patient with diabetes foot ulcer , 2016, BMC Endocrine Disorders.

[21]  J. Doupis,et al.  Diabetic foot disease: From the evaluation of the "foot at risk" to the novel diabetic ulcer treatment modalities. , 2016, World journal of diabetes.

[22]  M. Jørgensen,et al.  Increased healing in diabetic toe ulcers in a multidisciplinary foot clinic-An observational cohort study. , 2015, Diabetes research and clinical practice.

[23]  W. Jeffcoate,et al.  Cost of diabetic foot disease to the National Health Service in England , 2014, Diabetic medicine : a journal of the British Diabetic Association.

[24]  Dean Y. Huang,et al.  The Diabetic Foot: The Importance of Coordinated Care , 2014, Seminars in Interventional Radiology.

[25]  P. Holt,et al.  The association of ulceration of the foot with cardiovascular and all-cause mortality in patients with diabetes: a meta-analysis , 2012, Diabetologia.

[26]  E. Wong,et al.  Lower extremity amputation prevention in Singapore: economic analysis of results. , 2011, Singapore medical journal.

[27]  L. Lavery,et al.  The costs of diabetic foot: the economic case for the limb salvage team. , 2010, Journal of vascular surgery.

[28]  A. Nather,et al.  Value of team approach combined with clinical pathway for diabetic foot problems: a clinical evaluation , 2010, Diabetic foot & ankle.

[29]  P. Sidhu,et al.  Improving limb salvage rate in diabetic patients with critical leg ischaemia using a multidisciplinary approach , 2009, International journal of clinical practice.

[30]  David Aron,et al.  Mortality rates and diabetic foot ulcers: is it time to communicate mortality risk to patients with diabetic foot ulceration? , 2008, Journal of the American Podiatric Medical Association.

[31]  G. Rayman,et al.  Reduction in Diabetic Amputations Over 11 Years in a Defined U.K. Population , 2008, Diabetes Care.

[32]  M. Serrano-Ríos,et al.  Control of diabetes and cardiovascular risk factors in patients with type 2 diabetes in primary care. The gap between guidelines and reality in Spain , 2007, International journal of clinical practice.

[33]  J. Apelqvist,et al.  Health-economic consequences of diabetic foot lesions. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[34]  L. Vileikyte Diabetic foot ulcers: a quality of life issue , 2001, Diabetes/metabolism research and reviews.

[35]  G. Oster,et al.  Potential Economic Benefits of Lower-Extremity Amputation Prevention Strategies in Diabetes , 1998, Diabetes Care.

[36]  E. Boyko,et al.  Increased Mortality Associated with Diabetic Foot Ulcer , 1996, Diabetic medicine : a journal of the British Diabetic Association.