Acid ceramidase controls apoptosis and increases autophagy in human melanoma cells treated with doxorubicin

[1]  D. Piomelli,et al.  Ablation of Acid Ceramidase Impairs Autophagy and Mitochondria Activity in Melanoma Cells , 2021, International journal of molecular sciences.

[2]  Mark R. Marten,et al.  Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 , 2021, Autophagy.

[3]  S. Aiba,et al.  Treatment of Advanced Melanoma: Past, Present and Future , 2020, Life.

[4]  A. Pshezhetsky,et al.  Neuropathophysiology of Lysosomal Storage Diseases: Synaptic Dysfunction as a Starting Point for Disease Progression , 2020, Journal of clinical medicine.

[5]  Apoptotic , 2020, Definitions.

[6]  M. Pistello,et al.  Sphingolipid/Ceramide Pathways and Autophagy in the Onset and Progression of Melanoma: Novel Therapeutic Targets and Opportunities , 2019, International journal of molecular sciences.

[7]  M. Romans.  Altered , 2019 .

[8]  Y. Hannun,et al.  Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis[S] , 2018, Journal of Lipid Research.

[9]  Yingmei Zhang,et al.  Life and Death Partners in Post-PCI Restenosis: Apoptosis, Autophagy, and The Cross-talk Between Them. , 2018, Current drug targets.

[10]  B. Nagar,et al.  Structural basis for the activation of acid ceramidase , 2018, Nature Communications.

[11]  J. Jeng,et al.  Lysophosphatidylcholine induces cytotoxicity/apoptosis and IL-8 production of human endothelial cells: Related mechanisms , 2017, Oncotarget.

[12]  Shama P. Mirza,et al.  Acid ceramidase and its inhibitors: a de novo drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency , 2017, Oncotarget.

[13]  A. Ganesan,et al.  Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells , 2017, Scientific Reports.

[14]  T. Loughran,et al.  The emergence of acid ceramidase as a therapeutic target for acute myeloid leukemia , 2017, Expert opinion on therapeutic targets.

[15]  G. Pazour,et al.  Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness , 2017, Scientific Reports.

[16]  L. Ye,et al.  p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation , 2016, Cellular & Molecular Biology Letters.

[17]  A. Bielawska,et al.  Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells , 2016, Oncotarget.

[18]  A. Weeraratna,et al.  Autophagy- An emerging target for melanoma therapy , 2016, F1000Research.

[19]  Y. Hannun,et al.  Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response , 2016, Oncotarget.

[20]  G. E. Atilla‐Gokcumen,et al.  Differential Regulation of Specific Sphingolipids in Colon Cancer Cells during Staurosporine-Induced Apoptosis. , 2015, Chemistry & biology.

[21]  A. Ganesan,et al.  Acid Ceramidase in Melanoma , 2015, The Journal of Biological Chemistry.

[22]  Wei Li,et al.  Co-delivery of doxorubicin and PEGylated C16-ceramide by nanoliposomes for enhanced therapy against multidrug resistance. , 2015, Nanomedicine.

[23]  J. Stiban,et al.  Very long chain ceramides interfere with C16-ceramide-induced channel formation: A plausible mechanism for regulating the initiation of intrinsic apoptosis. , 2015, Biochimica et biophysica acta.

[24]  S. Grant,et al.  Targeting SQSTM1/p62 Induces Cargo Loading Failure and Converts Autophagy to Apoptosis via NBK/Bik , 2014, Molecular and Cellular Biology.

[25]  N. Ferreirós,et al.  The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS. , 2013, The international journal of biochemistry & cell biology.

[26]  Ying Sun,et al.  Altered autophagy in the mice with a deficiency of saposin A and saposin B , 2013, Autophagy.

[27]  P. O'dwyer,et al.  Autophagy Inhibition Sensitizes Colon Cancer Cells to Antiangiogenic and Cytotoxic Therapy , 2013, Clinical Cancer Research.

[28]  Maria Paola Costi,et al.  Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity , 2013, Scientific Reports.

[29]  E. Bertini,et al.  Spinal muscular atrophy associated with progressive myoclonic epilepsy is caused by mutations in ASAH1. , 2012, American journal of human genetics.

[30]  D. Klionsky,et al.  Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) , 2012, Autophagy.

[31]  T. Hornemann,et al.  C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages , 2012, Cell Death and Disease.

[32]  S. Milstien,et al.  Autophagy Induced by Deficiency of Sphingosine-1-phosphate Phosphohydrolase 1 Is Switched to Apoptosis by Calpain-mediated Autophagy-related Gene 5 (Atg5) Cleavage* , 2011, The Journal of Biological Chemistry.

[33]  C. Bedia,et al.  Acid Ceramidase Expression Modulates the Sensitivity of A375 Melanoma Cells to Dacarbazine* , 2011, The Journal of Biological Chemistry.

