The overlap of the EBA and the MT/V5 cluster

The extrastriate body area (EBA) is located in the lateral occipito-temporal cortex, in the vicinity of the motion-sensitive region hMT/V5+. To investigate the relationship of EBA to the recently mapped retinotopic areas of the MT/V5 cluster (Kolster et al., 2010), we evaluated the proportion of voxels responsive to the presentation of static human bodies (EBA voxels) in each of the four areas of the MT/V5 cluster and neighboring LO and phPIT areas. We evaluated this proportion as both a function of the number of voxels in a given area and the total number of voxels in a broader lateral occipito-temporal cortex (LOTC) ROI. We observed that each of the four retinotopic areas of the MT/V5 cluster includes substantial fractions of EBA voxels, in contrast to the LO and phPIT areas. This proportion was slightly greater in the right than left hemisphere, and did not depend on the control condition. While most EBA voxels in MT/V5 were only body-sensitive, those in pMSTv and pFST were also motion-sensitive. The main locus of EBA voxels outside the MT/V5 cluster was in the LOTC cortex just rostral to the MT/V5 cluster. Although this region contained more EBA voxels than the MT/V5 cluster, the proportion as a function of areal size was much reduced compared to the MT/V5 cluster. Our results show that EBA is not a single cortical area as EBA voxels are located in all four areas of the MT/V5 cluster, and that body-sensitivity is a key feature of the MT/V5 cluster, in keeping with its exquisite sensitivity to observed actions of others.

[1]  N. Kanwisher,et al.  Domain specificity in visual cortex. , 2006, Cerebral cortex.

[2]  Svetlana S. Georgieva,et al.  The Processing of Three-Dimensional Shape from Disparity in the Human Brain , 2009, The Journal of Neuroscience.

[3]  G. Orban,et al.  Charting the Lower Superior Temporal Region, a New Motion-Sensitive Region in Monkey Superior Temporal Sulcus , 2006, The Journal of Neuroscience.

[4]  Christopher C. Pack,et al.  temporal neurons Speed and direction selectivity of macaque middle , 2002 .

[5]  Marc Jeannerod,et al.  Visual and action cues contribute to the self–other distinction , 2004, Nature Neuroscience.

[6]  T. Albright.  Direction and orientation selectivity of neurons in visual area MT of the macaque. , 1984, Journal of neurophysiology.

[7]  G. Orban,et al.  Motion-responsive regions of the human brain , 1999, Experimental Brain Research.

[8]  A. Dale,et al.  Functional Analysis of V3A and Related Areas in Human Visual Cortex , 1997, The Journal of Neuroscience.

[9]  Alison J. Wiggett,et al.  Patterns of fMRI Activity Dissociate Overlapping Functional Brain Areas that Respond to Biological Motion , 2006, Neuron.

[10]  David J. Heeger,et al.  Pattern-motion responses in human visual cortex , 2002, Nature Neuroscience.

[11]  G. Orban,et al.  The Retinotopic Organization of the Human Middle Temporal Area MT/V5 and Its Cortical Neighbors , 2010, The Journal of Neuroscience.

[12]  N. Kanwisher,et al.  Cortical Regions Involved in Perceiving Object Shape , 2000, The Journal of Neuroscience.

[13]  Benjamin D. Singer,et al.  Retinotopic Organization of Human Ventral Visual Cortex , 2009, The Journal of Neuroscience.

[14]  C. Gross,et al.  Neural representations of faces and body parts in macaque and human cortex: a comparative FMRI study. , 2009, Journal of neurophysiology.

[15]  E. Zohary,et al.  Topographic Representation of the Human Body in the Occipitotemporal Cortex , 2010, Neuron.

[16]  G. Rees,et al.  Normal form from biological motion despite impaired ventral stream function , 2011, Neuropsychologia.

[17]  M. Sereno,et al.  Retinotopy and Attention in Human Occipital, Temporal, Parietal, and Frontal Cortex , 2008 .

[18]  Leslie G. Ungerleider,et al.  Scene-Selective Cortical Regions in Human and Nonhuman Primates , 2011, The Journal of Neuroscience.

[19]  P. Downing,et al.  Selectivity for the human body in the fusiform gyrus. , 2005, Journal of neurophysiology.

