Activation of the MEK5/ERK5 cascade is responsible for biliary dysgenesis in a rat model of Caroli's disease.

[1]  Y. Nakanuma,et al.  Isolation, culture and characterization of biliary epithelial cells from different anatomical levels of the intrahepatic and extrahepatic biliary tree from a mouse. , 2008, Liver.

[2]  T. Terada,et al.  Caroli's disease in congenital hepatic fibrosis and infantile polycystic disease. , 2008, Liver.

[3]  R. Schnellmann,et al.  Requirement of the epidermal growth factor receptor in renal epithelial cell proliferation and migration. , 2004, American journal of physiology. Renal physiology.

[4]  N. LaRusso,et al.  Defects in cholangiocyte fibrocystin expression and ciliary structure in the PCK rat. , 2003, Gastroenterology.

[5]  S. Hewitt,et al.  Effect of interleukin 1 receptor antagonist gene transduction on human melanoma xenografts in nude mice. , 2003, Cancer research.

[6]  D. Neal,et al.  MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion , 2003, Oncogene.

[7]  R. Maser,et al.  Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease. , 2003, Kidney international.

[8]  V. Gattone,et al.  Multiorgan mRNA misexpression in murine autosomal recessive polycystic kidney disease. , 2002, Kidney international.

[9]  E. Avner,et al.  PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats. , 2002, American journal of human genetics.

[10]  B. Magenheimer,et al.  Oxidant stress and reduced antioxidant enzyme protection in polycystic kidney disease. , 2002, Journal of the American Society of Nephrology : JASN.

[11]  Vicente E. Torres,et al.  The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein , 2002, Nature Genetics.

[12]  A. Berchuck,et al.  Progestin-induced apoptosis in the Macaque ovarian epithelium: differential regulation of transforming growth factor-beta. , 2002, Journal of the National Cancer Institute.

[13]  J. Pollard.  Tumour-stromal interactions: Transforming growth factor-beta isoforms and hepatocyte growth factor/scatter factor in mammary gland ductal morphogenesis , 2001, Breast Cancer Research.

[14]  Y. Nakanuma,et al.  Polycystic kidney rat is a novel animal model of Caroli's disease associated with congenital hepatic fibrosis. , 2001, The American journal of pathology.

[15]  D. Schuppan,et al.  Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis. , 2001, The American journal of pathology.

[16]  H. Lodish,et al.  Critical Role of Smads and AP-1 Complex in Transforming Growth Factor-β-dependent Apoptosis* , 2000, The Journal of Biological Chemistry.

[17]  G. Bauer.  Reactive oxygen and nitrogen species: efficient, selective, and interactive signals during intercellular induction of apoptosis. , 2000, Anticancer research.

[18]  J. Calvet,et al.  J Am Soc Nephrol 11: 1837–1847, 2000 Development of Autosomal Recessive Polycystic Kidney Disease in BALB/c-cpk/cpk Mice , 2022 .

[19]  V. Y. Wong,et al.  Apoptosis in polycystic kidney disease: involvement of caspases. , 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

[20]  M. Cooper,et al.  Endothelin receptor antagonism ameliorates mast cell infiltration, vascular hypertrophy, and epidermal growth factor expression in experimental diabetes. , 2000, Circulation research.

[21]  D. Brooks,et al.  Epithelin mRNA expression in polycystic kidney disease , 1999, Peptides.

[22]  A. Strosberg,et al.  Role of transforming growth factor β type II receptor in hepatic fibrosis: Studies of human chronic hepatitis C and experimental fibrosis in rats , 1999, Hepatology.

[23]  E. Avner,et al.  New insights into the molecular pathophysiology of polycystic kidney disease. , 1999, Kidney international.

[24]  J. Calvet,et al.  Matrix metalloproteinase-2 in a murine model of infantile-type polycystic kidney disease. , 1999, Journal of the American Society of Nephrology : JASN.

[25]  Shuang Huang,et al.  Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor , 1998, Nature.

[26]  N. Gretz,et al.  Increased epithelial cell proliferation and abnormal extracellular matrix in rat polycystic kidney disease. , 1998, Journal of the American Society of Nephrology : JASN.

[27]  E. Avner,et al.  Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease. , 1998, The Journal of clinical investigation.

[28]  P. Desmond,et al.  Sequential increases in the intrahepatic expression of epidermal growth factor, basic fibroblast growth factor, and transforming growth factor β in a bile duct ligated rat model of cirrhosis , 1997, Hepatology.

[29]  F. Levi-Schaffer,et al.  The human mast cell. , 1997, The Journal of allergy and clinical immunology.