[34]  D. D. Rosa,et al.  Pharmacokinetic evaluation of doxorubicin plasma levels in normal and overweight patients with breast cancer and simulation of dose adjustment by different indexes of body mass. , 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[35]  J. Norris,et al.  Autophagy is increased in prostate cancer cells over-expressing acid ceramidase and enhances resistance to C6-ceramide , 2010, Prostate Cancer and Prostatic Diseases.

[36]  N. Mizushima,et al.  Methods in Mammalian Autophagy Research , 2010, Cell.

[37]  Wei Hu,et al.  Alkaline Ceramidase 3 (ACER3) Hydrolyzes Unsaturated Long-chain Ceramides, and Its Down-regulation Inhibits Both Cell Proliferation and Apoptosis* , 2010, The Journal of Biological Chemistry.

[38]  H. Ackermann,et al.  Ceramide synthases and ceramide levels are increased in breast cancer tissue. , 2009, Carcinogenesis.

[39]  A. Kimchi,et al.  Life and death partners: apoptosis, autophagy and the cross-talk between them , 2009, Cell Death and Differentiation.

[40]  A. Bielawska,et al.  Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

[41]  S. Pattingre,et al.  Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy* , 2009, Journal of Biological Chemistry.

[42]  Wei Hu,et al.  Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. , 2008, The Journal of investigative dermatology.

[43]  Yusuf A. Hannun,et al.  Principles of bioactive lipid signalling: lessons from sphingolipids , 2008, Nature Reviews Molecular Cell Biology.

[44]  Guido Kroemer,et al.  Self-eating and self-killing: crosstalk between autophagy and apoptosis , 2007, Nature Reviews Molecular Cell Biology.

[45]  G. Evan,et al.  Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. , 2007, The Journal of clinical investigation.

[46]  S. Milstien,et al.  Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. , 2006, Biochimica et biophysica acta.

[47]  Thomas Schaffner,et al.  Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis , 2006, Nature Cell Biology.

[48]  J. Woodcock.  Sphingosine and ceramide signalling in apoptosis , 2006, IUBMB life.

[49]  A. Bielawska,et al.  Neutral Ceramidase Encoded by the Asah2 Gene Is Essential for the Intestinal Degradation of Sphingolipids* , 2006, Journal of Biological Chemistry.

[50]  Y. Hannun,et al.  The complex life of simple sphingolipids , 2004, EMBO reports.

[51]  Yusuf A. Hannun,et al.  Biologically active sphingolipids in cancer pathogenesis and treatment , 2004, Nature Reviews Cancer.

[52]  R. Kolesnick,et al.  Ceramide synthesis and metabolism as a target for cancer therapy. , 2004, Cancer letters.

[53]  Daniel J Klionsky,et al.  Development by self-digestion: molecular mechanisms and biological functions of autophagy. , 2004, Developmental cell.

[54]  S. Baksh,et al.  Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal , 2003, Cell.

[55]  S. Milstien,et al.  Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells , 2001, Cell Death and Differentiation.

[56]  M. Colombini,et al.  The Lipids C2- and C16-Ceramide Form Large Stable Channels , 2000, The Journal of Biological Chemistry.

[57]  J. Jaffrezou,et al.  Doxorubicin induces slow ceramide accumulation and late apoptosis in cultured adult rat ventricular myocytes. , 1999, Cardiovascular research.

[58]  S. Spiegel,et al.  Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate , 1996, Nature.

[59]  H. Moser,et al.  Stimulation of acid ceramidase activity by saposin D. , 1994, Archives of biochemistry and biophysics.

[60]  H. Moser,et al.  Ceramidase Deficiency in Farber's Disease (Lipogranulomatosis) , 1972, Science.

[61]  K. Maeda,et al.  Global Monitoring of the Mammalian Lipidome by Quantitative Shotgun Lipidomics. , 2017, Methods in molecular biology.

[62]  A. Ganesan,et al.  Acid Ceramidase in Melanoma EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION , 2016 .

[63]  Jing-Jing Fu,et al.  The crosstalk between autophagy and apoptosis , 2014 .

[64]  G. Gores,et al.  Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[65]  S. Grösch,et al.  Chain length-specific properties of ceramides. , 2012, Progress in lipid research.

[66]  D. Bratton.  Neutrophil Clearance: when the party’s over, cleanup begins , 2011 .

[67]  A. Bielawska,et al.  Acid ceramidase inhibition: a novel target for cancer therapy. , 2008, Frontiers in bioscience : a journal and virtual library.

[68]  E. Billy,et al.  Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. , 2006, Cancer research.

[69]  D. Holdstock.  Past, present--and future? , 2005, Medicine, conflict, and survival.