Targeting DNA topoisomerase II in cancer chemotherapy
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[1] Jason R. Evans,et al. Abstract A174: High‐throughput screening for natural product inhibitors of human tyrosyl‐DNA‐phosphodiesterase (Tdp‐1) , 2009 .
[2] M. J. Neale,et al. Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA. , 2009, Molecular cell.
[3] Joseph Schoepfer,et al. Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue , 2009, BMC Chemical Biology.
[4] M. Tejani,et al. Randomized Phase II Adjuvant Trial of Dose-Dense Docetaxel Before or After Doxorubicin Plus Cyclophosphamide in Axillary Node-Positive Breast Cancer , 2009 .
[5] Junjie Chen,et al. Topoisomerase IIα controls the decatenation checkpoint , 2009, Nature Cell Biology.
[6] L. Chow,et al. A phase I study of bortezomib, etoposide and carboplatin in patients with advanced solid tumors refractory to standard therapy , 2009, Investigational New Drugs.
[7] B. Strukelj,et al. Recent Advances in Protection against Doxorubicin-induced Toxicity , 2008, Technology in cancer research & treatment.
[8] N. Osheroff,et al. The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cells. , 2008, Biochemistry.
[9] K. Nishikawa,et al. NK314, a Topoisomerase II Inhibitor That Specifically Targets the α Isoform* , 2008, Journal of Biological Chemistry.
[10] V. Duronio,et al. An essential role for MCL-1 in ATR-mediated CHK1 phosphorylation. , 2008, Molecular biology of the cell.
[11] W. Richard McCombie,et al. Topoisomerase levels determine chemotherapy response in vitro and in vivo , 2008, Proceedings of the National Academy of Sciences.
[12] M. Boccadoro,et al. Bortezomib, doxorubicin and dexamethasone in advanced multiple myeloma. , 2008, Annals of oncology : official journal of the European Society for Medical Oncology.
[13] S. Powell,et al. Therapeutic exploitation of tumor cell defects in homologous recombination. , 2008, Anti-cancer agents in medicinal chemistry.
[14] W. Shih,et al. Sequential topoisomerase targeting and analysis of mechanisms of resistance to topotecan in patients with acute myelogenous leukemia , 2008, Anti-cancer drugs.
[15] N. Osheroff,et al. Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity. , 2008, Biochemistry.
[16] Xiaohua Wu,et al. Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair* , 2008, Journal of Biological Chemistry.
[17] Hsiang-Chin Chen,et al. Cellular processing pathways contribute to the activation of etoposide-induced DNA damage responses. , 2008, DNA repair.
[18] D. Neuberg,et al. Absence of secondary malignant neoplasms in children with high-risk acute lymphoblastic leukemia treated with dexrazoxane. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[19] Vincenzo Costanzo,et al. Plx1 is required for chromosomal DNA replication under stressful conditions , 2008, The EMBO journal.
[20] H. Koyama,et al. The requirement of Artemis in double-strand break repair depends on the type of DNA damage. , 2008, DNA and cell biology.
[21] T. Onda,et al. NK314, a novel topoisomerase II inhibitor, induces rapid DNA double-strand breaks and exhibits superior antitumor effects against tumors resistant to other topoisomerase II inhibitors. , 2008, Cancer letters.
[22] G. Yanik,et al. Bortezomib as a therapeutic candidate for neuroblastoma. , 2008, Journal of experimental therapeutics & oncology.
[23] M. Savio,et al. Loss of histone H2AX increases sensitivity of immortalized mouse fibroblasts to the topoisomerase II inhibitor etoposide. , 2008, International journal of oncology.
[24] R. Wieler,et al. Late formation and prolonged differentiation of the Moon inferred from W isotopes in lunar metals , 2007, Nature.
[25] J. Berger,et al. Structural basis for gate-DNA recognition and bending by type IIA topoisomerases , 2007, Nature.
[26] K. C. Nitiss,et al. Using Yeast Tools to Dissect the Action of Anticancer Drugs: Mechanisms of Enzyme Inhibition and Cell Killing by Agents Targeting DNA Topoisomerases , 2007 .
[27] R. Ghirlando,et al. Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. , 2007, Molecular cell.
[28] Jiri Bartek,et al. Human CtIP promotes DNA end resection , 2007, Nature.
