Thymic epithelial cells require lipid kinase Vps34 for CD4 but not CD8 T cell selection

Thymic epithelial cells present self-peptide/MHC complexes to developing T cells. Here, Postoak et al. describe a novel role for the lipid kinase Vps34 in controlling the production of self-peptides optimized for selection of CD4 but not CD8 T cells.

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