Resistance of tumor cells to chemo- and radiotherapy modulated by the three-dimensional architecture of solid tumors and spheroids.

[1]  W. Dukelow,et al.  Effects of a DNA‐specific fluorochrome, Hoechst 33258, on mouse sperm motility and fertilizing capacity , 2009, Andrologia.

[2]  E. Sham,et al.  Repopulation characteristics and cell kinetic parameters resulting from multi-fraction irradiation of xenograft tumors in SCID mice. , 1999, International journal of radiation oncology, biology, physics.

[3]  A. Oloumi,et al.  Cell fusion studies to examine the mechanism for etoposide resistance in Chinese hamster V79 spheroids. , 1998, Experimental cell research.

[4]  J. Hescheler,et al.  Doxorubicin distribution in multicellular prostate cancer spheroids evaluated by confocal laser scanning microscopy and the "optical probe technique". , 1998, Cytometry.

[5]  C. Naus,et al.  Radiation response of connexin43-transfected cells in relation to the "contact effect". , 1997, Experimental cell research.

[6]  F. Kiechle,et al.  Hoechst 33342-induced apoptosis in BC3H-1 myocytes. , 1997, Annals of clinical and laboratory science.

[7]  Rakesh K. Jain,et al.  Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation , 1997, Nature Medicine.

[8]  W. Patton,et al.  Analysis of the flow cytometer stain Hoechst 33342 on human spermatozoa. , 1996, Molecular human reproduction.

[9]  K. Hicks,et al.  Multicellular membranes as an in vitro model for extravascular diffusion in tumours. , 1996, The British journal of cancer. Supplement.

[10]  J. Rasey,et al.  Growth and radiation response of cells grown in macroporous gelatin microcarriers (CultiSpher-G). , 1996, The British journal of cancer. Supplement.

[11]  P. Venugopal,et al.  Regrowth resistance in cancer: why has it been largely ignored? , 1995, Cell proliferation.

[12]  M. Grever,et al.  Growth and chemotherapeutic response of cells in a hollow-fiber in vitro solid tumor model. , 1994, Journal of the National Cancer Institute.

[13]  J. Barrett,et al.  Gap junction function and cancer. , 1993, Cancer research.

[14]  B. Teicher,et al.  Acquired multicellular-mediated resistance to alkylating agents in cancer. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[15]  Durand.  Cell Kinetics and Repopulation During Multifraction Irradiation of Spheroids: Implications for Clinical Radiotherapy. , 1993, Seminars in radiation oncology.

[16]  H. H. Evans,et al.  Cell killing and DNA damage by etoposide in Chinese hamster V79 monolayers and spheroids: influence of growth kinetics, growth environment and DNA packaging. , 1993, British Journal of Cancer.

[17]  P. Olive.  DNA organization affects cellular radiosensitivity and detection of initial DNA strand breaks. , 1992, International journal of radiation biology.

[18]  R. Knüchel,et al.  Importance of tyrosine phosphatases in the effects of cell‐cell contact and microenvironments on EGF‐stimulated tyrosine phosphorylation , 1992, Journal of cellular physiology.

[19]  P. Olive,et al.  Radiation-induced DNA unwinding is influenced by cell shape and trypsin. , 1992, Radiation research.

[20]  J. Moore,et al.  MECHANISMS BEHIND THE RESISTANCE OF SPHEROIDS TO PHOTODYNAMIC TREATMENT: A FLOW CYTOMETRY STUDY , 1992, Photochemistry and photobiology.

[21]  R K Jain,et al.  Therapeutic implications of tumor physiology , 1991, Current opinion in oncology.

[22]  C. Lange,et al.  Serum, trypsin, and cell shape but not cell-to-cell contact influence the X-ray sensitivity of Chinese hamster V79 cells in monolayers and in spheroids. , 1991, Radiation research.

[23]  M. Smerdon,et al.  DNA repair and the role of chromatin structure. , 1991, Current opinion in cell biology.

[24]  J. Hendry,et al.  The lower radiosensitivity of mouse kidney cells irradiated in vivo than in vitro: a cell contact effect phenomenon. , 1991, International journal of radiation oncology, biology, physics.

[25]  Avri Ben-Ze've.  Animal cell shape changes and gene expression , 1991 .

