Reverse thermal gelation of aliphatically modified biodegradable triblock copolymers.

A simple aliphatic modification demonstrated how to turn a water-soluble biodegradable triblock copolymer synthesized from PEG, L-lactide, and epsilon-caprolactone into a thermoreversible polymer of which aqueous solution underwent a sol-to-gel phase transition upon a mild temperature rise. Thermogelling behavior of the aliphatically modified polymer was dependent on the degree of aliphatic modification and polymer concentration. When the polymer solutions were subcutaneously injected into rats, immediate depot formation has been observed. The polymeric gel depots have lasted for two weeks in vivo. This aliphatically modified thermogelling polymer can find applications in drug delivery.

[1]  S. Choi,et al.  Thermoreversible gelation of poly(ethylene oxide) biodegradable polyester block copolymers. II , 1999 .

[2]  Y. Bae,et al.  Thermogelling Poly(caprolactone-b-ethylene glycol-b-caprolactone) Aqueous Solutions , 2005 .

[3]  Y. Bae,et al.  Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[4]  Young Moo Lee,et al.  A Thermosensitive Poly(organophosphazene) Gel , 2002 .

[5]  Sung Wan Kim,et al.  Biodegradable block copolymers as injectable drug-delivery systems , 1997, Nature.

[6]  Pradeep Tyagi,et al.  Controlled Gene Delivery System Based on Thermosensitive Biodegradable Hydrogel , 2003, Pharmaceutical Research.

[7]  Suna Choi,et al.  Control of Blood Glucose by Novel GLP-1 Delivery Using Biodegradable Triblock Copolymer of PLGA-PEG-PLGA in Type 2 Diabetic Rats , 2004, Pharmaceutical Research.

[8]  Anna Gutowska,et al.  Sol-gel transition temperature of PLGA-g-PEG aqueous solutions. , 2002, Biomacromolecules.

[9]  A. Mikos,et al.  Synthesis and characterization of triblock copolymers of methoxy poly(ethylene glycol) and poly(propylene fumarate). , 2002, Biomacromolecules.

[10]  A. Mitra,et al.  Development of a novel formulation containing poly(d,l-lactide-co-glycolide) microspheres dispersed in PLGA-PEG-PLGA gel for sustained delivery of ganciclovir. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[11]  Sung Wan Kim,et al.  Thermoreversible Gelation of PEG−PLGA−PEG Triblock Copolymer Aqueous Solutions , 1999 .

[12]  Anna Gutowska,et al.  Biodegradable thermoreversible gelling PLGA-g-PEG copolymers , 2001 .

[13]  Anna Gutowska,et al.  Thermogelling Biodegradable Polymers with Hydrophilic Backbones: PEG-g-PLGA , 2000 .

[14]  Sung Wan Kim,et al.  Caprolactonic poloxamer analog: PEG-PCL-PEG. , 2005, Biomacromolecules.

[15]  Sung Wan Kim,et al.  Poly(D,L-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly (D,L-lactic acid-co-glycolic acid) triblock copolymer and thermoreversible phase transition in water. , 2002, Journal of biomedical materials research.

[16]  S. W. Kim,et al.  Biodegradable Triblock Copolymer Microspheres Based on Thermosensitive Sol-Gel Transition , 2004, Pharmaceutical Research.

[17]  J. Mestecky,et al.  Biodegradable block copolymers for delivery of proteins and water-insoluble drugs. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[18]  Sung Wan Kim,et al.  Novel Thermoreversible Gelation of Biodegradable PLGA-block-PEO-block-PLGA Triblock Copolymers in Aqueous Solution , 2001 .