High Throughput Screening for Inhibitors of Mycobacterium tuberculosis H 37 Rv
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R. Reynolds | E. White | S. Ananthan | A. Mehta | N. Shindo | L. Rasmussen | M. Sosa | J. Hobrath | R. Goldman | J. William | SUBRAMANIAM ANANTHAN | ELLEN R. FAALEOLEA | ROBERT C. GOLDMAN | JUDITH V. HOBRATH | CECIL D. KWONG | BARBARA E. LAUGHON | A. JOSEPH | MADDRY | ALKA MEHTA | LYNN RASMUSSEN | ROBERT C. REYNOLDS | A. JOHN | SECRIST | NICE SHINDO | DUSTIN N. SHOWE | MELINDA I. SOSA | J. WILLIAM | SULING | E. LUCILE WHITE | Ellen R Faaleolea | Dustin N Showe | Secrist | C. Kwong | B. Laughon | A. Joseph | Maddry | A. John | Su-ling | Ellen R. Faaleolea | Dustin N. Showe
[1] Amita Jain,et al. Extensively Drug-Resistant Mycobacterium tuberculosis, India , 2007, Emerging infectious diseases.
[2] L. Bekker,et al. Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[3] L. A. Basso,et al. Electron transfer kinetics and mechanistic study of the thionicotinamide coordinated to the pentacyanoferrate(III)/(II) complexes: a model system for the in vitro activation of thioamides anti-tuberculosis drugs. , 2005, Journal of inorganic biochemistry.
[4] F. Hadizadeh,et al. Synthesis of α-[5-(5-amino-1,3,4-thiadiazol-2-yl)-2-imidazolylthio]acetic acids , 2008 .
[5] A. Neher,et al. Extensively drug resistant tuberculosis in a high income country: A report of four unrelated cases , 2008, BMC infectious diseases.
[6] P. Ortiz de Montellano,et al. Oxidative activation of thiacetazone by the Mycobacterium tuberculosis flavin monooxygenase EtaA and human FMO1 and FMO3. , 2006, Chemical research in toxicology.
[7] K. Kliiman,et al. Clinical and operational value of the extensively drug-resistant tuberculosis definition , 2007, European Respiratory Journal.
[8] R. Gibbs,et al. Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase. , 2006, Bioorganic & medicinal chemistry letters.
[9] David Eisenberg,et al. A Novel Inhibitor of Mycobacterium tuberculosis Pantothenate Synthetase , 2007, Journal of biomolecular screening.
[10] L. Scheibel,et al. Antimalarial activity of selected aromatic chelators. , 1980, Molecular pharmacology.
[11] E. De Clercq,et al. Structure−Activity Relationship Studies of a Series of Antiviral and Antibacterial Aglycon Derivatives of the Glycopeptide Antibiotics Vancomycin, Eremomycin, and Dechloroeremomycin , 2005 .
[12] E. Chan,et al. Treatment outcomes in extensively resistant tuberculosis. , 2008, The New England journal of medicine.
[13] G. Schuster,et al. 8-Hydroxyquinolines with the Potential for Long-Term Anticaries Activity: Design, Synthesis, and In Vitro Evaluation , 1978, Journal of dental research.
[14] C. Bertozzi,et al. Drug Targeting Mycobacterium tuberculosis Cell Wall Synthesis: Development of a Microtiter Plate-Based Screen for UDP-Galactopyranose Mutase and Identification of an Inhibitor from a Uridine-Based Library , 2003, Antimicrobial Agents and Chemotherapy.
[15] M. N. Nasr,et al. Synthesis and In Vitro Antibacterial Evaluation of Novel Imidazo[2′, 1′:5, 1]‐1, 2, 4‐triazolo[4, 3‐c]‐quinazoline Derivatives of 5‐Thioxo‐1, 2, 4‐triazole, 4‐Oxothiazolidine, and their Open‐chain Counterparts , 2003, Archiv der Pharmazie.
[16] A. Verkman,et al. Small molecules with antimicrobial activity against E. coli and P. aeruginosa identified by high‐throughput screening , 2006, British journal of pharmacology.
[17] P. Selzer,et al. Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties. , 2000, Journal of medicinal chemistry.
[18] Sharon S. Choi,et al. Comprehensive treatment of extensively drug-resistant tuberculosis. , 2008, The New England journal of medicine.
[19] A. Kozikowski,et al. Design, Synthesis, and Pharmacological Evaluation of Mefloquine‐Based Ligands as Novel Antituberculosis Agents , 2007, ChemMedChem.
