HSV as a vector in vaccine development and gene therapy
暂无分享,去创建一个
A. Epstein | R. Manservigi | P. Marconi | R. Argnani | Roberto Manservigi | Rafaela Argnani | Peggy Marconi | Alberto L. Epstein
[1] S. Nomoto,et al. The potential of oncolytic virus therapy for pancreatic cancer , 2005, Cancer Gene Therapy.
[2] J. Glorioso,et al. Delivery using herpes simplex virus: an overview. , 2004, Methods in molecular biology.
[3] P. Grandi,et al. Expression of human immunodeficiency virus type 1 tat from a replication-deficient herpes simplex type 1 vector induces antigen-specific T cell responses. , 2006, Vaccine.
[4] D. Cory-Slechta,et al. Enhanced learning in mice parallels vector-mediated nerve growth factor expression in hippocampus. , 2000, Human gene therapy.
[5] D. Knipe,et al. Construction, Phenotypic Analysis, and Immunogenicity of a UL5/UL29 Double Deletion Mutant of Herpes Simplex Virus 2 , 2000, Journal of Virology.
[6] David M. Knipe,et al. Vaccine Protection against Simian Immunodeficiency Virus by Recombinant Strains of Herpes Simplex Virus , 2000, Journal of Virology.
[7] D. Leib,et al. Role of the virion host shutoff (vhs) of herpes simplex virus type 1 in latency and pathogenesis , 1995, Journal of virology.
[8] C. Strathdee,et al. An Enhanced Packaging System for Helper-Dependent Herpes Simplex Virus Vectors , 1998, Journal of Virology.
[9] A. Epstein,et al. Expression of hepatitis C virus envelope glycoproteins by herpes simplex virus type 1-based amplicon vectors. , 2002, The Journal of general virology.
[10] P. Scardino,et al. Oncolytic viral gene therapy for prostate cancer using two attenuated, replication‐competent, genetically engineered herpes simplex viruses , 2002, The Prostate.
[11] S. Brooke,et al. Over‐expression of antioxidant enzymes protects cultured hippocampal and cortical neurons from necrotic insults , 2003, Journal of neurochemistry.
[12] D. Kirn,et al. Oncolytic Viruses: Methods and Protocols , 1972, Nature.
[13] W. Heiss,et al. Imaging-guided gene therapy of experimental gliomas. , 2007, Cancer research.
[14] E. Tyminski,et al. An infectious transfer and expression system for genomic DNA loci in human and mouse cells , 2001, Nature Biotechnology.
[15] R. Manservigi,et al. Gene transfer into neurones for the molecular analysis of behaviour: focus on herpes simplex vectors , 2000, Trends in Neurosciences.
[16] Lingxin Kong,et al. Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson's disease , 2005, Brain Research.
[17] H. Federoff,et al. Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity. , 2002, Cancer research.
[18] N. DeLuca,et al. Immunogenicity of herpes simplex virus type 1 mutants containing deletions in one or more alpha-genes: ICP4, ICP27, ICP22, and ICP0. , 1999, Virology.
[19] S. Straus,et al. Herpesvirus vaccines. Development, controversies, and applications. , 1999, Infectious disease clinics of North America.
[20] D. Bernstein,et al. Pathogenesis of acyclovir-resistant herpes simplex type 2 isolates in animal models of genital herpes: models for antiviral evaluations. , 2000, Antiviral research.
[21] R. Martuza,et al. Oncolytic herpes simplex virus therapy for peripheral nerve tumors. , 2007, Neurosurgical focus.
[22] S. Moriuchi,et al. Enhanced tumor cell killing in the presence of ganciclovir by herpes simplex virus type 1 vector-directed coexpression of human tumor necrosis factor-alpha and herpes simplex virus thymidine kinase. , 1998, Cancer research.
[23] P. Kennedy,et al. Molecular biology of herpes simplex virus type 1 latency in the nervous system , 1993, Molecular Neurobiology.
[24] J. Cohen,et al. Comparative Efficacy and Immunogenicity of Replication-Defective, Recombinant Glycoprotein, and DNA Vaccines for Herpes Simplex Virus 2 Infections in Mice and Guinea Pigs , 2005, Journal of Virology.
[25] N. DeLuca,et al. Development and application of herpes simplex virus vectors for human gene therapy. , 1995, Annual review of microbiology.
[26] R. Weissleder,et al. In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.
[27] P. Ryan,et al. Effect of herpes simplex virus thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and the "bystander effect". , 1995, Human gene therapy.
[28] R. Longnecker,et al. In vivo behavior of genetically engineered herpes simplex viruses R7017 and R7020: construction and evaluation in rodents. , 1988, The Journal of infectious diseases.
[29] J. Naegele,et al. Long-Term Behavioral Recovery in Parkinsonian Rats by an HSV Vector Expressing Tyrosine Hydroxylase , 1994, Science.
[30] Ralph Weissleder,et al. Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo , 2003, Oncogene.
[31] S. Sabbioni,et al. Use of herpes simplex virus type 1-based amplicon vector for delivery of small interfering RNA , 2007, Gene Therapy.
