Nanocarriers for drug delivery applications

Nanobiotechnology research has recently provided numerous basic and applied advances in the health sector. Nanocarriers have been developed for efficient drug delivery and diagnostic tools. Nanocarrier enables an effective, targeted biomolecular interaction in order to lower side effects caused during the treatment. Here, we review the problems associated with the conventional drug development and its delivery system. The efficacy of the treatment can be improved by the usage of efficient nanocarriers such as polymeric nanocarriers, superparamagnetic nanoparticles, quantum dot, dendrimers and lipid nanoparticles. We discuss the mechanisms of delivery. This review may aid in providing better solutions for unsolved problems that prevails with the day-to-day in silico, in vitro and in vivo drug delivery model development.

[1]  M. Chamundeeswari,et al.  Preparation, characterization and evaluation of a biopolymeric gold nanocomposite with antimicrobial activity , 2010, Biotechnology and applied biochemistry.

[2]  Subinoy Rana,et al.  Gold nanoparticle-polymer/biopolymer complexes for protein sensing. , 2011, Faraday discussions.

[3]  Sanyog Jain,et al.  Augmented anticancer activity of a targeted, intracellularly activatable, theranostic nanomedicine based on fluorescent and radiolabeled, methotrexate-folic Acid-multiwalled carbon nanotube conjugate. , 2013, Molecular pharmaceutics.

[4]  M. Vallet‐Regí,et al.  Smart Mesoporous Nanomaterials for Antitumor Therapy , 2015, Nanomaterials.

[5]  J. Cortes,et al.  Final results of a phase III randomized trial of CPX-351 versus 7+3 in older patients with newly diagnosed high risk (secondary) AML. , 2016 .

[6]  Colin J Barrow,et al.  Recent trends in nanomaterials immobilised enzymes for biofuel production , 2016, Critical reviews in biotechnology.

[7]  H. Loh,et al.  Conjugation of insulin onto the sidewalls of single-walled carbon nanotubes through functionalization and diimide-activated amidation , 2016, International journal of nanomedicine.

[8]  D. Carroll,et al.  Rapid photothermal intracellular drug delivery using multiwalled carbon nanotubes. , 2009, Molecular pharmaceutics.

[9]  N. Barakat,et al.  Magnetically modulated nanosystems: a unique drug-delivery platform. , 2009, Nanomedicine.

[10]  S. Barry,et al.  Challenges in the development of magnetic particles for therapeutic applications , 2008, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[11]  Younan Xia,et al.  Nanomedicine: swarming towards the target. , 2011, Nature materials.

[12]  Francesco Stellacci,et al.  Effect of surface properties on nanoparticle-cell interactions. , 2010, Small.

[13]  M. Ferrari,et al.  Enzyme-responsive multistage vector for drug delivery to tumor tissue. , 2016, Pharmacological research.

[14]  G. Bendas,et al.  VCAM-1 directed immunoliposomes selectively target tumor vasculature in vivo. , 2008, Biochimica et biophysica acta.

[15]  Warren C W Chan,et al.  Strategies for the intracellular delivery of nanoparticles. , 2011, Chemical Society reviews.

[16]  K. G. Rajeev,et al.  Rational design of cationic lipids for siRNA delivery , 2010, Nature Biotechnology.

[17]  Huifeng Qian,et al.  A resonance energy transfer between chemiluminescent donors and luminescent quantum-dots as acceptors (CRET). , 2006, Angewandte Chemie.

[18]  New Ways to Treat Tuberculosis Using Dendrimers as Nanocarriers , 2018, Pharmaceutics.

[19]  H. W. Scheeren,et al.  "Cascade-release dendrimers" liberate all end groups upon a single triggering event in the dendritic core. , 2003, Angewandte Chemie.

[20]  Thommey P. Thomas,et al.  Synthesis, characterization, and intracellular uptake of carboxyl-terminated poly(amidoamine) dendrimer-stabilized iron oxide nanoparticles. , 2007, Physical chemistry chemical physics : PCCP.

