Senescence markers in subcutaneous preadipocytes differ in childhood‐ versus adult‐onset obesity before and after weight loss

The aim of this study was to determine the effect of age of obesity onset on senescence‐related markers in abdominal (AB) and femoral (FEM) subcutaneous adipose tissue (SAT) before and after moderate (~10%) weight loss.

[1]  C. Knibbe,et al.  Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce , 2021, Nature Medicine.

[2]  M. Jensen,et al.  Senescent cells in human adipose tissue: A cross‐sectional study , 2021, Obesity.

[3]  J. Morais,et al.  Sex Affects Regional Variations in Subcutaneous Adipose Tissue T Cells but not Macrophages in Adults with Obesity , 2020, Obesity.

[4]  K. Clément,et al.  Senescence-associated β-galactosidase in subcutaneous adipose tissue associates with altered glycaemic status and truncal fat in severe obesity , 2020, Diabetologia.

[5]  J. Morais,et al.  A reliable, reproducible flow cytometry protocol for immune cell quantification in human adipose tissue. , 2020, Analytical biochemistry.

[6]  J. Morais,et al.  Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity. , 2020, Endocrinology.

[7]  J. Manson,et al.  Association of Weight Loss Between Early Adulthood and Midlife With All-Cause Mortality Risk in the US , 2020, JAMA network open.

[8]  L. Lerman,et al.  Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells , 2020, Frontiers in Cell and Developmental Biology.

[9]  J. Morais,et al.  Obesity and ageing: Two sides of the same coin , 2020, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[10]  K. Saunders,et al.  Weight History in Clinical Practice: The State of the Science and Future Directions , 2020, Obesity.

[11]  U. Smith,et al.  Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells , 2019, Nature Communications.

[12]  B. Drossel,et al.  PCNA-Mediated Degradation of p21 Coordinates the DNA Damage Response and Cell Cycle Regulation in Individual Cells. , 2019, Cell reports.

[13]  D. Jacobs,et al.  Duration and Stability of Metabolically Healthy Obesity Over 30 Years , 2018, International Journal of Obesity.

[14]  M. Tschöp,et al.  Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function , 2017, Nature Communications.

[15]  J. Hokanson,et al.  The ratio of pericardial to subcutaneous adipose tissues is associated with insulin resistance , 2017, Obesity.

[16]  Chris Bakal,et al.  DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression , 2017, Nature Communications.

[17]  Elizabeth A. Jensen,et al.  Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice , 2016, Nutrition and healthy aging.

[18]  Zepeng Zhang,et al.  Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells , 2016, Nature Communications.

[19]  P. Froguel,et al.  DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes , 2016, Diabetes.

[20]  L. de las Fuentes,et al.  Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity. , 2016, Cell metabolism.

[21]  M. Jensen,et al.  Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue , 2016, Diabetes.

[22]  M. Jensen,et al.  Targeting senescent cells enhances adipogenesis and metabolic function in old age , 2015, eLife.

[23]  M. Jensen,et al.  JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age , 2015, Proceedings of the National Academy of Sciences.

[24]  M. Stumvoll,et al.  Telomere length differences between subcutaneous and visceral adipose tissue in humans. , 2015, Biochemical and biophysical research communications.

[25]  Alex D. Herbert,et al.  FindFoci: A Focus Detection Algorithm with Automated Parameter Training That Closely Matches Human Assignments, Reduces Human Inconsistencies and Increases Speed of Analysis , 2014, PloS one.

[26]  M. Blüher,et al.  Evidence of Early Alterations in Adipose Tissue Biology and Function and Its Association With Obesity-Related Inflammation and Insulin Resistance in Children , 2014, Diabetes.

[27]  Daniël Lakens,et al.  Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs , 2013, Front. Psychol..

[28]  R. Viner,et al.  Overweight in Childhood, Adolescence and Adulthood and Cardiovascular Risk in Later Life: Pooled Analysis of Three British Birth Cohorts , 2013, PloS one.

[29]  Johannes E. Schindelin,et al.  Fiji: an open-source platform for biological-image analysis , 2012, Nature Methods.

[30]  J. Campisi,et al.  DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion , 2011, Journal of Cell Science.

[31]  M. Jensen,et al.  Fat tissue, aging, and cellular senescence , 2010, Aging cell.

[32]  M. Marquès,et al.  Adipose Tissue Endothelial Cells From Obese Human Subjects: Differences Among Depots in Angiogenic, Metabolic, and Inflammatory Gene Expression and Cellular Senescence , 2010, Diabetes.

[33]  Masayuki Orimo,et al.  A crucial role for adipose tissue p53 in the regulation of insulin resistance , 2009, Nature Medicine.

[34]  A. S. Singh,et al.  Tracking of childhood overweight into adulthood: a systematic review of the literature , 2008, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[35]  A. Lichtenstein,et al.  Moderate weight loss: a self-directed protocol for women. , 2008, Canadian journal of dietetic practice and research : a publication of Dietitians of Canada = Revue canadienne de la pratique et de la recherche en dietetique : une publication des Dietetistes du Canada.

[36]  R. Verdun,et al.  The DNA Damage Machinery and Homologous Recombination Pathway Act Consecutively to Protect Human Telomeres , 2006, Cell.

[37]  Corby K. Martin,et al.  Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. , 2006, JAMA.

[38]  D. DiMaio,et al.  Senescence‐associated β‐galactosidase is lysosomal β‐galactosidase , 2006 .

[39]  D. DiMaio,et al.  Senescence-associated beta-galactosidase is lysosomal beta-galactosidase. , 2006, Aging cell.

[40]  A. Madan,et al.  Transforming growth factor beta1 release by human adipose tissue is enhanced in obesity. , 2005, Metabolism: clinical and experimental.

[41]  M. Jensen,et al.  Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots. , 2005, American journal of physiology. Endocrinology and metabolism.

[42]  John M Sedivy,et al.  Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). , 2004, Molecular cell.

[43]  N. Carter,et al.  A DNA damage checkpoint response in telomere-initiated senescence , 2003, Nature.

[44]  Stephen C. West,et al.  Molecular views of recombination proteins and their control , 2003, Nature Reviews Molecular Cell Biology.

[45]  R. J. Boik.  Contrasts and Effect Sizes in Behavioral Research: A Correlational Approach , 2001 .

[46]  M. Kenward,et al.  Small sample inference for fixed effects from restricted maximum likelihood. , 1997, Biometrics.

[47]  D G Altman,et al.  Statistics Notes: The use of transformation when comparing two means , 1996, BMJ.

[48]  Xiao-Fan Wang,et al.  Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[49]  M D Jensen,et al.  Measurement of abdominal and visceral fat with computed tomography and dual-energy x-ray absorptiometry. , 1995, The American journal of clinical nutrition.

[50]  M. Collins,et al.  Body figure perceptions and preferences among preadolescent children , 1991 .

[51]  A. Stunkard,et al.  Use of the Danish Adoption Register for the study of obesity and thinness. , 1983, Research publications - Association for Research in Nervous and Mental Disease.

[52]  M. Karvonen,et al.  The effects of training on heart rate; a longitudinal study. , 1957, Annales medicinae experimentalis et biologiae Fenniae.