A Fully Biodegradable Battery for Self-Powered Transient Implants.

Biodegradable transient devices represent an emerging type of electronics that could play an essential role in medical therapeutic/diagnostic processes, such as wound healing and tissue regeneration. The associated biodegradable power sources, however, remain as a major challenge toward future clinical applications, as the demonstrated electrical stimulation and sensing functions are limited by wired external power or wireless energy harvesters via near-field coupling. Here, materials' strategies and fabrication schemes that enable a high-performance fully biodegradable magnesium-molybdenum trioxide battery as an alternative approach for an in vivo on-board power supply are reported. The battery can deliver a stable high output voltage as well as prolonged lifetime that could satisfy requirements of representative implantable electronics. The battery is fully biodegradable and demonstrates desirable biocompatibility. The battery system provides a promising solution to advanced energy harvesters for self-powered transient bioresorbable implants as well as eco-friendly electronics.

[1]  T. Radu,et al.  Molybdenum effect on the structure of SiO₂-CaO-P₂O₅ bioactive xerogels and on their interface processes with simulated biofluids. , 2014, Journal of biomedical materials research. Part A.

[2]  Yonggang Huang,et al.  Transient, biocompatible electronics and energy harvesters based on ZnO. , 2013, Small.

[3]  Andreas Demosthenous,et al.  Advances in Microelectronics for Implantable Medical Devices , 2014 .

[4]  M. Allen,et al.  A MEMS-enabled biodegradable battery for powering transient implantable devices , 2014, 2014 IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS).

[5]  Xian Huang,et al.  Materials, Designs, and Operational Characteristics for Fully Biodegradable Primary Batteries , 2014, Advanced materials.

[6]  Fangfang Sun,et al.  A high-energy-density sugar biobattery based on a synthetic enzymatic pathway , 2014, Nature Communications.

[7]  Tian Sang,et al.  Biodegradable Monocrystalline Silicon Photovoltaic Microcells as Power Supplies for Transient Biomedical Implants , 2018 .

[8]  Yonggang Huang,et al.  Dissolvable Metals for Transient Electronics , 2014 .

[9]  R. Datta,et al.  Molybdenum Oxides – From Fundamentals to Functionality , 2017, Advanced materials.

[10]  J. Esquivel,et al.  A Metal‐Free and Biotically Degradable Battery for Portable Single‐Use Applications , 2017 .

[11]  Alberto Saiani,et al.  Degradation kinetics of poly(lactic-co-glycolic) acid block copolymer cast films in phosphate buffer solution as revealed by infrared and Raman spectroscopies , 2011 .

[12]  D. Aurbach,et al.  Electrochemical and spectroscopic analysis of Mg2+ intercalation into thin film electrodes of layered oxides: V2O5 and MoO3. , 2013, Langmuir : the ACS journal of surfaces and colloids.

[13]  Gordon G Wallace,et al.  Biocompatible ionic liquid-biopolymer electrolyte-enabled thin and compact magnesium-air batteries. , 2014, ACS applied materials & interfaces.

[14]  Cunjiang Yu,et al.  Moisture-triggered physically transient electronics , 2017, Science Advances.

[15]  B. Scrosati,et al.  Lithium batteries: Status, prospects and future , 2010 .

[16]  T. Radu,et al.  Synthesis, structure, bioactivity and biocompatibility of melt-derived P2O5‐CaO‐B2O3‐K2O‐MoO3 glasses , 2016 .

[17]  Anantha Chandrakasan,et al.  Design of Low-Voltage Digital Building Blocks and ADCs for Energy-Efficient Systems , 2012, IEEE Transactions on Circuits and Systems II: Express Briefs.

[18]  Kyung Jin Seo,et al.  Bioresorbable Silicon Electronics for Transient Spatio-temporal Mapping of Electrical Activity from the Cerebral Cortex , 2016, Nature materials.

[19]  A Göpferich,et al.  Polyanhydride degradation and erosion. , 2002, Advanced drug delivery reviews.

[20]  A. Chandrakasan,et al.  Prolonged energy harvesting for ingestible devices , 2016, Nature Biomedical Engineering.

[21]  Wenwen Xu,et al.  Food‐Materials‐Based Edible Supercapacitors , 2016 .

[22]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[23]  George M. Savage,et al.  An Ingestible Sensor for Measuring Medication Adherence , 2015, IEEE Transactions on Biomedical Engineering.

[24]  C. Pillai,et al.  Biodegradable Polymers- A Review on Recent Trends and Emerging Perspectives , 2011 .

[25]  Jae-Woong Jeong,et al.  Materials and Wireless Microfluidic Systems for Electronics Capable of Chemical Dissolution on Demand , 2015 .

[26]  Gurvinder Kaur,et al.  PLGA: a unique polymer for drug delivery. , 2015, Therapeutic delivery.

[27]  John A. Rogers,et al.  Biodegradable Thin Metal Foils and Spin‐On Glass Materials for Transient Electronics , 2015 .

[28]  Huanyu Cheng,et al.  Bioresorbable silicon electronic sensors for the brain , 2016, Nature.

[29]  G. Wallace,et al.  Toward Biodegradable Mg–Air Bioelectric Batteries Composed of Silk Fibroin–Polypyrrole Film , 2016 .

[30]  A. Heller Miniature biofuel cells , 2004 .

[31]  Hung Cao,et al.  Power Approaches for Implantable Medical Devices , 2015, Sensors.

[32]  Jahyun Koo,et al.  Fully Biodegradable Microsupercapacitor for Power Storage in Transient Electronics , 2017 .

[33]  Mark G. Allen,et al.  Biodegradable magnesium/iron batteries with polycaprolactone encapsulation: A microfabricated power source for transient implantable devices , 2015, Microsystems & Nanoengineering.

[34]  Wei Luo,et al.  Transient Rechargeable Batteries Triggered by Cascade Reactions. , 2015, Nano letters.

[35]  Huanyu Cheng,et al.  A Physically Transient Form of Silicon Electronics , 2012, Science.

[36]  Brian Litt,et al.  Dissolution of Monocrystalline Silicon Nanomembranes and Their Use as Encapsulation Layers and Electrical Interfaces in Water-Soluble Electronics. , 2017, ACS nano.

[37]  Fiorenzo G. Omenetto,et al.  A Biodegradable Thin-Film Magnesium Primary Battery Using Silk Fibroin–Ionic Liquid Polymer Electrolyte , 2017 .

[38]  Young Jo Kim,et al.  Biologically derived melanin electrodes in aqueous sodium-ion energy storage devices , 2013, Proceedings of the National Academy of Sciences.

[39]  Young Jo Kim,et al.  Self-deployable current sources fabricated from edible materials. , 2013, Journal of materials chemistry. B.

[40]  Reza Montazami,et al.  Physical–chemical hybrid transiency: A fully transient li-ion battery based on insoluble active materials , 2016 .

[41]  Xian Huang,et al.  Materials for Bioresorbable Radio Frequency Electronics , 2013, Advanced materials.

[42]  Huanyu Cheng,et al.  25th Anniversary Article: Materials for High‐Performance Biodegradable Semiconductor Devices , 2014, Advanced materials.

[43]  Liangbing Hu,et al.  Transient Electronics: Materials and Devices , 2016 .