[32] R. Manservigi,et al. Antitumor effects of non-replicative herpes simplex vectors expressing antiangiogenic proteins and thymidine kinase on Lewis lung carcinoma establishment and growth , 2007, Cancer Gene Therapy.
[33] G. Seelig,et al. Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system , 1996, Journal of virology.
[34] Bernard Roizman. HSV gene functions: what have we learned that could be generally applicable to its near and distant cousins? , 1999, Acta virologica.
[35] I. Mohr,et al. Suppression of the phenotype of gamma(1)34.5- herpes simplex virus 1: failure of activated RNA-dependent protein kinase to shut off protein synthesis is associated with a deletion in the domain of the alpha47 gene , 1997, Journal of virology.
[36] D M Coen,et al. Experimental therapy of human glioma by means of a genetically engineered virus mutant , 1991, Science.
[37] G. Cheng,et al. Herpes simplex virus 1 infection activates the endoplasmic reticulum resident kinase PERK and mediates eIF-2alpha dephosphorylation by the gamma(1)34.5 protein. , 2005, Journal of virology.
[38] Kaplitt,et al. Viral Vectors for Gene Delivery and Expression in the CNS , 1996, Methods.
[39] M. Halterman,et al. A novel approach to cancer therapy using an oncolytic herpes virus to package amplicons containing cytokine genes. , 2001, Molecular therapy : the journal of the American Society of Gene Therapy.
[40] A. Jacobs,et al. Herpes simplex virus 1 amplicon vector-mediated siRNA targeting epidermal growth factor receptor inhibits growth of human glioma cells in vivo. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.
[41] R. Vile,et al. Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA. , 1993, Cancer research.
[42] S. Inglis,et al. An efficient selection system for packaging herpes simplex virus amplicons. , 1998, The Journal of general virology.
[43] P. Scardino,et al. Suicide gene therapy toxicity after multiple and repeat injections in patients with localized prostate cancer. , 2000, The Journal of urology.
[44] J. B. Cohen,et al. HSV vector cytotoxicity is inversely correlated with effective TK/GCV suicide gene therapy of rat gliosarcoma , 2000, Gene Therapy.
[45] M. D'Angelica,et al. Efficient cotransduction of tumors by multiple herpes simplex vectors: Implications for tumor vaccine production , 2000, Cancer Gene Therapy.
[46] M. Halterman,et al. Selective infection and cytolysis of human head and neck squamous cell carcinoma with sparing of normal mucosa by a cytotoxic herpes simplex virus type 1 (G207). , 1999, Human gene therapy.
[47] A. Jacobs,et al. Helper virus-free herpes simplex virus type 1 amplicon vectors for granulocyte-macrophage colony-stimulating factor-enhanced vaccination therapy for experimental glioma. , 2000, Human gene therapy.
[48] E. Berto,et al. Development and application of replication-incompetent HSV-1-based vectors , 2005, Gene Therapy.
[49] B. Roizman,et al. In vivo behavior of genetically engineered herpes simplex viruses R7017 and R7020. II. Studies in immunocompetent and immunosuppressed owl monkeys (Aotus trivirgatus). , 1990, The Journal of infectious diseases.
[50] I. Mohr,et al. A Herpes Simplex Virus Type 1 γ34.5 Second-Site Suppressor Mutant That Exhibits Enhanced Growth in Cultured Glioblastoma Cells Is Severely Attenuated in Animals , 2001, Journal of Virology.
[51] A. Epstein,et al. Characterization of regulatory functions of the HSV-1 immediate-early protein ICP22. , 1996, Virology.
[52] N. DeLuca,et al. Persistence and Expression of the Herpes Simplex Virus Genome in the Absence of Immediate-Early Proteins , 1998, Journal of Virology.
[53] M. Woodle,et al. In Vivo Application of RNA Interference: From Functional Genomics to Therapeutics , 2005, Advances in Genetics.
[54] J. Scharf,et al. Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase. , 1994, Gene therapy.
[55] R. Martuza,et al. Ionizing radiation does not alter the antitumor activity of herpes simplex virus vector G207 in subcutaneous tumor models of human and murine prostate cancer. , 2001, Neoplasia.
[56] L. Soroceanu,et al. Evaluation of genetically engineered herpes simplex viruses as oncolytic agents for human malignant brain tumors. , 1997, Cancer research.
[57] S. Nishiguchi,et al. Structures of replacement vectors for efficient gene targeting. , 1994, Journal of biochemistry.
[58] S. Brown,et al. HSV1716 injection into the brain adjacent to tumour following surgical resection of high-grade glioma: safety data and long-term survival , 2004, Gene Therapy.
[59] B. Roizman,et al. Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture. , 1990, Science.
[60] R. Rees,et al. Preclinical evaluation of "whole" cell vaccines for prophylaxis and therapy using a disabled infectious single cycle-herpes simplex virus vector to transduce cytokine genes. , 2000, Cancer research.
[61] O. Isacson,et al. Effect of exogenous nerve growth factor on neurotoxicity of and neuronal gene delivery by a herpes simplex amplicon vector in the rat brain. , 1994, Human gene therapy.
[62] Erwin G. Van Meir,et al. Replicative oncolytic herpes simplex viruses in combination cancer therapies. , 2004, Current gene therapy.