[29] A. Liberati,et al. Antitumour Activity of Bortezomib-Pegylated Liposomal Doxorubicine Association as Salvage Therapy in Multiple Myeloma Patients. , 2007 .
[30] A. Younes,et al. Safety and Efficacy of Bortezomib Plus ICE (BICE) for the Treatment of Relapsed/Refractory Classical Hodgkin’s Lymphoma. , 2007 .
[31] P. Russell,et al. Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. , 2007, Molecular cell.
[32] L. Constine,et al. In reply [2] , 2007 .
[33] K. Hellmann. Dexrazoxane-associated risk for secondary malignancies in pediatric Hodgkin's disease: a claim without evidence. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[34] Giorgio Minotti,et al. Cardiotoxicity of antitumor drugs , 2007 .
[35] J. Bissler,et al. Replication Protein A is Required for Etoposide-Induced Assembly of MRE11/RAD50/NBS1 Complex Repair Foci , 2007, Cell cycle.
[36] M. Bjornsti,et al. Mutation of a conserved active site residue converts tyrosyl-DNA phosphodiesterase I into a DNA topoisomerase I-dependent poison. , 2007, Journal of molecular biology.
[37] Chao-Po Lin,et al. Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane. , 2007, Cancer research.
[38] N. Osheroff,et al. Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme. , 2007, Biochemistry.
[39] Chao-Po Lin,et al. Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies , 2007, Proceedings of the National Academy of Sciences.
[40] B. Cho,et al. Combination of topotecan and etoposide as a salvage treatment for patients with recurrent small cell lung cancer following irinotecan and platinum first-line chemotherapy , 2007, Cancer Chemotherapy and Pharmacology.
[41] D. Biard,et al. Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones , 2007, Nucleic acids research.
[42] S. Razin,et al. Chemotherapy-related secondary leukemias: A role for DNA repair by error-prone non-homologous end joining in topoisomerase II - Induced chromosomal rearrangements. , 2007, Gene.
[43] D. Biard,et al. Long-term XPC silencing reduces DNA double-strand break repair. , 2007, Cancer research.
[44] M. Highley,et al. Weekly cisplatin with oral etoposide: a well-tolerated and highly effective regimen in relapsed ovarian cancer , 2007, International Journal of Gynecologic Cancer.
[45] L. Constine,et al. Dexrazoxane-associated risk for acute myeloid leukemia/myelodysplastic syndrome and other secondary malignancies in pediatric Hodgkin's disease. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[46] M. van der Burg,et al. Role of Artemis in DSB repair and guarding chromosomal stability following exposure to ionizing radiation at different stages of cell cycle. , 2007, Mutation research.
[47] P. Zou,et al. hMRE11 plays an important role in U937 cellular response to DNA double-strand breaks following etoposide. , 2007, Zhongguo shi yan xue ye xue za zhi.
[48] V. Durbecq,et al. The 17q12-q21 amplicon: Her2 and topoisomerase-IIalpha and their importance to the biology of solid tumours. , 2007, Cancer treatment reviews.
[49] F. Berthold,et al. Topotecan and Etoposide in the Treatment of Relapsed High-risk Neuroblastoma: Results of a Phase 2 Trial , 2007, Journal of pediatric hematology/oncology.
[50] Erica S. Johnson,et al. Small ubiquitin-related modifier pathway is a major determinant of doxorubicin cytotoxicity in Saccharomyces cerevisiae. , 2007, Cancer research.
[51] S. Powell,et al. BRCA1- and BRCA2-deficient cells are sensitive to etoposide-induced DNA double-strand breaks via topoisomerase II. , 2005, Cancer research.
[52] J. Heitman,et al. Yeast as a tool in cancer research , 2007 .
[53] R. Ghirlando,et al. Supplemental Data Sae 2 Is an Endonuclease that Processes Hairpin DNA Cooperatively with the Mre 11 / Rad 50 / Xrs 2 Complex , 2007 .
[54] Chao-Po Lin,et al. A Protease Pathway for the Repair of Topoisomerase II-DNA Covalent Complexes* , 2006, Journal of Biological Chemistry.
[55] E. Arriola,et al. Predictive value of HER-2 and Topoisomerase IIalpha in response to primary doxorubicin in breast cancer. , 2006, European journal of cancer.
