Synthesis of new carbonyl and fluoroalkyl o-quinone methides from β-lapachone

[1]  H. Castro,et al.  Trypanocidal agents with low cytotoxicity to mammalian cell line: a comparison of the theoretical and biological features of lapachone derivatives. , 2006, Bioorganic & medicinal chemistry.

[2]  V. Ferreira,et al.  Oxyrane derivative of α-lapachone is potent growth inhibitor of Trypanosoma cruzi epimastigote forms , 2006, Parasitology Research.

[3]  Â. Pinto,et al.  New 1,2,3,4-tetrahydro-1-aza-anthraquinones and 2-aminoalkyl compounds from norlapachol with molluscicidal activity. , 2005, Bioorganic & medicinal chemistry.

[4]  Xiang Zhou,et al.  Quinone methide derivatives: important intermediates to DNA alkylating and DNA cross-linking actions. , 2005, Current medicinal chemistry.

[5]  K. Wojciechowski,et al.  Generation of ortho-quinone methides upon thermal extrusion of sulfur dioxide from benzosultones , 2005 .

[6]  Jae Hun Lee,et al.  Down-regulation of cyclooxygenase-2 and telomerase activity by beta-lapachone in human prostate carcinoma cells. , 2005, Pharmacological research.

[7]  Sang‐wook Lee,et al.  Susceptibility of cancer cells to β-lapachone is enhanced by ionizing radiation , 2005 .

[8]  F. Emery,et al.  Studies on the trypanocidal activity of semi-synthetic pyran[b-4,3]naphtho[1,2-d]imidazoles from beta-lapachone. , 2004, European journal of medicinal chemistry.

[9]  D. Hadjipavlou-Litina,et al.  Synthesis and evaluation of the antioxidant and antiinflammatory activities of some benzo[l]khellactone derivatives and analogues. , 2004, European journal of medicinal chemistry.

[10]  J. Carneiro,et al.  Quantitative structure-activity relationship in aziridinyl-1,4-naphthoquinone antimalarials: study of theoretical correlations by the PM3 method. , 2004, Bioorganic & medicinal chemistry.

[11]  V. Ferreira,et al.  Synthesis of new aldehyde derivatives from β-lapachone and nor-β-lapachone , 2003 .

[12]  M. Freccero,et al.  Selectivity of purine alkylation by a quinone methide. Kinetic or thermodynamic control? , 2003, The Journal of organic chemistry.

[13]  V. F. Ferreira,et al.  Um panorama atual da química e da farmacologia de naftoquinonas, com ênfase na beta-lapachona e derivados , 2003 .

[14]  D. Brousmiche,et al.  Photogeneration of quinone methide-type intermediates from pyridoxine and derivatives , 2002 .

[15]  R. Dorr,et al.  Aziridinyl quinone antitumor agents based on indoles and cyclopent[b]indoles: structure-activity relationships for cytotoxicity and antitumor activity. , 2001, Journal of medicinal chemistry.

[16]  A. Kiselyov.  A facile one-pot synthesis of polysubstituted naphthalenes , 2001 .

[17]  T. Pettus,et al.  A mild anionic method for generating o-quinone methides: facile preparations of ortho-functionalized phenols. , 2001, The Journal of organic chemistry.

[18]  A. Sant'ana,et al.  Molluscicidal and trypanocidal activities of lapachol derivatives. , 2001, Planta medica.

[19]  M. Teixeira,et al.  In vitro and in vivo Leishmanicidal activity of 2‐hydroxy‐3‐(3‐methyl‐2‐butenyl)‐1,4‐naphthoquinone (lapachol) , 2001, Phytotherapy research : PTR.

[20]  T. Pettus,et al.  New Construction of Ortho Ring-Alkylated Phenols via Generation and Reaction of Assorted o-Quinone Methides , 2000 .

[21]  R. Pugin,et al.  THERMAL DECOMPOSITION OF CHROMAN. REACTIVITY OF O-QUINONE METHIDE , 1997 .

[22]  J. Wolfender,et al.  Antifungal and antibacterial naphthoquinones from Newbouldia laevis roots. , 1996, Phytochemistry.

[23]  M. Taing,et al.  o-Quinone Methides from 4-Allenylcyclobutenones: Synthesis and Chemistry , 1996 .

[24]  R. Weaver,et al.  Cytochrome P450 2C9 is responsible for hydroxylation of the naphthoquinone antimalarial drug 58C80 in human liver. , 1993, Biochemical pharmacology.

[25]  A. A. da Silva Filho,et al.  Antiinflammatory action of lapachol. , 1990, Journal of ethnopharmacology.

[26]  H. R. Mehra.  Certain new and already known distomes of the family Lepodermatidae Odhner (Trematoda), with a discussion on the classification of the family , 1937 .