PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk

[1]  Murat Cirit,et al.  PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk , 2011, Molecular Systems Biology.

[2]  A. Ougolkov,et al.  Inhibition of glycogen synthase kinase-3. , 2008, Methods in molecular biology.

[3]  Necmettin Yildirim,et al.  β2-Adrenergic Receptor Signaling and Desensitization Elucidated by Quantitative Modeling of Real Time cAMP Dynamics* , 2008, Journal of Biological Chemistry.

[4]  Liang Qiao,et al.  Bistability and Oscillations in the Huang-Ferrell Model of MAPK Signaling , 2007, PLoS Comput. Biol..

[5]  A. Catling,et al.  MEK1 activation by PAK: a novel mechanism. , 2007, Cellular signalling.

[6]  M. Zvelebil,et al.  Exploring the specificity of the PI3K family inhibitor LY294002. , 2007, The Biochemical journal.

[7]  Christopher R. Myers,et al.  Universally Sloppy Parameter Sensitivities in Systems Biology Models , 2007, PLoS Comput. Biol..

[8]  P. Hawkins,et al.  Signalling through Class I PI3Ks in mammalian cells. , 2006, Biochemical Society transactions.

[9]  Ji Luo,et al.  The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism , 2006, Nature Reviews Genetics.

[10]  Boris N Kholodenko,et al.  Scaffolding Protein Grb2-associated Binder 1 Sustains Epidermal Growth Factor-induced Mitogenic and Survival Signaling by Multiple Positive Feedback Loops* , 2006, Journal of Biological Chemistry.

[11]  Robbie Loewith,et al.  A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling , 2006, Cell.

[12]  J. Haugh.  Deterministic model of dermal wound invasion incorporating receptor-mediated signal transduction and spatial gradient sensing. , 2006, Biophysical journal.

[13]  T. Elston,et al.  Bistability, stochasticity, and oscillations in the mitogen-activated protein kinase cascade. , 2006, Biophysical journal.

[14]  B. Kholodenko.  Cell-signalling dynamics in time and space , 2006, Nature Reviews Molecular Cell Biology.

[15]  Annie Z. Tremp.  Malaria: Plasmodium develops in lymph nodes , 2006, Nature Reviews Microbiology.

[16]  S. Sugano,et al.  Centaurin-α1 Is a Phosphatidylinositol 3-Kinase-dependent Activator of ERK1/2 Mitogen-activated Protein Kinases* , 2006, Journal of Biological Chemistry.

[17]  Jason M. Haugh,et al.  Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts , 2005, The Journal of cell biology.

[18]  J. Chernoff,et al.  Role of Group A p21-activated Kinases in Activation of Extracellular-regulated Kinase by Growth Factors* , 2005, Journal of Biological Chemistry.

[19]  Ronald N Germain,et al.  Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses , 2005, PLoS biology.

[20]  R. Iyengar,et al.  Toward predictive models of mammalian cells. , 2005, Annual review of biophysics and biomolecular structure.

[21]  Takashi Tsuruo,et al.  Involvement of 3-Phosphoinositide-dependent Protein Kinase-1 in the MEK/MAPK Signal Transduction Pathway* , 2004, Journal of Biological Chemistry.

[22]  Shinpei Katou,et al.  植物のMAP kinase phosphataseはカルモジュリンと結合する , 2004 .

[23]  B. Kholodenko,et al.  Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades , 2004, The Journal of cell biology.

[24]  Chang Shin Park,et al.  Kinetic Analysis of Platelet-derived Growth Factor Receptor/Phosphoinositide 3-Kinase/Akt Signaling in Fibroblasts* , 2003, Journal of Biological Chemistry.

[25]  K. S. Brown,et al.  Statistical mechanical approaches to models with many poorly known parameters. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[26]  R. Wetzker,et al.  Serine 338 Phosphorylation Is Dispensable for Activation of c-Raf1* , 2003, The Journal of Biological Chemistry.

[27]  Katherine C. Chen,et al.  Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. , 2003, Current opinion in cell biology.

[28]  A. Carrera,et al.  The p85 Regulatory Subunit Controls Sequential Activation of Phosphoinositide 3-Kinase by Tyr Kinases and Ras* , 2002, The Journal of Biological Chemistry.

[29]  Prahlad T. Ram,et al.  MAP Kinase Phosphatase As a Locus of Flexibility in a Mitogen-Activated Protein Kinase Signaling Network , 2002, Science.

[30]  B. Neel,et al.  Receptor-Specific Regulation of Phosphatidylinositol 3′-Kinase Activation by the Protein Tyrosine Phosphatase Shp2 , 2002, Molecular and Cellular Biology.

[31]  J. Ferrell.  Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. , 2002, Current opinion in cell biology.

[32]  M. Garrett,et al.  Ecdysone-inducible expression of oncogenic Ha-Ras in NIH 3T3 cells leads to transient nuclear localization of activated extracellular signal-regulated kinase regulated by mitogen-activated protein kinase phosphatase-1. , 2002, The Biochemical journal.