[56] S. White,et al. Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[57] B. Jensen. Cardiotoxic consequences of anthracycline-containing therapy in patients with breast cancer. , 2006, Seminars in oncology.
[58] M. Malik,et al. Roles of nonhomologous end-joining pathways in surviving topoisomerase II–mediated DNA damage , 2006, Molecular Cancer Therapeutics.
[59] N. Curtin,et al. Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. , 2006, Cancer research.
[60] T. Merchant,et al. Concomitant administration of vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide for high‐risk sarcomas , 2006, Cancer.
[61] K. Kohn,et al. A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex , 2006, Molecular Cancer Therapeutics.
[62] G. Biamonti,et al. The dispersal of replication proteins after Etoposide treatment requires the cooperation of Nbs1 with the ataxia telangiectasia Rad3-related/Chk1 pathway. , 2006, Cancer research.
[63] Y. Pommier,et al. Repair of topoisomerase I-mediated DNA damage. , 2006, Progress in nucleic acid research and molecular biology.
[64] D. Goodrich,et al. The retinoblastoma tumor suppressor protein is required for efficient processing and repair of trapped topoisomerase II-DNA-cleavable complexes , 2005, Oncogene.
[65] N. Curtin,et al. Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. , 2005, Journal of medicinal chemistry.
[66] M. J. Neale,et al. Endonucleolytic processing of covalent protein-linked DNA double-strand breaks , 2005, Nature.
[67] O. Hyrien,et al. Topoisomerase II–DNA complexes trapped by ICRF‐193 perturb chromatin structure , 2005, EMBO reports.
[68] J. Champoux,et al. SCAN1 mutant Tdp1 accumulates the enzyme–DNA intermediate and causes camptothecin hypersensitivity , 2005, The EMBO journal.
[69] H. Koyama,et al. Evidence for a role of vertebrate Rad52 in the repair of topoisomerase II-mediated DNA damage. , 2005, DNA and cell biology.
[70] C. Deng,et al. Multiple Endonucleases Function to Repair Covalent Topoisomerase I Complexes in Saccharomyces cerevisiae , 2005, Genetics.
[71] M. Segal,et al. DNA topoisomerase II in therapy-related acute promyelocytic leukemia. , 2005, The New England journal of medicine.
[72] C. Koch,et al. Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and γ radiation , 2005, Molecular Cancer Therapeutics.
[73] Y. Pommier,et al. Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery. , 2005, Trends in pharmacological sciences.
[74] N. Osheroff,et al. Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II , 2005, Nucleic acids research.
[75] Xiaofeng Jiang. Random mutagenesis of the B'A' core domain of yeast DNA topoisomerase II and large-scale screens of mutants resistant to the anticancer drug etoposide. , 2005, Biochemical and biophysical research communications.
[76] Y. Pommier,et al. A Mutation in Escherichia coli DNA Gyrase Conferring Quinolone Resistance Results in Sensitivity to Drugs Targeting Eukaryotic Topoisomerase II , 2004, Antimicrobial Agents and Chemotherapy.
[77] R. Margolis,et al. Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase. , 2004, Molecular cell.
[78] M. Tilby,et al. A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. , 2004, Blood.
[79] Yves Pommier,et al. Mechanisms of camptothecin resistance by human topoisomerase I mutations. , 2004, Journal of molecular biology.
[80] H. Koyama,et al. Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage. , 2004, Biochemical and biophysical research communications.
[81] Chunyan Liu,et al. The role of TDP1 from budding yeast in the repair of DNA damage. , 2004, DNA repair.
[82] D. Leach,et al. Repair of DNA covalently linked to protein. , 2004, Molecular cell.
[83] M. Malik,et al. DNA Repair Functions That Control Sensitivity to Topoisomerase-Targeting Drugs , 2004, Eukaryotic Cell.
[84] K. Kreuzer,et al. Mutational alteration of the breakage/resealing subunit of bacteriophage T4 DNA topoisomerase confers resistance to antitumor agent m-AMSA , 1990, Molecular and General Genetics MGG.
[85] E. Estey,et al. Combination of topotecan with cytarabine or etoposide in patients with refractory or relapsed acute myeloid leukemia: Results of a randomized phase I/II study , 2004, Investigational New Drugs.