[63] Andrew Freese,et al. An HSV‐1 Vector Expressing Tyrosine Hydroxylase Causes Production and Release of l‐DOPA from Cultured Rat Striatal Cells , 1995, Journal of neurochemistry.
[64] R. Vile,et al. Delivery systems intended for in vivo gene therapy of cancer: targeting and replication competent viral vectors. , 2001, Critical reviews in oncology/hematology.
[65] I. Mohr,et al. Enhanced antitumor efficacy of a herpes simplex virus mutant isolated by genetic selection in cancer cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[66] J. Markert,et al. Oncolytic HSV-1 for the treatment of brain tumours. , 2006, Herpes : the journal of the IHMF.
[67] R. Martuza,et al. Attenuated, Replication-Competent Herpes Simplex Virus Type 1 Mutant G207: Safety Evaluation of Intracerebral Injection in Nonhuman Primates , 1999, Journal of Virology.
[68] J. Markert,et al. Engineered herpes simplex virus expressing IL-12 in the treatment of experimental murine brain tumors. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[69] J. B. Cohen,et al. Connexin 43-enhanced suicide gene therapy using herpesviral vectors. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.
[70] Z. Ram,et al. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells , 1997, Nature Medicine.
[71] P. Lam,et al. Engineering an improved cell cycle-regulatable herpes simplex virus type 1 amplicon vector with enhanced transgene expression in proliferating cells yet attenuated activities in resting cells. , 2007, Human gene therapy.
[72] R. Rouse,et al. Rapid method for construction of recombinant HSV gene transfer vectors , 1997, Gene Therapy.
[73] S. Korsching,et al. The neurotrophic factor concept: a reexamination , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[74] B. Roizman,et al. Separation of receptor-binding and profusogenic domains of glycoprotein D of herpes simplex virus 1 into distinct interacting proteins , 2007, Proceedings of the National Academy of Sciences.
[75] R. Sapolsky,et al. Herpes simplex virus vector system: analysis of its in vivo and in vitro cytopathic effects , 1995, Journal of Neuroscience Methods.
[76] T. Pawlik,et al. Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene , 2002, Cancer.
[77] J. Glorioso,et al. Herpes simplex-mediated gene transfer of nerve growth factor protects against peripheral neuropathy in streptozotocin-induced diabetes in the mouse. , 2002, Diabetes.
[78] E. Chiocca,et al. The effect of ganciclovir on herpes simplex virus-mediated oncolysis. , 1997, The Journal of surgical research.
[79] A. Epstein,et al. Gene Transfer of NMDAR1 Subunit Sequences to the Rat CNS Using Herpes Simplex Virus Vectors Interfered with Habituation , 2002, Cellular and Molecular Neurobiology.
[80] B Roizman,et al. The nine ages of herpes simplex virus. , 2001, Herpes : the journal of the IHMF.
[81] R. Ramakrishnan,et al. Deletion of multiple immediate–early genes from herpes simplex virus reduces cytotoxicity and permits long-term gene expression in neurons , 1998, Gene Therapy.
[82] M. Ranasinghe,et al. Infectious delivery of the 132 kb CDKN2A/CDKN2B genomic DNA region results in correctly spliced gene expression and growth suppression in glioma cells , 2004, Gene Therapy.
[83] B. Roizman,et al. The diversity and unity of Herpesviridae. , 1991, Comparative immunology, microbiology and infectious diseases.
[84] S. Advani,et al. Friendly fire: redirecting herpes simplex virus-1 for therapeutic applications. , 2002, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
[85] L. Kaiser,et al. Herpes simplex 1716--an ICP 34.5 mutant--is severely replication restricted in human skin xenografts in vivo. , 1996, Virology.
[86] N. DeLuca,et al. Relationship of herpes simplex virus genome configuration to productive and persistent infections , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[87] L. Corey,et al. Recent Progress in Herpes Simplex Virus Immunobiology and Vaccine Research , 2003, Clinical Microbiology Reviews.
[88] D. Pfaff,et al. Specific Patterns of Defective HSV-1 Gene Transfer in the Adult Central Nervous System: Implications for Gene Targeting , 1994, Experimental Neurology.
[89] R. Martuza,et al. In situ expression of soluble B7-1 in the context of oncolytic herpes simplex virus induces potent antitumor immunity. , 2001, Cancer research.
[90] T. Pawlik,et al. Multimodality therapy with a replication-conditional herpes simplex virus 1 mutant that expresses yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine to 5-fluorouracil. , 2001, Cancer research.
[91] K. Nakano,et al. HSV trafficking and development of gene therapy vectors with applications in the nervous system , 2005, Gene Therapy.
[92] P. Grandi,et al. HSV-1 virions engineered for specific binding to cell surface receptors. , 2004, Molecular therapy : the journal of the American Society of Gene Therapy.
[93] R. Spaete,et al. Evaluation of a live attenuated recombinant virus RAV 9395 as a herpes simplex virus type 2 vaccine in guinea pigs. , 1998, The Journal of infectious diseases.
[94] V. Hukkanen,et al. Immune response to herpes simplex virus and gamma134.5 deleted HSV vectors. , 2005, Current gene therapy.
