4 Experimental Twin Studies

[1]  S. O’Rahilly,et al.  A comparative study of the central effects of specific proopiomelancortin (POMC)-derived melanocortin peptides on food intake and body weight in pomc null mice. , 2006, Endocrinology.

[2]  R. Cone,et al.  Central receptors mediating the cardiovascular actions of melanocyte stimulating hormones , 2006, Journal of hypertension.

[3]  Olivier Boss,et al.  Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake , 2006, Neuron.

[4]  M. Hulver,et al.  Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. , 2006, Endocrinology.

[5]  A. Butler The melanocortin system and energy balance , 2006, Peptides.

[6]  M. Low,et al.  Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice. , 2006, The Journal of clinical investigation.

[7]  A. Murphy,et al.  Agouti-related protein-deficient mice display an age-related lean phenotype. , 2005, Cell metabolism.

[8]  G. Barsh,et al.  Effects of Hypothalamic Neurodegeneration on Energy Balance , 2005, PLoS biology.

[9]  Robert A. McGovern,et al.  Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure , 2005, Cell.

[10]  R. Palmiter,et al.  NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates , 2005, Science.

[11]  M. Ghatei,et al.  Postembryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[12]  A. Butler,et al.  Double leptin and melanocortin-4 receptor gene mutations have an additive effect on fat mass and are associated with reduced effects of leptin on weight loss and food intake. , 2005, Endocrinology.

[13]  K. Mori,et al.  Neuromedin s is a novel anorexigenic hormone. , 2005, Endocrinology.

[14]  Thorsten Buch,et al.  Agouti-related peptide–expressing neurons are mandatory for feeding , 2005, Nature Neuroscience.

[15]  T. Ludwig,et al.  Neuronal deletion of Lepr elicits diabesity in mice without affecting cold tolerance or fertility. , 2005, American journal of physiology. Endocrinology and metabolism.

[16]  G. Kilroy,et al.  Targeted deletion of melanocortin receptor subtypes 3 and 4, but not CART, alters nutrient partitioning and compromises behavioral and metabolic responses to leptin , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[17]  Minghua Li,et al.  Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. , 2005, Cell metabolism.

[18]  J. Jeon,et al.  Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms. , 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

[19]  R. Cone Anatomy and regulation of the central melanocortin system , 2005, Nature Neuroscience.

[20]  Jimmy D Bell,et al.  The role of insulin receptor substrate 2 in hypothalamic and beta cell function. , 2005, The Journal of clinical investigation.

[21]  T. Kowalski,et al.  Transgenic overexpression of neuromedin U promotes leanness and hypophagia in mice. , 2005, The Journal of endocrinology.

[22]  A. Häkkinen,et al.  Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins. , 2005, American journal of physiology. Endocrinology and metabolism.

[23]  M. Seifert,et al.  Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. , 2005, Molecular endocrinology.

[24]  N. Billestrup,et al.  Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling. , 2005, Journal of molecular endocrinology.

[25]  R. Kulkarni,et al.  Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. , 2005, Cell metabolism.

[26]  D. Porte,et al.  Diabetes, Obesity, and the Brain , 2005, Science.

[27]  M. Cowley,et al.  The electrophysiology of feeding circuits , 2004, Trends in Endocrinology & Metabolism.

[28]  M. Myers,et al.  LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. , 2004, Diabetes.

[29]  G. Feng,et al.  Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[30]  H. Münzberg,et al.  Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. , 2004, Endocrinology.

[31]  S. Woods,et al.  Mice lacking the syndecan-3 gene are resistant to diet-induced obesity. , 2004, The Journal of clinical investigation.

[32]  T. Noda,et al.  Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. , 2004, The Journal of clinical investigation.

[33]  M. Ikawa,et al.  Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway , 2004, Nature Medicine.

[34]  M. White,et al.  Disruption of the SH2-B Gene Causes Age-Dependent Insulin Resistance and Glucose Intolerance , 2004, Molecular and Cellular Biology.

[35]  S. Chua,et al.  Metabolic effects of transgenic melanocyte-stimulating hormone overexpression in lean and obese mice. , 2004, Endocrinology.

