Preparation and Characterization of Benzydamine Hydrochloride-Loaded Lyophilized Mucoadhesive Wafers for the Treatment of Oral Mucositis

[1]  B. Grimling FORMULATION AND CHARACTERISATION OF MUCOADHESIVE DENTAL APPLICATIONS CONTAINING BENZYDAMINE HYDROCHLORIDE , 2021, Progress on Chemistry and Application of Chitin and its Derivatives.

[2]  Corneliu E. Havârneanu,et al.  Evaluation of the Wound Healing Potential of Some Natural Polymers on Three Experimental Models , 2021, Pharmaceuticals.

[3]  W. Xia,et al.  Development of a bioactive chitosan HPMC-based membrane with tea polyphenols encapsulated in β-cyclodextrin as an effective enhancement , 2021 .

[4]  M. Taşpınar,et al.  Comparative evaluation of the cytotoxic effects of different oral antiseptics: A primary culture study , 2021, Nigerian journal of clinical practice.

[5]  R. Bensadoun,et al.  The role of benzydamine in prevention and treatment of chemoradiotherapy-induced mucositis , 2021, Supportive Care in Cancer.

[6]  S. Reis,et al.  Oromucosal precursors of in loco hydrogels for wound-dressing and drug delivery in oral mucositis: Retain, resist, and release. , 2021, Materials science & engineering. C, Materials for biological applications.

[7]  V. Grumezescu,et al.  Scaffolds for Wound Healing Applications , 2020, Polymers.

[8]  Jianhui Li,et al.  Antibacterial activity of chitosan and its derivatives and their interaction mechanism with bacteria: Current state and perspectives , 2020 .

[9]  M. T. El‐Saadony,et al.  Antimicrobial and antioxidant properties of chitosan and its derivatives and their applications: A review. , 2020, International journal of biological macromolecules.

[10]  G. Zengin,et al.  The Versatility of Antioxidant Assays in Food Science and Safety—Chemistry, Applications, Strengths, and Limitations , 2020, Antioxidants.

[11]  Yu Zhao,et al.  Citral-loaded chitosan/carboxymethyl cellulose copolymer hydrogel microspheres with improved antimicrobial effects for plant protection. , 2020, International journal of biological macromolecules.

[12]  E. Guerra,et al.  Topical Treatment of Oral Mucositis in Cancer Patients: A Systematic Review of Randomized Clinical Trials , 2020, Asian Pacific journal of cancer prevention : APJCP.

[13]  E. Souto,et al.  Bilayer Mucoadhesive Buccal Film for Mucosal Ulcers Treatment: Development, Characterization, and Single Study Case , 2020, Pharmaceutics.

[14]  Pengcheng Li,et al.  Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications. , 2020, Carbohydrate polymers.

[15]  A. Al-Shohani,et al.  Current topical trends and novel therapeutic approaches and delivery systems for oral mucositis management , 2020, Journal of pharmacy & bioallied sciences.

[16]  H. Yilmaz Atay Antibacterial Activity of Chitosan-Based Systems , 2020, Functional Chitosan.

[17]  S. Elad The MASCC/ISOO mucositis guidelines 2019: the second set of articles and future directions , 2020, Supportive Care in Cancer.

[18]  S. Hariri,et al.  Characterization of dexamethasone loaded collagen-chitosan sponge and in vitro release study , 2020 .

[19]  Ioannis D. Karantas,et al.  Recent trends on wound management: New therapeutic choices based on polymeric carriers , 2020, Asian journal of pharmaceutical sciences.

[20]  S. Mortazavi,et al.  Fabrication and In-vitro Evaluation of Buccal Mucoadhesive Tablet of Meloxicam , 2020, Iranian journal of pharmaceutical research : IJPR.

[21]  S. Mortazavi,et al.  Propranolol Hydrochloride Buccoadhesive Tablet: Development and In-vitro Evaluation , 2020, Iranian journal of pharmaceutical research : IJPR.

