An assessment of the toxicological properties of pyrethroids and their neurotoxicity.

Abstract1. Most pyrethroids can be divided into two classes on the basis of differences in the signs of toxicity (T- orCS-syndromes). Since these syndromes also correspond to particular aspects of their chemical structure and since the order of appearance of the signs of poisoning is the same in each class, it is concluded that these syndromes originate from a single primary action of the pyrethroid.2. Pyrethroids cause morphological changes in peripheral nerves of rats when given in high doses. The production of these minor lesions are correlated with a dose of the pyrethroid that causes death in some of the treated rats. Lower doses do not cause these effects. Therefore, the morphological changes are produced as a secondary consequence of the primary action of pyrethroids and are not due to a different form of toxicity.3. Pyrethroids have been shown to cause functional changes (behavioral) in rats shown as a deficit in performance on an inclined plane. Increases in peripheral nerves of β-glucuronidase a...

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