De novo lipogenesis in humans: metabolic and regulatory aspects

[1]  J. Hirsch,et al.  Human fatty acid synthesis is reduced after the substitution of dietary starch for sugar. , 1998, The American journal of clinical nutrition.

[2]  J. Hill,et al.  Fat and Energy Balance , 1997, Annals of the New York Academy of Sciences.

[3]  J. Hirsch,et al.  Fatty acid composition of adipose tissue, an indication of dietary fatty acids, and breast cancer prognosis. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[4]  J. Hill,et al.  Reduced insulin suppression of glucose appearance is related to susceptibility to dietary obesity in rats. , 1997, The American journal of physiology.

[5]  D. Chinkes,et al.  Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. , 1996, The Journal of clinical investigation.

[6]  R. Hammer,et al.  Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. , 1996, The Journal of clinical investigation.

[7]  J Hirsch,et al.  Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet. , 1996, The Journal of clinical investigation.

[8]  L. Sidossis,et al.  Glucose and insulin-induced inhibition of fatty acid oxidation: the glucose-fatty acid cycle reversed. , 1996, The American journal of physiology.

[9]  M. Hellerstein,et al.  Regulation of hepatic de novo lipogenesis in humans. , 1996, Annual review of nutrition.

[10]  E. Jéquier,et al.  Assessment of glucose metabolism in humans with the simultaneous use of indirect calorimetry and tracer techniques. , 2008, Clinical physiology.

[11]  M. Hellerstein Isotopic studies of carbohydrate metabolism in non-insulin-dependent diabetes mellitus , 1995 .

[12]  S. Turner,et al.  Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel selection. , 1995, The Journal of clinical investigation.

[13]  Robert V Farese,et al.  A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine. , 1995, The Journal of clinical investigation.

[14]  J. Proietto,et al.  Impaired glucose tolerance and increased weight gain in transgenic rats overexpressing a non-insulin-responsive phosphoenolpyruvate carboxykinase gene. , 1995, Molecular endocrinology.

[15]  J. Clore,et al.  Loss of hepatic autoregulation after carbohydrate overfeeding in normal man. , 1995, The Journal of clinical investigation.

[16]  M. Hellerstein,et al.  Gluconeogenesis and Intrahepatic Triose Phosphate Flux in Response to Fasting or Substrate Loads. APPLICATION OF THE MASS ISOTOPOMER DISTRIBUTION ANALYSIS TECHNIQUE WITH TESTING OF ASSUMPTIONS AND POTENTIAL PROBLEMS (*) , 1995, The Journal of Biological Chemistry.

[17]  R. Pederson,et al.  Meal frequency influences circulating hormone levels but not lipogenesis rates in humans. , 1995, Metabolism: clinical and experimental.

[18]  N. Benowitz,et al.  Metabolic interactions between surplus dietary energy intake and cigarette smoking or its cessation. , 1994, The American journal of physiology.

[19]  F. Bosch,et al.  Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[20]  D. Schoeller,et al.  Measurement of fractional lipid synthesis using deuterated water (2H2O) and mass isotopomer analysis. , 1994, The American journal of physiology.

[21]  A. Ghosh,et al.  Glycogen storage disease. , 1994, Indian pediatrics.

[22]  J. Girard,et al.  Regulation of lipogenic enzyme gene expression by nutrients and hormones , 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[23]  Rena R Wing,et al.  Caloric Restriction Per Se Is a Significant Factor in Improvements in Glycemic Control and Insulin Sensitivity During Weight Loss in Obese NIDDM Patients , 1994, Diabetes Care.

[24]  J. Gordon,et al.  Genetic and biochemical studies of protein N-myristoylation. , 1994, Annual review of biochemistry.

[25]  M. Hellerstein,et al.  Quantification of menstrual and diurnal periodicities in rates of cholesterol and fat synthesis in humans. , 1993, Journal of lipid research.

[26]  R. Wing,et al.  Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus. , 1993, The Journal of clinical endocrinology and metabolism.

[27]  C. Grunfeld,et al.  Increased de novo hepatic lipogenesis in human immunodeficiency virus infection. , 1993, The Journal of clinical endocrinology and metabolism.

[28]  P. J. Jones,et al.  Measurement of human lipogenesis using deuterium incorporation. , 1993, Journal of lipid research.

[29]  M. Hellerstein,et al.  Mass isotopomer distribution analysis: a technique for measuring biosynthesis and turnover of polymers. , 1992, The American journal of physiology.

[30]  P. Pasquet,et al.  Massive overfeeding and energy balance in men: the Guru Walla model. , 1992, The American journal of clinical nutrition.

[31]  K. Feingold,et al.  Metabolic disturbances and wasting in the acquired immunodeficiency syndrome. , 1992, The New England journal of medicine.

[32]  O. Park,et al.  Effects of recombinant monokines on hepatic pyruvate dehydrogenase, pyruvate dehydrogenase kinase, lipogenesis de novo and plasma triacylglycerols. Abolition by prior fasting. , 1992, The Biochemical journal.

[33]  M. Prentki,et al.  Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion. , 1992, The Journal of biological chemistry.

[34]  O. Park,et al.  Mechanisms of fructose-induced hypertriglyceridaemia in the rat. Activation of hepatic pyruvate dehydrogenase through inhibition of pyruvate dehydrogenase kinase. , 1992, The Biochemical journal.

[35]  E. Ravussin,et al.  Insulin resistance associated with lower rates of weight gain in Pima Indians. , 1991, The Journal of clinical investigation.

