Wnt signaling in cancer

[1]  M. Scott,et al.  Prickle Mediates Feedback Amplification to Generate Asymmetric Planar Cell Polarity Signaling , 2002, Cell.

[2]  F. Bard,et al.  WLS retrograde transport to the endoplasmic reticulum during Wnt secretion. , 2014, Developmental cell.

[3]  A. Bell,et al.  Aberrant Wnt/β-Catenin Signaling in Pancreatic Adenocarcinoma , 2006 .

[4]  Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. , 2010, The American journal of pathology.

[5]  Yoichi Kato,et al.  Wnt/Frizzled Activation of Rho Regulates Vertebrate Gastrulation and Requires a Novel Formin Homology Protein Daam1 , 2001, Cell.

[6]  Doulaye Dembélé,et al.  β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL. , 2013, Blood.

[7]  G. Klarmann,et al.  Epigenetic gene silencing in the Wnt pathway in breast cancer , 2008, Epigenetics.

[8]  Jeffrey S. Morris,et al.  The Consensus Molecular Subtypes of Colorectal Cancer , 2015, Nature Medicine.

[9]  M. Hung,et al.  Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[10]  Chi-Hung Lin,et al.  MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells , 2014, Nature Cell Biology.

[11]  Y. Minami,et al.  Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. , 2011, Developmental cell.

[12]  Raghu Kalluri,et al.  Exosomes in tumor microenvironment influence cancer progression and metastasis , 2013, Journal of Molecular Medicine.

[13]  C. Niehrs,et al.  R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. , 2004, Developmental cell.

[14]  Yusuke Nakamura,et al.  AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 , 2000, Nature Genetics.

[15]  T. Gajewski,et al.  Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity , 2015, Nature.

[16]  M. Varella‐Garcia,et al.  Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation , 2008, Nature.

[17]  Taichi Isobe,et al.  miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway , 2014, eLife.

[18]  D. Haber,et al.  Circulating tumor cells: a window into cancer biology and metastasis. , 2010, Current opinion in genetics & development.

[19]  W. Stolz,et al.  Association of early malignant melanoma with nevocytic nevi , 1989, Cancer.

[20]  Guanpeng Dong,et al.  Multilevel Modelling with Spatial Interaction Effects with Application to an Emerging Land Market in Beijing, China , 2015, PloS one.

[21]  Ye Guang Chen,et al.  Dishevelled: The hub of Wnt signaling. , 2010, Cellular signalling.

[22]  T. Saida,et al.  Loss of β‐catenin expression associated with disease progression in malignant melanoma , 2001, The British journal of dermatology.

[23]  Louise R Howe,et al.  Wnt Signaling and Breast Cancer , 2004, Cancer biology & therapy.

[24]  M. Fischer,et al.  Abstract 1907: Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor growth and reduces tumor-initiating cell frequency in patient-derived hepatocellular carcinoma and ovarian cancer xenograft models , 2014 .

[25]  Wolfram Goessling,et al.  The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML , 2010, Science.

[26]  C. Nüsslein-Volhard,et al.  Mutations affecting segment number and polarity in Drosophila , 1980, Nature.

[27]  R. Moon,et al.  Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos , 2003, The Journal of cell biology.

[28]  Hong Peng,et al.  Interactions between cancer stem cells and their niche govern metastatic colonization , 2011, Nature.

[29]  S. Jones,et al.  Many roads lead to oncogene-induced senescence , 2008, Oncogene.

[30]  F. Staal,et al.  WNT signalling in the immune system: WNT is spreading its wings , 2015, Nature Reviews Immunology.

[31]  N. Brünner,et al.  Abstract A116: Targeting the Wnt-5a signaling pathway as a novel anti-metastatic therapy , 2015 .

[32]  Robert D Cardiff,et al.  Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis. , 2003, Genes & development.

[33]  Katherine M White,et al.  A randomised controlled trial of a theory-based intervention to improve sun protective behaviour in adolescents ('you can still be HOT in the shade'): study protocol , 2012, BMC Cancer.

[34]  M. Hung,et al.  β-Catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression , 2000 .

[35]  Leonid Peshkin,et al.  A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis , 2014, Cell.