[26]  S. Vanderbyl,et al.  Resistance to DNA denaturation in irradiated Chinese hamster V79 fibroblasts is linked to cell shape. , 1991, Experimental cell research.

[27]  R. Durand.  Keynote address: the influence of microenvironmental factors on the activity of radiation and drugs. , 1991, International journal of radiation oncology, biology, physics.

[28]  M. Trotter,et al.  Effect of vascular marker Hoechst 33342 on tumour perfusion and cardiovascular function in the mouse. , 1990, British Journal of Cancer.

[29]  P. Smith,et al.  Reduced nuclear binding of a DNA minor groove ligand (Hoechst 33342) and its impact on cytotoxicity in drug resistant murine cell lines. , 1990, British Journal of Cancer.

[30]  R. E. Durand,et al.  Cisplatin and CCNU synergism in spheroid cell subpopulations. , 1990, British Journal of Cancer.

[31]  H. Yamasaki.  Gap junctional communication and carcinogenesis , 1990 .

[32]  H. Yamasaki,et al.  Gap junctional intercellular communication and carcinogenesis. , 1990, Carcinogenesis.

[33]  T. Tenforde,et al.  Host cell cytotoxicity, cellular repopulation dynamics, and phase-specific cell survival in X-irradiated rat rhabdomyosarcoma tumors. , 1990, Radiation research.

[34]  R. Durand.  Invited review Multicell spheroids as a model for cell kinetic studies , 1990, Cell and tissue kinetics.

[35]  R. Hill,et al.  Radiation sensitivity of tumour cells stained in vitro or in vivo with the bisbenzimide fluorochrome Hoechst 33342. , 1989, British Journal of Cancer.

[36]  J. Carlsson,et al.  Tumour spheroid technology in cancer therapy research. , 1989, European journal of cancer & clinical oncology.

[37]  C. West,et al.  Size-dependent resistance of human tumour spheroids to photodynamic treatment. , 1989, British Journal of Cancer.

[38]  R. Durand.  Distribution and activity of antineoplastic drugs in a tumor model. , 1989, Journal of the National Cancer Institute.

[39]  P. Dijkwel,et al.  Matrix attachment regions are positioned near replication initiation sites, genes, and an interamplicon junction in the amplified dihydrofolate reductase domain of Chinese hamster ovary cells , 1988, Molecular and cellular biology.

[40]  H. Yamasaki,et al.  Further evidence for the involvement of gap-junctional intercellular communication in induction and maintenance of transformed foci in BALB/c 3T3 cells. , 1988, Cancer research.

[41]  R. Sutherland.  Cell and environment interactions in tumor microregions: the multicell spheroid model. , 1988, Science.

[42]  A. C. Begg,et al.  Validation of the fluorescent dye Hoechst 33342 as a vascular space marker in tumours. , 1988, British Journal of Cancer.

[43]  P C Hanawalt,et al.  Heterogeneous DNA damage and repair in the mammalian genome. , 1987, Cancer research.

[44]  P. Olive,et al.  Characterization of a carbocyanine derivative as a fluorescent penetration probe. , 1987, Cytometry.

[45]  D. Dexter,et al.  Artificial capillary culture studies of human tumor cell growth, differentiation, and marker production. , 1987, Journal of the National Cancer Institute.

[46]  E. Alpen,et al.  Radiation-induced division delay in 9L spheroid versus monolayer cells. , 1987, Radiation research.

[47]  G. Nicolson,et al.  Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression. , 1987, Cancer research.

[48]  D. Chaplin,et al.  Intermittent blood flow in a murine tumor: radiobiological effects. , 1987, Cancer research.

[49]  P. Keng,et al.  Cell cycle specific toxicity of the Hoechst 33342 stain in untreated or irradiated murine tumor cells. , 1986, Cancer research.

[50]  R. Durand.  Chemosensitivity testing in V79 spheroids: drug delivery and cellular microenvironment. , 1986, Journal of the National Cancer Institute.

[51]  R. Durand.  Use of a cell sorter for assays of cell clonogenicity. , 1986, Cancer research.

[52]  N. Bleehen,et al.  Cell-cell contact affects cellular sensitivity to hyperthermia. , 1985, British Journal of Cancer.

[53]  D. Chaplin,et al.  Pharmacokinetics, binding and distribution of Hoechst 33342 in spheroids and murine tumours. , 1985, British Journal of Cancer.