[95] S. Inglis,et al. Protective vaccination against primary and recurrent disease caused by herpes simplex virus (HSV) type 2 using a genetically disabled HSV-1. , 1995, The Journal of infectious diseases.
[96] X. Breakefield,et al. Improved HSV-1 amplicon packaging system using ICP27-deleted, oversized HSV-1 BAC DNA. , 2003, Methods in molecular medicine.
[97] B. Sodeik,et al. Herpes simplex virus type 1 infection of polarized epithelial cells requires microtubules and access to receptors present at cell-cell contact sites. , 2004, The Journal of general virology.
[98] H. Huynh,et al. An efficient and safe herpes simplex virus type 1 amplicon vector for transcriptionally targeted therapy of human hepatocellular carcinomas. , 2007, Molecular therapy : the journal of the American Society of Gene Therapy.
[99] W. Heiss,et al. Improved herpes simplex virus type 1 amplicon vectors for proportional coexpression of positron emission tomography marker and therapeutic genes. , 2003, Human gene therapy.
[100] K. Shah,et al. HSV amplicon vectors for cancer therapy. , 2006, Current gene therapy.
[101] P. Lam,et al. Optimal purification method for Herpes-based viral vectors that confers minimal cytotoxicity for systemic route of vector administration. , 2007, Journal of virological methods.
[102] S. Dewhurst,et al. Amplicons as vaccine vectors. , 2006, Current gene therapy.
[103] L D Lunsford,et al. Effective treatment of experimental glioblastoma by HSV vector-mediated TNF alpha and HSV-tk gene transfer in combination with radiosurgery and ganciclovir administration. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.
[104] G. Comi,et al. Cytokine therapy in immune-mediated demyelinating diseases of the central nervous system: a novel gene therapy approach , 2000, Journal of Neuroimmunology.
[105] P. Lam,et al. Targeting proliferating tumor cells via the transcriptional control of therapeutic genes , 2006, Cancer Gene Therapy.
[106] D. Benos,et al. Oncolytic Viruses: Clinical Applications as Vectors for the Treatment of Malignant Gliomas , 2003, Journal of Neuro-Oncology.
[107] Y. Kawaguchi,et al. Identification of Proteins Phosphorylated Directly by the Us3 Protein Kinase Encoded by Herpes Simplex Virus 1 , 2005, Journal of Virology.
[108] J. Bertino,et al. Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi‐mutated herpes simplex virus type‐1 (G207) , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[109] X. Breakefield,et al. Generation of stable retrovirus packaging cell lines after transduction with herpes simplex virus hybrid amplicon vectors ‡ , 2002, The journal of gene medicine.
[110] W. Jarnagin,et al. Effective treatment of pancreatic tumors with two multimutated herpes simplex oncolytic viruses , 2000, Journal of Gastrointestinal Surgery.
[111] J. Markert,et al. Treatment of intracranial gliomas in immunocompetent mice using herpes simplex viruses that express murine interleukins , 1998, Gene Therapy.
[112] R. D. Wiley,et al. Expression of Human Immunodeficiency Virus Type 1 gp120 from Herpes Simplex Virus Type 1-Derived Amplicons Results in Potent, Specific, and Durable Cellular and Humoral Immune Responses , 2002, Journal of Virology.
[113] R. Martuza,et al. Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas , 1995, Nature Medicine.
[114] K. Tsumoto,et al. Herpes simplex virus targeting to the EGF receptor by a gD-specific soluble bridging molecule. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.
[115] W. Herr,et al. DNA Recognition by the Herpes Simplex Virus Transactivator VP16: a Novel DNA-Binding Structure , 2001, Molecular and Cellular Biology.
[116] R. Desrosiers,et al. Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus. , 2007, Virology.
[117] Robert E. White,et al. Stable correction of a genetic deficiency in human cells by an episome carrying a 115 kb genomic transgene , 2000, Nature Biotechnology.
[118] J. Subak-Sharpe,et al. Hsv Molecular Biology: General Aspects of Herpes Simplex Virus Molecular Biology , 2004, Virus Genes.
[119] R. Martuza,et al. Viral shedding and biodistribution of G207, a multimutated, conditionally replicating herpes simplex virus type 1, after intracerebral inoculation in aotus. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.
[120] K. Tanabe,et al. Viral oncolysis. , 2002, The oncologist.
[121] X. Breakefield,et al. Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies. , 1998, Journal of the National Cancer Institute.
[122] A. Barzilai,et al. The Herpes Simplex Virus Type 1 vhs-UL41 Gene Secures Viral Replication by Temporarily Evading Apoptotic Cellular Response to Infection: Vhs-UL41 Activity Might Require Interactions with Elements of Cellular mRNA Degradation Machinery , 2006, Journal of Virology.
[123] J. B. Cohen,et al. Double suicide gene therapy using a replication defective herpes simplex virus vector reveals reciprocal interference in a malignant glioma model , 2002, Gene Therapy.
[124] A. Epstein,et al. HSV-1-derived recombinant and amplicon vectors for gene transfer and gene therapy. , 2005, Current gene therapy.
[125] E. Chiocca,et al. Infectious delivery of a 135-kb LDLR genomic locus leads to regulated complementation of low-density lipoprotein receptor deficiency in human cells. , 2003, Molecular therapy : the journal of the American Society of Gene Therapy.
