Progressive resistance training in head and neck cancer patients undergoing concomitant chemoradiotherapy

Patients with head and neck squamous cell carcinoma undergoing concomitant chemoradiotherapy (CCRT) frequently experience weight loss, especially loss of lean body mass (LBM), and reduced functional performance. This study investigated whether a 12‐week hospital‐based progressive resistance training (PRT) program during CCRT is feasible in the clinical setting before planning initiation of a larger randomized study which is the long‐term goal.

[1]  J. Gehl,et al.  Voluntary Exercise Prevents Cisplatin-Induced Muscle Wasting during Chemotherapy in Mice , 2014, PloS one.

[2]  Howard Zisser,et al.  Physical activity and exercise. , 2014, Diabetes technology & therapeutics.

[3]  A. Garden,et al.  Association of Body Composition With Survival and Locoregional Control of Radiotherapy-Treated Head and Neck Squamous Cell Carcinoma. , 2016, JAMA oncology.

[4]  J. Overgaard,et al.  Feasibility and efficacy of progressive resistance training and dietary supplements in radiotherapy treated head and neck cancer patients – the DAHANCA 25A study , 2013, Acta oncologica.

[5]  P. Aagaard,et al.  Effects of strength training on muscle fiber types and size; consequences for athletes training for high‐intensity sport , 2010, Scandinavian journal of medicine & science in sports.

[6]  E. Ibrahim,et al.  Physical activity and survival after breast cancer diagnosis: meta-analysis of published studies , 2011, Medical oncology.

[7]  A. Vissink,et al.  Changes in nutritional status and dietary intake during and after head and neck cancer treatment , 2011, Head & neck.

[8]  A. D. Di Palma,et al.  Influence of weight loss on outcomes in patients with head and neck cancer undergoing concomitant chemoradiotherapy , 2008, Head & neck.

[9]  J. Overgaard,et al.  Lean body mass and muscle function in head and neck cancer patients and healthy individuals – results from the DAHANCA 25 study , 2013, Acta oncologica.

[10]  S. Jolly,et al.  Maintaining physical activity during head and neck cancer treatment: Results of a pilot controlled trial , 2016, Head & neck.

[11]  S. Kjaer,et al.  A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, 2000–2010: The largest registry‐based study to date , 2015, International journal of cancer.

[12]  L. Bastholt,et al.  A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. , 1998, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[13]  J. Giese-Davis,et al.  Patient‐reported outcomes, body composition, and nutrition status in patients with head and neck cancer: Results from an exploratory randomized controlled exercise trial , 2016, Cancer.

[14]  K. Courneya,et al.  Physical activity correlates and barriers in head and neck cancer patients , 2007, Supportive Care in Cancer.

[15]  김은주.  노인 통증사정을 위한 한국어 판 Short-form McGill Pain Questionnaire [SF-MPQ]의 신뢰도와 타당도 , 2004 .

[16]  D. Rietveld,et al.  Critical weight loss is a major prognostic indicator for disease-specific survival in patients with head and neck cancer receiving radiotherapy , 2013, British Journal of Cancer.

[17]  E. Gazzano,et al.  The pentose phosphate pathway: an antioxidant defense and a crossroad in tumor cell fate. , 2012, Free radical biology & medicine.

[18]  Brad J. Schoenfeld,et al.  Effects of Resistance Training Frequency on Measures of Muscle Hypertrophy: A Systematic Review and Meta-Analysis , 2016, Sports Medicine.

[19]  Position Stand.  American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. , 2009, Medicine and science in sports and exercise.

[20]  M. Mann,et al.  MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification , 2008, Nature Biotechnology.

[21]  B. Murphy,et al.  Changes in body mass, energy balance, physical function, and inflammatory state in patients with locally advanced head and neck cancer treated with concurrent chemoradiation after low‐dose induction chemotherapy , 2007, Head & neck.