[22]  Daniel Espinobarro-Velázquez,et al.  Photoluminescence in non-conjugated polyelectrolyte films containing 7-hydroxy-flavylium cation , 2019, Polymer Bulletin.

[23]  S. Hadi,et al.  Synthesis and Characterization of Pectin-Chitosan as Candidate Materials for Slow Release System , 2019, IOP Conference Series: Materials Science and Engineering.

[24]  A. Kandwal,et al.  Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines. , 2019, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.

[25]  B. Luppi,et al.  Freeze-Dried Matrices Based on Polyanion Polymers for Chlorhexidine Local Release in the Buccal and Vaginal Cavities. , 2019, Journal of pharmaceutical sciences.

[26]  L. Oliveira-Nascimento,et al.  A mini-review on drug delivery through wafer technology: Formulation and manufacturing of buccal and oral lyophilizates , 2019, Journal of advanced research.

[27]  Max Jelkmann,et al.  In Vitro-in Vivo Correlation of Mucoadhesion Studies on Buccal Mucosa. , 2019, Molecular pharmaceutics.

[28]  P. Shih,et al.  A Potential Antifungal Effect of Chitosan Against Candida albicans Is Mediated via the Inhibition of SAGA Complex Component Expression and the Subsequent Alteration of Cell Surface Integrity , 2019, Front. Microbiol..

[29]  Z. Mohammadi,et al.  Evaluation of physicochemical, mechanical and biological properties of chitosan/carboxymethyl cellulose reinforced with multiphasic calcium phosphate whisker-like fibers for bone tissue engineering. , 2019, Materials science & engineering. C, Materials for biological applications.

[30]  Alexandra Muñoz-Bonilla,et al.  Bio-Based Polymers with Antimicrobial Properties towards Sustainable Development , 2019, Materials.

[31]  L. Tan,et al.  Preparation, characterization and in vitro release study of drug-loaded sodium carboxy-methylcellulose/chitosan composite sponge , 2018, PloS one.

[32]  O. Abdallah,et al.  Exploiting polymer blending approach for fabrication of buccal chitosan‐based composite sponges with augmented mucoadhesive characteristics , 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[33]  A. Oronsky,et al.  A Review of Clinical Radioprotection and Chemoprotection for Oral Mucositis , 2018, Translational oncology.

[34]  E. U. Cidon Chemotherapy induced oral mucositis: prevention is possible. , 2017, Chinese clinical oncology.

[35]  Youjiang Wang,et al.  Physicochemical and Antimicrobial Properties of Gamma Irradiated HPMC-ZnO BNC Films , 2018 .

[36]  Shifang Luan,et al.  Chitosan/hydroxyapatite (HA)/hydroxypropylmethyl cellulose (HPMC) spongy scaffolds-synthesis and evaluation as potential alveolar bone substitutes. , 2017, Colloids and surfaces. B, Biointerfaces.

[37]  D. Xia,et al.  Design and fabrication of porous chitosan scaffolds with tunable structures and mechanical properties. , 2017, Carbohydrate polymers.

[38]  F. Danesi,et al.  Is cytotoxicity a determinant of the different in vitro and in vivo effects of bioactives? , 2017, BMC Complementary and Alternative Medicine.

[39]  M. Sillanpää,et al.  The pH sensitive properties of carboxymethyl chitosan nanoparticles cross-linked with calcium ions. , 2017, Colloids and surfaces. B, Biointerfaces.

[40]  Baolin Guo,et al.  Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing. , 2017, Biomaterials.

[41]  Rana Ihab Reda,et al.  Ketoprofen-loaded Eudragit electrospun nanofibers for the treatment of oral mucositis , 2017, International journal of nanomedicine.

[42]  L. Moura,et al.  Protocols for management of oral complications of chemotherapy and/or radiotherapy for oral cancer: Systematic review and meta-analysis current , 2016, Medicina oral, patologia oral y cirugia bucal.

[43]  P. Sengupta,et al.  Mucoadhesive polymers and their mode of action: a recent update , 2017 .

