[Evaluation of anesthetic effect of ropivacaine in surgery of chronic periapical lessions].

INTRODUCTION Ropivacaine is used in orthopedcs, gyneacology, surgery, ophtamology, whereas experience about its usage in dentistry is still limited. The aim of this research was to compare the anesthetic effect between local anesthetics ropivacaine and bupivacaine, in surgical disposals of chronical periapical lessions in maxilla. MATERIAL AND METHODS The study included the patients that had indications for surgical removal of chronical periapical lessions at one of the frontal teeth of upper jaw. The total total number of examinees was 60, and they were devided in two groups. Ropivacaine chloride (0.75%) was used as a local anesthetic in one group (Naropin 0.75%; Astra Zeneca), and in the other one bupivacaine chloride (0.5%) (Vexelit 0.5%; Zdravlje). The authors applied 1.8 ml of block anesthesia for the n. infraorbitalis (intra-oral approach) as well as 0.2 ml of the local anesthetic from the palatine side for the final branches of N. nasopalatinus in order to observe the following anesthetic parameters. (I) Beginning of anesthesia was followed by the appearence of upper lip numbness. (II) Pain rating scale according to Sisk was used for the objective measurement of the anesthesia quality. (III) The pain intensity during the intervention was measured by visual analogous scale, on which the patient denoted the intensity of pain he had felt during the intervention. (IV) Duration of anesthetic effect--it is followed by soft tissues numbness. RESULTS AND DISCUSSION After the ropivacaine application anesthesia effect started in 1.57 min. and after the usage of bupivacaine in 1.67 min. The mean duration of soft tissue numbness after the application of ropivacaine was 321 minutes. Bupivacaine had a shorter anesthetic effect--296.5 minutes. The quality of anesthesia after the usage of ropivacaine was assessed by the surgeons with average mark--1.76. Interventions in which this anesthetic was used were performed with minimal pain and without additional anesthesia. The quality of anesthesia after the usage of bupivacaine (3.03) was statistically much worse (p < 0.01) in comparison to ropivacaine. In visual analogous scale where patients denoted the intensity of pain during the intervention with ropivacaine the marked average value was 30.1 mm while the average value with usage of bupivacaine was 41.7 mm. The patients from the control group, where bupivacaine was used, had much stronger pain, statistically significant (p < 0.05) in comparison to the group where ropivacaine was used. Our results show that the quality of anesthesia that was attained with 0.5% bupivacaine was much worse than the quality of anesthesia after the application of 0.75% ropivacaine. CONCLUSION Ropivacaine has a potential to replace bupivacaine completely in cases when there is the indication for its usage in oral surgery (longlasting intervention, interventions followed by intensive postoperational pain, nerve blockade).

[1]  L. Mather,et al.  Cardiotoxicity with Modern Local Anaesthetics , 2012, Drugs.

[2]  M. Nazir,et al.  Local anaesthetic drugs: adverse effects as reported through the ADROIT system in the UK , 2009, Pharmacoepidemiology and drug safety.

[3]  J. Bansard,et al.  Electrocardiographic and Hemodynamic Effects of Intravenous Infusion of Bupivacaine, Ropivacaine, Levobupivacaine, and Lidocaine In Anesthetized Ewes , 2008, Regional Anesthesia & Pain Medicine.

[4]  M. Zdravković,et al.  [William Stewart Halsted--110 years of the use of surgical gloves]. , 2007, Medicinski pregled.

[5]  N. Burić The assessment of anesthetic efficacy of ropivacaine in oral surgery. , 2006, The New York state dental journal.

[6]  J. Yagiela,et al.  Anesthetic efficacy of different ropivacaine concentrations for inferior alveolar nerve block. , 2006, Anesthesia progress.

[7]  E. Vasquez,et al.  Effects of regional anesthesia with ropivacaine on arterial pressure and heart rate in healthy subjects. , 2006, European journal of oral sciences.

[8]  S. Axelsson,et al.  The efficacy of ropivacaine as a dental local anaesthetic. , 2004, Swedish dental journal.

[9]  M. Ernberg,et al.  Ropivacaine for dental anesthesia: a dose-finding study. , 2002, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[10]  T. Horlocker,et al.  Local anesthetic toxicity: Does product labeling reflect actual risk? , 2002 .