[21]  Giles Richardson,et al.  Mathematical modelling of magnetically targeted drug delivery , 2005 .

[22]  V. Muzykantov,et al.  Ferritin‐based drug delivery systems: Hybrid nanocarriers for vascular immunotargeting , 2018, Journal of controlled release : official journal of the Controlled Release Society.

[23]  Paula T Hammond,et al.  Layer-by-layer nanoparticles with a pH-sheddable layer for in vivo targeting of tumor hypoxia. , 2011, ACS nano.

[24]  Chapter 2 Nanoparticles Types , Classifi cation , Characterization , Fabrication Methods and Drug Delivery Applications , 2020 .

[25]  Marilena Loizidou,et al.  Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer. , 2009, Trends in pharmacological sciences.

[26]  R. Minshall,et al.  Delivery of nanoparticle‐complexed drugs across the vascular endothelial barrier via caveolae , 2011, IUBMB life.

[27]  R. Sanyal,et al.  Dendrimers and Dendrons as Versatile Building Blocks for the Fabrication of Functional Hydrogels , 2016, Molecules.

[28]  T. Niidome,et al.  Conversion of rod-shaped gold nanoparticles to spherical forms and their effect on biodistribution in tumor-bearing mice , 2012, Nanoscale Research Letters.

[29]  Younan Xia,et al.  Engineered Nanoparticles for Drug Delivery in Cancer Therapy * , 2015, Nanomaterials and Neoplasms.

[30]  Xuanmiao Zhang,et al.  Novel lipid hybrid albumin nanoparticle greatly lowered toxicity of pirarubicin. , 2013, Molecular pharmaceutics.

[31]  G. Baskar,et al.  Conjugation, labeling and characterization of asparaginase bound silver nanoparticles for anticancer applications , 2017 .

[32]  Madan Lal Verma,et al.  Immobilization of β-d-galactosidase from Kluyveromyces lactis on functionalized silicon dioxide nanoparticles: characterization and lactose hydrolysis. , 2012, International journal of biological macromolecules.

[33]  M. O’Donnell,et al.  Multifunctional nanoparticles as coupled contrast agents. , 2010, Nature communications.

[34]  Y. Kalia,et al.  Selective delivery of adapalene to the human hair follicle under finite dose conditions using polymeric micelle nanocarriers. , 2018, Nanoscale.

[35]  Qi Zhou,et al.  Tumor-Targeting Nanocomplex Delivery of Novel Tumor Suppressor RB94 Chemosensitizes Bladder Carcinoma Cells In vitro and In vivo , 2008, Clinical Cancer Research.

[36]  Madan Lal Verma,et al.  Nanobiotechnology advances in enzymatic biosensors for the agri-food industry , 2017, Environmental Chemistry Letters.

[37]  Mauro Ferrari,et al.  Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. , 2008, Nature nanotechnology.

[38]  Vincent M. Rotello,et al.  Tuning Payload Delivery in Tumour Cylindroids using Gold Nanoparticles , 2010, Nature nanotechnology.

[39]  Chad A. Mirkin,et al.  Gene regulation with polyvalent siRNA-nanoparticle conjugates. , 2009, Journal of the American Chemical Society.

[40]  Itamar Willner,et al.  Chemiluminescent and chemiluminescence resonance energy transfer (CRET) detection of DNA, metal ions, and aptamer-substrate complexes using hemin/G-quadruplexes and CdSe/ZnS quantum dots. , 2011, Journal of the American Chemical Society.

[41]  D. Peer,et al.  Advances in RNAi therapeutic delivery to leukocytes using lipid nanoparticles , 2016, Journal of drug targeting.

[42]  Dong-Dong Zhang,et al.  Erythrocyte membrane bioinspired near-infrared persistent luminescence nanocarriers for in vivo long-circulating bioimaging and drug delivery. , 2018, Biomaterials.