[126] B. Roizman,et al. The UL13 protein kinase and the infected cell type are determinants of posttranslational modification of ICP0. , 1997, Virology.
[127] S. McMahon,et al. The Glial Cell Line-Derived Neurotrophic Factor Family Receptor Components Are Differentially Regulated within Sensory Neurons after Nerve Injury , 2000, The Journal of Neuroscience.
[128] K. Dobberstein,et al. New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol. , 1998, Human gene therapy.
[129] R. Herman,et al. The herpes simplex virus type 1 ICP6 gene is regulated by a 'leaky' early promoter. , 1992, Virus research.
[130] A. Epstein,et al. A novel approach for herpes simplex virus type 1 amplicon vector production, using the Cre-loxP recombination system to remove helper virus. , 2001, Human gene therapy.
[131] S. Ylä-Herttuala,et al. Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses. , 2000, Human gene therapy.
[132] J. Glorioso,et al. Pseudotyping of Glycoprotein D-Deficient Herpes Simplex Virus Type 1 with Vesicular Stomatitis Virus Glycoprotein G Enables Mutant Virus Attachment and Entry , 2000, Journal of Virology.
[133] R. Reichman. Herpes simplex virus infections , 1984, European Journal of Clinical Microbiology.
[134] R. Coffin,et al. Comparative analysis of genomic HSV vectors for gene delivery to motor neurons following peripheral inoculation in vivo , 2004, Gene Therapy.
[135] P. Stricklett,et al. Site-specific recombination using an epitope tagged bacteriophage P1 Cre recombinase. , 1998, Gene.
[136] A. Kudoh,et al. Establishment of a novel foreign gene delivery system combining an HSV amplicon with an attenuated replication-competent virus, HSV-1 HF10. , 2006, Journal of virological methods.
[137] K. Delman,et al. Combination Vascular Delivery of Herpes Simplex Oncolytic Viruses and Amplicon Mediated Cytokine Gene Transfer Is Effective Therapy for Experimental Liver Cancer , 2001, Molecular medicine.
[138] H. Neumann,et al. Bystander killing of malignant glioma by bone marrow-derived tumor-infiltrating progenitor cells expressing a suicide gene. , 2007, Molecular therapy : the journal of the American Society of Gene Therapy.
[139] H. Federoff,et al. Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma , 2004, Journal of Gastrointestinal Surgery.
[140] B. Rouse,et al. Herpes simplex virus latency and the immune response. , 1998, Current opinion in microbiology.
[141] G. Holmes,et al. Enhanced auditory reversal learning by genetic activation of protein kinase C in small groups of rat hippocampal neurons. , 2001, Brain research. Molecular brain research.
[142] C. Fraefel,et al. Herpes simplex virus type-1 amplicon vectors for vaccine generation in acute lymphoblastic leukemia , 2005, Gene Therapy.
[143] L. Stanberry. Clinical trials of prophylactic and therapeutic herpes simplex virus vaccines. , 2004, Herpes : the journal of the IHMF.
[144] A. Epstein. HSV-1-based amplicon vectors: design and applications , 2005, Gene Therapy.
[145] J. Glorioso,et al. Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer's disease-related amyloid-beta peptide in vivo. , 2006, Gene therapy.
[146] D. Andrews,et al. Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP. , 1996, The EMBO journal.
[147] C. Brandt,et al. Herpes simplex virus-mediated gene delivery to the rodent visual system. , 2000, Investigative ophthalmology & visual science.
[148] M. Hamon,et al. Therapeutic Efficacy in Experimental Polyarthritis of Viral-Driven Enkephalin Overproduction in Sensory Neurons , 2001, The Journal of Neuroscience.
[149] L. Morrison,et al. Comparison of different forms of herpes simplex replication-defective mutant viruses as vaccines in a mouse model of HSV-2 genital infection. , 2001, Virology.
[150] T. Daikoku,et al. Role of viral ribonucleotide reductase in the increase of dTTP pool size in herpes simplex virus-infected Vero cells. , 1991, The Journal of general virology.
[151] T. Friedmann,et al. Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1 , 1992, Journal of virology.
[152] F. Cosset,et al. Defective herpes simplex virus type 1 vectors harboring gag, pol, and env genes can be used to rescue defective retrovirus vectors , 1997, Journal of virology.
[153] J. Markert,et al. Genetically engineered human herpes simplex virus in the treatment of brain tumours. , 2001, Herpes : the journal of the IHMF.
[154] M. D'Angelica,et al. In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors , 1999, Cancer Immunology, Immunotherapy.
[155] E. Burton,et al. Gene therapy progress and prospects: Parkinson's disease , 2003, Gene Therapy.
[156] D. Busch,et al. Protection from Bacterial Infection by a Single Vaccination with Replication-Deficient Mutant Herpes Simplex Virus Type 1 , 2004, Journal of Virology.
[157] R. Vile,et al. Expression of a fusogenic membrane glycoprotein by an oncolytic herpes simplex virus potentiates the viral antitumor effect. , 2003, Molecular therapy : the journal of the American Society of Gene Therapy.
[158] M. Kaplitt,et al. Defective viral vectors as agents for gene transfer in the nervous system , 1997, Journal of Neuroscience Methods.