[20] P. Brennan,et al. N-D-aldopentofuranosyl-N'-[p-(isoamyloxy)phenyl]-thiourea derivatives: potential anti-TB therapeutic agents. , 2008, Bioorganic & medicinal chemistry letters.
[21] M. Laurenzi,et al. Challenges associated with current and future TB treatment. , 2007, Infectious disorders drug targets.
[22] S. Schenone,et al. N-acylated and N,N'-diacylated imidazolidine-2-thione derivatives and N,N'-diacylated tetrahydropyrimidine-2(1H)-thione analogues: synthesis and antiproliferative activity. , 2009, European journal of medicinal chemistry.
[23] D. Sriram,et al. Synthesis and antimicrobial activities of some novel substituted 2-imidazolyl-N-(4-oxo-quinazolin-3(4H)-yl)-acetamides. , 2007, Chemical & pharmaceutical bulletin.
[24] I. Orme,et al. Rapid Microbiologic and Pharmacologic Evaluation of Experimental Compounds against Mycobacterium tuberculosis , 2006, Antimicrobial Agents and Chemotherapy.
[25] P. Brennan,et al. Isoxyl Activation Is Required for Bacteriostatic Activity against Mycobacterium tuberculosis , 2007, Antimicrobial Agents and Chemotherapy.
[26] Rahul Jain,et al. Synthesis, anti-tuberculosis activity, and 3D-QSAR study of 4-(adamantan-1-yl)-2-substituted quinolines. , 2007, Bioorganic & medicinal chemistry.
[27] S. Franzblau,et al. Low-Oxygen-Recovery Assay for High-Throughput Screening of Compounds against Nonreplicating Mycobacterium tuberculosis , 2007, Antimicrobial Agents and Chemotherapy.
[28] Z. Tao,et al. Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics. , 2007, Bioorganic & medicinal chemistry letters.
[29] A. Katritzky,et al. Solid phase synthesis and application of trisubstituted thioureas. , 2003, Journal of combinatorial chemistry.
[30] M. Parry,et al. Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles. , 1985, Journal of medicinal chemistry.
[31] K. Weismann. Chelating drugs and zinc. , 1986, Danish medical bulletin.
[32] K. Kliiman,et al. Resistance to second-line injectables and treatment outcomes in multidrug-resistant and extensively drug-resistant tuberculosis cases , 2008, European Respiratory Journal.
[33] S. Meshnick,et al. Molecular Basis for Atovaquone Binding to the Cytochrome bc1 Complex* , 2003, Journal of Biological Chemistry.
[34] B. Hammock,et al. Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. , 2005, Journal of medicinal chemistry.
[35] Martin Wu,et al. Genomic Approach to Identifying the Putative Target of and Mechanisms of Resistance to Mefloquine in Mycobacteria , 2005, Antimicrobial Agents and Chemotherapy.
[36] G. Besra,et al. EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR. , 2008, The Biochemical journal.
[37] M. Espinal,et al. The global situation of MDR-TB. , 2003, Tuberculosis.
[38] H. Rubin,et al. Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[39] Maurizio Fermeglia,et al. Antimycobacterial activity of new 3-substituted 5-(pyridin-4-yl)-3H-1,3,4-oxadiazol-2-one and 2-thione derivatives. Preliminary molecular modeling investigations. , 2005, Bioorganic & medicinal chemistry.
[40] A. Albert,et al. Selective Toxicity , 1973, Springer US.
[41] Richard E. Lee,et al. Nitrofurans as novel anti-tuberculosis agents: identification, development and evaluation. , 2007, Current topics in medicinal chemistry.
[42] C. S. Reddy,et al. Synthesis and antimicrobial activity of N-(substituted)-N'-(2,3-dihydro-2-oxido-5-benzoyl-1H-1,3,2-benzodiazaphosphol-2-yl) ureas. , 2003 .
[43] G. Evan,et al. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. , 2007, The Journal of clinical investigation.
[44] K. Castro,et al. Tuberculosis trends in the United States, 1992-2001. , 2003, Tuberculosis.
[45] Ted Cohen,et al. Modeling epidemics of multidrug-resistant M. tuberculosis of heterogeneous fitness , 2004, Nature Medicine.
[46] R. Slayden,et al. Use of genomics and combinatorial chemistry in the development of new antimycobacterial drugs. , 2000, Biochemical pharmacology.
