Nanoliposomes: preparation and analysis.

Nanoliposome, or submicron bilayer lipid vesicle, is a new technology for the encapsulation and delivery of bioactive agents. The list of bioactive material that can be incorporated to nanoliposomes is immense, ranging from pharmaceuticals to cosmetics and nutraceuticals. Because of their biocompatibility and biodegradability, along with their nanosize, nanoliposomes have potential applications in a vast range of fields, including nanotherapy (e.g. diagnosis, cancer therapy, gene delivery), cosmetics, food technology and agriculture. Nanoliposomes are able to enhance the performance of bioactive agents by improving their solubility and bioavailability, in vitro and in vivo stability, as well as preventing their unwanted interactions with other molecules. Another advantage of nanoliposomes is cell-specific targeting, which is a prerequisite to attain drug concentrations required for optimum therapeutic efficacy in the target site while minimising adverse effects on healthy cells and tissues. This chapter covers nanoliposomes, particularly with respect to their properties, preparation methods and analysis.

[1]  P. Shek,et al.  Liposomes and bronchoalveolar lavage fluid : release of vesicle-entrapped glutathione , 1992 .

[2]  Leaf Huang,et al.  Large scale production of DC-Chol cationic liposomes by microfluidization , 1996 .

[3]  C. Rhodes,et al.  Preparation and characterization of liposomes as therapeutic delivery systems: a review. , 1995, Pharmaceutica acta Helvetiae.

[4]  H. Kikuchi,et al.  A POLYOL DILUTION METHOD FOR MASS PRODUCTION OF LIPOSOMES , 1994 .

[5]  V. Hasırcı,et al.  Mechanism of calcium ion induced multilamellar vesicle-DNA interaction. , 1998, Journal of microencapsulation.

[6]  M. Brandl,et al.  Filter extrusion of liposomes using different devices: comparison of liposome size, encapsulation efficiency, and process characteristics. , 2001, International journal of pharmaceutics.

[7]  Eric S. Richardson,et al.  Reducing Liposome Size with Ultrasound: Bimodal Size Distributions , 2006, Journal of liposome research.

[8]  M. Hope,et al.  Extrusion technique to generate liposomes of defined size. , 2003, Methods in enzymology.

[9]  Paul Jelen,et al.  Methods for disruption of microbial cells for potential use in the dairy industry—a review , 2002 .

[10]  B. Bhandari,et al.  Nano-Emulsion Production by Sonication and Microfluidization—A Comparison , 2006 .

[11]  C. Nastruzzi,et al.  Preparation of liposomes by reverse-phase evaporation using alternative organic solvents. , 1999, Journal of microencapsulation.

[12]  Ion C. Baianu,et al.  Novel liposome microencapsulation techniques for food applications , 1991 .

[13]  A. Baeumner,et al.  Analysis of liposomes. , 2006, Talanta.

[14]  N. Ganguly,et al.  Predicting the Effect of Nonionic Surfactants on Dispersed Droplet Radii in Submicron Oil-in-Water Emulsions , 1992, Pharmaceutical Research.

[15]  F. Szoka,et al.  Comparative properties and methods of preparation of lipid vesicles (liposomes). , 1980, Annual review of biophysics and bioengineering.

[16]  D. Banerjee,et al.  Preparation, isolation, and characterization of liposomes containing natural and synthetic lipids. , 2002, Methods in molecular biology.

[17]  Yechezkel Barenholz,et al.  Prolongation of the Circulation Time of Doxorubicin Encapsulated in Liposomes Containing a Polyethylene Glycol-Derivatized Phospholipid: Pharmacokinetic Studies in Rodents and Dogs , 1993, Pharmaceutical Research.

[18]  M. R. Mozafari,et al.  TRANSFECTION OF HUMAN AIRWAY EPITHELIAL CELLS USING A LIPID- BASED VECTOR PREPARED BY THE HEATING METHOD , 2004 .

[19]  G. Ourisson,et al.  Single-Chain Polyprenyl Phosphates Form “Primitive” Membranes , 1996 .

[20]  M. R. Mozafari,et al.  Microscopical investigations of nisin-loaded nanoliposomes prepared by Mozafari method and their bacterial targeting. , 2007, Micron.