[44]  M. Bhatt,et al.  Role of benzydamine hydrochloride in the prevention of oral mucositis in head and neck cancer patients treated with radiotherapy (>50 Gy) with or without chemotherapy , 2017, Supportive Care in Cancer.

[45]  T. Nandgude,et al.  Formulation of Bilayer Benzydamine HCl Patch Targeted For Gingivitis , 2016, Journal of drug delivery.

[46]  R. Mccullough Actual duration of patient-reported mucositis: Far longer than 2 to 4 weeks and may be avoidable altogether , 2016 .

[47]  P. Minghetti,et al.  A focus on mucoadhesive polymers and their application in buccal dosage forms , 2016 .

[48]  S. Jafari,et al.  Evaluation of different factors affecting antimicrobial properties of chitosan. , 2016, International journal of biological macromolecules.

[49]  M. Balouiri,et al.  Methods for in vitro evaluating antimicrobial activity: A review☆ , 2015, Journal of pharmaceutical analysis.

[50]  G. Rath,et al.  Radiation induced oral mucositis: a review of current literature on prevention and management , 2016, European Archives of Oto-Rhino-Laryngology.

[51]  A. Hebeish,et al.  Novel nanocomposite hydrogel for wound dressing and other medical applications , 2015 .

[52]  V. Ostafe,et al.  Chitosan as a starting material for wound healing applications. , 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[53]  Xuemei M He,et al.  Cr(VI) Removal from Aqueous Solution by Chitosan/Carboxylmethyl Cellulose/Silica Hybrid Membrane , 2015 .

[54]  S. Ribeiro,et al.  Synthesis and Characterization of Methylcellulose Produced from Bacterial Cellulose under Heterogeneous Condition , 2015 .

[55]  Lalduhsanga Pachuau Recent developments in novel drug delivery systems for wound healing , 2015, Expert opinion on drug delivery.

[56]  R. Jayakumar,et al.  Drug loaded bi-layered sponge for wound management in hyperfibrinolytic conditions. , 2015, Journal of materials chemistry. B.

[57]  G. Lima,et al.  Amniotic membrane as a biological dressing for 5-fluoruracil-induced oral mucositis in rats. , 2015, International journal of oral and maxillofacial surgery.

[58]  A. Fernández-Medarde,et al.  Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy. , 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[59]  M. Hiorth,et al.  Advanced drug delivery systems for local treatment of the oral cavity. , 2015, Therapeutic delivery.

[60]  Ching Mien Oh,et al.  Influence of Hydroxypropyl Methylcellulose on Metronidazole Crystallinity in Spray-Congealed Polyethylene Glycol Microparticles and Its Impact with Various Additives on Metronidazole Release , 2015, AAPS PharmSciTech.

[61]  A. C. Jayasuriya,et al.  Current wound healing procedures and potential care. , 2015, Materials science & engineering. C, Materials for biological applications.

[62]  K. Chennazhi,et al.  Chitosan-hyaluronic acid/VEGF loaded fibrin nanoparticles composite sponges for enhancing angiogenesis in wounds. , 2015, Colloids and surfaces. B, Biointerfaces.

[63]  R. Nisticò,et al.  Advanced physico-chemical characterization of chitosan by means of TGA coupled on-line with FTIR and GCMS: Thermal degradation and water adsorption capacity , 2015 .

[64]  P. Boonme,et al.  Formulation, Physicochemical Characterization, and In Vitro Study of Chitosan/HPMC Blends-Based Herbal Blended Patches , 2014, AAPS PharmSciTech.

[65]  Rui‐Biao Lin,et al.  Single-crystal X-ray diffraction studies on structural transformations of porous coordination polymers. , 2014, Chemical Society reviews.

[66]  J. Boateng,et al.  Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. , 2014, Journal of pharmaceutical sciences.

[67]  D. Peterson,et al.  Chemotherapy or radiation-induced oral mucositis. , 2014, Dental clinics of North America.