[43]  Robert Langer,et al.  Nanoparticle delivery of cancer drugs. , 2012, Annual review of medicine.

[44]  V. Torchilin.  Recent advances with liposomes as pharmaceutical carriers , 2005, Nature Reviews Drug Discovery.

[45]  N. Mishra,et al.  Lipid polymer hybrid as emerging tool in nanocarriers for oral drug delivery , 2016, Artificial cells, nanomedicine, and biotechnology.

[46]  Jan E Schnitzer,et al.  Overcoming in vivo barriers to targeted nanodelivery. , 2011, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[47]  P. Cullis,et al.  Drug Delivery Systems: Entering the Mainstream , 2004, Science.

[48]  Madan Lal Verma,et al.  Nanobiotechnology as a novel paradigm for enzyme immobilisation and stabilisation with potential applications in biodiesel production , 2012, Applied Microbiology and Biotechnology.

[49]  Wei Pan,et al.  Hollow Mesoporous Silica Nanoparticles with Tunable Structures for Controlled Drug Delivery. , 2017, ACS applied materials & interfaces.

[50]  Hans-Gerd Löhmannsröben,et al.  Quantum dot biosensors for ultrasensitive multiplexed diagnostics. , 2010, Angewandte Chemie.

[51]  Warren C W Chan,et al.  Nanoparticle-mediated cellular response is size-dependent. , 2008, Nature nanotechnology.

[52]  Wei Lu,et al.  Photoacoustic imaging of living mouse brain vasculature using hollow gold nanospheres. , 2010, Biomaterials.

[53]  A. Seifalian,et al.  Organic nanocarriers for cancer drug delivery. , 2012, Current opinion in pharmacology.

[54]  Maohong Fan,et al.  Charge‐Reversal Drug Conjugate for Targeted Cancer Cell Nuclear Drug Delivery , 2009 .

[55]  Kaushal Rege,et al.  Inorganic nanoparticles for cancer imaging and therapy. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[56]  D. Chirio,et al.  Recent studies on the delivery of hydrophilic drugs in nanoparticulate systems , 2016 .

[57]  Ick Chan Kwon,et al.  In vivo targeted delivery of nanoparticles for theranosis. , 2011, Accounts of chemical research.

[58]  Norman C. Billingham,et al.  Degradation of Polymers , 2002 .

[59]  G. Riess,et al.  Micellization of block copolymers , 2003 .

[60]  S. Iijima.  Helical microtubules of graphitic carbon , 1991, Nature.

[61]  B. Lindman,et al.  Micelles. Physical chemistry of surfactant association , 1979 .

[62]  Catherine C. Berry,et al.  Progress in functionalization of magnetic nanoparticles for applications in biomedicine , 2009 .

[63]  V. Patravale,et al.  Polymeric nanoparticles for targeted treatment in oncology: current insights , 2015, International journal of nanomedicine.

[64]  Xiaohua Huang,et al.  Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. , 2006, Journal of the American Chemical Society.

[65]  Joseph M. DeSimone,et al.  Strategies in the design of nanoparticles for therapeutic applications , 2010, Nature Reviews Drug Discovery.

[66]  Yulei Chang,et al.  Synthesis and characterization of DOX-conjugated dendrimer-modified magnetic iron oxide conjugates for magnetic resonance imaging, targeting, and drug delivery , 2012 .

[67]  A. Linkous,et al.  Novel therapeutic approaches for targeting tumor angiogenesis. , 2012, Anticancer research.

[68]  Jun Lin,et al.  Inorganic nanocarriers for platinum drug delivery , 2015 .

[69]  G. Baskar,et al.  Synthesis and Characterization of Asparaginase Bound Silver Nanocomposite Against Ovarian Cancer Cell Line A2780 and Lung Cancer Cell Line A549 , 2016, Journal of Inorganic and Organometallic Polymers and Materials.

[70]  Esther H Chang,et al.  Does a targeting ligand influence nanoparticle tumor localization or uptake? , 2008, Trends in biotechnology.

