Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential.

[1]  B. Aggarwal,et al.  Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. , 2010, Biochemical pharmacology.

[2]  Zhiwei Wang,et al.  Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer. , 2009, Cancer research.

[3]  V. Adhami,et al.  Effective Prostate Cancer Chemopreventive Intervention with Green Tea Polyphenols in the TRAMP Model Depends on the Stage of the Disease , 2009, Clinical Cancer Research.

[4]  Yin Ren,et al.  In vivo tumor cell targeting with "click" nanoparticles. , 2008, Bioconjugate chemistry.

[5]  Mingyao Liu,et al.  Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways , 2008, Molecular Cancer Therapeutics.

[6]  B. Aggarwal,et al.  Targeting Nuclear Factor-κB Activation Pathway by Thymoquinone: Role in Suppression of Antiapoptotic Gene Products and Enhancement of Apoptosis , 2008, Molecular Cancer Research.

[7]  David J Newman,et al.  Natural products as leads to potential drugs: an old process or the new hope for drug discovery? , 2008, Journal of medicinal chemistry.

[8]  A. Al-Ali,et al.  Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats. , 2008, Journal of Ayub Medical College, Abbottabad : JAMC.

[9]  S. Nie,et al.  Therapeutic Nanoparticles for Drug Delivery in Cancer , 2008, Clinical Cancer Research.

[10]  M. Gleeson.  Generation of a set of simple, interpretable ADMET rules of thumb. , 2008, Journal of medicinal chemistry.

[11]  Chun-ching Lin,et al.  Preparation, physicochemical characterization, and antioxidant effects of quercetin nanoparticles. , 2008, International journal of pharmaceutics.

[12]  P. Ramarao,et al.  Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: can the simple nutritional supplements be used as first line therapeutic agents for prophylaxis/therapy? , 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[13]  M. Menon,et al.  Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer. , 2007, Cancer research.

[14]  R. Schneider-Stock,et al.  Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models , 2007, Journal of cellular and molecular medicine.

[15]  G. Feldmann,et al.  Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy , 2007, Journal of nanobiotechnology.

[16]  Hala Gali-Muhtasib,et al.  Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells , 2007, Cancer biology & therapy.

[17]  S. Bhatia,et al.  Biomimetic amplification of nanoparticle homing to tumors , 2007, Proceedings of the National Academy of Sciences.

[18]  V. Torchilin,et al.  Micellar Nanocarriers: Pharmaceutical Perspectives , 2006, Pharmaceutical Research.

[19]  U. Bakowsky,et al.  Design of Estradiol Loaded PLGA Nanoparticulate Formulations: A Potential Oral Delivery System for Hormone Therapy , 2006, Pharmaceutical Research.

[20]  Mansoor M Amiji,et al.  Multi-functional polymeric nanoparticles for tumour-targeted drug delivery , 2006, Expert opinion on drug delivery.

[21]  M. R. Kumar,et al.  Analytical methods for assay of ellagic acid and its solubility studies. , 2006, Journal of pharmaceutical and biomedical analysis.

[22]  Marie-Hélène Dufresne,et al.  Block copolymer micelles: preparation, characterization and application in drug delivery. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[23]  G. Wani,et al.  Thymoquinone induces apoptosis through activation of caspase‐8 and mitochondrial events in p53‐null myeloblastic leukemia HL‐60 cells , 2005, International journal of cancer.

[24]  Michael Hawkins,et al.  Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[25]  B. Aggarwal,et al.  From chemoprevention to chemotherapy: common targets and common goals , 2004, Expert opinion on investigational drugs.

[26]  R. Schneider-Stock,et al.  Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. , 2004, International journal of oncology.

[27]  P. Crooks,et al.  Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes , 2004, Anti-cancer drugs.

[28]  M. Cho,et al.  Novel Oral Formulation of Paclitaxel Inhibits Neointimal Hyperplasia in a Rat Carotid Artery Injury Model , 2004, Circulation.

[29]  H. Matsuda,et al.  Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa. , 2004, Organic letters.

[30]  R. Stafford,et al.  Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[31]  S. Feng,et al.  A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[32]  J. Singer,et al.  Synthesis and in Vivo Antitumor Activity of Poly(l-glutamic acid) Conjugates of 20(S)-Camptothecin , 2003 .

[33]  O. Badary,et al.  Thymoquinone Is a Potent Superoxide Anion Scavenger , 2003, Drug and chemical toxicology.

[34]  P. Couvreur,et al.  Nanoparticles in cancer therapy and diagnosis. , 2002, Advanced drug delivery reviews.

[35]  Erkki Ruoslahti,et al.  A tumor-homing peptide with a targeting specificity related to lymphatic vessels , 2002, Nature Medicine.

[36]  A. El‐Khatib,et al.  Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT‐diaphorase in different tissues of mice: a possible mechanism of action , 2002, Cell biochemistry and function.

[37]  O. Badary,et al.  Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone. , 1999, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[38]  P. Crooks,et al.  The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L. , 1998, Anticancer research.

[39]  Kei Yamamoto,et al.  Transcriptional Roles of Nuclear Factor B and Nuclear Factor-Interleukin-6 in the Tumor Necrosis Factor -Dependent Induction of Cyclooxygenase-2 in MC3T3-E1 Cells (*) , 1995, The Journal of Biological Chemistry.

[40]  F. Hamada,et al.  Anticlastogenic activity of thymoquinone against benzo(a)pyrene in mice. , 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[41]  H. Benghuzzi,et al.  Effects of (-)epigallocatechin gallate and thymoquinone on proliferation of a PANC-1 cell line in culture. , 2006, Biomedical sciences instrumentation.

[42]  P. Dudrick,et al.  In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone. , 2003, International journal of oncology.

[43]  O. Badary,et al.  Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis. , 2001, Cancer detection and prevention.

[44]  L. Murray,et al.  Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[45]  A. Mathur,et al.  Dovepress Open Access to Scientific and Medical Research Open Access Full Text Article Fabrication and Characterization of Silk Fibroin-derived Curcumin Nanoparticles for Cancer Therapy , 2022 .