[47] J. Yim,et al. Impact of extensive drug resistance on treatment outcomes in non-HIV-infected patients with multidrug-resistant tuberculosis. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[48] S. Merali,et al. Ubiquinone Synthesis and its Regulation in Pneumocystis carinii , 2006, The Journal of eukaryotic microbiology.
[49] Y. Av‐Gay,et al. A protein kinase inhibitor as an antimycobacterial agent. , 2001, FEMS microbiology letters.
[50] R. Jain,et al. Substituted 4-methylquinolines as a new class of anti-tuberculosis agents. , 2003, Bioorganic & medicinal chemistry letters.
[51] Y. Zhuang,et al. Suppression of Ulcerative Colitis in Mice by Orally Available Inhibitors of Sphingosine Kinase , 2008, Digestive Diseases and Sciences.
[52] Linghang Zhuang,et al. Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells. , 2003, Journal of medicinal chemistry.
[53] R. Durmaz,et al. Synthesis and antimicrobial activity of electron rich olefin derived cyclic ureas. , 1996, Arzneimittel-Forschung.
[54] F. Lombardo,et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. , 2001, Advanced drug delivery reviews.
[55] Kate S Carroll,et al. Drug targets in mycobacterial sulfur metabolism. , 2007, Infectious disorders drug targets.
[56] Jordi Bolós,et al. Structure-activity relationships of p38 mitogen-activated protein kinase inhibitors. , 2005, Mini reviews in medicinal chemistry.
[57] S. Boyce,et al. The search for novel TRPV1-antagonists: from carboxamides to benzimidazoles and indazolones. , 2006, Bioorganic & medicinal chemistry letters.
[58] A. Malde,et al. Synthesis, anti-tuberculosis activity, and 3D-QSAR study of ring-substituted-2/4-quinolinecarbaldehyde derivatives. , 2006, Bioorganic & medicinal chemistry.
[59] A. Kozikowski,et al. Design, Synthesis, and SAR Studies of Mefloquine‐Based Ligands as Potential Antituberculosis Agents , 2006, ChemMedChem.
[60] R. Chisin,et al. Formation of fluorine-18 labeled diaryl ureas--labeled VEGFR-2/PDGFR dual inhibitors as molecular imaging agents for angiogenesis. , 2008, Bioorganic & medicinal chemistry.
[61] S. Royce,et al. Extensively drug-resistant tuberculosis in california, 1993-2006. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[62] Erin E. Carlson,et al. Chemical probes of UDP-galactopyranose mutase. , 2006, Chemistry & biology.
[63] Chi‐Huey Wong,et al. Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention. , 2007, Journal of medicinal chemistry.
[64] J. Domagala,et al. Structure-activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors. , 2007, Bioorganic & medicinal chemistry letters.
[65] D. Russell,et al. Ubiquitin Trafficking to the Lysosome: Keeping the House Tidy and Getting Rid of Unwanted Guests , 2007, Autophagy.
[66] D. Sriram,et al. Synthesis, Antitubercular and Anticancer Activities of Substituted Furyl‐quinazolin‐3(4H)‐ones , 2007, Archiv der Pharmazie.
[67] Scott G. Franzblau,et al. Drug Targeting Mycobacterium tuberculosis Cell Wall Synthesis: Genetics of dTDP-Rhamnose Synthetic Enzymes and Development of a Microtiter Plate-Based Screen for Inhibitors of Conversion of dTDP-Glucose to dTDP-Rhamnose , 2001, Antimicrobial Agents and Chemotherapy.
[68] A. Gori,et al. Extensively Drug-resistant Tuberculosis, Italy and Germany , 2007, Emerging infectious diseases.
[69] J. Jackson,et al. Anti-tumor virus activity of copper-binding drugs. , 1977, Advances in experimental medicine and biology.
[70] R. Chakraborty,et al. Antibacterial activity of some 3-(arylideneamino)-2-phenylquinazoline-4(3H)-ones: synthesis and preliminary QSAR studies. , 2007, Molecules.
[71] S. Kaur,et al. Ring-substituted quinolines as potential anti-tuberculosis agents. , 2004, Bioorganic & medicinal chemistry.
[72] Vipan Kumar,et al. Synthesis and biological activity of novel antibacterial quinazolines. , 2004, Bioorganic & medicinal chemistry letters.
[73] C. Aldrich,et al. Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine. , 2008, Journal of medicinal chemistry.
[74] P. Ortiz de Montellano,et al. Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides. , 2007, Bioorganic & medicinal chemistry.
