Wnt signaling in cancer
暂无分享,去创建一个
[1] M. Scott,et al. Prickle Mediates Feedback Amplification to Generate Asymmetric Planar Cell Polarity Signaling , 2002, Cell.
[2] F. Bard,et al. WLS retrograde transport to the endoplasmic reticulum during Wnt secretion. , 2014, Developmental cell.
[3] A. Bell,et al. Aberrant Wnt/β-Catenin Signaling in Pancreatic Adenocarcinoma , 2006 .
[4] Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. , 2010, The American journal of pathology.
[5] Yoichi Kato,et al. Wnt/Frizzled Activation of Rho Regulates Vertebrate Gastrulation and Requires a Novel Formin Homology Protein Daam1 , 2001, Cell.
[6] Doulaye Dembélé,et al. β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL. , 2013, Blood.
[7] G. Klarmann,et al. Epigenetic gene silencing in the Wnt pathway in breast cancer , 2008, Epigenetics.
[8] Jeffrey S. Morris,et al. The Consensus Molecular Subtypes of Colorectal Cancer , 2015, Nature Medicine.
[9] M. Hung,et al. Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[10] Chi-Hung Lin,et al. MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells , 2014, Nature Cell Biology.
[11] Y. Minami,et al. Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. , 2011, Developmental cell.
[12] Raghu Kalluri,et al. Exosomes in tumor microenvironment influence cancer progression and metastasis , 2013, Journal of Molecular Medicine.
[13] C. Niehrs,et al. R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. , 2004, Developmental cell.
[14] Yusuke Nakamura,et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 , 2000, Nature Genetics.
[15] T. Gajewski,et al. Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity , 2015, Nature.
[16] M. Varella‐Garcia,et al. Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation , 2008, Nature.
[17] Taichi Isobe,et al. miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway , 2014, eLife.
[18] D. Haber,et al. Circulating tumor cells: a window into cancer biology and metastasis. , 2010, Current opinion in genetics & development.
[19] W. Stolz,et al. Association of early malignant melanoma with nevocytic nevi , 1989, Cancer.
[20] Guanpeng Dong,et al. Multilevel Modelling with Spatial Interaction Effects with Application to an Emerging Land Market in Beijing, China , 2015, PloS one.
[21] Ye Guang Chen,et al. Dishevelled: The hub of Wnt signaling. , 2010, Cellular signalling.
[22] T. Saida,et al. Loss of β‐catenin expression associated with disease progression in malignant melanoma , 2001, The British journal of dermatology.
[23] Louise R Howe,et al. Wnt Signaling and Breast Cancer , 2004, Cancer biology & therapy.
[24] M. Fischer,et al. Abstract 1907: Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor growth and reduces tumor-initiating cell frequency in patient-derived hepatocellular carcinoma and ovarian cancer xenograft models , 2014 .
[25] Wolfram Goessling,et al. The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML , 2010, Science.
[26] C. Nüsslein-Volhard,et al. Mutations affecting segment number and polarity in Drosophila , 1980, Nature.
[27] R. Moon,et al. Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos , 2003, The Journal of cell biology.
[28] Hong Peng,et al. Interactions between cancer stem cells and their niche govern metastatic colonization , 2011, Nature.
[29] S. Jones,et al. Many roads lead to oncogene-induced senescence , 2008, Oncogene.
[30] F. Staal,et al. WNT signalling in the immune system: WNT is spreading its wings , 2015, Nature Reviews Immunology.
[31] N. Brünner,et al. Abstract A116: Targeting the Wnt-5a signaling pathway as a novel anti-metastatic therapy , 2015 .
[32] Robert D Cardiff,et al. Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis. , 2003, Genes & development.
[33] Katherine M White,et al. A randomised controlled trial of a theory-based intervention to improve sun protective behaviour in adolescents ('you can still be HOT in the shade'): study protocol , 2012, BMC Cancer.
[34] M. Hung,et al. β-Catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression , 2000 .
[35] Leonid Peshkin,et al. A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis , 2014, Cell.
[36] J. Reis-Filho,et al. β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation , 2011, Modern Pathology.
[37] A. Weeraratna,et al. Wnt5A activates the calpain-mediated cleavage of filamin A. , 2009, The Journal of investigative dermatology.
[38] Raffaella Zamponi,et al. Dishevelled promotes Wnt receptor degradation through recruitment of ZNRF3/RNF43 E3 ubiquitin ligases. , 2015, Molecular cell.
[39] R. Nusse,et al. Wnt signaling in skin development, homeostasis, and disease. , 2013, Cold Spring Harbor perspectives in biology.
