The ISIS-model allows a better understanding for managers and regional authorities of the ongoing change towards the information based “New Economy” and towards an information society. New policies have become possible for generating sustainable regional growth, sustainable in both, regional economic success and ecological health. The ISIS-model is build for evaluating policies for sustainability in this holistic setting, as advanced by Naveh and Lieberman 1994. The model also allows to test possible coalitions between the population of a region, the regional economy and the regional nature environment. In this context the model explains and evaluates crucial links between the sectors Information Potential as a main driving power, know-how, New Key People which are behind the present transformation, mature economy, New Economy, land use and quality of life. The model is based on results and applications from several projects, in particular in the EU-project MOSES (Modelling Sustainable Regional Evolution in the Information Society) with partners from Israel, Great Britain, Spain, Austria. Switzerland and Germany .