[75] G. Besra,et al. EthA, a Common Activator of Thiocarbamide-Containing Drugs Acting on Different Mycobacterial Targets , 2007, Antimicrobial Agents and Chemotherapy.
[76] W. Rohde,et al. INACTIVATION AND INHIBITION OF ROUS SARCOMA VIRUS BY COPPER‐BINDING LIGANDS: THIOSEMICARBAZONES, 8‐HYDROXYQUINOLINES, AND ISONICOTINIC ACID HYDRAZIDE * , 1977, Annals of the New York Academy of Sciences.
[77] R. Reynolds,et al. Programs to facilitate tuberculosis drug discovery: the tuberculosis antimicrobial acquisition and coordinating facility. , 2007, Infectious disorders drug targets.
[78] J. Sacchettini,et al. M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs) , 2006, Molecular microbiology.
[79] R. Reynolds,et al. Antimycobacterial agents. 1. Thio analogues of purine. , 2004, Journal of medicinal chemistry.
[80] H. Rubin,et al. Type II NADH: menaquinone oxidoreductase of Mycobacterium tuberculosis. , 2007, Infectious disorders drug targets.
[81] M. Spigelman,et al. New tuberculosis therapeutics: a growing pipeline. , 2007, The Journal of infectious diseases.
[82] Gurdyal S Besra,et al. Unique Mechanism of Action of the Thiourea Drug Isoxyl on Mycobacterium tuberculosis* , 2003, Journal of Biological Chemistry.
[83] J. Whitcher,et al. Hydroxyquinolines Inhibit Ribonucleic Acid-Dependent Deoxyribonucleic Acid Polymerase and Inactivate Rous Sarcoma Virus and Herpes Simplex Virus , 1976, Antimicrobial Agents and Chemotherapy.
[84] D. Saini,et al. High-Throughput Microplate Phosphorylation Assays Based on DevR-DevS/Rv2027c 2-Component Signal Transduction Pathway to Screen for Novel Antitubercular Compounds , 2005, Journal of biomolecular screening.
[85] K. Berlin,et al. Synthesis and bioactivity of some new N-aryl/alkyl/cyclohexyl-N'-(2,3-dihydro-2-oxo-4H-benz[e][1,3,2]oxazaphosphorin-2-yl) ureas. , 2005, Pest management science.
[86] R. Borchardt. Catechol O-methyltransferase. 2. In vitro inhibition by substituted 8-hydroxyquinolines. , 1973, Journal of medicinal chemistry.
[87] Vikramdeep Monga,et al. Ring-substituted quinolines. Part 2: Synthesis and antimycobacterial activities of ring-substituted quinolinecarbohydrazide and ring-substituted quinolinecarboxamide analogues. , 2004, Bioorganic & medicinal chemistry.
[88] C. Lingwood,et al. 3'Sulfogalactolipid binding specifically inhibits Hsp70 ATPase activity in vitro. , 2003, Biochemistry.
[89] Rahul Jain,et al. 3D-QSAR study of ring-substituted quinoline class of anti-tuberculosis agents. , 2006, Bioorganic & medicinal chemistry.
[90] D. Crick,et al. Expression, essentiality, and a microtiter plate assay for mycobacterial GlmU, the bifunctional glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase. , 2008, The international journal of biochemistry & cell biology.
[91] Vikramdeep Monga,et al. Synthesis and antimycobacterial activities of ring-substituted quinolinecarboxylic acid/ester analogues. Part 1. , 2004, Bioorganic & medicinal chemistry.
[92] S. Blower,et al. Predicting the future of XDR tuberculosis. , 2007, The Lancet. Infectious diseases.
[93] L. Gundersen,et al. Synthesis, biological activity, and SAR of antimycobacterial 2- and 8-substituted 6-(2-furyl)-9-(p-methoxybenzyl)purines. , 2007, Bioorganic & medicinal chemistry.
[94] K. Hevener,et al. Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents. , 2004, Journal of medicinal chemistry.
[95] C. Ackerley,et al. Inhibition of Multidrug Resistance by AdamantylGb3, a Globotriaosylceramide Analog* , 2008, Journal of Biological Chemistry.
[96] T. Weisbrod,et al. Characterization of the Mycobacterium tuberculosis iniBAC Promoter, a Promoter That Responds to Cell Wall Biosynthesis Inhibition , 2000, Journal of bacteriology.
[97] A. Shafiee,et al. Synthesis and antimycobacterial activity of some alkyl [5-(nitroaryl)-1,3,4-thiadiazol-2-ylthio]propionates. , 2006, Bioorganic & medicinal chemistry letters.
