Occurrence of leukemia and lymphoma in patients with agammaglobulinemia.

1) Two case reports of children with congenital agammaglobulinemia who later developed malignant lymphoma are presented. 2) Two additional cases of malignant lymphoma developing in adult patients with hypogammaglobulinemia are reviewed. 3) The occurrence of diseases of this group among patients with this immunologic defect appears to be a greater-than-chance association. Possible reasons for the association are discussed.

[1]  H. Kunkel,et al.  The occurrence of rheumatoid factor and other abnormalities in families of patients with agammaglobulinemia. , 1962, Arthritis and rheumatism.

[2]  J. K. Wolf.  Primary acquired agammaglobulinemia, with a family history of collagen disease and hematologic disorders. , 1962, The New England journal of medicine.

[3]  J. Kersey,et al.  Skin Homograft Survival in Thymectomized Mice.∗ , 1962, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[4]  A. Solomon,et al.  “Acquired Agammaglobulinemia” with Auto‐Immune Hemolytic Disease: Graft‐versus‐Host Reaction? , 1961, Vox sanguinis.

[5]  J. Haserick,et al.  Dermatomyositis and malignant neoplasms in adults. A survey of twenty years' experience. , 1960, Archives of dermatology.

[6]  R. Good,et al.  Fatal complications of virus hepatitis in two patients with agammaglobulinemia. , 1960, The American journal of medicine.

[7]  D. Michaeli,et al.  Idiopathic acquired agammaglobulinemia associated with thymoma. Report of two cases and review of the literature. , 1960, The New England journal of medicine.

[8]  R. K. Meyer,et al.  Precipitin production in chickens. XXI. Antibody production in bursectomized chickens and in chickens injected with 19-nortestosterone on the fifth day of incubasion. , 1960, Journal of immunology.

[9]  R. Good,et al.  Clinical investigation of patients with agammaglobulinemia and hypogammaglobulinemia. , 1960, Pediatric clinics of North America.

[10]  T. Makinodan,et al.  Precipitin Production in Chickens , 1946, The Journal of Immunology.

[11]  R. Good,et al.  Immunochemical studies of human serum gamma globulins. , 1959, The Journal of clinical investigation.

[12]  S. Zelman,et al.  Adult agammaglobulinemia associated with multiple congenital anomalies. , 1958, The American journal of medicine.

[13]  J. H. Humphrey.  What are gamma globulins? , 1958, Lectures on the scientific basis of medicine.

[14]  C. Janeway,et al.  The gamma globulins. , 1966, Advances in pediatrics.

[15]  R. Jim.  SERUM GAMMA GLOBULIN LEVELS IN CHRONIC LYMPHOCYTIC LEUKEMIA , 1957, The American journal of the medical sciences.

[16]  S. Sommers,et al.  Clinicopathologic conference; refractory anemia, agammaglobulinemia, and mediastinal tumor. , 1957, American journal of clinical pathology.

[17]  D. W. Van Gelder.  Clinical Significance of Alterations in Gamma Globulin Levels , 1957, Southern medical journal.

[18]  V. Dw.  Clinical significance of alterations in gamma globulin levels. , 1957 .

[19]  R. Varco,et al.  Thymic tumor and acquired agammaglobulinemia: a clinical and experimental study of the immune response. , 1956, Surgery.

[20]  H. Kaplan,et al.  Indirect induction of lymphomas in irradiated mice. IV. Genetic evidence of the origin of the tumor cells from the thymic grafts. , 1956, Cancer research.

[21]  R. Good,et al.  The simultaneous occurrence of leukemia and mongolism; report of four cases. , 1956, A.M.A. journal of diseases of children.

[22]  B. Glick,et al.  The Bursa of Fabricius and Antibody Production , 1956 .

[23]  C. Sheard,et al.  Dermatomyositis and the incidence of associated malignancy. , 1956, Connecticut state medical journal.

[24]  M. Morton,et al.  Defective serum gamma globulin formation. , 1955, Annals of internal medicine.

[25]  E. Fitzsimons,et al.  Hypogammaglobulinemia associated with a severe wound infection. , 1955, Journal of the American Medical Association.

[26]  H. Bernhardt.  [Diagnostic problems]. , 1953, Medizinische Klinik.

[27]  A. Curtis,et al.  Malignant lesions associated with dermatomyositis. , 1952, Journal of the American Medical Association.

[28]  Hans Sunde.  Dermatomyositis in Children , 1949, Acta paediatrica.

[29]  J. Furth,et al.  On the Role of Thymus, Spleen, and Gonads in the Development of Leukemia in a High-Leukemia Stock of Mice , 1944 .