[36]  J. Reis-Filho,et al.  β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation , 2011, Modern Pathology.

[37]  A. Weeraratna,et al.  Wnt5A activates the calpain-mediated cleavage of filamin A. , 2009, The Journal of investigative dermatology.

[38]  Raffaella Zamponi,et al.  Dishevelled promotes Wnt receptor degradation through recruitment of ZNRF3/RNF43 E3 ubiquitin ligases. , 2015, Molecular cell.

[39]  R. Nusse,et al.  Wnt signaling in skin development, homeostasis, and disease. , 2013, Cold Spring Harbor perspectives in biology.

[40]  M. Biffoni,et al.  CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. , 2014, Cell stem cell.

[41]  Adam T Froemming,et al.  Detection of Recurrent Prostate Cancer After Radical Prostatectomy: Comparison of 11C-Choline PET/CT with Pelvic Multiparametric MR Imaging with Endorectal Coil , 2014, The Journal of Nuclear Medicine.

[42]  Randy L. Johnson,et al.  Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size , 2011, Science.

[43]  K. Kinzler,et al.  Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma , 1997, Science.

[44]  Louis Vermeulen,et al.  Wnt activity defines colon cancer stem cells and is regulated by the microenvironment , 2010, Nature Cell Biology.

[45]  Raghu Kalluri,et al.  EMT: when epithelial cells decide to become mesenchymal-like cells. , 2009, The Journal of clinical investigation.

[46]  Ping Ji,et al.  Translocation Products in Acute Myeloid Leukemia Activate the Wnt Signaling Pathway in Hematopoietic Cells , 2004, Molecular and Cellular Biology.

[47]  C. Rudin,et al.  Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer. , 2015, The New England journal of medicine.

[48]  Nam‐Gyun Kim,et al.  Regulation of protein stability by GSK3 mediated phosphorylation , 2009, Cell cycle.

[49]  Charles P. Lin,et al.  Differential niche and Wnt requirements during acute myeloid leukemia progression. , 2011, Blood.

[50]  M. Pagano,et al.  The human F box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin , 1999, Oncogene.

[51]  Antara De,et al.  Wnt/Ca2+ signaling pathway: a brief overview. , 2011, Acta biochimica et biophysica Sinica.

[52]  J. Blay,et al.  SYNFRIZZ-A phase Ia/Ib of a radiolabelled monoclonal AB for the treatment of relapsing synovial sarcoma , 2014 .

[53]  R. Moon,et al.  Activated Wnt/ß-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model , 2009, Proceedings of the National Academy of Sciences.

[54]  K. Basler,et al.  Identification of an Endocytosis Motif in an Intracellular Loop of Wntless Protein, Essential for Its Recycling and the Control of Wnt Protein Signaling* , 2011, The Journal of Biological Chemistry.

[55]  L. Akslen,et al.  Importance of P-Cadherin, β-Catenin, and Wnt5a/Frizzled for Progression of Melanocytic Tumors and Prognosis in Cutaneous Melanoma , 2005, Clinical Cancer Research.

[56]  Richard F. Kefford,et al.  Targeted BRAF Inhibition Impacts Survival in Melanoma Patients with High Levels of Wnt/β-Catenin Signaling , 2014, PloS one.

[57]  Gabriela Kalna,et al.  ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation , 2013, Cell stem cell.

[58]  T. Tsukamoto,et al.  Chromosomal instability by β-catenin/TCF transcription in APC or β-catenin mutant cells , 2007, Oncogene.

[59]  S. Cheng,et al.  Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia. , 2008, Blood.

[60]  Hans Clevers,et al.  Sequential cancer mutations in cultured human intestinal stem cells , 2015, Nature.

[61]  H. Varmus,et al.  Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice , 1988, Cell.

[62]  Ursula Pieper,et al.  A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. , 2013, Cell stem cell.

[63]  J. Reis-Filho,et al.  Oncogenic Braf induces melanocyte senescence and melanoma in mice. , 2009, Cancer cell.

[64]  A. Ashworth,et al.  Tankyrase-targeted therapeutics: expanding opportunities in the PARP family , 2012, Nature Reviews Drug Discovery.

