Inwardly rectifying potassium channels.

Inwardly rectifying potassium (Kir) channels regulate the resting membrane potential of the cell and thereby modulate the electrical activity of cardiac and neuronal cells, insulin secretion and epithelial K(+) transport. Considerable progress in understanding the molecular structure of Kir channels and the way in which they are regulated by extracellular and intracellular modulators has been made during the past year.

[1]  F. Ashcroft,et al.  Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor , 1997, Nature.

[2]  D. Hilgemann,et al.  Regulation of Cardiac Na+,Ca2+ Exchange and KATP Potassium Channels by PIP2 , 1996, Science.

[3]  J. Slightom,et al.  Cloning and Characterization of Two K+ Inward Rectifier (Kir) 1.1 Potassium Channel Homologs from Human Kidney (Kir1.2 and Kir1.3)* , 1997, The Journal of Biological Chemistry.

[4]  F. Ashcroft,et al.  Molecular determinants of KATP channel inhibition by ATP , 1998, The EMBO journal.

[5]  P. Welling,et al.  Novel Subunit Composition of a Renal Epithelial KATPChannel* , 1998, The Journal of Biological Chemistry.

[6]  A. Karschin,et al.  Mutations in the ROMK gene in antenatal Bartter syndrome are associated with impaired K+ channel function. , 1997, Biochemical and biophysical research communications.

[7]  Frances M. Ashcroft,et al.  Correlating structure and function in ATP-sensitive K+ channels , 1998, Trends in Neurosciences.

[8]  D. Clapham,et al.  A Novel Inward Rectifier K+ Channel with Unique Pore Properties , 1998, Neuron.

[9]  C. Nichols,et al.  Membrane phospholipid control of nucleotide sensitivity of KATP channels. , 1998, Science.

[10]  J. Ruppersberg,et al.  PIP2 and PIP as determinants for ATP inhibition of KATP channels. , 1998, Science.

[11]  C. Nichols,et al.  Control of Rectification and Gating of Cloned KATP Channels by the Kir6.2 Subunit , 1997, The Journal of general physiology.

[12]  R. Schneggenburger,et al.  The Epithelial Inward Rectifier Channel Kir7.1 Displays Unusual K+ Permeation Properties , 1998, The Journal of Neuroscience.

[13]  T. Maeda,et al.  Characterization of G-Protein-Gated K+ Channels Composed of Kir3.2 Subunits in Dopaminergic Neurons of the Substantia Nigra , 1999, The Journal of Neuroscience.

[14]  H. Lester,et al.  RGS proteins reconstitute the rapid gating kinetics of Gβγ-activated inwardly rectifying K+ channels , 1997 .

[15]  B. Chait,et al.  The structure of the potassium channel: molecular basis of K+ conduction and selectivity. , 1998, Science.

[16]  J. Ruppersberg,et al.  pH-dependent Gating of ROMK (Kir1.1) Channels Involves Conformational Changes in Both N and C Termini* , 1998, The Journal of Biological Chemistry.

[17]  F. Ashcroft,et al.  Direct Photoaffinity Labeling of the Kir6.2 Subunit of the ATP-sensitive K+ Channel by 8-Azido-ATP* , 1999, The Journal of Biological Chemistry.

[18]  J. Clement,et al.  Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. , 1995, Science.

[19]  D. Clapham,et al.  Identification of Native Atrial G-protein-regulated Inwardly Rectifying K+ (GIRK4) Channel Homomultimers* , 1998, The Journal of Biological Chemistry.

[20]  J. Miyazaki,et al.  Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[21]  C. Higgins,et al.  The ABC of channel regulation , 1995, Cell.

[22]  A. Karschin,et al.  Kir2.4: A Novel K+ Inward Rectifier Channel Associated with Motoneurons of Cranial Nerve Nuclei , 1998, The Journal of Neuroscience.

[23]  F. Ashcroft,et al.  Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels. , 1998, Diabetes.

[24]  Y. Jan,et al.  Evidence that direct binding of Gβγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation , 1995, Neuron.

[25]  Y. Jan,et al.  Transmembrane Structure of an Inwardly Rectifying Potassium Channel , 1999, Cell.

[26]  F. Ashcroft,et al.  Molecular Analysis of ATP-sensitive K Channel Gating and Implications for Channel Inhibition by ATP , 1998, The Journal of general physiology.

[27]  J. Bryan,et al.  A Family of Sulfonylurea Receptors Determines the Pharmacological Properties of ATP-Sensitive K+ Channels , 1996, Neuron.

[28]  Y. Jan,et al.  A New ER Trafficking Signal Regulates the Subunit Stoichiometry of Plasma Membrane KATP Channels , 1999, Neuron.

[29]  S. John,et al.  Novel Gating Mechanism of Polyamine Block in the Strong Inward Rectifier K Channel Kir2.1 , 1999, The Journal of general physiology.

[30]  H. Lester,et al.  Asymmetrical contributions of subunit pore regions to ion selectivity in an inward rectifier K+ channel. , 1998, Biophysical journal.

[31]  L. Jan,et al.  Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[32]  Zhe Lu,et al.  A novel high-affinity inhibitor for inward-rectifier K+ channels. , 1998, Biochemistry.

[33]  E. Lightner,et al.  Mutation of the pancreatic islet inward rectifier Kir6.2 also leads to familial persistent hyperinsulinemic hypoglycemia of infancy. , 1996, Human molecular genetics.

[34]  K. Kunjilwar,et al.  Association and Stoichiometry of KATP Channel Subunits , 1997, Neuron.

[35]  D. Hilgemann,et al.  Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ , 1998, Nature.

[36]  R. MacKinnon,et al.  Mutations in the K+ channel signature sequence. , 1994, Biophysical journal.

[37]  D. Logothetis,et al.  Activation of the atrial KACh channel by the βγ subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates , 1998 .

[38]  L. Jan,et al.  Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH. , 1996, The EMBO journal.

[39]  C. Nichols,et al.  Inward rectifier potassium channels. , 1997, Annual review of physiology.

[40]  P. Drain,et al.  KATP channel inhibition by ATP requires distinct functional domains of the cytoplasmic C terminus of the pore-forming subunit. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[41]  J. Makielski,et al.  Anionic Phospholipids Activate ATP-sensitive Potassium Channels* , 1997, The Journal of Biological Chemistry.

[42]  G. Giebisch,et al.  Sensitivity of a renal K+ channel (ROMK2) to the inhibitory sulfonylurea compound glibenclamide is enhanced by coexpression with the ATP-binding cassette transporter cystic fibrosis transmembrane regulator. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[43]  F. Ashcroft,et al.  The essential role of the Walker A motifs of SUR1 in K‐ATP channel activation by Mg‐ADP and diazoxide , 1997, The EMBO journal.

[44]  Xinmin Zhang,et al.  Architecture of a K+ Channel Inner Pore Revealed by Stoichiometric Covalent Modification , 1999, Neuron.

[45]  M. Permutt,et al.  Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy. , 1998, Diabetes.

[46]  H. Lester,et al.  The inward rectifier potassium channel family , 1995, Current Opinion in Neurobiology.

[47]  Y. Kubo,et al.  RGS8 accelerates G-protein-mediated modulation of K+currents , 1997, Nature.