[36]  J. Wess,et al.  Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice. , 2004, Diabetes.

[37]  J. Flier,et al.  Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3 , 2004, Nature Medicine.

[38]  A. Yoshimura,et al.  Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity , 2004, Nature Medicine.

[39]  B. Lowell,et al.  Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis , 2004, Neuron.

[40]  S. O’Rahilly,et al.  Proopiomelanocortin and energy balance: insights from human and murine genetics. , 2004, The Journal of clinical endocrinology and metabolism.

[41]  A. Blanks,et al.  Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus , 2004, Nature Neuroscience.

[42]  S. Bouret,et al.  Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding , 2004, Science.

[43]  Kanji A. Takahashi,et al.  Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system , 2004, Nature Neuroscience.

[44]  J Dixon,et al.  Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[45]  T. Horvath,et al.  Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[46]  S. Bouret,et al.  Formation of Projection Pathways from the Arcuate Nucleus of the Hypothalamus to Hypothalamic Regions Implicated in the Neural Control of Feeding Behavior in Mice , 2004, The Journal of Neuroscience.

[47]  Qiong Li,et al.  Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice. , 2004, American journal of physiology. Endocrinology and metabolism.

[48]  C. Bouchard,et al.  Role of candidate genes in the responses to long‐term overfeeding: review of findings , 2004, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[49]  C. Mobbs,et al.  Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice. , 2003, Diabetes.

[50]  A. Mark,et al.  Role of Melanocortin-4 Receptors in Mediating Renal Sympathoactivation to Leptin and Insulin , 2003, The Journal of Neuroscience.

[51]  E. H. Goulding,et al.  Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor , 2003, Nature Neuroscience.

[52]  M. Low,et al.  Lack of Proopiomelanocortin Peptides Results in Obesity and Defective Adrenal Function but Normal Melanocyte Pigmentation in the Murine C57BL/6 Genetic Background , 2003, Annals of the New York Academy of Sciences.

[53]  R. Seeley,et al.  Syndecan‐3 Modulates Food Intake by Interacting with the Melanocortin/AgRP Pathway , 2003, Annals of the New York Academy of Sciences.

[54]  Xiaomei Wang,et al.  NPY ablation in C57BL/6 mice leads to mild obesity and to an impaired refeeding response to fasting. , 2003, American journal of physiology. Endocrinology and metabolism.

[55]  A. Tsuchida,et al.  Antiobesity and antidiabetic effects of brain-derived neurotrophic factor in rodent models of leptin resistance , 2003, International Journal of Obesity.

[56]  H. Iwaasa,et al.  Chronic intracerebroventricular infusion of MCH causes obesity in mice. Melanin-concentrating hormone. , 2003, American journal of physiology. Endocrinology and metabolism.

[57]  R. Seeley,et al.  Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. , 2003, Diabetes.

[58]  A. Bradley,et al.  Tools for targeted manipulation of the mouse genome. , 2002, Physiological genomics.

[59]  C. Saper,et al.  The Need to Feed Homeostatic and Hedonic Control of Eating , 2002, Neuron.

[60]  M. Low,et al.  Activation of Central Melanocortin Pathways by Fenfluramine , 2002, Science.

[61]  A. Rissanen,et al.  Acquired preference especially for dietary fat and obesity: a study of weight-discordant monozygotic twin pairs , 2002, International Journal of Obesity.

[62]  D. Macneil,et al.  Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice , 2002, Molecular and Cellular Biology.

[63]  R. Cone,et al.  The melanocortin receptors: Lessons from knockout models , 2002, Neuropeptides.

[64]  B. Kennedy,et al.  Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. , 2002, Developmental cell.

[65]  Young-Bum Kim,et al.  PTP1B regulates leptin signal transduction in vivo. , 2002, Developmental cell.

[66]  C. Bouchard,et al.  Skeletal muscle characteristics predict body fat gain in response to overfeeding in never-obese young men. , 2002, Metabolism: clinical and experimental.

[67]  Yue Feng,et al.  Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[68]  H. Grill,et al.  The Neuroanatomical Axis for Control of Energy Balance , 2002, Frontiers in Neuroendocrinology.