[65]  Melanie A. Huntley,et al.  Recurrent R-spondin fusions in colon cancer , 2012, Nature.

[66]  Kristian Cibulskis,et al.  RNF43 is frequently mutated in colorectal and endometrial cancers , 2014, Nature Genetics.

[67]  Ying Sun,et al.  The expression of β-catenin in different subtypes of breast cancer and its clinical significance , 2014, Tumor Biology.

[68]  J. Mesirov,et al.  β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis , 2013, Cell.

[69]  R. Moon,et al.  Wnt/β-Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV600E in Human Melanoma , 2012, Science Signaling.

[70]  Ratna Chakrabarti,et al.  MicroRNA expressions associated with progression of prostate cancer cells to antiandrogen therapy resistance , 2014, Molecular Cancer.

[71]  A. Ravaud,et al.  Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma. , 2015, The New England journal of medicine.

[72]  S. Gestl,et al.  Tumor cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers , 2014, Nature.

[73]  Julia Christina Gross,et al.  Active Wnt proteins are secreted on exosomes , 2012, Nature Cell Biology.

[74]  N Harmston,et al.  Wnt addiction of genetically defined cancers reversed by PORCN inhibition , 2015, Oncogene.

[75]  J. Plouhinec,et al.  Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes , 2010, Cell.

[76]  K. Kinzler,et al.  Cancer Genome Landscapes , 2013, Science.

[77]  M. Fischer,et al.  Abstract A30: Predictive and pharmacodynamic biomarkers of vantictumab (OMP-18R5; anti-Frizzled) in non-small cell lung cancer , 2015 .

[78]  Christopher R. Schmidt,et al.  Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway , 2014, Hepatology.

[79]  D. Cox,et al.  Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15 , 1984, Nature.

[80]  C. So,et al.  β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells. , 2010, Cancer cell.

[81]  Hideki Yamamoto,et al.  New insights into the mechanism of Wnt signaling pathway activation. , 2011, International review of cell and molecular biology.

[82]  M. Valsecchi.  Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. , 2015, The New England journal of medicine.

[83]  A. Ferrando,et al.  The role of NOTCH1 signaling in T-ALL. , 2009, Hematology. American Society of Hematology. Education Program.

[84]  H. Korswagen,et al.  Wnt Gradient Formation Requires Retromer Function in Wnt-Producing Cells , 2006, Science.

[85]  K. Blyth,et al.  Wnt signaling potentiates nevogenesis , 2013, Proceedings of the National Academy of Sciences.

[86]  Petar Stojanov,et al.  Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL. , 2012, Blood.

[87]  C. Cruciat,et al.  LGR4 and LGR5 are R‐spondin receptors mediating Wnt/β‐catenin and Wnt/PCP signalling , 2011, EMBO reports.

[88]  H. Kouji,et al.  A phase Ib dose-escalation study of PRI-724, a CBP/beta-catenin modulator, plus gemcitabine (GEM) in patients with advanced pancreatic adenocarcinoma (APC) as second-line therapy after FOLFIRINOX or FOLFOX. , 2015 .

[89]  Harold E. Varmus,et al.  Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome , 1982, Cell.

[90]  H. Clevers,et al.  Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors , 2012, Nature.

[91]  Mariann Bienz,et al.  Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization , 2010, Journal of Cell Science.

[92]  T. Andersson,et al.  Interleukin‐6 drives melanoma cell motility through p38α‐MAPK‐dependent up‐regulation of WNT5A expression , 2014, Molecular oncology.

[93]  S. Weiss,et al.  Canonical Wnt signaling regulates Slug activity and links epithelial–mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression , 2012, Proceedings of the National Academy of Sciences.

[94]  H. Varmus,et al.  Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[95]  Christof Niehrs,et al.  Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation , 2015, Cell.

[96]  R. Weinberg,et al.  Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. , 2012, Seminars in cancer biology.

[97]  Yolanda Fernández,et al.  β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer , 2012, Nature Medicine.

[98]  R. Dummer,et al.  In vivo switching of human melanoma cells between proliferative and invasive states. , 2008, Cancer research.

[99]  Hans Clevers,et al.  Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas , 2012, Science.