[68]  Krishna K. Rao,et al.  Development of Polymeric Blend Microspheres from Chitosan-Hydroxypropylmethyl Cellulose for Controlled Release of an Anti-Cancer Drug , 2013 .

[69]  C. Setty,et al.  Drug Delivery from the Oral Cavity: A Focus on Mucoadhesive Buccal Drug Delivery Systems , 2012, PDA Journal of Pharmaceutical Science and Technology.

[70]  G. Campisi,et al.  Oral local drug delivery and new perspectives in oral drug formulation. , 2012, Oral surgery, oral medicine, oral pathology and oral radiology.

[71]  Shantikumar V. Nair,et al.  Flexible and microporous chitosan hydrogel/nano ZnO composite bandages for wound dressing: in vitro and in vivo evaluation. , 2012, ACS applied materials & interfaces.

[72]  S. Mortazavi,et al.  Development and In-vitro Evaluation of a Contraceptive Vagino-Adhesive Propranolol Hydrochloride Gel , 2012, Iranian journal of pharmaceutical research : IJPR.

[73]  R. Pallela,et al.  Biophysicochemical evaluation of chitosan-hydroxyapatite-marine sponge collagen composite for bone tissue engineering. , 2012, Journal of biomedical materials research. Part A.

[74]  A. Effendy,et al.  The use of modified Masson’s trichrome staining in collagen evaluation in wound healing study , 2012 .

[75]  G. M. Gelfuso,et al.  Enhancing and sustaining the topical ocular delivery of fluconazole using chitosan solution and poloxamer/chitosan in situ forming gel. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[76]  J. Epstein,et al.  Efficacy of topical benzydamine hydrochloride gel on oral mucosal ulcers: an in vivo animal study. , 2011, International journal of oral and maxillofacial surgery.

[77]  R. Sarıkaya,et al.  Genotoxicity of two mouthwash products in the Drosophila Wing-Spot Test. , 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[78]  M. Castillo‐Ortega,et al.  Chitosan composite films: Thermal, structural, mechanical and antifungal properties , 2010 .

[79]  V. H. Sarmento,et al.  A poloxamer/chitosan in situ forming gel with prolonged retention time for ocular delivery. , 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[80]  R. Misra,et al.  Controlled and extended drug release behavior of chitosan-based nanoparticle carrier. , 2010, Acta biomaterialia.

[81]  Yuquan Wei,et al.  Chitosan-Alginate Sponge: Preparation and Application in Curcumin Delivery for Dermal Wound Healing in Rat , 2009, Journal of biomedicine & biotechnology.

[82]  M. Semalty,et al.  Formulation and Characterization of Mucoadhesive Buccal Films of Glipizide , 2008, Indian journal of pharmaceutical sciences.

[83]  Changyou Gao,et al.  Chitosan–hyaluronic acid hybrid film as a novel wound dressing: in vitro and in vivo studies , 2007 .

[84]  A. Garden,et al.  Risk, outcomes, and costs of radiation-induced oral mucositis among patients with head-and-neck malignancies. , 2007, International journal of radiation oncology, biology, physics.

[85]  V. Soldi,et al.  Blends of hydroxypropyl methylcellulose and poly(1-vinylpyrrolidone-co-vinyl acetate) : Miscibility and thermal stability , 2005 .

[86]  E. Espuche,et al.  Hydration mechanism of polysaccharides: A comparative study , 2005 .

[87]  S. Grelier,et al.  Antimicrobial and physicochemical properties of chitosan-HPMC-based films. , 2004, Journal of agricultural and food chemistry.

[88]  N. Senzer,et al.  Benzydamine HCl for prophylaxis of radiation‐induced oral mucositis , 2001, Cancer.

[89]  S. Panomsuk,et al.  A Study of the Hydrophilic Cellulose Matrix: Effect of Drugs on Swelling Properties , 1996 .

[90]  N. Fanaki,et al.  Antimicrobial activity of benzydamine, a non-steroid anti-inflammatory agent. , 1992, Journal of chemotherapy.