[40] M. Biffoni,et al. CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. , 2014, Cell stem cell.
[41] Adam T Froemming,et al. Detection of Recurrent Prostate Cancer After Radical Prostatectomy: Comparison of 11C-Choline PET/CT with Pelvic Multiparametric MR Imaging with Endorectal Coil , 2014, The Journal of Nuclear Medicine.
[42] Randy L. Johnson,et al. Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size , 2011, Science.
[43] K. Kinzler,et al. Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma , 1997, Science.
[44] Louis Vermeulen,et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment , 2010, Nature Cell Biology.
[45] Raghu Kalluri,et al. EMT: when epithelial cells decide to become mesenchymal-like cells. , 2009, The Journal of clinical investigation.
[46] Ping Ji,et al. Translocation Products in Acute Myeloid Leukemia Activate the Wnt Signaling Pathway in Hematopoietic Cells , 2004, Molecular and Cellular Biology.
[47] C. Rudin,et al. Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer. , 2015, The New England journal of medicine.
[48] Nam‐Gyun Kim,et al. Regulation of protein stability by GSK3 mediated phosphorylation , 2009, Cell cycle.
[49] Charles P. Lin,et al. Differential niche and Wnt requirements during acute myeloid leukemia progression. , 2011, Blood.
[50] M. Pagano,et al. The human F box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin , 1999, Oncogene.
[51] Antara De,et al. Wnt/Ca2+ signaling pathway: a brief overview. , 2011, Acta biochimica et biophysica Sinica.
[52] J. Blay,et al. SYNFRIZZ-A phase Ia/Ib of a radiolabelled monoclonal AB for the treatment of relapsing synovial sarcoma , 2014 .
[53] R. Moon,et al. Activated Wnt/ß-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model , 2009, Proceedings of the National Academy of Sciences.
[54] K. Basler,et al. Identification of an Endocytosis Motif in an Intracellular Loop of Wntless Protein, Essential for Its Recycling and the Control of Wnt Protein Signaling* , 2011, The Journal of Biological Chemistry.
[55] L. Akslen,et al. Importance of P-Cadherin, β-Catenin, and Wnt5a/Frizzled for Progression of Melanocytic Tumors and Prognosis in Cutaneous Melanoma , 2005, Clinical Cancer Research.
[56] Richard F. Kefford,et al. Targeted BRAF Inhibition Impacts Survival in Melanoma Patients with High Levels of Wnt/β-Catenin Signaling , 2014, PloS one.
[57] Gabriela Kalna,et al. ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation , 2013, Cell stem cell.
[58] T. Tsukamoto,et al. Chromosomal instability by β-catenin/TCF transcription in APC or β-catenin mutant cells , 2007, Oncogene.
[59] S. Cheng,et al. Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia. , 2008, Blood.
[60] Hans Clevers,et al. Sequential cancer mutations in cultured human intestinal stem cells , 2015, Nature.
[61] H. Varmus,et al. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice , 1988, Cell.
[62] Ursula Pieper,et al. A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. , 2013, Cell stem cell.
[63] J. Reis-Filho,et al. Oncogenic Braf induces melanocyte senescence and melanoma in mice. , 2009, Cancer cell.
[64] A. Ashworth,et al. Tankyrase-targeted therapeutics: expanding opportunities in the PARP family , 2012, Nature Reviews Drug Discovery.
[65] Melanie A. Huntley,et al. Recurrent R-spondin fusions in colon cancer , 2012, Nature.
[66] Kristian Cibulskis,et al. RNF43 is frequently mutated in colorectal and endometrial cancers , 2014, Nature Genetics.
[67] Ying Sun,et al. The expression of β-catenin in different subtypes of breast cancer and its clinical significance , 2014, Tumor Biology.
[68] J. Mesirov,et al. β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis , 2013, Cell.
[69] R. Moon,et al. Wnt/β-Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV600E in Human Melanoma , 2012, Science Signaling.
[70] Ratna Chakrabarti,et al. MicroRNA expressions associated with progression of prostate cancer cells to antiandrogen therapy resistance , 2014, Molecular Cancer.
[71] A. Ravaud,et al. Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma. , 2015, The New England journal of medicine.
[72] S. Gestl,et al. Tumor cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers , 2014, Nature.
[73] Julia Christina Gross,et al. Active Wnt proteins are secreted on exosomes , 2012, Nature Cell Biology.
[74] N Harmston,et al. Wnt addiction of genetically defined cancers reversed by PORCN inhibition , 2015, Oncogene.
[75] J. Plouhinec,et al. Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes , 2010, Cell.
[76] K. Kinzler,et al. Cancer Genome Landscapes , 2013, Science.