[100]  S. Barry,et al.  WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. , 2015, The Journal of clinical investigation.

[101]  M. Boutros,et al.  Cell cycle control of wnt receptor activation. , 2009, Developmental cell.

[102]  Giusi Moffa,et al.  Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells , 2013, Nature Communications.

[103]  H. Clevers,et al.  Wnt signalling in stem cells and cancer , 2005, Nature.

[104]  Yusuke Nakamura,et al.  Inverse correlation of the up‐regulation of FZD10 expression and the activation of β‐catenin in synchronous colorectal tumors , 2009, Cancer science.

[105]  H. Clevers,et al.  Visualization of a short-range Wnt gradient in the intestinal stem-cell niche , 2016, Nature.

[106]  R. Nusse,et al.  Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility , 2011, Proceedings of the National Academy of Sciences.

[107]  F. Luciani,et al.  Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development. , 2007, Genes & development.

[108]  R. Green,et al.  APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice , 2007, The Journal of cell biology.

[109]  Jill P. Mesirov,et al.  β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis , 2012, Cell.

[110]  Le Zhang,et al.  Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling , 2015, Nature Communications.

[111]  Marc W. Kirschner,et al.  Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling , 2009, Nature.

[112]  Takanori Kanai,et al.  Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids , 2015, Nature Medicine.

[113]  A. Gurney,et al.  Canonical wnt signaling is required for pancreatic carcinogenesis. , 2013, Cancer research.

[114]  M. Caplan,et al.  Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling , 2010, The Journal of cell biology.

[115]  Giuseppe Basso,et al.  YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response , 2014, Cell.

[116]  Feng Cong,et al.  Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma , 2013, Proceedings of the National Academy of Sciences.

[117]  W. de Lau,et al.  The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength , 2014, Genes & development.

[118]  K. Basler,et al.  Wntless, a Conserved Membrane Protein Dedicated to the Secretion of Wnt Proteins from Signaling Cells , 2006, Cell.

[119]  M. Mlodzik,et al.  Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt). , 2015, Annual review of cell and developmental biology.

[120]  H. Ruffner,et al.  ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner , 2012, Nature.

[121]  F. Berthold,et al.  Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas. , 2001, Cancer research.

[122]  Shuji Ogino,et al.  Restriction of intestinal stem cell expansion and the regenerative response by YAP , 2012, Nature.

[123]  Owen J. Sansom,et al.  Genetic Dissection of Differential Signaling Threshold Requirements for the Wnt/β-Catenin Pathway In Vivo , 2010, PLoS genetics.

[124]  E. Rosen,et al.  Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERα-negative and ERα-positive mammary preneoplasia and cancer , 2008, Oncogene.

[125]  A. Weng,et al.  Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling. , 2015, Blood.

[126]  G. Riggins,et al.  Activated macrophages promote Wnt/β-catenin signaling in cholangiocarcinoma cells , 2014, Tumor Biology.

[127]  D. Schadendorf,et al.  Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature. , 2006, Pigment cell research.

[128]  C. Niehrs,et al.  Mitotic wnt signaling promotes protein stabilization and regulates cell size. , 2014, Molecular cell.

[129]  B. Vogelstein,et al.  PD-1 blockade in tumors with mismatch repair deficiency. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[130]  M. Katoh,et al.  WNT/PCP signaling pathway and human cancer (review). , 2005, Oncology reports.

[131]  H. Korswagen,et al.  Mammalian Wnt3a is Released on Lipoprotein Particles , 2009, Traffic.

[132]  R. Sears,et al.  Diminished WNT → β-catenin → c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumors , 2014, Genes & development.

[133]  Elisa de Stanchina,et al.  Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT , 2016, Cell.

[134]  Andrew L. Kung,et al.  Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[135]  Detlef Weigel,et al.  The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless , 1987, Cell.

[136]  C. Alexander,et al.  Differentiation Generates Paracrine Cell Pairs That Maintain Basaloid Mouse Mammary Tumors: Proof of Concept , 2011, PloS one.

[137]  Moonsup Lee,et al.  PAF and EZH2 induce Wnt/β-catenin signaling hyperactivation. , 2013, Molecular cell.