[71]  Hong Zhao,et al.  Colorimetric Assay for Determination of Lead (II) Based on Its Incorporation into Gold Nanoparticles during Their Synthesis , 2010, Sensors.

[72]  Lihong V. Wang,et al.  Photoacoustic tomography of a nanoshell contrast agent in the in vivo rat brain , 2004 .

[73]  J. Michaelis,et al.  Nanostructured silica materials as drug-delivery systems for Doxorubicin: single molecule and cellular studies. , 2009, Nano letters.

[74]  Weihong Tan,et al.  Nanotechnology in therapeutics : a focus on nanoparticles as a drug delivery system Review , 2008 .

[75]  F. Vögtle,et al.  Dendrimers and Dendrons: Concepts, Syntheses, Applications , 2001 .

[76]  Hong Zhao,et al.  Colorimetric detection of glucose in rat brain using gold nanoparticles. , 2010, Angewandte Chemie.

[77]  Alberto Bianco,et al.  Carbon nanotubes for the delivery of therapeutic molecules , 2004, Expert opinion on drug delivery.

[78]  Y. Barenholz.  Doxil®--the first FDA-approved nano-drug: lessons learned. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[79]  Roy Bicknell,et al.  Tumour vascular targeting , 2005, Nature Reviews Cancer.

[80]  S. Sahoo,et al.  PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect. , 2011, Advanced drug delivery reviews.

[81]  S. Wise.  Nanocarriers as an emerging platform for cancer therapy , 2007 .

[82]  Y. S. Rao,et al.  Mucoadhesive microspheres for controlled drug delivery. , 2004, Biological & pharmaceutical bulletin.

[83]  Takuro Niidome,et al.  PEG-modified gold nanorods with a stealth character for in vivo applications. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[84]  Vincent M Rotello,et al.  Nano meets biology: structure and function at the nanoparticle interface. , 2011, Langmuir : the ACS journal of surfaces and colloids.

[85]  Neetu Singh,et al.  Nanoparticles that communicate in vivo to amplify tumour targeting. , 2011, Nature materials.

[86]  Michael J Sailor,et al.  Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas. , 2009, Cancer research.

[87]  M. García,et al.  Surface plasmons in metallic nanoparticles: fundamentals and applications , 2012 .

[88]  U. Dianzani,et al.  Development and Characterization of Solid Lipid Nanoparticles Loaded with a Highly Active Doxorubicin Derivative , 2018, Nanomaterials.

[89]  T. Muthukumar,et al.  Carbon nanoparticle from a natural source fabricated for folate receptor targeting, imaging and drug delivery application in A549 lung cancer cells. , 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[90]  A. Rasedee,et al.  Tamoxifen-loaded nanostructured lipid carrier as a drug delivery system: characterization, stability assessment and cytotoxicity. , 2013, Colloids and surfaces. B, Biointerfaces.

[91]  P. Cullis,et al.  Advances in Lipid Nanoparticles for siRNA Delivery , 2013, Pharmaceutics.

[92]  J. Eriksson,et al.  Cancer-cell-specific induction of apoptosis using mesoporous silica nanoparticles as drug-delivery vectors. , 2010, Small.

[93]  Rainer Haag,et al.  Dendritic Polymers in Biomedical Applications: From Potential to Clinical Use in Diagnostics and Therapy , 2002 .

[94]  J. West,et al.  Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy. , 2007, Nano letters.

[95]  Dan Peer,et al.  Progress and challenges towards targeted delivery of cancer therapeutics , 2018, Nature Communications.

[96]  F. Szoka,et al.  A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas , 2006, Proceedings of the National Academy of Sciences.

[97]  Robert Langer,et al.  Nanoparticle technologies for cancer therapy. , 2010, Handbook of experimental pharmacology.