[20]  Alison J. Wiggett,et al.  Dissociation of extrastriate body and biological-motion selective areas by manipulation of visual-motor congruency , 2009, Neuropsychologia.

[21]  Kalanit Grill-Spector,et al.  Not one extrastriate body area: Using anatomical landmarks, hMT+, and visual field maps to parcellate limb-selective activations in human lateral occipitotemporal cortex , 2011, NeuroImage.

[22]  W. Singer,et al.  Cortical responses to self and others , 2009, Human brain mapping.

[23]  J W Belliveau,et al.  Borders of multiple visual areas in humans revealed by functional magnetic resonance imaging. , 1995, Science.

[24]  D. Heeger,et al.  Two Retinotopic Visual Areas in Human Lateral Occipital Cortex , 2006, The Journal of Neuroscience.

[25]  J. Kaas,et al.  A representation of the visual field in the caudal third of the middle tempral gyrus of the owl monkey (Aotus trivirgatus). , 1971, Brain research.

[26]  N. Kanwisher,et al.  Location and spatial profile of category‐specific regions in human extrastriate cortex , 2006, Human brain mapping.

[27]  G. Orban,et al.  Human Functional Magnetic Resonance Imaging Reveals Separation and Integration of Shape and Motion Cues in Biological Motion Processing , 2009, The Journal of Neuroscience.

[28]  Guy A. Orban,et al.  Integration of shape and motion cues in biological motion processing in the monkey STS , 2012, NeuroImage.

[29]  Hannah E. Smithson,et al.  Modulation of the face- and body-selective visual regions by the motion and emotion of point-light face and body stimuli , 2012, NeuroImage.

[30]  E. DeYoe,et al.  Mapping striate and extrastriate visual areas in human cerebral cortex. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[31]  Nancy Kanwisher,et al.  A cortical representation of the local visual environment , 1998, Nature.

[32]  Anders M. Dale,et al.  Cortical Surface-Based Analysis I. Segmentation and Surface Reconstruction , 1999, NeuroImage.

[33]  Alison J. Wiggett,et al.  fMRI-adaptation studies of viewpoint tuning in the extrastriate and fusiform body areas. , 2010, Journal of neurophysiology.

[34]  A. Dale,et al.  Cortical Surface-Based Analysis II: Inflation, Flattening, and a Surface-Based Coordinate System , 1999, NeuroImage.

[35]  P. Downing,et al.  The neural basis of visual body perception , 2007, Nature Reviews Neuroscience.

[36]  S. Zeki.  Functional organization of a visual area in the posterior bank of the superior temporal sulcus of the rhesus monkey , 1974, The Journal of physiology.

[37]  B. Wandell,et al.  Visual field maps, population receptive field sizes, and visual field coverage in the human MT+ complex. , 2009, Journal of neurophysiology.

[38]  Wim Vanduffel,et al.  Stimulus representations in body-selective regions of the macaque cortex assessed with event-related fMRI , 2012, NeuroImage.

[39]  Andrew N. Meltzoff,et al.  Neural circuits involved in imitation and perspective-taking , 2006, NeuroImage.

[40]  M. D’Esposito,et al.  An Area within Human Ventral Cortex Sensitive to “Building” Stimuli Evidence and Implications , 1998, Neuron.

[41]  N. Kanwisher,et al.  The Fusiform Face Area: A Module in Human Extrastriate Cortex Specialized for Face Perception , 1997, The Journal of Neuroscience.

[42]  Z. Kourtzi,et al.  Multivoxel Pattern Selectivity for Perceptually Relevant Binocular Disparities in the Human Brain , 2008, The Journal of Neuroscience.

[43]  N. Kanwisher,et al.  The Human Body , 2001 .

[44]  M. Corbetta,et al.  Extrastriate body area in human occipital cortex responds to the performance of motor actions , 2004, Nature Neuroscience.

[45]  Doris Y. Tsao,et al.  Faces and objects in macaque cerebral cortex , 2003, Nature Neuroscience.

[46]  D. Ts'o,et al.  Functional organization of primate visual cortex revealed by high resolution optical imaging. , 1990, Science.

[47]  Alison J. Wiggett,et al.  Behavioral / Systems / Cognitive Functional Magnetic Resonance Imaging Investigation of Overlapping Lateral Occipitotemporal Activations Using Multi-Voxel Pattern Analysis , 2006 .