[30]  G. Lindemann,et al.  Renal expression of a transforming growth factor-alpha transgene accelerates the progression of inherited, slowly progressive polycystic kidney disease in the mouse. , 1996, The Journal of laboratory and clinical medicine.

[31]  B. Cowley,et al.  Abnormal expression of epidermal growth factor and sulfated glycoprotein SGP-2 messenger RNA in a rat model of autosomal dominant polycystic kidney disease. , 1995, Journal of the American Society of Nephrology : JASN.

[32]  E. Avner,et al.  Biliary Epithelial Cells from Mice with Congenital Polycystic Kidney Disease Are Hyperresponsive to Epidermal Growth Factor , 1995, Pediatric Research.

[33]  V. Gattone,et al.  Epidermal growth factor ameliorates autosomal recessive polycystic kidney disease in mice. , 1995, Developmental biology.

[34]  D. Cui,et al.  Epidermal growth factor secreted from the salivary gland is necessary for liver regeneration. , 1995, The American journal of physiology.

[35]  E. Avner,et al.  Epidermal growth factor receptor expression is abnormal in murine polycystic kidney. , 1995, Kidney international.

[36]  M. Soley,et al.  Relationship between epidermal growth factor in mouse submandibular glands, plasma, and bile: effects of catecholamines and fasting. , 1994, Endocrinology.

[37]  M. Raff,et al.  Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor. , 1993, Development.

[38]  P. Wilson,et al.  Autocrine, endocrine and paracrine regulation of growth abnormalities in autosomal dominant polycystic kidney disease. , 1993, European journal of cell biology.

[39]  V. Desmet.  Congenital diseases of intrahepatic bile ducts: Variations on the theme “ductal plate malformation” , 1992, Hepatology.

[40]  M. Rocco,et al.  Attenuated expression of epithelial cell adhesion molecules in murine polycystic kidney disease. , 1992, The American journal of physiology.

[41]  J. Calvet,et al.  Localization of overexpressed c-myc mRNA in polycystic kidneys of the cpk mouse. , 1992, Kidney international.

[42]  H. Stein,et al.  Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease. , 1991, The American journal of pathology.

[43]  J. Calvet,et al.  Elevated proto-oncogene expression in polycystic kidneys of the C57BL/6J (cpk) mouse. , 1991, Journal of the American Society of Nephrology : JASN.

[44]  N. LaRusso,et al.  Morphologic demonstration of receptor-mediated endocytosis of epidermal growth factor by isolated bile duct epithelial cells. , 1990, Gastroenterology.

[45]  J. Calvet,et al.  Defective epidermal growth factor gene expression in mice with polycystic kidney disease. , 1990, Developmental biology.

[46]  K. Bauer,et al.  Cyst-derived cells do not exhibit accelerated growth or features of transformed cells in vitro. , 1989, Kidney international.

[47]  A. Evan,et al.  Autosomal recessive polycystic kidney disease in a murine model. A gross and microscopic description. , 1988, Laboratory investigation; a journal of technical methods and pathology.

[48]  G. Laurie,et al.  Altered mRNA expression of basement membrane components in a murine model of polycystic kidney disease. , 1988, Laboratory investigation; a journal of technical methods and pathology.

[49]  E. Avner,et al.  Renal dysfunction but not cystic change is ameliorated by neonatal epidermal growth factor in bpk mice , 2001, Pediatric Nephrology.

[50]  V. Torres,et al.  The pck rat: a new model that resembles human autosomal dominant polycystic kidney and liver disease. , 2001, Kidney international.

[51]  H. Takahashi,et al.  Characterization of a novel polycystic kidney rat model with accompanying polycystic liver. , 2000, Experimental animals.

[52]  Y Chen,et al.  Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor. , 2000, Kidney international.

[53]  J. Baselga,et al.  ZD1839 ('Iressa') as an anticancer agent. , 2000, Drugs.

[54]  Y. Tomino,et al.  Altered extracellular matrix component gene expression in murine polycystic kidney. , 1995, Renal physiology and biochemistry.

[55]  Y. Tomino,et al.  Growth factor gene expression in kidney of murine polycystic kidney disease. , 1993, Journal of the American Society of Nephrology : JASN.

[56]  W. Dippold,et al.  Expression of differentiation antigens and growth-related genes in normal kidney, autosomal dominant polycystic kidney disease, and renal cell carcinoma. , 1992, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[57]  P. Klotman,et al.  Epidermal growth factor (EGF) expression in the congenital polycystic mouse kidney. , 1991, Kidney international.