An easily assembled double T-shape microfluidic devices for the preparation of submillimeter-sized polyacronitrile (PAN) microbubbles and polystyrene (PS) double emulsions

Abstract A simple way to prepare water-in-oil-in-water (W1/O/W2) and oil-in-water-in-oil (O1/W/O2) double emulsions which is based on commercial double T-junction tubes was set up, which shows the remarkable advantages of simplicity, operatability and cost-efficiency comparing with the traditional poly(dimethylsiloxane) (PDMS) microchip. By this device, the stable polyacrylonitrile (PAN) microbubbles have also been produced based during the experiments. The success in producing PAN microbubbles provides a new possibility for the preparation of hollow microspheres with polymer materials, which have the further potential applications in numerous particular fields.

[1]  Yong Wang,et al.  A 3D easily-assembled Micro-Cross for droplet generation. , 2014, Lab on a chip.

[2]  Toru Torii,et al.  Controlled production of monodisperse double emulsions by two-step droplet breakup in microfluidic devices. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[3]  Ran Chen,et al.  Controllable gas/liquid/liquid double emulsions in a dual-coaxial microfluidic device. , 2012, Lab on a chip.

[4]  Xin Du,et al.  Facile Preparation of F and N Codoped Pinecone-Like Titania Hollow Microparticles with Visible Light Photocatalytic Activity , 2009 .

[5]  Yundong Wang,et al.  Controllable microfluidic production of gas-in-oil-in-water emulsions for hollow microspheres with thin polymer shells. , 2012, Lab on a chip.

[6]  M. Dhanaraju,et al.  Floating controlled drug delivery system of famotidine loaded hollow microspheres (microballoons) in the stomach. , 2010, Current drug delivery.

[7]  J. Aguilera,et al.  Aerated food gels: fabrication and potential applications , 2008 .

[8]  Dhananjay Dendukuri,et al.  The Synthesis and Assembly of Polymeric Microparticles Using Microfluidics , 2009 .

[9]  Eleanor Stride,et al.  Calcium Alginate Foams Prepared by a Microfluidic T-Junction System: Stability and Food Applications , 2012, Food and Bioprocess Technology.

[10]  Bernard P. Binks,et al.  Phase inversion of particle-stabilized materials from foams to dry water , 2006, Nature materials.

[11]  Eleanor Stride,et al.  Microbubbling by co-axial electrohydrodynamic atomization , 2007, Medical & Biological Engineering & Computing.

[12]  Shangfu Li,et al.  Formation of monodisperse microbubbles in a microfluidic device , 2006 .

[13]  J. Lindner.  Contrast ultrasound molecular imaging: harnessing the power of bubbles. , 2009, Cardiovascular research.

[14]  G. Luo,et al.  Controllable preparation of monodisperse O/W and W/O emulsions in the same microfluidic device. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[15]  Changzheng Wu,et al.  Synthesis of New‐Phased VOOH Hollow “Dandelions” and Their Application in Lithium‐Ion Batteries , 2006 .

[16]  G. Luo,et al.  Shear force induced monodisperse droplet formation in a microfluidic device by controlling wetting properties. , 2006, Lab on a chip.

[17]  E Stride,et al.  Preparation of microbubble suspensions by co-axial electrohydrodynamic atomization. , 2007, Medical engineering & physics.

[18]  O. Ozdemir,et al.  A review of induction and attachment times of wetting thin films between air bubbles and particles and its relevance in the separation of particles by flotation. , 2010, Advances in colloid and interface science.

[19]  E Stride,et al.  Increasing the nonlinear character of microbubble oscillations at low acoustic pressures , 2008, Journal of The Royal Society Interface.

[20]  E. Kumacheva,et al.  Continuous microfluidic reactors for polymer particles. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[21]  Paul A Dayton,et al.  On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging. , 2007, Lab on a chip.

[22]  M. Edirisinghe,et al.  A device for the fabrication of multifunctional particles from microbubble suspensions , 2012 .

[23]  S. Seiffert.  Functional microgels tailored by droplet-based microfluidics. , 2011, Macromolecular rapid communications.

[24]  Detlef Lohse,et al.  Microbubble generation in a co-flow device operated in a new regime. , 2011, Lab on a chip.

[25]  Y. Kameda,et al.  The steric effect of solvent molecules in the dissolution of polyacrylonitrile from five different N,N-dimethylformamide derivatives as studied using Raman spectroscopy , 1996 .

[26]  M. Oelze,et al.  Influences of microbubble diameter and ultrasonic parameters on in vitro sonothrombolysis efficacy. , 2012, Journal of vascular and interventional radiology : JVIR.

[27]  Jianhong Xu,et al.  Preparation of highly monodisperse droplet in a T‐junction microfluidic device , 2006 .

[28]  Eleanor Stride,et al.  Novel preparation techniques for controlling microbubble uniformity: a comparison , 2009, Medical & Biological Engineering & Computing.

[29]  Jonathan R. Lindner,et al.  Microbubbles in medical imaging: current applications and future directions , 2004, Nature Reviews Drug Discovery.