Treatment planning for hyperthermia with ultrasound phased arrays

Treatment planning for ultrasound phased arrays suggests a strategy for hyperthermia therapy which satisfies therapeutic conditions at the target and spares other sensitive anatomical structures. To predict both desirable and harmful interactions between ultrasound and important structures such as the tumor, bones, and air pockets, a hyperthermia treatment planning system has been developed for ultrasound phased arrays. This collection of treatment planning routines consists of geometric and thermal optimization procedures specific to ultrasound phased arrays, where geometric treatment planning, combined with thermal treatment planning and three-dimensional visualization, provides essential information for the optimization of individual patient treatments. A patient image data set for cancer of the prostate, a difficult target situated in the midst of multiple pelvic bone obstructions, illustrates the geometric treatment planning algorithm and other tools for treatment analysis. The results indicate that the analysis of complex three-dimensional relationships between the applicator, anatomical structures, and incident fields provides an important means of predicting treatment limiting conditions, thereby allowing the hyperthermia applicator to electronically adapt to individual patients and specific sites.

[1]  K. Paulsen,et al.  Finite element computations of specific absorption rates in anatomically conforming full-body models for hyperthermia treatment analysis , 1993, IEEE Transactions on Biomedical Engineering.

[2]  T Inaba,et al.  Quantitative measurements of prostatic blood flow and blood volume by positron emission tomography. , 1992, The Journal of urology.

[3]  K Hynynen,et al.  Hot spots created at skin-air interfaces during ultrasound hyperthermia. , 1990, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[4]  R B Roemer,et al.  Optimization of temperature distributions in scanned, focused ultrasound hyperthermia. , 1992, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[5]  D. Sullivan,et al.  Direct use of CT scans for hyperthermia treatment planning , 1992, IEEE Transactions on Biomedical Engineering.

[6]  C.A. Cain,et al.  Multiple-focus ultrasound phased-array pattern synthesis: optimal driving-signal distributions for hyperthermia , 1989, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[7]  S K Das,et al.  Hyperthermia treatment planning and temperature distribution reconstruction: a case study. , 1996, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[8]  Andrew William Dutton A three-dimensional geometrical patient treatment planning program for scanned focussed ultrasound hyperthermia , 1990 .

[9]  G. R. Lockwood,et al.  A Ray Tracing Method for Calculating the Speed of Sound in a Nonparallel Layered Model Using Pulse Echo Ultrasound , 1989 .

[10]  J. Overgaard The current and potential role of hyperthermia in radiotherapy. , 1989, International journal of radiation oncology, biology, physics.

[11]  S Onitsuka,et al.  Effect of endocrine treatment on prostatic blood flow in patients with prostatic adenocarcinoma. , 1988, The Journal of urology.

[12]  Robert B. Roemer,et al.  A Survey of Computer Simulations of Hyperthermia Treatments , 1984, IEEE Transactions on Biomedical Engineering.

[13]  D. Sullivan,et al.  Stanford 3D hyperthermia treatment planning system. Technical review and clinical summary. , 1993, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[14]  J W Hunt,et al.  A ray tracing method for calculating the speed of sound in a nonparallel layered model using pulse echo ultrasound. , 1989, Ultrasonic imaging.

[15]  W Swindell,et al.  A scanned, focused, multiple transducer ultrasonic system for localized hyperthermia treatments. , 1987, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[16]  K. B. Ocheltree,et al.  Sound field calculation for rectangular sources , 1989, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[17]  K. Hynynen Biophysics and Technology of Ultrasound Hyperthermia , 1990 .

[18]  K. Hynynen,et al.  The effects of curved tissue layers on the power deposition patterns of therapeutic ultrasound beams. , 1994, Medical physics.

[19]  W. Dewey,et al.  Cell biology of hyperthermia and radiation , 1979 .

[20]  C. Cain,et al.  A spherical-section ultrasound phased array applicator for deep localized hyperthermia , 1991, IEEE Transactions on Biomedical Engineering.

[21]  K Hynynen,et al.  Temperature elevation at muscle-bone interface during scanned, focused ultrasound hyperthermia. , 1988, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[22]  D. Kapp,et al.  Noninvasive microwave phased arrays for local hyperthermia: a review. , 1990, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[23]  P. VanBaren,et al.  Dynamic focusing in ultrasound hyperthermia treatments using implantable hydrophone arrays , 1994, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[24]  F Dunn,et al.  Ultrasonic absorption and attenuation in mammalian tissues. , 1979, Ultrasound in medicine & biology.

[25]  K Hynynen,et al.  A comparison of theoretical and experimental ultrasound field distributions in canine muscle tissue in vivo. , 1992, Ultrasound in medicine & biology.

[26]  John W. Strohbehn,et al.  Experience with a Multitransducer Ultrasound System for Localized Hyperthermia of Deep Tissues , 1984, IEEE Transactions on Biomedical Engineering.

[27]  S. Sapareto,et al.  Sequencing of the total course of hyperthermia and irradiation. , 1984, Cancer research.

[28]  J. Hunt Principles of Ultrasound Used for Hyperthermia , 1987 .

[29]  E.S. Ebbini,et al.  Direct computation of ultrasound phased-array driving signals from a specified temperature distribution for hyperthermia , 1992, IEEE Transactions on Biomedical Engineering.

[30]  R L Magin,et al.  Noninvasive microwave phased arrays for local hyperthermia: a review. , 1989, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[31]  Robert J. McGough,et al.  Limits on focused ultrasound for deep hyperthermia , 1994, 1994 Proceedings of IEEE Ultrasonics Symposium.

[32]  Hong Wang,et al.  Phase aberration correction and motion compensation for ultrasonic hyperthermia phased arrays: experimental results , 1994, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.