[33]  Mengwei Zang,et al.  Interaction between Active Pak1 and Raf-1 Is Necessary for Phosphorylation and Activation of Raf-1* , 2002, The Journal of Biological Chemistry.

[34]  Jason M Haugh,et al.  A unified model for signal transduction reactions in cellular membranes. , 2002, Biophysical journal.

[35]  K. Guan,et al.  Function of the Rho Family GTPases in Ras-stimulated Raf Activation* , 2001, The Journal of Biological Chemistry.

[36]  R. Marais,et al.  S338 Phosphorylation of Raf-1 Is Independent of Phosphatidylinositol 3-Kinase and Pak3 , 2001, Molecular and Cellular Biology.

[37]  W. Kolch.  Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. , 2000, The Biochemical journal.

[38]  J. Schlessinger,et al.  Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.

[39]  J. Schlessinger.  Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.

[40]  M. H. Cobb,et al.  Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338 , 2000, Current Biology.

[41]  A. King,et al.  Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak , 2000, Current Biology.

[42]  T. Hunter,et al.  Signaling—2000 and Beyond , 2000, Cell.

[43]  K. Moelling,et al.  Phosphorylation and regulation of Raf by Akt (protein kinase B). , 1999, Science.

[44]  J. Downward,et al.  Role of Phosphoinositide 3-Kinase in Activation of Ras and Mitogen-Activated Protein Kinase by Epidermal Growth Factor , 1999, Molecular and Cellular Biology.

[45]  C. Heldin,et al.  Mechanism of action and in vivo role of platelet-derived growth factor. , 1999, Physiological reviews.

[46]  L. Cantley,et al.  Conditional Inhibition of the Mitogen-activated Protein Kinase Cascade by Wortmannin , 1997, The Journal of Biological Chemistry.

[47]  J. Brugge,et al.  Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation , 1997, Molecular and cellular biology.

[48]  D A Lauffenburger,et al.  Physical modulation of intracellular signaling processes by locational regulation. , 1997, Biophysical journal.

[49]  J. Pouysségur,et al.  The Dual Specificity Mitogen-activated Protein Kinase Phosphatase-1 and −2 Are Induced by the p42/p44MAPK Cascade* , 1997, The Journal of Biological Chemistry.

[50]  J. Ferrell.  Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs. , 1996, Trends in biochemical sciences.

[51]  L. Cantley,et al.  Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity , 1996, Molecular and cellular biology.

[52]  A. Klippel,et al.  Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways , 1996, Molecular and cellular biology.

[53]  R. Lefkowitz,et al.  Phosphatidylinositol 3-Kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein Kinase Signaling Pathway (*) , 1996, The Journal of Biological Chemistry.

[54]  J. Reusch,et al.  Functional interactions of phosphatidylinositol 3-kinase with GTPase-activating protein in 3T3-L1 adipocytes , 1996, Molecular and cellular biology.

[55]  J. Olefsky,et al.  Negative Feedback Regulation and Desensitization of Insulin- and Epidermal Growth Factor-stimulated p21ras Activation (*) , 1995, The Journal of Biological Chemistry.

[56]  A. Cherniack,et al.  Divergent Mechanisms for Homologous Desensitization of p21ras by Insulin and Growth Factors (*) , 1995, The Journal of Biological Chemistry.

[57]  K. Guan,et al.  Desensitization of Ras Activation by a Feedback Disassociation of the SOS-Grb2 Complex (*) , 1995, The Journal of Biological Chemistry.

[58]  L. A. Burns,et al.  Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway , 1995, Molecular and cellular biology.

[59]  W. Fantl,et al.  Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. , 1995, Science.

[60]  G. Boss,et al.  Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: comparison of parental and Ras-overproducing NIH 3T3 fibroblasts. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[61]  L. Claesson-Welsh,et al.  Platelet-derived growth factor receptor signals. , 1994, The Journal of biological chemistry.

[62]  Michael J. Fry,et al.  Phosphatidylinositol-3-OH kinase direct target of Ras , 1994, Nature.

[63]  Jonathan A. Cooper,et al.  Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase. , 1990, The EMBO journal.

[64]  D. Bray,et al.  Intracellular signalling as a parallel distributed process. , 1990, Journal of theoretical biology.

[65]  N. Metropolis,et al.  Equation of State Calculations by Fast Computing Machines , 1953, Resonance.

[66]  Jason M Haugh,et al.  Quantitative model of Ras-phosphoinositide 3-kinase signalling cross-talk based on co-operative molecular assembly. , 2006, The Biochemical journal.

[67]  Jason M Haugh,et al.  Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: II. Parameter estimates for individual cells from experiments. , 2004, Biophysical journal.

[68]  D. Lauffenburger,et al.  Computational modeling of the EGF-receptor system: a paradigm for systems biology. , 2003, Trends in cell biology.

[69]  M. Waterfield,et al.  Synthesis and function of 3-phosphorylated inositol lipids. , 2001, Annual review of biochemistry.