[54]  T. Kwok,et al.  The relationship between tumour geometry and the response of tumour cells to cytotoxic drugs — An in vitro study using EMT6 multicellular spheroids , 1985, International journal of cancer.

[55]  M. Melamed,et al.  Denaturation and condensation of DNA in situ induced by acridine orange in relation to chromatin changes during growth and differentiation of Friend erythroleukemia cells. , 1985, Cytometry.

[56]  D. Chaplin,et al.  Cell selection from a murine tumour using the fluorescent probe Hoechst 33342. , 1985, British Journal of Cancer.

[57]  R. Sutherland,et al.  Increased thermoresistance developed during growth of small multicellular spheroids , 1985, Journal of cellular physiology.

[58]  P. Smith,et al.  Modification of the radiation sensitivity of human tumour cells by a bis-benzimidazole derivative. , 1984, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[59]  N. Oleinick,et al.  Hypersensitivity of DNA in transcriptionally active chromatin to ionizing radiation. , 1982, Biochimica et biophysica acta.

[60]  J. Fried,et al.  Effects of Hoechst 33342 on survival and growth of two tumor cell lines and on hematopoietically normal bone marrow cells. , 1982, Cytometry.

[61]  R. Durand.  Use of Hoechst 33342 for cell selection from multicell systems. , 1982, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[62]  P. Olive,et al.  Cytotoxicity, Mutagenicity and DNA damage by Hoechst 33342. , 1982, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[63]  R. Durand.  Flow cytometry studies of intracellular adriamycin in multicell spheroids in vitro. , 1981, Cancer research.

[64]  P. Olive,et al.  Flow cytometry studies of intracellular adriamycin in single cells in vitro. , 1981, Cancer research.

[65]  R. Sutherland,et al.  Influences of growth conditions and cell-cell contact on responses of tumor cells to ultrasound. , 1981, Radiation research.

[66]  R. Mulcahy,et al.  The survival of thyroid cells: in vivo irradiation and in situ repair. , 1980, Radiation research.

[67]  R. Weichselbaum,et al.  Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy. , 1980, Cancer research.

[68]  Sheldon Penman,et al.  Protein synthesis requires cell-surface contact while nuclear events respond to cell shape in anchorage-dependent fibroblasts , 1980, Cell.

[69]  R. Ganapathi,et al.  Laser flow cytometry and cancer chemotherapy: detection of intracellular anthracyclines by flow cytometry. , 1979, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[70]  R. Sutherland,et al.  Resistance to adriamycin in multicellular spheroids. , 1979, International journal of radiation oncology, biology, physics.

[71]  R. Hill,et al.  Cell cycle distribution of chronically hypoxic cells and determination of the clonogenic potential of cells accumulated in G2 + M phases after irradiation of a solid tumor in vivo. , 1979, Cancer research.

[72]  P. Olive,et al.  Radiation-induced DNA damage in V79 spheroids and monolayers. , 1979, Radiation research.

[73]  R. Durand.  Effects of hyperthermia on the cycling, noncycling, and hypoxic cells of irradiated and unirradiated multicell spheroids. , 1978, Radiation research.

[74]  J. Folkman,et al.  Role of cell shape in growth control , 1978, Nature.

[75]  J. Yuhas,et al.  A simplified method for production and growth of multicellular tumor spheroids. , 1977, Cancer research.

[76]  J. Carlsson,et al.  A proliferation gradient in three‐dimensional colonies of cultured human glioma cells , 1977, International journal of cancer.

[77]  T. Jovin,et al.  Analysis and sorting of living cells according to deoxyribonucleic acid content. , 1977, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[78]  R E Durand,et al.  CELL CYCLE KINETICS IN AN IN VITRO TUMOR MODEL , 1976, Cell and tissue kinetics.

[79]  R. Durand.  Isolation of cell subpopulations from in vitro tumor models according to sedimentation velocity. , 1975, Cancer research.

[80]  R. Sutherland,et al.  Growth and radiation survival characteristics of V79-171b Chinese hamster cells: a possible influence of intercellular contact. , 1973, Radiation research.

[81]  P. Cook.  Hypothesis on Differentiation and the Inheritance of Gene Superstructure , 1973, Nature.