[69]  T. Pedrazzini,et al.  Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism , 2001, Molecular and Cellular Endocrinology.

[70]  M. Schwartz,et al.  Intracellular signalling: Key enzyme in leptin-induced anorexia , 2001, Nature.

[71]  G. Barsh,et al.  Transgenic Expression of Syndecan-1 Uncovers a Physiological Control of Feeding Behavior by Syndecan-3 , 2001, Cell.

[72]  R. Cone,et al.  Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat , 2001, Nature Neuroscience.

[73]  M. Low,et al.  Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus , 2001, Nature.

[74]  M. Fujimiya,et al.  Modest overexpression of neuropeptide Y in the brain leads to obesity after high-sucrose feeding. , 2001, Diabetes.

[75]  A. Stunkard,et al.  A twin study of weight loss and metabolic efficiency , 2001, International Journal of Obesity.

[76]  A. Yamanaka,et al.  Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean , 2001, Nature.

[77]  B. Lowell,et al.  Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. , 2001, The Journal of clinical investigation.

[78]  D. Barford,et al.  Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. , 2000, Molecular cell.

[79]  R. Palmiter,et al.  A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[80]  B. Borowsky,et al.  Identification and Characterization of Two Neuromedin U Receptors Differentially Expressed in Peripheral Tissues and the Central Nervous System* , 2000, The Journal of Biological Chemistry.

[81]  Rüdiger Klein,et al.  Role of Brain Insulin Receptor in Control of Body Weight and Reproduction , 2000 .

[82]  Yue Feng,et al.  Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass , 2000, Nature Genetics.

[83]  A. Stunkard,et al.  Intrapair resemblance in very low calorie diet-induced weight loss in female obese identical twins , 2000, International Journal of Obesity.

[84]  Min-Seon Kim,et al.  Investigation of the melanocyte stimulating hormones on food intake Lack of evidence to support a role for the melanocortin-3-receptor , 2000, Brain Research.

[85]  Reynaldo Sequerra,et al.  High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP , 2000, Nature Genetics.

[86]  Alexander S. Banks,et al.  Activation of Downstream Signals by the Long Form of the Leptin Receptor* , 2000, The Journal of Biological Chemistry.

[87]  J. Metzger,et al.  Role of the melanocortin-4 receptor in metabolic rate and food intake in mice , 2000, Transgenic Research.

[88]  M. Stryker,et al.  Cortical Degeneration in the Absence of Neurotrophin Signaling Dendritic Retraction and Neuronal Loss after Removal of the Receptor TrkB , 2000, Neuron.

[89]  C. Wihler,et al.  Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[90]  E. Arenas,et al.  Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor , 1999, Nature Medicine.

[91]  G. Barsh,et al.  Anatomy of an Endogenous Antagonist: Relationship between Agouti-Related Protein and Proopiomelanocortin in Brain , 1999, The Journal of Neuroscience.

[92]  L. Yaswen,et al.  Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin , 1999, Nature Medicine.

[93]  R. Cone,et al.  Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus Evidence of a Cellular Basis for the Adipostat , 1999, Neuron.

[94]  A. Rissanen,et al.  Environmental factors in the development of obesity in identical twins , 1999, International Journal of Obesity.

[95]  B. Kennedy,et al.  Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. , 1999, Science.

[96]  Motonao Nakamura,et al.  Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[97]  B. Lowell,et al.  Mice lacking melanin-concentrating hormone are hypophagic and lean , 1998, Nature.

[98]  L. Tecott,et al.  Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene , 1998, Nature Medicine.

[99]  R. Palmiter,et al.  Role of the Y5 neuropeptide Y receptor in feeding and obesity , 1998, Nature Medicine.

[100]  J. Flier,et al.  Identification of SOCS-3 as a potential mediator of central leptin resistance. , 1998, Molecular cell.

[101]  G. Shulman,et al.  Disruption of IRS-2 causes type 2 diabetes in mice , 1998, Nature.

[102]  R. Seeley,et al.  Melanocortin receptors in leptin effects , 1997, Nature.

[103]  L. Mathews,et al.  Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling , 1997, Molecular and cellular biology.