[77] M. Fischer,et al. Abstract A30: Predictive and pharmacodynamic biomarkers of vantictumab (OMP-18R5; anti-Frizzled) in non-small cell lung cancer , 2015 .
[78] Christopher R. Schmidt,et al. Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway , 2014, Hepatology.
[79] D. Cox,et al. Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15 , 1984, Nature.
[80] C. So,et al. β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells. , 2010, Cancer cell.
[81] Hideki Yamamoto,et al. New insights into the mechanism of Wnt signaling pathway activation. , 2011, International review of cell and molecular biology.
[82] M. Valsecchi. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. , 2015, The New England journal of medicine.
[83] A. Ferrando,et al. The role of NOTCH1 signaling in T-ALL. , 2009, Hematology. American Society of Hematology. Education Program.
[84] H. Korswagen,et al. Wnt Gradient Formation Requires Retromer Function in Wnt-Producing Cells , 2006, Science.
[85] K. Blyth,et al. Wnt signaling potentiates nevogenesis , 2013, Proceedings of the National Academy of Sciences.
[86] Petar Stojanov,et al. Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL. , 2012, Blood.
[87] C. Cruciat,et al. LGR4 and LGR5 are R‐spondin receptors mediating Wnt/β‐catenin and Wnt/PCP signalling , 2011, EMBO reports.
[88] H. Kouji,et al. A phase Ib dose-escalation study of PRI-724, a CBP/beta-catenin modulator, plus gemcitabine (GEM) in patients with advanced pancreatic adenocarcinoma (APC) as second-line therapy after FOLFIRINOX or FOLFOX. , 2015 .
[89] Harold E. Varmus,et al. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome , 1982, Cell.
[90] H. Clevers,et al. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors , 2012, Nature.
[91] Mariann Bienz,et al. Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization , 2010, Journal of Cell Science.
[92] T. Andersson,et al. Interleukin‐6 drives melanoma cell motility through p38α‐MAPK‐dependent up‐regulation of WNT5A expression , 2014, Molecular oncology.
[93] S. Weiss,et al. Canonical Wnt signaling regulates Slug activity and links epithelial–mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression , 2012, Proceedings of the National Academy of Sciences.
[94] H. Varmus,et al. Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[95] Christof Niehrs,et al. Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation , 2015, Cell.
[96] R. Weinberg,et al. Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. , 2012, Seminars in cancer biology.
[97] Yolanda Fernández,et al. β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer , 2012, Nature Medicine.
[98] R. Dummer,et al. In vivo switching of human melanoma cells between proliferative and invasive states. , 2008, Cancer research.
[99] Hans Clevers,et al. Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas , 2012, Science.
[100] S. Barry,et al. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. , 2015, The Journal of clinical investigation.
[101] M. Boutros,et al. Cell cycle control of wnt receptor activation. , 2009, Developmental cell.
[102] Giusi Moffa,et al. Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells , 2013, Nature Communications.
[103] H. Clevers,et al. Wnt signalling in stem cells and cancer , 2005, Nature.
[104] Yusuke Nakamura,et al. Inverse correlation of the up‐regulation of FZD10 expression and the activation of β‐catenin in synchronous colorectal tumors , 2009, Cancer science.
[105] H. Clevers,et al. Visualization of a short-range Wnt gradient in the intestinal stem-cell niche , 2016, Nature.
[106] R. Nusse,et al. Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility , 2011, Proceedings of the National Academy of Sciences.
[107] F. Luciani,et al. Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development. , 2007, Genes & development.
[108] R. Green,et al. APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice , 2007, The Journal of cell biology.
[109] Jill P. Mesirov,et al. β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis , 2012, Cell.
[110] Le Zhang,et al. Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling , 2015, Nature Communications.
[111] Marc W. Kirschner,et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling , 2009, Nature.
[112] Takanori Kanai,et al. Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids , 2015, Nature Medicine.
[113] A. Gurney,et al. Canonical wnt signaling is required for pancreatic carcinogenesis. , 2013, Cancer research.
[114] M. Caplan,et al. Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling , 2010, The Journal of cell biology.
[115] Giuseppe Basso,et al. YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response , 2014, Cell.
[116] Feng Cong,et al. Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma , 2013, Proceedings of the National Academy of Sciences.
[117] W. de Lau,et al. The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength , 2014, Genes & development.
[118] K. Basler,et al. Wntless, a Conserved Membrane Protein Dedicated to the Secretion of Wnt Proteins from Signaling Cells , 2006, Cell.
[119] M. Mlodzik,et al. Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt). , 2015, Annual review of cell and developmental biology.