[82]  R. Sutherland,et al.  Effects of intercellular contact on repair of radiation damage. , 1972, Experimental cell research.

[83]  Inch Wr,et al.  Growth of nodular carcinomas in rodents compared with multi-cell spheroids in tissue culture. , 1970 .

[84]  R. Huebner,et al.  Colonial growth in agar of cells derived from adenovirus-induced hamster tumors. , 1967, Journal of the National Cancer Institute.

[85]  A. Moscona,et al.  Aggregation of embryonic cells in a serum-free medium and its inhibition at suboptimal temperatures. , 1966, Experimental cell research.

[86]  M. Mendelsohn,et al.  Autoradiographic analysis of cell proliferation in spontaneous breast cancer of C3H mouse. I. Typical cell cycle and timing of DNA synthesis. , 1960, Journal of the National Cancer Institute.

[87]  L. H. Gray,et al.  The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy , 1955, British Journal of Cancer.

[88]  W. V. Mayneord.  On a Law of Growth of Jensen's Rat Sarcoma , 1932 .

[89]  K. Clow,et al.  Multilayers of cells growing on a permeable support. An in vitro tumour model. , 1997, Acta oncologica.

[90]  R. Durand,et al.  Contribution of transient blood flow to tumour hypoxia in mice. , 1995, Acta oncologica.

[91]  R. Durand.  Contributions of flow cytometry to studies with multicell spheroids. , 1994, Methods in cell biology.

[92]  P. Olive,et al.  Evaluation of bioreductive drugs in multicell spheroids. , 1992, International journal of radiation oncology, biology, physics.

[93]  H. H. Evans,et al.  Etoposide sensitivity and topoisomerase II activity in Chinese hamster V79 monolayers and small spheroids. , 1991, International journal of radiation biology.

[94]  T. Chou,et al.  Synergism and antagonism in chemotherapy , 1991 .

[95]  R K Jain,et al.  Haemodynamic and transport barriers to the treatment of solid tumours. , 1991, International journal of radiation biology.

[96]  D. Chaplin,et al.  Cell sorting with Hoechst or carbocyanine dyes as perfusion probes in spheroids and tumors. , 1990, Methods in cell biology.

[97]  S. Vanderbyl,et al.  Tumor resistance to therapy: a genetic or kinetic problem? , 1989, Cancer communications.

[98]  P. Olive.  Distribution, oxygenation, and clonogenicity of macrophages in a murine tumor. , 1989, Cancer communications.

[99]  K. Nilsson,et al.  Microcarrier cell culture. , 1988, Biotechnology & genetic engineering reviews.

[100]  D. Kerr,et al.  In vitro chemosensitivity testing using the multicellular tumor spheroid model. , 1987, Cancer drug delivery.

[101]  T. Nederman.  Effects of vinblastine and 5-fluorouracil on human glioma and thyroid cancer cell monolayers and spheroids. , 1984, Cancer Research.

[102]  P. Olive,et al.  Uptake and mutagenicity of AF‐2 in chinese hamster V‐79 spheroids under aerobic and hypoxic conditions , 1981 .

[103]  B. Warren,et al.  The effect of intercellular contact on the radiation sensitivity of KHT sarcoma cells. , 1979, Radiation research.

[104]  M. Gould,et al.  Evidence for a unique in situ component of the repair of radiation damage. , 1979, Radiation research.

[105]  Durand Re,et al.  Radiation response of multicell spheroids--an in vitro tumour model. , 1976 .

[106]  R. Berezney,et al.  The nuclear protein matrix: isolation, structure, and functions. , 1976, Advances in enzyme regulation.

[107]  H. Madoc‐Jones,et al.  Studies on the radiobiology of a rat sarcoma treated in situ and assayed in vitro. , 1973, European journal of cancer.

[108]  R. Sutherland,et al.  Growth of multicell spheroids in tissue culture as a model of nodular carcinomas. , 1971, Journal of the National Cancer Institute.

[109]  R. Sutherland,et al.  A multi-component radiation survival curve using an in vitro tumour model. , 1970, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[110]  L. Tolmach,et al.  Variations in several responses of HeLa cells to x-irradiation during the division cycle. , 1963, Biophysical journal.

[111]  C. Winsor,et al.  The Gompertz Curve as a Growth Curve. , 1932, Proceedings of the National Academy of Sciences of the United States of America.