论文信息 - Distribution of the apical dendritic spines of the layer V pyramidal cells of the hamster neocortex.

Distribution of the apical dendritic spines of the layer V pyramidal cells of the hamster neocortex.

Abstract The distribution of the spines along the apical dendrites of 45 layer V pyramidal cells of the neocortex of young hamsters has been investigated. All visible spines present along the apical dendrite from the cell body to the end of the dendrite were counted and represented graphically. This study has shown: (a) The distribution of the apical dendritic spines of the layer V pyramidal cells of the hamster's neocortex follows a characteristic pattern which is similar to those described for man and mouse. (b) The graphic representation of the spine distribution consists of a characteristically shaped curve with distinct components or deflections. There appears to be a relationship between the different spine density and the cortical layers crossed by the apical dendrite. (c) The first portion of the curve of the spine distribution can be represented as an exponential function. (d) A computer analysis of the shape of the entire curve of the spine distribution in the apical dendrites of the layer V pyramidal cells of the hamster's neocortex was carried out. This approach has suggested that the curve and its deflections may be the result of the superposition of 4 distinct populations of spines. Each of these populations of spines has a distinct cortical depth, roughly corresponding to layers V, IV, III-II and I, and a distinct Gaussian distribution. The significance of this phenomenon and the possible application of this method are discussed.

G R Stibitz | G. Stibitz | M Marin-Padilla | M. Marín‐padilla

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