[138]  C. Fenoglio-Preiser,et al.  beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. , 2002, Cancer research.

[139]  C. Nguyên,et al.  Small molecule inhibition of CBP/catenin interactions eliminates drug resistant clones in acute lymphoblastic leukemia , 2013, Oncogene.

[140]  G. Bu,et al.  LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy , 2010, Proceedings of the National Academy of Sciences.

[141]  K. Basler,et al.  A genome‐wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion , 2011, EMBO reports.

[142]  R. Moon,et al.  WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors. , 2014, The Journal of clinical investigation.

[143]  M. Hebrok,et al.  Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. , 2010, The Journal of clinical investigation.

[144]  M. Boutros,et al.  p24 proteins are required for secretion of Wnt ligands , 2011, EMBO reports.

[145]  A. Weeraratna,et al.  A Wnt-er Migration: The Confusing Role of β-Catenin in Melanoma Metastasis , 2013, Science Signaling.

[146]  Runsheng Chen,et al.  The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. , 2015, Cell stem cell.

[147]  J. Wrana,et al.  Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration , 2012, Cell.

[148]  R. Moon,et al.  WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma , 2013, Oncogene.

[149]  K. Kinzler,et al.  Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. , 1991, Science.

[150]  Hans Clevers,et al.  Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer , 2015, Cell.

[151]  Swe Swe Myint,et al.  Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers , 2013, Nature Genetics.

[152]  Hayley E. Francies,et al.  Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients , 2015, Cell.

[153]  L. Lum,et al.  Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-Acyltransferase Porcupine* , 2012, The Journal of Biological Chemistry.

[154]  A. Weeraratna,et al.  Wnt5A promotes an adaptive, senescent‐like stress response, while continuing to drive invasion in melanoma cells , 2015, Pigment cell & melanoma research.

[155]  Hans Clevers,et al.  Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling , 2011, Nature.

[156]  C. Blanpain,et al.  Unravelling cancer stem cell potential , 2013, Nature Reviews Cancer.

[157]  Sticking Around: Short-Range Activity of Wnt Ligands. , 2016, Developmental cell.

[158]  Tom Royce,et al.  A comprehensive catalogue of somatic mutations from a human cancer genome , 2010, Nature.

[159]  H. Bastians,et al.  Wnt‐mediated protein stabilization ensures proper mitotic microtubule assembly and chromosome segregation , 2015, EMBO reports.

[160]  E. Fuchs,et al.  Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling , 2014, Genes & development.

[161]  D. Busam,et al.  Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis , 2012, Oncogene.

[162]  Yann S. Dufour,et al.  Adaptability of non-genetic diversity in bacterial chemotaxis , 2014, eLife.

[163]  M. Pagano,et al.  The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. , 1999, Oncogene.

[164]  H. Clevers,et al.  Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties , 2013, Cell.

[165]  H. Clevers.  Wnt/beta-catenin signaling in development and disease. , 2006, Cell.

[166]  K. Koeneman.  R-spondin2 is a secreted activator of Wnt/β-catenin signaling and is required for Xenopus myogenesis , 2009 .

[167]  谷口 智憲.  Immune suppression and resistance mediated by constitutive activation of Wnt/β-catenin signaling in human melanoma cells , 2013 .

[168]  A. Bell,et al.  Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma. , 2006, Neoplasia.

[169]  Y. Minami,et al.  Receptor Tyrosine Kinase Ror2 Mediates Wnt5a-induced Polarized Cell Migration by Activating c-Jun N-terminal Kinase via Actin-binding Protein Filamin A* , 2008, Journal of Biological Chemistry.

[170]  Michael Kahn,et al.  Can we safely target the WNT pathway? , 2014, Nature Reviews Drug Discovery.

[171]  Y. Minami,et al.  Insight into the role of Wnt5a-induced signaling in normal and cancer cells. , 2015, International review of cell and molecular biology.

[172]  R. Nusse,et al.  Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context , 2006, PLoS biology.

[173]  M. Fischer,et al.  Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors , 2012, Proceedings of the National Academy of Sciences.

[174]  D. Rimm,et al.  β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. , 2011, Cancer cell.

[175]  Michael Boutros,et al.  Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein , 2006, Cell.

