TECHNIQUES FOR RECOGNITION OF TRANSLATION INITIATION SITES

Correct prediction of the translation initiation site is an important issue in genomic research. In this chapter, an in-depth survey of half a dozen methods for computational recognization of translation initiation sites from mRNA, cDNA, and genomic DNA sequences are given. These methods span two decades of research on this topic, from the perceptron of Stormo et al. in 1982 to the systematic method of explicit feature generation and selection of Wong et al. in 2002.