[11]  J. P. Fawcett,et al.  Comparative efficacy and pharmacokinetics of racemic bupivacaine and S-bupivacaine in third molar surgery. , 2002, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[12]  S. Ohmura,et al.  Systemic Toxicity and Resuscitation in Bupivacaine-, Levobupivacaine-, or Ropivacaine-Infused Rats , 2001, Anesthesia and analgesia.

[13]  A. Reader,et al.  Anesthetic efficacy of ropivacaine in maxillary anterior infiltration. , 2001, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[14]  S. Malamed,et al.  Efficacy of articaine: a new amide local anesthetic. , 2000, Journal of the American Dental Association.

[15]  B. Graf,et al.  Stereospecific Effect of Bupivacaine Isomers on Atrioventricular Conduction in the Isolated Perfused Guinea Pig Heart , 1997, Anesthesiology.

[16]  K. Hargreaves,et al.  Toxic systemic reactions of bupivacaine and etidocaine. , 1995, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[17]  A. Sisk Long-acting local anesthetics in dentistry. , 1992, Anesthesia progress.

[18]  I. Cederholm,et al.  Effect of intradermal injection of saline or a local anaesthetic agent on skin blood flow – a methodological study in man , 1991, Acta anaesthesiologica Scandinavica.

[19]  B. Covino,et al.  A827 TREATMENT OF ACUTE TOXICITY AFTER RAPID INTRAVENOUS ROPIVACAINE AND BUPIVACAINE IN THE CONSCIOUS DOG , 1990 .

[20]  B. Covino,et al.  Cardiac electrophysiologic properties of bupivacaine and lidocaine compared with those of ropivacaine, a new amide local anesthetic. , 1990, Anesthesiology.

[21]  B. Covino,et al.  Comparative Systemic Toxicity of Convulsant and Supraconvulsant Doses of Intravenous Ropivacaine, Bupivacaine, and Lidocaine in the Conscious Dog , 1989, Anesthesia and analgesia.

[22]  Alistair Lee,et al.  Acute Toxicity of Ropivacaine Compared with That of Bupivacaine , 1989, Anesthesia and analgesia.

[23]  D. Kopacz,et al.  Effect of ropivacaine on cutaneous capillary blood flow in pigs. , 1989, Anesthesiology.

[24]  G. Johansson,et al.  Cardiotoxicity of ropivacaine – a new amide local anaesthetic agent , 1989, Acta anaesthesiologica Scandinavica.

[25]  B. Covino,et al.  Comparative Pharmacokinetics of Bupivacaine and Ropivacaine, a New Amide Local Anesthetic , 1988, Anesthesia and analgesia.

[26]  B. Akerman,et al.  Primary evaluation of the local anaesthetic properties of the amino amide agent ropivacaine (LEA 103) , 1988, Acta anaesthesiologica Scandinavica.

[27]  P. Chapman,et al.  Prolonged analgesia following preoperative bupivacaine neural blockade for oral surgery performed under general anesthesia. , 1987, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[28]  A. Sisk Evaluation of the Akinosi mandibular block technique in oral surgery. , 1986, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[29]  P. Moore,et al.  Bupivacaine: a long-lasting local anesthetic for dentistry. , 1984, Oral surgery, oral medicine, and oral pathology.

[30]  P. Moore,et al.  Bupivacaine anesthesia--a clinical trial for endodontic therapy. , 1983, Oral surgery, oral medicine, and oral pathology.

[31]  O. Jensen,et al.  Advantages of long-acting local anesthesia using etidocaine hydrochloride. , 1981, The Journal of Oral Surgery.

[32]  G A Albright,et al.  Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. , 1979, Anesthesiology.

[33]  J. Laskin Use of etidocaine hydrochloride in oral surgery: a clinical study. , 1979, The Journal of Oral Surgery.

[34]  D. Pricco An evaluation of bupivacaine for regional nerve block in oral surgery. , 1977, The Journal of Oral Surgery.

[35]  B. Deleo,et al.  Use of bupivacaine hydrochloride in oral surgery-a clinical study. , 1977, The Journal of Oral Surgery.

[36]  J. A. Nespeca Clinical trials with bupivacaine in oral surgery. , 1976, Oral surgery, oral medicine, and oral pathology.