[86] Stuart L Schreiber,et al. Small molecule modulation of the human chromatid decatenation checkpoint. , 2003, Chemistry & biology.
[87] H. Koyama,et al. Hypersensitivity of Nonhomologous DNA End-joining Mutants to VP-16 and ICRF-193 , 2003, Journal of Biological Chemistry.
[88] J. Berger,et al. Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187 , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[89] D. Leach,et al. Nucleolytic processing of a protein-bound DNA end by the E. coli SbcCD (MR) complex. , 2003, DNA repair.
[90] G. Stark,et al. G2 arrest in response to topoisomerase II inhibitors: the role of p53. , 2003, Cancer research.
[91] S. Howell,et al. Loss of atm sensitises p53-deficient cells to topoisomerase poisons and antimetabolites. , 2003, Annals of oncology : official journal of the European Society for Medical Oncology.
[92] Jaulang Hwang,et al. The topoisomerase IIβ circular clamp arrests transcription and signals a 26S proteasome pathway , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[93] N. Osheroff,et al. A Two-drug Model for Etoposide Action against Human Topoisomerase IIα* , 2003, The Journal of Biological Chemistry.
[94] M. Kastan,et al. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation , 2003, Nature.
[95] K. Drlica,et al. Fluoroquinolones: action and resistance. , 2003, Current topics in medicinal chemistry.
[96] G. Stark,et al. G 2 Arrest in Response to Topoisomerase II Inhibitors : The Role of p 53 1 , 2003 .
[97] Lance Stewart,et al. The mechanism of topoisomerase I poisoning by a camptothecin analog , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[98] T. E. Wilson,et al. Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[99] J. Champoux,et al. The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1. , 2002, Structure.
[100] J. Nitiss,et al. DNA Topoisomerase II as a Target for Cancer Chemotherapy , 2002, Cancer investigation.
[101] D. Eastmond,et al. Catalytic inhibitors of topoisomerase II are DNA‐damaging agents: induction of chromosomal damage by merbarone and ICRF‐187 , 2002, Environmental and molecular mutagenesis.
[102] J. Darbon,et al. Etoposide and adriamycin but not genistein can activate the checkpoint kinase Chk2 independently of ATM/ATR. , 2001, Biochemical and biophysical research communications.
[103] Hanlin Gao,et al. Topoisomerase II Poisoning by ICRF-193* , 2001, The Journal of Biological Chemistry.
[104] Chun-Yuan Ting,et al. 26 S Proteasome-mediated Degradation of Topoisomerase II Cleavable Complexes* , 2001, The Journal of Biological Chemistry.
[105] J. Pouliot,et al. Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae , 2001, Genes to cells : devoted to molecular & cellular mechanisms.
[106] H. Piwnica-Worms,et al. ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1 , 2001, Molecular and Cellular Biology.
[107] J. Dong,et al. A Mutation in Yeast Topoisomerase II That Confers Hypersensitivity to Multiple Classes of Topoisomerase II Poisons* , 2000, The Journal of Biological Chemistry.
[108] N. Osheroff,et al. A Novel Mechanism of Cell Killing by Anti-topoisomerase II Bisdioxopiperazines* , 2000, The Journal of Biological Chemistry.
[109] M. Adamcová,et al. Anthracycline-induced cardiotoxicity. , 2000, Acta medica.
[110] N. Osheroff,et al. Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice. , 2000, Progress in nucleic acid research and molecular biology.
[111] F. Errington,et al. Murine transgenic cells lacking DNA topoisomerase IIbeta are resistant to acridines and mitoxantrone: analysis of cytotoxicity and cleavable complex formation. , 1999, Molecular pharmacology.
[112] J. Pouliot,et al. Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes. , 1999, Science.
[113] Jorma Isola,et al. Characterization of topoisomerase IIα gene amplification and deletion in breast cancer , 1999 .
[114] D. Gewirtz,et al. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. , 1999, Biochemical pharmacology.
[115] N. Osheroff,et al. Binding of etoposide to topoisomerase II in the absence of DNA: decreased affinity as a mechanism of drug resistance. , 1999, Biochemistry.
[116] E. Eisenhauer,et al. Phase I trial of sequential topotecan followed by etoposide in adults with myeloid leukemia: a National Cancer Institute of Canada Clinical Trials Group Study , 1999, Leukemia.