[104]  J. Shutter,et al.  Overexpression of Agrt leads to obesity in transgenic mice , 1997, Nature Genetics.

[105]  G. Barsh,et al.  Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. , 1997, Science.

[106]  J. Shutter,et al.  Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. , 1997, Genes & development.

[107]  R. Cone,et al.  Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice , 1997, Cell.

[108]  R. Palmiter,et al.  Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y , 1996, Science.

[109]  R. Seeley,et al.  Identification of targets of leptin action in rat hypothalamus. , 1996, The Journal of clinical investigation.

[110]  S. Dymecki Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[111]  R. Palmiter,et al.  Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y , 1996, Nature.

[112]  S. Gammeltoft,et al.  A role for melanin-concentrating hormone in the central regulation of feeding behaviour , 1996, Nature.

[113]  J. Halford,et al.  Serotonin, eating behavior, and fat intake. , 1995, Obesity research.

[114]  David Julius,et al.  Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors , 1995, Nature.

[115]  F. Rohner-Jeanrenaud,et al.  Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats , 1994, Diabetologia.

[116]  C. Bouchard,et al.  The response to exercise with constant energy intake in identical twins. , 1994, Obesity research.

[117]  T. Rönnemaa,et al.  Autonomic nervous system function in identical twins discordant for obesity. , 1994, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[118]  C. Berdanier Nutrient‐gene interactions: today and tomorrow , 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[119]  M. Mortrud,et al.  Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[120]  M. Mortrud,et al.  Cloning and Functional Characterization of a Family of Receptors for the Melanotropic Peptides , 1993, Annals of the New York Academy of Sciences.

[121]  C. Bouchard,et al.  Non linear weight gain with long term overfeeding in man. , 1993, Obesity research.

[122]  A Tremblay,et al.  Overfeeding and energy expenditure in humans. , 1992, The American journal of clinical nutrition.

[123]  M. Herkenham,et al.  Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. , 1990, Neuroendocrinology.

[124]  A Tremblay,et al.  The response to long-term overfeeding in identical twins. , 1990, The New England journal of medicine.

[125]  N. Henderson,et al.  Cre-stimulated recombination at loxP-containing DNA sequences placed into the mammalian genome. , 1989, Nucleic acids research.

[126]  S. Leibowitz,et al.  Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity , 1986, Peptides.

[127]  G. Forbes,et al.  Deliberate overfeeding in women and men: energy cost and composition of the weight gain , 1986, British Journal of Nutrition.

[128]  J. Durnin,et al.  The effect of 6 weeks of overfeeding on the body weight, body composition, and energy metabolism of young men. , 1980, The American journal of clinical nutrition.

[129]  S. Woods,et al.  Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons , 1979, Nature.

[130]  R Plomin,et al.  Genotype-environment interaction and correlation in the analysis of human behavior. , 1977, Psychological bulletin.

[131]  T. Ludwig,et al.  The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. , 2005, Cell metabolism.

[132]  T. Spector,et al.  From The Cover : Epigenetic differences arise during the lifetime of monozygotic twins , 2005 .

[133]  W. Richards,et al.  Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice. , 2004, Endocrinology.

[134]  M. Myers,et al.  The role of leptin→STAT3 signaling in neuroendocrine function: an integrative perspective , 2004, Journal of Molecular Medicine.

[135]  Rachel Jones Visual attention: Now you see it... , 2002, Nature Reviews Neuroscience.

[136]  R. Palmiter,et al.  Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides , 1999, Nature Genetics.

[137]  L. Pérusse,et al.  Using MZ twins in experimental research to test for the presence of a genotype-environment interaction effect. , 1990, Acta geneticae medicae et gemellologiae.

[138]  Printed in U.S.A. Copyright © 2003 by The Endocrine Society doi: 10.1210/en.2003-0241 Minireview: From Anorexia to Obesity—The Yin and Yang of Body Weight Control , 2022 .

[139]  Printed in U.S.A. Copyright © 2004 by The Endocrine Society doi: 10.1210/en.2004-0231 Minireview: Leptin and Development of Hypothalamic Feeding Circuits , 2022 .