[176]  Linda Wordeman,et al.  Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells , 2014, Nature Cell Biology.

[177]  I. Tomlinson,et al.  Colorectal cancer and genetic alterations in the Wnt pathway , 2006, Oncogene.

[178]  Björn Titz,et al.  MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells , 2015, Proceedings of the National Academy of Sciences.

[179]  Dean Y. Li,et al.  The Small GTPase ARF6 Stimulates β-Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis , 2013, Science Signaling.

[180]  D. Carrasco,et al.  Targeted Disruption of the BCL9/β-Catenin Complex Inhibits Oncogenic Wnt Signaling , 2012, Science Translational Medicine.

[181]  G. Berx,et al.  Regulatory networks defining EMT during cancer initiation and progression , 2013, Nature Reviews Cancer.

[182]  T. Tsukamoto,et al.  Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells. , 2007, Oncogene.

[183]  Sridhar Ramaswamy,et al.  RNA sequencing of pancreatic circulating tumour cells implicates WNT signaling in metastasis , 2012, Nature.

[184]  C. Niehrs,et al.  Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis , 2015, Proceedings of the National Academy of Sciences.

[185]  R. Bhadra,et al.  NIH Public Access , 2014 .

[186]  Paul Polakis,et al.  Wnt signaling in cancer. , 2012, Cold Spring Harbor perspectives in biology.

[187]  F. Staal,et al.  Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development , 2012, Leukemia.

[188]  K. Zhang,et al.  FZD7 has a critical role in cell proliferation in triple negative breast cancer , 2011, Oncogene.

[189]  A. Weeraratna,et al.  Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2. , 2013, Cancer discovery.

[190]  K. Kinzler,et al.  Association of the APC tumor suppressor protein with catenins. , 1993, Science.

[191]  J. Hoheisel,et al.  Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia , 2012, BMC Cancer.

[192]  S. Krauss,et al.  A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. , 2013, Cancer research.

[193]  Sridhar Ramaswamy,et al.  RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance , 2015, Science.

[194]  F. Masiarz,et al.  Association of the APC gene product with beta-catenin. , 1993, Science.

[195]  Andrew P. McMahon,et al.  Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis , 1989, Cell.

[196]  M. J. van de Vijver,et al.  Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. , 2011, Cell stem cell.

[197]  Hans Clevers,et al.  The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. , 2011, Cell stem cell.

[198]  Roland Baron,et al.  WNT signaling in bone homeostasis and disease: from human mutations to treatments , 2013, Nature Medicine.

[199]  Hans Clevers,et al.  Crypt stem cells as the cells-of-origin of intestinal cancer , 2009, Nature.

[200]  M. Peifer,et al.  Original CIN: reviewing roles for APC in chromosome instability , 2008, The Journal of cell biology.

[201]  Timothy D. Veenstra,et al.  Telomerase modulates Wnt signalling by association with target gene chromatin , 2009, Nature.

[202]  T. Kipps,et al.  Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[203]  Yingqun Wang,et al.  Wnt/Planar cell polarity signaling: A new paradigm for cancer therapy , 2009, Molecular Cancer Therapeutics.

[204]  H. Moch,et al.  ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1 , 2014, Nature Cell Biology.

[205]  S. Altschul,et al.  Identification of FAP locus genes from chromosome 5q21. , 1991, Science.

[206]  R. Moon,et al.  WNT signalling pathways as therapeutic targets in cancer , 2012, Nature Reviews Cancer.

[207]  A. Chien,et al.  Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers. , 2012, Gastroenterology.

[208]  R. Hakem,et al.  LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction. , 2013, Cell reports.

[209]  N. Perrimon,et al.  The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. , 1996, Genes & development.

[210]  O. Olopade,et al.  β-Catenin Is Required for the Tumorigenic Behavior of Triple-Negative Breast Cancer Cells , 2015, PloS one.

[211]  C. Voermans,et al.  Wnt signaling in normal and malignant hematopoiesis. , 2013, Cold Spring Harbor perspectives in biology.

[212]  J. Rubin,et al.  Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells , 2012, Journal of cellular physiology.

[213]  G. Jönsson,et al.  WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells , 2014, Molecular Cancer.