[22]  Dympna Gallagher,et al.  Assessment methods in human body composition , 2008, Current opinion in clinical nutrition and metabolic care.

[23]  K. Courneya,et al.  Physical activity and quality of life in head and neck cancer survivors , 2006, Supportive Care in Cancer.

[24]  L. Jones,et al.  A framework for prescription in exercise-oncology research† , 2015, Journal of cachexia, sarcopenia and muscle.

[25]  C. Leemans,et al.  More Than 10% Weight Loss in Head and Neck Cancer Patients During Radiotherapy Is Independently Associated with Deterioration in Quality of Life , 2013, Nutrition and cancer.

[26]  J. Gehl,et al.  Progressive resistance training in head and neck cancer patients during concomitant chemoradiotherapy -- design of the DAHANCA 31 randomized trial , 2017, BMC Cancer.

[27]  S. Azen,et al.  Reliability of maximal voluntary muscle strength and power testing in older men. , 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

[28]  Robert U Newton,et al.  American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. , 2011, Medicine and science in sports and exercise.

[29]  A. Villa,et al.  Toxicities associated with head and neck cancer treatment and oncology-related clinical trials. , 2016, Current problems in cancer.

[30]  B. Saltin,et al.  Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases , 2015, Scandinavian journal of medicine & science in sports.

[31]  D. Osoba,et al.  The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. , 1993, Journal of the National Cancer Institute.

[32]  M. Vidyasagar,et al.  Effect of exercise training on functional capacity & quality of life in head & neck cancer patients receiving chemoradiotherapy , 2013, The Indian journal of medical research.

[33]  K. Schmitz,et al.  Cancer, physical activity, and exercise. , 2012, Comprehensive Physiology.

[34]  Matthias Mann,et al.  Combination of FASP and StageTip-based fractionation allows in-depth analysis of the hippocampal membrane proteome. , 2009, Journal of proteome research.

[35]  B. Zackrisson,et al.  Weight loss in patients with head and neck cancer during and after conventional and accelerated radiotherapy , 2012, Acta oncologica.

[36]  J. Wiśniewski,et al.  Absolute quantitative profiling of the key metabolic pathways in slow and fast skeletal muscle. , 2015, Journal of proteome research.

[37]  J. Meyerhardt,et al.  Association between physical activity and mortality in colorectal cancer: A meta‐analysis of prospective cohort studies , 2013, International journal of cancer.

[38]  S. Jolly,et al.  Characterization of changes in total body composition for patients with head and neck cancer undergoing chemoradiotherapy using dual‐energy x‐ray absorptiometry , 2013, Head & neck.

[39]  J. Bernier,et al.  Predictors of severe late radiotherapy-related toxicity after hyperfractionated radiotherapy with or without concomitant cisplatin in locally advanced head and neck cancer. Secondary retrospective analysis of a randomized phase III trial (SAKK 10/94). , 2012, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[40]  I. Nookaew,et al.  Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution. , 2016, Cell metabolism.

[41]  K. Courneya,et al.  Pilot, randomized trial of resistance exercise during radiation therapy for head and neck cancer , 2013, Head & neck.

[42]  Anurag K. Singh,et al.  Pretreatment weight status and weight loss among head and neck cancer patients receiving definitive concurrent chemoradiation therapy: implications for nutrition integrated treatment pathways , 2013, Supportive Care in Cancer.

[43]  Esther Kim,et al.  Human papillomavirus and rising oropharyngeal cancer incidence in the United States. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[44]  J. Christensen,et al.  Effects of Exercise on Tumor Physiology and Metabolism , 2015, Cancer journal.

[45]  A. Fortin,et al.  Predictors of severe acute and late toxicities in patients with localized head-and-neck cancer treated with radiation therapy. , 2012, International journal of radiation oncology, biology, physics.

[46]  D. Frankenfield,et al.  Bias and accuracy of resting metabolic rate equations in non-obese and obese adults. , 2013, Clinical nutrition.