PREVENTION OF ACUTE GASTRIC ULCERATION IN THE RAT BY CIMETIDINE, A HISTAMINE H2‐RECEPTOR ANTAGONIST

1. Intraperitoneal injections of cimetidine into rats markedly reduced gastric acid production. When given at a dose of 50 mg/kg body weight, rate of acid production fell from a mean of 2.73 μmol/min (s.d. = 0.32) to a lowest level of 0.81 (s.d. = 0.28): the difference was highly significant (P< 0.005). When given in a dose of 100 mg/kg, the rate of acid production further fell to 0.18 μmmol/min (s.d. = 0.12; P< 0.001).

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