[159] M. Chao. Trophic factors: An evolutionary cul‐de‐sac or door into higher neuronal function? , 2000, Journal of neuroscience research.
[160] R. Manservigi,et al. HIV-1 matrix protein p17 modulates in vivo preactivated murine T-cell response and enhances the induction of systemic and mucosal immunity against intranasally co-administered antigens. , 2006, Viral immunology.
[161] C. Fraefel,et al. HSV-1 amplicon vectors--simplicity and versatility. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.
[162] H. Federoff,et al. Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival , 2007, Brain Research.
[163] D. Leib,et al. Protection from primary infection and establishment of latency by vaccination with a herpes simplex virus type 1 recombinant deficient in the virion host shutoff (vhs) function. , 1998, Vaccine.
[164] A. Epstein,et al. Reduced immune responses after vaccination with a recombinant herpes simplex virus type 1 vector in the presence of antiviral immunity. , 2005, The Journal of general virology.
[165] A. Kwong,et al. Minireview: the herpes simplex virus amplicon--a versatile defective virus vector. , 1994, Gene therapy.
[166] R. Coffin,et al. ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties , 2003, Gene Therapy.
[167] B. Roizman,et al. Construction and properties of a herpes simplex virus 1 designed to enter cells solely via the IL-13alpha2 receptor. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[168] B. Roizman. The function of herpes simplex virus genes: a primer for genetic engineering of novel vectors. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[169] O. Wildner,et al. Synergy between expression of fusogenic membrane proteins, chemotherapy and facultative virotherapy in colorectal cancer , 2006, Gene Therapy.
[170] J. Weir,et al. Incorporation of a lambda phage recombination system and EGFP detection to simplify mutagenesis of Herpes simplex virus bacterial artificial chromosomes , 2007, BMC biotechnology.
[171] D. Goldstein,et al. Correction of a rat model of Parkinson's disease by coexpression of tyrosine hydroxylase and aromatic amino acid decarboxylase from a helper virus-free herpes simplex virus type 1 vector. , 2003, Human gene therapy.
[172] R. Everett. ICP0, a regulator of herpes simplex virus during lytic and latent infection. , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.
[173] J. Glorioso,et al. Herpes simplex virus vector-mediated expression of Bcl-2 prevents 6-hydroxydopamine-induced degeneration of neurons in the substantia nigra in vivo. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[174] L. Soroceanu,et al. Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[175] R. Manservigi,et al. Molecular analysis of behavior by gene transfer into neurons with herpes simplex vectors 1 Published on the World Wide Web on 5 March 1999. 1 , 1999, Brain Research.
[176] A. Jacobs,et al. Therapeutic efficiency and safety of a second-generation replication-conditional HSV1 vector for brain tumor gene therapy. , 1997, Human gene therapy.
[177] P. Kaufman,et al. Herpes simplex virus mediated gene transfer to primate ocular tissues. , 1999, Experimental eye research.
[178] D. Kondziolka,et al. Gene transfer to glial tumors using herpes simplex virus. , 2004, Methods in molecular biology.
[179] S. Kuriyama,et al. Bystander effect caused by suicide gene expression indicates the feasibility of gene therapy for hepatocellular carcinoma , 1995, Hepatology.
[180] X. Breakefield,et al. Prodrug activation enzymes in cancer gene therapy , 2000, The journal of gene medicine.
[181] Ajay Niranjan,et al. Treatment of rat gliosarcoma brain tumors by HSV-based multigene therapy combined with radiosurgery. , 2003, Molecular therapy : the journal of the American Society of Gene Therapy.
[182] M. D. De Angelis,et al. A direct gene transfer strategy via brain internal capsule reverses the biochemical defect in Tay-Sachs disease. , 2005, Human molecular genetics.
[183] D. Alsop,et al. Treatment of experimental intracranial murine melanoma with a neuroattenuated herpes simplex virus 1 mutant. , 1995, Virology.
[184] J. Shah,et al. Cytokine gene transfer enhances herpes oncolytic therapy in murine squamous cell carcinoma. , 2001, Human gene therapy.
[185] P. Rennie,et al. An HSV-1 amplicon system for prostate-specific expression of ICP4 to complement oncolytic viral replication for in vitro and in vivo treatment of prostate cancer cells , 2007, Cancer Gene Therapy.
[186] R. Lachmann,et al. Herpes simplex virus‐based vectors , 2004, International journal of experimental pathology.
[187] B. Roizman. Introduction: objectives of herpes simplex virus vaccines seen from a historical perspective. , 1991, Reviews of infectious diseases.
[188] P. Lam,et al. Glioma-specific and cell cycle-regulated herpes simplex virus type 1 amplicon viral vector. , 2004, Human gene therapy.
[189] C. Hartnick,et al. Defective HSV-1 vector expressing BDNF in auditory ganglia elicits neurite outgrowth: model for treatment of neuron loss following cochlear degeneration. , 1996, Human gene therapy.
[190] Xiaoliu Zhang,et al. Potent antitumor activity after systemic delivery of a doubly fusogenic oncolytic herpes simplex virus against metastatic prostate cancer , 2004, The Prostate.
