Photonic sensing technology is opening new frontiers in biophotonics

In advanced sensing photonics it is of great importance to explore the detection limits of extremely weak optical signals and imaging using state-of-the art technology. In this paper we describe recent progress in photonic sensing technology achieved in practice in the standard quantum limit of optical detection imposed by the signal-limited shot noise, which can be realized by both the optical heterodyne detection and photon counting techniques. Then, with particular attention on imaging of ultraweak photonic signals by these techniques, their applications in developing new frontiers in the field of biophotonics such as laser computed tomography, and the imaging and characterization of ultraweak biophoton emission phenomena are described and discussed as one of the typical examples of future trends in this field.

[1]  Dirk-Gunnar Welsch,et al.  Lectures on Quantum Optics , 1994 .

[2]  J J Snyder Wide dynamic range optical power measurement using coherent heterodyne radiometry. , 1988, Applied optics.

[3]  Mark C. W. van Rossum,et al.  OSA Proceedings on Advances in Optical Imaging and Photon Migration , 1994 .

[4]  H. Inaba,et al.  Measuring Methods for Ultra-Low Light Intensity and Their Application to Extra-Weak Spontaneous Bioluminescence from Living Tissues , 1973 .

[5]  H. Inaba,et al.  Measurement of Very Weak Light Signals and Spectra , 1975 .

[6]  V. Corcoran Directional Characteristics in Optical Heterodyne Detection Processes. II , 1965 .

[7]  N. Kozukue,et al.  Organic Acid, Sugar and Amino Acid Composition of Bamboo Shoots , 1983 .

[8]  H. Inaba,et al.  PHOTON COUNTING SPECTRAL ANALYZING SYSTEM OF EXTRA‐WEAK CHEMI‐ AND BIOLUMINESCENCE FOR BIOCHEMICAL APPLICATIONS , 1979 .

[9]  Humio Inaba,et al.  Ultraweak emission imagery of mitosing soybeans , 1989 .

[10]  Makoto Kondo,et al.  Experimental verification of image detection in highly scattering media using antenna properties of optical heterodyne microscope scheme , 1990 .

[11]  H. Inaba,et al.  SPECTRAL ANALYSES OF LOW LEVEL CHEMILUMINESCENCE OF A SHORT LIFETIME USING A HIGHLY SENSITIVE POLYCHROMATIC SPECTROMETER INCORPORATING A TWO DIMENSIONAL PHOTON‐COUNTING TYPE DETECTOR , 1992 .

[12]  David Lorge Parnas Invited Plenary Talk , 1994 .

[13]  M. Teich,et al.  Squeezed state of light , 1989 .

[14]  G. Müller,et al.  Medical Optical Tomography: Functional Imaging and Monitoring , 1993 .

[15]  Humio Inaba,et al.  Optical computer-assisted tomography realized by coherent detection imaging incorporating laser heterodyne method for biomedical applications , 1991, Other Conferences.

[16]  A. Yariv Introduction to optical electronics , 1971 .

[17]  H. Haus,et al.  Preparation, measurement and information capacity of optical quantum states , 1986 .

[18]  A. Siegman,et al.  The antenna properties of optical heterodyne receivers. , 1966, Applied optics.

[19]  Balasigamani Devaraj,et al.  First demonstration of laser computed tomography of human tooth by coherent detection imaging , 1995 .

[20]  Dejan M. Gvozdíc Ultrafast and ultra-parallel optoelectronics , 1997 .

[21]  Nobuyuki Watanabe,et al.  Two-dimensional imaging and counting of ultraweak emission patterns from injured plant seedlings , 1991 .

[22]  Balasigamani Devaraj,et al.  Optical imaging through highly scattering media by use of heterodyne detection in the 1.3-microm wavelength region. , 1995, Optics letters.