[98] E. De Clercq,et al. Anti-HIV activity of N-1-adamantyl-4-aminophthalimide. , 1997, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[99] P. Shukla,et al. Synthesis and Biological Evaluation of Novel (L)-α-Amino Acid Methyl Ester, Heteroalkyl, and Aryl Substituted 1,4-Naphthoquinone Derivatives as Antifungal and Antibacterial Agents. , 2006 .
[100] R. Jain,et al. Recent advances in new structural classes of anti-tuberculosis agents. , 2005, Current medicinal chemistry.
[101] S. Yee,et al. Synthesis and antimycobacterial activity of 7-O-substituted-4-methyl-2H-2-chromenone derivatives vs Mycobacterium tuberculosis , 2005, Journal of enzyme inhibition and medicinal chemistry.
[102] K. Bush,et al. A MurF Inhibitor That Disrupts Cell Wall Biosynthesis in Escherichia coli , 2007, Antimicrobial Agents and Chemotherapy.
[103] W. W. Barrow,et al. anti‐HIV Natural Product (+)‐Calanolide A Is Active Against Both Drug‐Susceptible and Drug‐Resistant Strains of Mycobacterium tuberculosis. , 2004 .
[104] L. Tanoue. Facing Extensively Drug-Resistant Tuberculosis — A Hope and a Challenge , 2009 .
[105] K. V. Ramseshu,et al. Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-butyl-3-substituted quinazolin-4-(3H)-ones. , 2005, Biological & pharmaceutical bulletin.
[106] P. Shukla,et al. Synthesis and biological evaluation of novel 1,4-naphthoquinone derivatives as antibacterial and antiviral agents. , 2005, Bioorganic & medicinal chemistry letters.
[107] Carol Winter,et al. Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors. , 2006, Bioorganic & medicinal chemistry letters.
[108] D. Janssen,et al. The Prodrug Activator EtaA from Mycobacterium tuberculosis Is a Baeyer-Villiger Monooxygenase* , 2004, Journal of Biological Chemistry.
[109] S. Gracheck,et al. In Vitro and In Vivo Activities of PD 0305970 and PD 0326448, New Bacterial Gyrase/Topoisomerase Inhibitors with Potent Antibacterial Activities versus Multidrug-Resistant Gram-Positive and Fastidious Organism Groups , 2007, Antimicrobial Agents and Chemotherapy.
[110] V. K. Tandon,et al. Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents. , 2004, Bioorganic & medicinal chemistry letters.
[111] B. Walker,et al. Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors. , 2007, Bioorganic & medicinal chemistry letters.
[112] K. Kliiman,et al. Extensively drug-resistant tuberculosis is worse than multidrug-resistant tuberculosis: different methodology and settings, same results. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[113] K. Duncan. Progress in TB drug development and what is still needed. , 2003, Tuberculosis.
[114] L. Tanoue. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa , 2008 .
[115] J. Schwartz,et al. Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity. , 1996, Journal of medicinal chemistry.
[116] N. Lall,et al. Activity of 7-methyljuglone derivatives against Mycobacterium tuberculosis and as subversive substrates for mycothiol disulfide reductase. , 2007, Bioorganic & medicinal chemistry.
[117] Y Av-Gay,et al. The eukaryotic-like Ser/Thr protein kinases of Mycobacterium tuberculosis. , 2000, Trends in microbiology.
[118] N. Lall,et al. Activity of 7-methyljuglone in combination with antituberculous drugs against Mycobacterium tuberculosis. , 2006, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[119] D. Minnikin,et al. Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis. , 2006, Bioorganic & medicinal chemistry letters.
[120] N. Takaishi,et al. Biologically active polycycloalkanes. 1. Antiviral adamantane derivatives. , 1975, Journal of medicinal chemistry.
[121] R. Ahmad,et al. Synthesis and bioevaluation of glycosyl ureas as alpha-glucosidase inhibitors and their effect on mycobacterium. , 2003, Bioorganic & medicinal chemistry.
[122] K. Glaser,et al. Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors. , 2008, Bioorganic & medicinal chemistry letters.
[123] D. Plant,et al. High-Throughput Screening of RNA Polymerase Inhibitors Using a Fluorescent UTP Analog , 2006, Journal of biomolecular screening.
[124] J. Domagala,et al. Synthesis and structural-activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents. , 2004, Bioorganic & medicinal chemistry letters.