[117] Å. Borg,et al. Characterization of topoisomerase II alpha gene amplification and deletion in breast cancer. , 1999, Genes, chromosomes & cancer.
[118] T. Andoh,et al. Catalytic inhibitors of DNA topoisomerase II. , 1998, Biochimica et biophysica acta.
[119] C. Felix. Secondary leukemias induced by topoisomerase-targeted drugs. , 1998, Biochimica et biophysica acta.
[120] G. Capranico,et al. DNA sequence selectivity of topoisomerases and topoisomerase poisons. , 1998, Biochimica et biophysica acta.
[121] S. Kaufmann. Cell death induced by topoisomerase-targeted drugs: more questions than answers. , 1998, Biochimica et biophysica acta.
[122] N. Osheroff,et al. Merbarone Inhibits the Catalytic Activity of Human Topoisomerase IIα by Blocking DNA Cleavage* , 1998, The Journal of Biological Chemistry.
[123] S. Inoue,et al. Differential etoposide sensitivity of cells deficient in the Ku and DNA-PKcs components of the DNA-dependent protein kinase. , 1998, Carcinogenesis.
[124] W. Kaufmann. Human Topoisomerase II Function, Tyrosine Phosphorylation and Cell Cycle Checkpoints , 1998, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.
[125] T. Naoe,et al. Etoposide-related acute promyelocytic leukemia , 1998, Leukemia.
[126] B. Teicher,et al. Sequence effect of irinotecan (CPT-11) and topoisomerase II inhibitors in vivo , 1998, Cancer Chemotherapy and Pharmacology.
[127] Y. Pommier,et al. Aclacinomycin A stabilizes topoisomerase I covalent complexes. , 1997, Cancer research.
[128] M. Sehested,et al. DNA topoisomerase II rescue by catalytic inhibitors: a new strategy to improve the antitumor selectivity of etoposide. , 1997, Biochemical pharmacology.
[129] S. Prinz,et al. Isolation of COM1, a new gene required to complete meiotic double-strand break-induced recombination in Saccharomyces cerevisiae. , 1997, Genetics.
[130] M. Stanulla,et al. DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis , 1997, Molecular and cellular biology.
[131] J. Lindsley,et al. Type II DNA topoisomerase from Saccharomyces cerevisiae is a stable dimer. , 1997, Biochemistry.
[132] S. Keeney,et al. Meiosis-Specific DNA Double-Strand Breaks Are Catalyzed by Spo11, a Member of a Widely Conserved Protein Family , 1997, Cell.
[133] Junfang Zhou,et al. Using Yeast to Understand Drugs that Target Topoisomerases a , 1996, Annals of the New York Academy of Sciences.
[134] A. Burgin,et al. A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[135] W. T. Beck,et al. Antitopoisomerase drug action and resistance. , 1996, European journal of cancer.
[136] H. Koyama,et al. Effects of DNA topoisomerase inhibitors on nonhomologous and homologous recombination in mammalian cells. , 1996, Mutation research.
[137] J. Berger,et al. Structure and mechanism of DNA topoisomerase II , 1996, Nature.
[138] P. Houghton,et al. Evaluation of irinotecan in combination with 5-fluorouracil or etoposide in xenograft models of colon adenocarcinoma and rhabdomyosarcoma. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.
[139] S. Keeney,et al. Covalent protein-DNA complexes at the 5' strand termini of meiosis-specific double-strand breaks in yeast. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[140] N. Zeleznik-Le,et al. Therapy-related acute leukemia associated with t(11q23) after primary acute myeloid leukemia with t(8;21): a report of two cases [letter] , 1995 .
[141] N. Osheroff,et al. A Mutation in Yeast TOP2 Homologous to a Quinolone-resistant Mutation in Bacteria , 1995, The Journal of Biological Chemistry.
[142] K. Kreuzer,et al. Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[143] J. Wang,et al. Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[144] S. Larsen,et al. Therapy-related myelodysplasia and acute myeloid leukemia. Cytogenetic characteristics of 115 consecutive cases and risk in seven cohorts of patients treated intensively for malignant diseases in the Copenhagen series. , 1993, Leukemia.
[145] R. Brown,et al. Expression of topoisomerase II alpha and beta in an adenocarcinoma cell line carrying amplified topoisomerase II alpha and retinoic acid receptor alpha genes. , 1993, British Journal of Cancer.