[98]  Qinfu Zhao,et al.  Hybrid lipid-capped mesoporous silica for stimuli-responsive drug release and overcoming multidrug resistance. , 2015, ACS applied materials & interfaces.

[99]  J. Panyam,et al.  Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[100]  G. Baskar,et al.  Gold nanoparticle mediated delivery of fungal asparaginase against cancer cells , 2018 .

[101]  P. Kantoff,et al.  Cancer nanomedicine: progress, challenges and opportunities , 2016, Nature Reviews Cancer.

[102]  R. Arceci,et al.  Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[103]  J. West,et al.  Immunotargeted nanoshells for integrated cancer imaging and therapy. , 2005, Nano letters.

[104]  Honglai Liu,et al.  Copolymer micelles function as pH-responsive nanocarriers to enhance the cytotoxicity of a HER2 aptamer in HER2-positive breast cancer cells , 2018, International journal of nanomedicine.

[105]  Sven Christian,et al.  Nucleolin expressed at the cell surface is a marker of endothelial cells in tumor blood vessels , 2003 .

[106]  T. Imae.  Physicochemical Properties of Dendrimers and Dendrimer Complexes , 2012 .

[107]  R. Duncan,et al.  Dendrimer-platinate: a novel approach to cancer chemotherapy. , 1999, Anti-cancer drugs.

[108]  L. Potocký,et al.  Influence of the melt overheating and the cooling rate on the magnetic properties of Fe83.4B16.6 amorphous alloys , 1980 .

[109]  L. Liao,et al.  Applications of Nanoparticles for Anticancer Drug Delivery: A Review. , 2015, Journal of nanoscience and nanotechnology.

[110]  Erkki Ruoslahti,et al.  Targeted quantum dot conjugates for siRNA delivery. , 2007, Bioconjugate chemistry.

[111]  B Shapiro,et al.  Magnetic nanoparticle transport within flowing blood and into surrounding tissue. , 2010, Nanomedicine.

[112]  S. Yadav,et al.  Nanoencapsulation for drug delivery , 2014, EXCLI journal.

[113]  V. Torchilin,et al.  Drug targeting. , 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[114]  M. Repka,et al.  Recent advancements in mucoadhesive floating drug delivery systems: A mini-review , 2016 .

[115]  Qiang Zhang,et al.  Core-shell type lipid/rPAA-Chol polymer hybrid nanoparticles for in vivo siRNA delivery. , 2014, Biomaterials.

[116]  A. Seifalian,et al.  A new era of cancer treatment: carbon nanotubes as drug delivery tools , 2011, International journal of nanomedicine.

[117]  Ying Wang,et al.  Mesoporous silica nanoparticles in drug delivery and biomedical applications. , 2015, Nanomedicine : nanotechnology, biology, and medicine.

[118]  A. Alivisatos.  Semiconductor Clusters, Nanocrystals, and Quantum Dots , 1996, Science.

[119]  Erkki Ruoslahti,et al.  Targeting of drugs and nanoparticles to tumors , 2010, The Journal of cell biology.

[120]  C. Barrow,et al.  Enzyme immobilization on nanomaterials for biofuel production. , 2013, Trends in biotechnology.

[121]  Jun Fang,et al.  The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. , 2011, Advanced drug delivery reviews.

[122]  B. Mishra,et al.  Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery. , 2010, Nanomedicine : nanotechnology, biology, and medicine.

[123]  G. Giammona,et al.  Nanostructured Lipid Carriers-Containing Anticancer Compounds: Preparation, Characterization, and Cytotoxicity Studies , 2007, Drug delivery.

[124]  P. Low,et al.  Tumor detection using folate receptor-targeted imaging agents , 2008, Cancer and Metastasis Reviews.

[125]  Vladimir Torchilin,et al.  Tumor delivery of macromolecular drugs based on the EPR effect. , 2011, Advanced drug delivery reviews.

[126]  Christian Plank,et al.  Generation of magnetic nonviral gene transfer agents and magnetofection in vitro , 2007, Nature Protocols.