[21]  A. Ozer.  Applications of Light and Electron Microscopic Techniques in Liposome Research , 2007 .

[22]  M. R. Mozafari,et al.  Construction of stable anionic liposome-plasmid particles using the heating method: a preliminary investigation. , 2002, Cellular & molecular biology letters.

[23]  M. R. Mozafari,et al.  The properties of liposomes produced from milk fat globule membrane material using different techniques , 2007 .

[24]  P. Paquin,et al.  Fragmentation of chitosan by microfluidization process , 2003 .

[25]  R. Macdonald,et al.  Small-volume extrusion apparatus for preparation of large, unilamellar vesicles. , 1991, Biochimica et biophysica acta.

[26]  M. R. Mozafari,et al.  Recent trends in the lipid-based nanoencapsulation of antioxidants and their role in foods , 2006 .

[27]  A. Bangham,et al.  Diffusion of univalent ions across the lamellae of swollen phospholipids. , 1965, Journal of molecular biology.

[28]  Gary A Reineccius,et al.  Encapsulation and controlled release of food ingredients , 1995 .

[29]  Aldo Jesorka,et al.  Liposomes: technologies and analytical applications. , 2008, Annual review of analytical chemistry.

[30]  M. R. Mozafari,et al.  Preparation of liposomal gene therapy vectors by a scalable method without using volatile solvents or detergents. , 2007, Journal of biotechnology.

[31]  A. Dwivedi.  Residual Solvent Analysis in Pharmaceuticals , 2002 .

[32]  M. R. Mozafari,et al.  Cytotoxicity evaluation of anionic nanoliposomes and nanolipoplexes prepared by the heating method without employing volatile solvents and detergents. , 2007, Die Pharmazie.

[33]  M. R. Mozafari.  Nanocarrier Technologies: Frontiers of Nanotherapy , 2006 .

[34]  Huagang Chen,et al.  Hydrolysis of Cellulose Acetate and Cellulose Acetate Butyrate Pseudolatexes Prepared by a Solvent Evaporation-Microfluidization Method , 1993 .

[35]  M. R. Mozafari,et al.  The role of high-resolution imaging in the evaluation of nanosystems for bioactive encapsulation and targeted nanotherapy , 2007, Micron.

[36]  G. Reineccius.  Liposomes for Controlled Release in the Food Industry , 1995 .

[37]  M. R. Mozafari,et al.  Liposomes: an overview of manufacturing techniques. , 2005, Cellular & molecular biology letters.

[38]  Y. Maa,et al.  Performance of sonication and microfluidization for liquid-liquid emulsification. , 1999, Pharmaceutical development and technology.

[39]  M. R. Mozafari,et al.  Prospects of anionic nanolipoplexes in nanotherapy: transmission electron microscopy and light scattering studies. , 2007, Micron.

[40]  M. Bally,et al.  Production of large unilamellar vesicles by a rapid extrusion procedure: characterization of size distribution, trapped volume and ability to maintain a membrane potential. , 1985, Biochimica et biophysica acta.

[41]  O. Zelphati,et al.  Immunoliposome-Mediated Delivery of Nucleic Acids: A Review of Our Laboratory's Experience , 1994 .

[42]  S. Vemuri,et al.  LARGE-SCALE PRODUCTION OF LIPOSOMES BY A MICROFLUIDIZER , 1990 .

[43]  R. New,et al.  Liposomes : a practical approach , 1990 .

[44]  P. Paquin,et al.  Effects of microfluidization on the functional properties of xanthan gum , 1998 .

[45]  G. Ourisson,et al.  Towards Proto‐Cells: “Primitive” Lipid Vesicles Encapsulating Giant DNA and Its Histone Complex , 2001, Cellular & molecular biology letters.

[46]  S. Hui,et al.  Temperature-controlled content release from liposomes encapsulating Pluronic F127. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[47]  T. Rades,et al.  Characterisation of bicontinuous cubic liquid crystalline systems of phytantriol and water using cryo field emission scanning electron microscopy (cryo FESEM). , 2007, Micron.

[48]  P. Shek,et al.  Distribution studies of liposome-encapsulated glutathione administered to the lung , 1990 .

[49]  Lisa Cencia-Rohan,et al.  Effect of solvent system on microfluidization-induced mechanical degradation , 1993 .