[120] H. Ruffner,et al. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner , 2012, Nature.
[121] F. Berthold,et al. Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas. , 2001, Cancer research.
[122] Shuji Ogino,et al. Restriction of intestinal stem cell expansion and the regenerative response by YAP , 2012, Nature.
[123] Owen J. Sansom,et al. Genetic Dissection of Differential Signaling Threshold Requirements for the Wnt/β-Catenin Pathway In Vivo , 2010, PLoS genetics.
[124] E. Rosen,et al. Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERα-negative and ERα-positive mammary preneoplasia and cancer , 2008, Oncogene.
[125] A. Weng,et al. Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling. , 2015, Blood.
[126] G. Riggins,et al. Activated macrophages promote Wnt/β-catenin signaling in cholangiocarcinoma cells , 2014, Tumor Biology.
[127] D. Schadendorf,et al. Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature. , 2006, Pigment cell research.
[128] C. Niehrs,et al. Mitotic wnt signaling promotes protein stabilization and regulates cell size. , 2014, Molecular cell.
[129] B. Vogelstein,et al. PD-1 blockade in tumors with mismatch repair deficiency. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[130] M. Katoh,et al. WNT/PCP signaling pathway and human cancer (review). , 2005, Oncology reports.
[131] H. Korswagen,et al. Mammalian Wnt3a is Released on Lipoprotein Particles , 2009, Traffic.
[132] R. Sears,et al. Diminished WNT → β-catenin → c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumors , 2014, Genes & development.
[133] Elisa de Stanchina,et al. Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT , 2016, Cell.
[134] Andrew L. Kung,et al. Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[135] Detlef Weigel,et al. The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless , 1987, Cell.
[136] C. Alexander,et al. Differentiation Generates Paracrine Cell Pairs That Maintain Basaloid Mouse Mammary Tumors: Proof of Concept , 2011, PloS one.
[137] Moonsup Lee,et al. PAF and EZH2 induce Wnt/β-catenin signaling hyperactivation. , 2013, Molecular cell.
[138] C. Fenoglio-Preiser,et al. beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. , 2002, Cancer research.
[139] C. Nguyên,et al. Small molecule inhibition of CBP/catenin interactions eliminates drug resistant clones in acute lymphoblastic leukemia , 2013, Oncogene.
[140] G. Bu,et al. LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy , 2010, Proceedings of the National Academy of Sciences.
[141] K. Basler,et al. A genome‐wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion , 2011, EMBO reports.
[142] R. Moon,et al. WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors. , 2014, The Journal of clinical investigation.
[143] M. Hebrok,et al. Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. , 2010, The Journal of clinical investigation.
[144] M. Boutros,et al. p24 proteins are required for secretion of Wnt ligands , 2011, EMBO reports.
[145] A. Weeraratna,et al. A Wnt-er Migration: The Confusing Role of β-Catenin in Melanoma Metastasis , 2013, Science Signaling.
[146] Runsheng Chen,et al. The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. , 2015, Cell stem cell.
[147] J. Wrana,et al. Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration , 2012, Cell.
[148] R. Moon,et al. WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma , 2013, Oncogene.
[149] K. Kinzler,et al. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. , 1991, Science.
[150] Hans Clevers,et al. Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer , 2015, Cell.
[151] Swe Swe Myint,et al. Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers , 2013, Nature Genetics.
[152] Hayley E. Francies,et al. Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients , 2015, Cell.
[153] L. Lum,et al. Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-Acyltransferase Porcupine* , 2012, The Journal of Biological Chemistry.
[154] A. Weeraratna,et al. Wnt5A promotes an adaptive, senescent‐like stress response, while continuing to drive invasion in melanoma cells , 2015, Pigment cell & melanoma research.
[155] Hans Clevers,et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling , 2011, Nature.
[156] C. Blanpain,et al. Unravelling cancer stem cell potential , 2013, Nature Reviews Cancer.
[157] Sticking Around: Short-Range Activity of Wnt Ligands. , 2016, Developmental cell.
[158] Tom Royce,et al. A comprehensive catalogue of somatic mutations from a human cancer genome , 2010, Nature.
[159] H. Bastians,et al. Wnt‐mediated protein stabilization ensures proper mitotic microtubule assembly and chromosome segregation , 2015, EMBO reports.
[160] E. Fuchs,et al. Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling , 2014, Genes & development.
[161] D. Busam,et al. Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis , 2012, Oncogene.
[162] Yann S. Dufour,et al. Adaptability of non-genetic diversity in bacterial chemotaxis , 2014, eLife.
[163] M. Pagano,et al. The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. , 1999, Oncogene.