[127]  H. Yoo,et al.  Self-assembled nanoparticles containing hydrophobically modified glycol chitosan for gene delivery. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[128]  May D. Wang,et al.  In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags , 2008, Nature Biotechnology.

[129]  V. Torchilin,et al.  Current trends in the use of liposomes for tumor targeting. , 2013, Nanomedicine.

[130]  A. Elaissari,et al.  Lipid nanocarriers as skin drug delivery systems: Properties, mechanisms of skin interactions and medical applications. , 2018, International journal of pharmaceutics.

[131]  Chee Wee Gan,et al.  Transferrin-conjugated nanoparticles of poly(lactide)-D-alpha-tocopheryl polyethylene glycol succinate diblock copolymer for targeted drug delivery across the blood-brain barrier. , 2010, Biomaterials.

[132]  Christine Allen,et al.  The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles. , 2010, Molecular pharmaceutics.

[133]  Colin J Barrow,et al.  Immobilization of β-glucosidase on a magnetic nanoparticle improves thermostability: application in cellobiose hydrolysis. , 2013, Bioresource technology.

[134]  G. Yener,et al.  Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives , 2007, International journal of nanomedicine.

[135]  R. Zhuo,et al.  In vitro release of 5-fluorouracil with cyclic core dendritic polymer. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[136]  Vincent M Rotello,et al.  Detection and identification of proteins using nanoparticle-fluorescent polymer 'chemical nose' sensors. , 2007, Nature nanotechnology.

[137]  B. Michniak-Kohn,et al.  Polymeric nanoparticles-based topical delivery systems for the treatment of dermatological diseases. , 2013, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[138]  Christopher J. Destache,et al.  Nanotechnology: A Focus on Nanoparticles as a Drug Delivery System , 2006, Journal of Neuroimmune Pharmacology.

[139]  T. Nishimura,et al.  Monoclonal antibody A7-superparamagnetic iron oxide as contrast agent of MR imaging of rectal carcinoma , 2005, British Journal of Cancer.

[140]  Lisa Brannon-Peppas,et al.  Active targeting schemes for nanoparticle systems in cancer therapeutics. , 2008, Advanced drug delivery reviews.

[141]  D. Balding,et al.  HLA Sequence Polymorphism and the Origin of Humans , 2006 .

[142]  R H Guy,et al.  Skin penetration and distribution of polymeric nanoparticles. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[143]  Rajesh Singh,et al.  Nanoparticle-based targeted drug delivery. , 2009, Experimental and molecular pathology.

[144]  J. Rosenholm,et al.  Lipid Bilayer-Gated Mesoporous Silica Nanocarriers for Tumor-Targeted Delivery of Zoledronic Acid in Vivo. , 2017, Molecular pharmaceutics.

[145]  Hui Zhang,et al.  Gold nanocages: bioconjugation and their potential use as optical imaging contrast agents. , 2005, Nano letters.

[146]  C. Houtman,et al.  Sulfonated Amphiphilic Block Copolymers: Synthesis, Self-Assembly in Water, and Application as Stabilizer in Emulsion Polymerization , 2009 .

[147]  Shilong Wang,et al.  pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release , 2012, International journal of nanomedicine.

[148]  Mark E. Davis,et al.  Nanoparticle therapeutics: an emerging treatment modality for cancer , 2008, Nature Reviews Drug Discovery.

[149]  Minoo Naebe,et al.  Enzyme Immobilisation on Amino-Functionalised Multi-Walled Carbon Nanotubes: Structural and Biocatalytic Characterisation , 2013, PloS one.

[150]  Yong-Keun Lee,et al.  Targeting to carcinoma cells with chitosan- and starch-coated magnetic nanoparticles for magnetic hyperthermia. , 2009, Journal of biomedical materials research. Part A.

[151]  Younan Xia,et al.  Gold nanocages covered by smart polymers for controlled release with near-infrared light , 2009, Nature materials.

