Exercise and Weight Loss in Obese Older Adults with Knee Osteoarthritis: A Preliminary Study

OBJECTIVE: The purposes of this pilot study were to determine if a combined dietary and exercise intervention would result in significant weight loss in older obese adults with knee osteoarthritis, and to compare the effects of exercise plus dietary therapy with exercise alone on gait, strength, knee pain, biomarkers of cartilage degradation, and physical function.

[1]  C. Helmick,et al.  Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. , 1998, Arthritis and rheumatism.

[2]  W. Ettinger,et al.  Effects of Long-Term Aerobic or Weight Training Regimens on Gait in an Older, Osteoarthritic Population , 1997 .

[3]  W. Applegate,et al.  A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. The Fitness Arthritis and Seniors Trial (FAST). , 1997, JAMA.

[4]  W. Ettinger,et al.  Assessing performance-related disability in patients with knee osteoarthritis. , 1995, Osteoarthritis and cartilage.

[5]  A M Walker,et al.  Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization. , 1995, Arthritis and rheumatism.

[6]  W. Ettinger,et al.  The evaluation of pain in patients with knee osteoarthritis: the knee pain scale. , 1995, The Journal of rheumatology.

[7]  R. Loeser,et al.  Osteoarthritis in cynomolgus macaques II. Detection of modulated proteoglycan epitopes in cartilage and synovial fluid , 1995, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[8]  Alan C. Wilson,et al.  Trial of Nonpharmacologic Intervention in the Elderly (TONE). Design and rationale of a blood pressure control trial. , 1995, Annals of epidemiology.

[9]  G. E. Gresham,et al.  Effects of a quantitative progressive rehabilitation program applied unilaterally to the osteoarthritic knee. , 1993, Archives of physical medicine and rehabilitation.

[10]  J. Brown,et al.  Sensitive enzyme-linked immunosorbent assay for detection of Clostridium botulinum neurotoxins A, B, and E using signal amplification via enzyme-linked coagulation assay , 1993, Journal of clinical microbiology.

[11]  J. Pelletier,et al.  Cytokines and inflammation in cartilage degradation. , 1993, Rheumatic diseases clinics of North America.

[12]  E. Thonar,et al.  Body fluid markers of cartilage changes in osteoarthritis. , 1993, Rheumatic diseases clinics of North America.

[13]  M L O'Toole,et al.  Eccentric muscle performance of elbow and knee muscle groups in untrained men and women. , 1993, Medicine and science in sports and exercise.

[14]  D A Bloch,et al.  Risk factors for physical disability in an aging cohort: the NHANES I Epidemiologic Followup Study. , 1993, The Journal of rheumatology.

[15]  J C Otis,et al.  Effect of a walking program on gait characteristics in patients with osteoarthritis. , 1993, Arthritis care and research : the official journal of the Arthritis Health Professions Association.

[16]  R. Brand,et al.  The biomechanics and motor control of human gait: Normal, elderly, and pathological , 1992 .

[17]  G. Pawelec,et al.  Determination of cytokines in synovial fluids: correlation with diagnosis and histomorphological characteristics of synovial tissue. , 1992, Annals of the rheumatic diseases.

[18]  J P Allegrante,et al.  Supervised Fitness Walking in Patients with Osteoarthritis of the Knee , 1992, Annals of Internal Medicine.

[19]  D. Felson,et al.  Weight Loss Reduces the Risk for Symptomatic Knee Osteoarthritis in Women , 1992, Annals of Internal Medicine.

[20]  C M Wise,et al.  Osteoarthritis of the knee: effects on gait, strength, and flexibility. , 1992, Archives of physical medicine and rehabilitation.

[21]  R. Bunning,et al.  A rational program of exercise for patients with osteoarthritis. , 1991, Seminars in arthritis and rheumatism.

[22]  D R Pendergast,et al.  Muscle rehabilitation: its effect on muscular and functional performance of patients with knee osteoarthritis. , 1991, Archives of physical medicine and rehabilitation.

[23]  J. Kramer,et al.  Effect of activation force on knee extensor torques. , 1991, Medicine and science in sports and exercise.

[24]  Static pre-load effect on knee extensor isokinetic concentric and eccentric performance. , 1991, Medicine and science in sports and exercise.

[25]  J. Neuhaus,et al.  Obesity and osteoarthritis of the knee: evidence from the National Health and Nutrition Examination Survey (NHANES I). , 1990, Seminars in arthritis and rheumatism.

[26]  D. Felson.  The epidemiology of knee osteoarthritis: results from the Framingham Osteoarthritis Study. , 1990, Seminars in arthritis and rheumatism.

[27]  P. Jokl.  Prevention of disuse muscle atrophy in chronic arthritides. , 1990, Rheumatic diseases clinics of North America.

[28]  L. Lipsitz,et al.  High-intensity strength training in nonagenarians. Effects on skeletal muscle. , 1990, JAMA.

[29]  J E Hewett,et al.  Efficacy of physical conditioning exercise in patients with rheumatoid arthritis and osteoarthritis. , 1989, Arthritis and rheumatism.

[30]  D Hamerman,et al.  The biology of osteoarthritis. , 1989, The New England journal of medicine.

[31]  D. Felson,et al.  Obesity and knee osteoarthritis. The Framingham Study. , 1988, Annals of internal medicine.

[32]  J J Anderson,et al.  Factors associated with osteoarthritis of the knee in the first national Health and Nutrition Examination Survey (HANES I). Evidence for an association with overweight, race, and physical demands of work. , 1988, American journal of epidemiology.

[33]  D. Felson,et al.  Epidemiology of hip and knee osteoarthritis. , 1988, Epidemiologic reviews.

[34]  L. Kazis,et al.  The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. , 1987, Arthritis and rheumatism.

[35]  E. Thonar,et al.  Quantification of keratan sulfate in blood as a marker of cartilage catabolism. , 1985, The Journal of rheumatology.

[36]  R. Moskowitz,et al.  Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. , 1986, Arthritis and rheumatism.

[37]  A A Rimm,et al.  The association of obesity with joint pain and osteoarthritis in the HANES data. , 1986, Journal of chronic diseases.

[38]  R. Graham,et al.  Stimulation by human interleukin 1 of cartilage breakdown and production of collagenase and proteoglycanase by human chondrocytes but not by human osteoblasts in vitro. , 1984, Biochimica et biophysica acta.

[39]  R W Farndale,et al.  A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures. , 1982, Connective tissue research.