A Sensitivity Model for Predicting Photonic Crystal Biosensor Performance

We present a model for predicting photonic crystal label-free biosensor performance based primarily on the spatial distribution of electromagnetic near fields at device resonance. To achieve maximum device sensitivity, the resonant fields can be shaped by careful choice of material and geometrical parameters. The effect of each property on the resonant mode profile, and consequently on sensor performance, is illustrated. A comparison of device sensitivity calculated by both the proposed model and direct rigorous coupled wave analysis simulation supports the validity of our model.

[1]  B. Cunningham,et al.  Photonic crystal optical biosensor incorporating structured low-index porous dielectric , 2005, IEEE Sensors, 2005..

[2]  Janos Vörös,et al.  The density and refractive index of adsorbing protein layers. , 2004, Biophysical journal.

[3]  O. Wolfbeis.  Fiber-optic chemical sensors and biosensors. , 2004, Analytical chemistry.

[4]  Lance G. Laing,et al.  Label-Free Assays on the BIND System , 2004, Journal of biomolecular screening.

[5]  W. Karl,et al.  High-resolution biosensor spectral peak shift estimation , 2003, IEEE Transactions on Signal Processing.

[6]  S. S. Wang,et al.  Theory and applications of guided-mode resonance filters. , 1993, Applied optics.

[7]  C. Balanis.  Advanced Engineering Electromagnetics , 1989 .

[8]  A. Friesem,et al.  Resonant grating waveguide structures , 1997 .

[9]  Paul Lambeck,et al.  Evanescent wave sensor of sensitivity larger than a free space wave , 2000 .

[10]  Brian T. Cunningham,et al.  High sensitivity photonic crystal biosensor incorporating nanorod structures for enhanced surface area , 2008 .

[11]  A. A. Oliner,et al.  A New Theory of Wood’s Anomalies on Optical Gratings , 1965 .

[12]  Brian T. Cunningham,et al.  A new method for label-free imaging of biomolecular interactions , 2004 .

[13]  Robert Magnusson,et al.  Photonic devices enabled by waveguide-mode resonance effects in periodically modulated films , 2003, SPIE Optics + Photonics.

[14]  J R Smith,et al.  Hydrogen ion buffers for biological research. , 1966, Analytical biochemistry.