[152]  H. Tan,et al.  Delivery of paclitaxel by physically loading onto poly(ethylene glycol) (PEG)-graftcarbon nanotubes for potent cancer therapeutics , 2010, Nanotechnology.

[153]  P. Babinec,et al.  In vivo heating of magnetic nanoparticles in alternating magnetic field. , 2004, Medical physics.

[154]  S. Jain,et al.  A PEGylated dendritic nanoparticulate carrier of fluorouracil. , 2003, International journal of pharmaceutics.

[155]  R. Müller,et al.  Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. , 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[156]  Igor L. Medintz,et al.  Multiplex charge-transfer interactions between quantum dots and peptide-bridged ruthenium complexes. , 2009, Analytical chemistry.

[157]  C. Mirkin,et al.  Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection. , 2002, Science.

[158]  Karl-Titus Hoffmann,et al.  Post-mortem studies in glioblastoma patients treated with thermotherapy using magnetic nanoparticles. , 2009, Biomaterials.

[159]  M. Amiji,et al.  Targeted Drug Delivery to Tumor Cells Using Colloidal Carriers , 2004 .

[160]  Christian Bergemann,et al.  Physiological aspects in magnetic drug-targeting , 1999 .

[161]  S. Thayumanavan,et al.  Molecular Recognition in Dendrimers , 2004 .

[162]  M. Gottesman.  Mechanisms of cancer drug resistance. , 2002, Annual review of medicine.

[163]  A. Fernández-Medarde,et al.  Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy. , 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[164]  Zhuo Georgia Chen,et al.  Advances of cancer therapy by nanotechnology. , 2009, Cancer research and treatment : official journal of Korean Cancer Association.

[165]  V. Rotello,et al.  Beauty is skin deep: a surface monolayer perspective on nanoparticle interactions with cells and bio-macromolecules. , 2011, Small.

[166]  David C. Zhu,et al.  Magnetic glyco-nanoparticles: a tool to detect, differentiate, and unlock the glyco-codes of cancer via magnetic resonance imaging. , 2010, Journal of the American Chemical Society.

[167]  Véronique Préat,et al.  To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[168]  Erkki Ruoslahti,et al.  Nanocrystal targeting in vivo , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[169]  T. Young,et al.  Doxorubicin delivery by polyamidoamine dendrimer conjugation and photochemical internalization for cancer therapy. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[170]  S. Little,et al.  Biomimetic Delivery with Micro‐ and Nanoparticles , 2012, Advanced materials.

[171]  San-Yuan Chen,et al.  Dual-drug nanomedicine with hydrophilic F127-modified magnetic nanocarriers assembled in amphiphilic gelatin for enhanced penetration and drug delivery in deep tumor tissue , 2018, International journal of nanomedicine.

[172]  E. Agostinelli,et al.  Iron nanoparticles from animal blood for cellular imaging and targeted delivery for cancer treatment. , 2013, Biochimica et biophysica acta.

[173]  Dong‐sheng Zhang,et al.  Using thermal energy produced by irradiation of Mn-Zn ferrite magnetic nanoparticles (MZF-NPs) for heat-inducible gene expression. , 2008, Biomaterials.

[174]  Vincent M. Rotello,et al.  Cell surface-based differentiation of cell types and cancer states using a gold nanoparticle-GFP based sensing array , 2010 .

[175]  E. Frenkel,et al.  Nanoparticles for drug delivery in cancer treatment. , 2008, Urologic oncology.

[176]  A. Al-sabagh,et al.  Investigate the Demulsification Efficiency of Some Novel Demulsifiers in Relation to Their Surface Active Properties , 2007 .

[177]  H. Santos,et al.  Inorganic Nanoparticles in Targeted Drug Delivery and Imaging , 2015 .

[178]  Weian Zhao,et al.  Tumour targeting: Nanoantennas heat up. , 2009, Nature materials.

[179]  H. Maeda,et al.  A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. , 1986, Cancer research.