Brain infiltration of CD 4 lymphocytes contributes to neurodegeneration in Parkinson ’ s disease model

[1]  S. Appel,et al.  CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS , 2008, Proceedings of the National Academy of Sciences.

[2]  W. Paul,et al.  CD4 T cells: fates, functions, and faults. , 2008, Blood.

[3]  H. Gendelman,et al.  Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice , 2008, PloS one.

[4]  H. Braak,et al.  Assessing fetal nerve cell grafts in Parkinson's disease , 2008, Nature Medicine.

[5]  H. Gendelman,et al.  Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons , 2008, PloS one.

[6]  B. Ritz,et al.  Nonsteroidal anti-inflammatory drugs may protect against Parkinson disease , 2007, Neurology.

[7]  Nathalie Arbour,et al.  Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation , 2007, Nature Medicine.

[8]  P. Carvey,et al.  TNF-α knockout and minocycline treatment attenuates blood–brain barrier leakage in MPTP-treated mice , 2007, Neurobiology of Disease.

[9]  P S Whitton,et al.  Inflammation as a causative factor in the aetiology of Parkinson's disease , 2007, British journal of pharmacology.

[10]  Sylvie Faucher,et al.  Involvement of Interferon-γ in Microglial-Mediated Loss of Dopaminergic Neurons , 2007, The Journal of Neuroscience.

[11]  L. Lefrançois,et al.  Evidence that a significant number of naive T cells enter non‐lymphoid organs as part of a normal migratory pathway , 2006, European journal of immunology.

[12]  B. Engelhardt.  Molecular mechanisms involved in T cell migration across the blood–brain barrier , 2006, Journal of Neural Transmission.

[13]  J. O'Callaghan,et al.  Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor‐α , 2006, Journal of neurochemistry.

[14]  J. Miklossy,et al.  Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys , 2006, Experimental Neurology.

[15]  R. Alon,et al.  Immune cell migration in inflammation: present and future therapeutic targets , 2005, Nature Immunology.

[16]  Eric Jacobs,et al.  Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease , 2005, Annals of neurology.

[17]  R. Uitti,et al.  Alterations of T-lymphocyte populations in Parkinson disease. , 2005, Parkinsonism & related disorders.

[18]  A. Dagher,et al.  Defective Fas expression exacerbates neurotoxicity in a model of Parkinson's disease , 2005, The Journal of experimental medicine.

[19]  J. Bart,et al.  Blood–brain barrier dysfunction in parkinsonian midbrain in vivo , 2005, Annals of neurology.

[20]  H. Gendelman,et al.  Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[21]  J. Feldon,et al.  Genetic ablation of tumor necrosis factor‐alpha (TNF‐α) and pharmacological inhibition of TNF‐synthesis attenuates MPTP toxicity in mouse striatum , 2004, Journal of neurochemistry.

[22]  David S. Park,et al.  Regulation of Dopaminergic Loss by Fas in a 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson's Disease , 2004, The Journal of Neuroscience.

[23]  B. Winblad,et al.  Reduced susceptibility to Kainic Acid-induced excitoxicity in T-cell deficient CD4/CD8(−/−) and middle-aged C57BL/6 mice , 2004, Journal of Neuroimmunology.

[24]  Chulhee Choi,et al.  Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses , 2004, Brain Research Reviews.

[25]  Pasko Rakic,et al.  JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[26]  W. Dauer,et al.  Parkinson's Disease Mechanisms and Models , 2003, Neuron.

[27]  J. Antel,et al.  Vulnerability of Human Neurons to T Cell-Mediated Cytotoxicity1 , 2003, The Journal of Immunology.

[28]  P. Kiener,et al.  Fas (CD95) Induces Proinflammatory Cytokine Responses by Human Monocytes and Monocyte-Derived Macrophages12 , 2003, The Journal of Immunology.

[29]  E. Fikrig,et al.  STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[30]  Andrzej Członkowski,et al.  Immune processes in the pathogenesis of Parkinson's disease - a potential role for microglia and nitric oxide. , 2002, Medical science monitor : international medical journal of experimental and clinical research.

[31]  Masanori Kato,et al.  Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases , 2002, Journal of Neuroimmunology.

[32]  H. Przuntek,et al.  Integrity of the blood–cerebrospinal fluid barrier in early Parkinson's disease , 2001, Neuroscience Letters.

[33]  I. Ferrer,et al.  Fas and Fas‐L expression in Huntington's disease and Parkinson's disease , 2000, Neuropathology and applied neurobiology.

[34]  R. Vos,et al.  Pathological features of cerebral cortical capillaries are doubled in Alzheimer’s disease and Parkinson’s disease , 2000, Acta Neuropathologica.

[35]  V. Sanders,et al.  Exacerbation of Facial Motoneuron Loss after Facial Nerve Transection in Severe Combined Immunodeficient (scid) Mice , 1999, The Journal of Neuroscience.

[36]  E. Hirsch,et al.  FcεRII/CD23 Is Expressed in Parkinson’s Disease and Induces, In Vitro, Production of Nitric Oxide and Tumor Necrosis Factor-α in Glial Cells , 1999, The Journal of Neuroscience.

[37]  A. Członkowska,et al.  The Inflammatory Reaction Following 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Intoxication in Mouse , 1999, Experimental Neurology.

[38]  P. Jenner,et al.  Understanding cell death in parkinson's disease , 1998, Annals of neurology.

[39]  Y Agid,et al.  Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[40]  D. German,et al.  The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. , 1996, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.

[41]  C. Janeway.  Immunobiology: The Immune System in Health and Disease , 1996 .

[42]  E. Lacy,et al.  Th1 CD4+ lymphocytes delete activated macrophages through the Fas/APO-1 antigen pathway. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[43]  S. Ju,et al.  Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[44]  N. Jenkins,et al.  Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand , 1994, Cell.

[45]  T. Springer.  Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm , 1994, Cell.

[46]  L. Klaidman,et al.  Effects of MPTP on the cerebrovasculature , 1991, International Journal of Developmental Neuroscience.

[47]  M. Schilham,et al.  Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4 , 1991, Nature.

[48]  Haruhiko Akiyama,et al.  Rate of cell death in parkinsonism indicates active neuropathological process , 1988, Annals of neurology.

[49]  H. Gendelman,et al.  Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease. , 2007, Journal of leukocyte biology.

[50]  A. Członkowska,et al.  Dynamics of expression of the mRNA for cytokines and inducible nitric synthase in a murine model of the Parkinson's disease. , 2003, Acta neurobiologiae experimentalis.

[51]  S. Hunot,et al.  Neuroinflammatory processes in Parkinson's disease , 2003, Annals of neurology.

[52]  E. Hirsch,et al.  Role of TNF-alpha receptors in mice intoxicated with the parkinsonian toxin MPTP. , 2002, Experimental neurology.

[53]  H. Ichinose,et al.  Changes in cytokines and neurotrophins in Parkinson's disease. , 2000, Journal of neural transmission. Supplementum.

[54]  M. Rudnicki,et al.  Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages. , 1992, Nature.

[55]  T. Mak,et al.  CD8 is needed for development of cytotoxic T cells but not helper T cells. , 1991, Cell.