[146] I. Roninson,et al. Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[147] A. Harris,et al. Topoisomerase II alpha co-amplification with erbB2 in human primary breast cancer and breast cancer cell lines: relationship to m-AMSA and mitoxantrone sensitivity. , 1993, Oncogene.
[148] G. Wishart,et al. Co-amplification of erbB2, topoisomerase II α and retinoic acid receptor α genes in breast cancer and allelic loss at topoisomerase I on chromosome 20 , 1993 .
[149] G. Wishart,et al. Co-amplification of erbB2, topoisomerase II alpha and retinoic acid receptor alpha genes in breast cancer and allelic loss at topoisomerase I on chromosome 20. , 1993, European journal of cancer.
[150] W. T. Beck,et al. Drug resistance associated with altered DNA topoisomerase II. , 1993, Advances in enzyme regulation.
[151] J. Roca,et al. The capture of a DNA double helix by an ATP-dependent protein clamp: A key step in DNA transport by type II DNA topoisomerases , 1992, Cell.
[152] J. Wang,et al. Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II. , 1992, Cancer research.
[153] M J Ratain,et al. Therapy-related acute myeloid leukemia secondary to inhibitors of topoisomerase II: from the bedside to the target genes. , 1992, Annals of oncology : official journal of the European Society for Medical Oncology.
[154] K. Kohn,et al. Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide. , 1991, Nucleic acids research.
[155] T. Andoh,et al. Inhibition of intracellular topoisomerase II by antitumor bis(2,6-dioxopiperazine) derivatives: mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors. , 1991, Cancer research.
[156] T. Andoh,et al. Inhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperazine) derivatives. , 1991, Cancer research.
[157] N. Osheroff,et al. Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage. , 1991, The Journal of biological chemistry.
[158] K. Kohn,et al. Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin. , 1990, Nucleic acids research.
[159] L. Liu,et al. Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. , 1990, Cancer research.
[160] A. Collins. Topoisomerase II can relax; novobiocin is a mitochondrial poison after all. , 1990, BioEssays : news and reviews in molecular, cellular and developmental biology.
[161] N. Kleckner,et al. A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae , 1990, Cell.
[162] H. Hansen,et al. Antagonistic effect of aclarubicin on the cytotoxicity of etoposide and 4'-(9-acridinylamino)methanesulfon-m-anisidide in human small cell lung cancer cell lines and on topoisomerase II-mediated DNA cleavage. , 1990, Cancer research.
[163] Y. Pommier,et al. Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells. , 1989, Cancer research.
[164] N. Osheroff,et al. Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate. , 1989, Biochemistry.
[165] R. Hertzberg,et al. In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone. , 1989, Cancer research.
[166] L. Liu,et al. DNA topoisomerase poisons as antitumor drugs. , 1989, Annual review of biochemistry.
[167] P. Lawson,et al. Cell line selectivity and DNA breakage properties of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide: role of DNA topoisomerase II. , 1988, European journal of cancer & clinical oncology.
[168] R. Knippers,et al. Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks , 1988, Molecular and cellular biology.
[169] K. Kohn,et al. Topoisomerase II-mediated DNA damage produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide and related acridines in L1210 cells and isolated nuclei: relation to cytotoxicity. , 1988, Cancer research.
[170] K. Kohn,et al. Protein-linked DNA strand breaks produced by etoposide and teniposide in mouse L1210 and human VA-13 and HT-29 cell lines: relationship to cytotoxicity. , 1987, NCI monographs : a publication of the National Cancer Institute.
[171] R. Chalkley,et al. Novobiocin precipitates histones at concentrations normally used to inhibit eukaryotic type II topoisomerase. , 1986, Nucleic acids research.
[172] K. Kohn,et al. Effects of DNA intercalating agents on topoisomerase II induced DNA strand cleavage in isolated mammalian cell nuclei. , 1985, Biochemistry.
[173] L. Liu,et al. Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. , 1984, The Journal of biological chemistry.
[174] L. Liu,et al. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. , 1984, Science.
[175] P. Brown,et al. Energy coupling in DNA gyrase and the mechanism of action of novobiocin. , 1978, Proceedings of the National Academy of Sciences of the United States of America.