[191] D. Bernstein,et al. Herpes simplex virus vaccines. , 1999, Vaccine.
[192] L. Aurelian. HSV-induced apoptosis in herpes encephalitis. , 2005, Current topics in microbiology and immunology.
[193] B. Roizman,et al. Processing of the herpes simplex virus regulatory protein alpha 22 mediated by the UL13 protein kinase determines the accumulation of a subset of alpha and gamma mRNAs and proteins in infected cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[194] J. Shah,et al. Efficient gene transfer to human squamous cell carcinomas by the herpes simplex virus type 1 amplicon vector. , 1998, American journal of surgery.
[195] B Roizman,et al. Replication-competent, nonneuroinvasive genetically engineered herpes virus is highly effective in the treatment of therapy-resistant experimental human tumors. , 1999, Cancer research.
[196] B. Roizman,et al. The Second-Site Mutation in the Herpes Simplex Virus Recombinants Lacking the γ134.5 Genes Precludes Shutoff of Protein Synthesis by Blocking the Phosphorylation of eIF-2α , 1998, Journal of Virology.
[197] T. Pawlik,et al. Regulation of Herpes Simplex Virus 1 Replication Using Tumor-Associated Promoters , 2002, Annals of surgery.
[198] A. Epstein,et al. Hippocampal infection with HSV‐1‐derived vectors expressing an NMDAR1 antisense modifies behavior , 2003, Genes, brain, and behavior.
[199] X. Breakefield,et al. Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies. , 1999, Cancer research.
[200] C. Fraefel,et al. Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: rescue of replication-competent virus progeny and packaging of amplicon vectors. , 1998, Human gene therapy.
[201] S. Mohan,et al. HSV-1 amplicon-mediated transfer of 128-kb BMP-2 genomic locus stimulates osteoblast differentiation in vitro. , 2004, Biochemical and biophysical research communications.
[202] O. Wildner,et al. Comparison of herpes simplex virus- and conditionally replicative adenovirus-based vectors for glioblastoma treatment , 2007, Cancer Gene Therapy.
[203] E. Petersen,et al. Herpes simplex viruses. , 2009 .
[204] D. Knipe,et al. Herpes Simplex Virus Vectors Elicit Durable Immune Responses in the Presence of Preexisting Host Immunity , 2002, Journal of Virology.
[205] J. Glorioso,et al. Replication-defective genomic HSV gene therapy vectors: design, production and CNS applications. , 2005, Current opinion in molecular therapeutics.
[206] B. Paradiso,et al. Effects of defective herpes simplex vectors expressing neurotrophic factors on the proliferation and differentiation of nervous cells in vivo , 2005, Gene Therapy.
[207] R. Martuza,et al. In situ cancer vaccination: an IL-12 defective vector/replication-competent herpes simplex virus combination induces local and systemic antitumor activity. , 1998, Journal of immunology.
[208] Y. Becker,et al. Effect of herpes simplex virus type-1 UL41 gene on the stability of mRNA from the cellular genes: β-actin, fibronectin, glucose transporter-1, and docking protein, and on virus intraperitoneal pathogenicity to newborn mice , 1993, Virus Genes.
[209] C. Lilley,et al. Development and Optimization of Herpes Simplex Virus Vectors for Multiple Long-Term Gene Delivery to the Peripheral Nervous System , 2000, Journal of Virology.
[210] R. Sapolsky,et al. Overexpression of HSP72 after Induction of Experimental Stroke Protects Neurons from Ischemic Damage , 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[211] M. Halterman,et al. Improved HSV‐1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity , 2006, The journal of gene medicine.
[212] J. Garrido,et al. Defining Responsiveness of Avian Cochlear Neurons to Brain‐Derived Neurotrophic Factor and Nerve Growth Factor by HSV‐1‐Mediated Gene Transfer , 1998, Journal of neurochemistry.
[213] N. Markovitz,et al. Oncolytic viruses derived from the gamma34.5-deleted herpes simplex virus recombinant R3616 encode a truncated UL3 protein. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.
[214] F. Moolten,et al. Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors. , 1990, Journal of the National Cancer Institute.
[215] Y. Kawaguchi,et al. Construction of an Excisable Bacterial Artificial Chromosome Containing a Full-Length Infectious Clone of Herpes Simplex Virus Type 1: Viruses Reconstituted from the Clone Exhibit Wild-Type Properties In Vitro and In Vivo , 2003, Journal of Virology.
[216] James N. Davis,et al. BCL-2 Transduction, Using a Herpes Simplex Virus Amplicon, Protects Hippocampal Neurons from Transient Global Ischemia , 1999, Experimental Neurology.
[217] R. Martuza,et al. Flip-Flop HSV-BAC: Bacterial Artificial Chromosome Based System for Rapid Generation of Recombinant Herpes Simplex Virus Vectors Using Two Independent Site-specific Recombinases , 2006 .
[218] R. Martuza,et al. Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial , 2000, Gene Therapy.
[219] C. Fraefel,et al. In vivo gene transfer to the rat retina using herpes simplex virus type 1 (HSV-1)-based amplicon vectors , 2005, Gene Therapy.
[220] H. Federoff,et al. HSV vector-mediated gene delivery to the central nervous system. , 2001, Current opinion in molecular therapeutics.