[36]  M. Hellerstein,et al.  Sampling the lipogenic hepatic acetyl-CoA pool in vivo in the rat. Comparison of xenobiotic probe to values predicted from isotopomeric distribution in circulating lipids and measurement of lipogenesis and acetyl-CoA dilution. , 1991, The Journal of biological chemistry.

[37]  M. Hellerstein Relationship between precursor enrichment and ratio of excess M2/excess M1 isotopomer frequencies in a secreted polymer. , 1991, The Journal of biological chemistry.

[38]  M. Hellerstein,et al.  Measurement of de novo hepatic lipogenesis in humans using stable isotopes. , 1991, The Journal of clinical investigation.

[39]  G. Gibbons,et al.  Effect of nutritional state on the utilization of fatty acids for hepatitic triacylglycerol synthesis and secretion as very-low-density lipoprotein. , 1991, The Biochemical journal.

[40]  G. Gibbons Assembly and secretion of hepatic very-low-density lipoprotein. , 1990, The Biochemical journal.

[41]  J. Peters,et al.  Changes in blood lipids during six days of overfeeding with medium or long chain triglycerides. , 1990, Journal of lipid research.

[42]  E Jéquier,et al.  Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man. , 1988, The American journal of clinical nutrition.

[43]  M. Elia,et al.  Theory and validity of indirect calorimetry during net lipid synthesis. , 1988, The American journal of clinical nutrition.

[44]  J. Flatt Dietary fat, carbohydrate balance, and weight maintenance: effects of exercise. , 1987, The American journal of clinical nutrition.

[45]  E. Jéquier,et al.  Assessment of energy expenditure and fuel utilization in man. , 1987, Annual review of nutrition.

[46]  H. Kolb,et al.  Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase. , 1986, Biological chemistry Hoppe-Seyler.

[47]  J. Katz,et al.  Determination of gluconeogenesis in vivo with 14C-labeled substrates. , 1985, The American journal of physiology.

[48]  N. Ruderman,et al.  Diabetes as an atherogenic factor. , 1984, Progress in cardiovascular diseases.

[49]  E. Ravussin,et al.  Nutritional influences on lipogenesis and thermogenesis after a carbohydrate meal. , 1984, The American journal of physiology.

[50]  K. Acheson,et al.  Glycogen synthesis versus lipogenesis after a 500 gram carbohydrate meal in man. , 1982, Metabolism: clinical and experimental.

[51]  M. Russek Current status of the hepatostatic theory of food intake control , 1981, Appetite.

[52]  D. Collins Respiratory changes induced by the large glucose loads of total parenteral nutrition , 1980 .

[53]  J. McGarry,et al.  Regulation of hepatic fatty acid oxidation and ketone body production. , 1980, Annual review of biochemistry.

[54]  Sims Ea,et al.  The woodchuck, Marmota monax, as a laboratory animal. , 1979 .

[55]  E. A. Sims,et al.  The woodchuck, Marmota monax, as a laboratory animal. , 1979, Laboratory animal science.

[56]  R. Campbell,et al.  Control of insulin secretion during fasting in man. , 1978, Metabolism: clinical and experimental.

[57]  D. J. Millward,et al.  Protein turnover in mammalian tissues and in the whole body , 1978 .

[58]  D. Vance,et al.  Control mechanisms in the synthesis of saturated fatty acids. , 1977, Annual review of biochemistry.

[59]  N. Grunnet,et al.  Ethanol metabolism and lipid synthesis by isolated liver cells from fed rats. , 1976, Biochimica et biophysica acta.

[60]  H G Hers,et al.  The control of glycogen metabolism in the liver. , 1976, Annual review of biochemistry.

[61]  M. Brown,et al.  Effect of alterations of the specific activity of the intracellular acetyl CoA pool on apparent rates of hepatic cholesterogenesis. , 1974, Journal of lipid research.

[62]  L. Sjöström Fatty acid synthesis de novo in adipose tissue from obese subjects on a hypercaloric high-carbohydrate diet. , 1973, Scandinavian journal of clinical and laboratory investigation.

[63]  J. Stevenson,et al.  Correlation between the effects of several substances on food intake and on the hepatic concentration of reducing sugars. , 1972, Physiology & behavior.

[64]  J. Glennon,et al.  Comparative aspects of lipogenesis in mammalian tissues. , 1971, Metabolism: clinical and experimental.

[65]  G F Cahill,et al.  Starvation in man. , 1970, The New England journal of medicine.

[66]  M. Florkin,et al.  Comprehensive biochemistry. Volume 18. Lipid metabolism. , 1970 .

[67]  E. Gordon,et al.  Fatty acid synthesis in human adipose tissue. , 1969, The Journal of biological chemistry.

[68]  N. Ruderman,et al.  Role of free fatty acids in glucose homeostasis. , 1969, Archives of internal medicine.

[69]  R. Jungas Fatty acid synthesis in adipose tissue incubated in tritiated water. , 1968, Biochemistry.

[70]  C. Lieber,et al.  Role of acetate in the reduction of plasma free fatty acids produced by ethanol in man. , 1968, Journal of lipid research.

[71]  N. Ruderman,et al.  Glucose regulation of hepatic gluconeogenesis. , 1968, The American journal of physiology.

[72]  R. Passmore,et al.  Observations on the respiratory quotients and weight gain of man after eating large quantities of carbohydrate , 1963, British Journal of Nutrition.

[73]  M. Russek Participation of Hepatic Glucoreceptors in the Control of Intake of Food , 1963, Nature.