A Novel Efficient Four-and Five-Component, One-Pot Synthesis of 4-Semicarbazonoalkyl-2-Naphthols

One-pot, multicomponent coupling reaction of two or three molecules of aldehydes with 2-naphthols and semicarbazide hydrochloride is described for the preparation of 4-semicarbazonoalkyl-2-naphthols using PTSA/NaOAc as an efficient catalyst system in THF at room temperature or solvent-free conditions at elevated temperature.