[221] M. Tsukuda,et al. Therapeutic efficiency of IL-2 gene transduced tumor vaccine for head and neck carcinoma. , 2000, Cancer letters.
[222] C. Link,et al. Antitumor effects on human melanoma xenografts of an amplicon vector transducing the herpes thymidine kinase gene followed by ganciclovir , 2002, Cancer Gene Therapy.
[223] David L. Zimmerman,et al. Construction and characterization of bacterial artificial chromosomes containing HSV-1 strains 17 and KOS. , 2006, Journal of virological methods.
[224] N. DeLuca,et al. Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4 , 1985, Molecular and cellular biology.
[225] J. Yewdell,et al. Herpes simplex virus turns off the TAP to evade host immunity , 1995, Nature.
[226] C. Lilley,et al. Deletion of the Virion Host Shutoff Protein (vhs) from Herpes Simplex Virus (HSV) Relieves the Viral Block to Dendritic Cell Activation: Potential of vhs− HSV Vectors for Dendritic Cell-Mediated Immunotherapy , 2003, Journal of Virology.
[227] C. Fraefel,et al. BAC-VAC, a novel generation of (DNA) vaccines: A bacterial artificial chromosome (BAC) containing a replication-competent, packaging-defective virus genome induces protective immunity against herpes simplex virus 1. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[228] R. Weichselbaum,et al. Genetically engineered HSV in the treatment of glioma: a review , 2000, Reviews in medical virology.
[229] S. Landolfo,et al. The interferon-inducible IFI16 gene inhibits tube morphogenesis and proliferation of primary, but not HPV16 E6/E7-immortalized human endothelial cells. , 2004, Experimental cell research.
[230] R. Spaete,et al. Evaluation of AD472, a live attenuated recombinant herpes simplex virus type 2 vaccine in guinea pigs. , 2005, Vaccine.
[231] H. Federoff,et al. Herpes Simplex Virus Amplicon Delivery of a Hypoxia-Inducible Soluble Vascular Endothelial Growth Factor Receptor (sFlk-1) Inhibits Angiogenesis and Tumor Growth in Pancreatic Adenocarcinoma , 2005, Annals of Surgical Oncology.
[232] L. Aurelian,et al. Vaccine potential of a herpes simplex virus type 2 mutant deleted in the PK domain of the large subunit of ribonucleotide reductase (ICP10). , 1999, Vaccine.
[233] R. F. Cook,et al. The Active Site of ICP47, a Herpes Simplex Virus–encoded Inhibitor of the Major Histocompatibility Complex (MHC)-encoded Peptide Transporter Associated with Antigen Processing (TAP), Maps to the NH2-terminal 35 Residues , 1997, The Journal of experimental medicine.
[234] X. Breakefield,et al. HSV-1 amplicon vectors. , 2002, Methods in enzymology.
[235] H. H. Wu,et al. Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion , 2001, Gene Therapy.
[236] Chang-Zheng Chen,et al. MicroRNAs as oncogenes and tumor suppressors. , 2005, The New England journal of medicine.
[237] B. Roizman,et al. The herpes simplex virus 1 gene for ICP34.5, which maps in inverted repeats, is conserved in several limited-passage isolates but not in strain 17syn+ , 1990, Journal of virology.
[238] An efficient in vivo recombination cloning procedure for modifying and combining HSV-1 cosmids. , 1999, Journal of virological methods.
[239] J. Glorioso,et al. Herpes vector-mediated gene transfer in treatment of diseases of the nervous system. , 2004, Annual review of microbiology.
[240] P. Grandi,et al. Targeting HSV amplicon vectors. , 2004, Methods.
[241] Simon C Watkins,et al. Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22 , 1996, Journal of virology.
[242] P. Schaffer,et al. ICP22 and the UL13 Protein Kinase Are both Required for Herpes Simplex Virus-Induced Modification of the Large Subunit of RNA Polymerase II , 1999, Journal of Virology.
[243] R. Rouse,et al. Development of herpes simplex virus replication-defective multigene vectors for combination gene therapy applications , 1998, Gene Therapy.
[244] R. Weissleder,et al. Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapy. , 2004, Cancer research.
[245] H. Wakimoto,et al. Development of a rapid method to generate multiple oncolytic HSV vectors and their in vivo evaluation using syngeneic mouse tumor models , 2006, Gene Therapy.
[246] N. DeLuca,et al. The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27 , 1997, Journal of virology.
[247] Yaming Wang,et al. Helper Virus-Free Herpes Simplex Virus-1 Plasmid Vectors for Gene Therapy of Parkinson's Disease and Other Neurological Disorders , 1997, Experimental Neurology.
[248] R. Martuza,et al. Systemic antitumor immunity in experimental brain tumor therapy using a multimutated, replication-competent herpes simplex virus. , 1999, Human gene therapy.
[249] T. Ndung’u,et al. Properties of a herpes simplex virus multiple immediate-early gene-deleted recombinant as a vaccine vector. , 2007, Virology.
[250] R. Ramakrishnan,et al. Replication-defective herpes simplex virus vectors for gene transfer in vivo. , 1996, Proceedings of the National Academy of Sciences of the United States of America.