[164] H. Clevers,et al. Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties , 2013, Cell.
[165] H. Clevers. Wnt/beta-catenin signaling in development and disease. , 2006, Cell.
[166] K. Koeneman. R-spondin2 is a secreted activator of Wnt/β-catenin signaling and is required for Xenopus myogenesis , 2009 .
[167] 谷口 智憲. Immune suppression and resistance mediated by constitutive activation of Wnt/β-catenin signaling in human melanoma cells , 2013 .
[168] A. Bell,et al. Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma. , 2006, Neoplasia.
[169] Y. Minami,et al. Receptor Tyrosine Kinase Ror2 Mediates Wnt5a-induced Polarized Cell Migration by Activating c-Jun N-terminal Kinase via Actin-binding Protein Filamin A* , 2008, Journal of Biological Chemistry.
[170] Michael Kahn,et al. Can we safely target the WNT pathway? , 2014, Nature Reviews Drug Discovery.
[171] Y. Minami,et al. Insight into the role of Wnt5a-induced signaling in normal and cancer cells. , 2015, International review of cell and molecular biology.
[172] R. Nusse,et al. Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context , 2006, PLoS biology.
[173] M. Fischer,et al. Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors , 2012, Proceedings of the National Academy of Sciences.
[174] D. Rimm,et al. β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. , 2011, Cancer cell.
[175] Michael Boutros,et al. Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein , 2006, Cell.
[176] Linda Wordeman,et al. Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells , 2014, Nature Cell Biology.
[177] I. Tomlinson,et al. Colorectal cancer and genetic alterations in the Wnt pathway , 2006, Oncogene.
[178] Björn Titz,et al. MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells , 2015, Proceedings of the National Academy of Sciences.
[179] Dean Y. Li,et al. The Small GTPase ARF6 Stimulates β-Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis , 2013, Science Signaling.
[180] D. Carrasco,et al. Targeted Disruption of the BCL9/β-Catenin Complex Inhibits Oncogenic Wnt Signaling , 2012, Science Translational Medicine.
[181] G. Berx,et al. Regulatory networks defining EMT during cancer initiation and progression , 2013, Nature Reviews Cancer.
[182] T. Tsukamoto,et al. Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells. , 2007, Oncogene.
[183] Sridhar Ramaswamy,et al. RNA sequencing of pancreatic circulating tumour cells implicates WNT signaling in metastasis , 2012, Nature.
[184] C. Niehrs,et al. Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis , 2015, Proceedings of the National Academy of Sciences.
[185] R. Bhadra,et al. NIH Public Access , 2014 .
[186] Paul Polakis,et al. Wnt signaling in cancer. , 2012, Cold Spring Harbor perspectives in biology.
[187] F. Staal,et al. Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development , 2012, Leukemia.
[188] K. Zhang,et al. FZD7 has a critical role in cell proliferation in triple negative breast cancer , 2011, Oncogene.
[189] A. Weeraratna,et al. Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2. , 2013, Cancer discovery.
[190] K. Kinzler,et al. Association of the APC tumor suppressor protein with catenins. , 1993, Science.
[191] J. Hoheisel,et al. Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia , 2012, BMC Cancer.
[192] S. Krauss,et al. A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. , 2013, Cancer research.
[193] Sridhar Ramaswamy,et al. RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance , 2015, Science.
[194] F. Masiarz,et al. Association of the APC gene product with beta-catenin. , 1993, Science.
[195] Andrew P. McMahon,et al. Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis , 1989, Cell.
[196] M. J. van de Vijver,et al. Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. , 2011, Cell stem cell.
[197] Hans Clevers,et al. The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. , 2011, Cell stem cell.
[198] Roland Baron,et al. WNT signaling in bone homeostasis and disease: from human mutations to treatments , 2013, Nature Medicine.
[199] Hans Clevers,et al. Crypt stem cells as the cells-of-origin of intestinal cancer , 2009, Nature.
[200] M. Peifer,et al. Original CIN: reviewing roles for APC in chromosome instability , 2008, The Journal of cell biology.
[201] Timothy D. Veenstra,et al. Telomerase modulates Wnt signalling by association with target gene chromatin , 2009, Nature.
[202] T. Kipps,et al. Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[203] Yingqun Wang,et al. Wnt/Planar cell polarity signaling: A new paradigm for cancer therapy , 2009, Molecular Cancer Therapeutics.
[204] H. Moch,et al. ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1 , 2014, Nature Cell Biology.
[205] S. Altschul,et al. Identification of FAP locus genes from chromosome 5q21. , 1991, Science.
[206] R. Moon,et al. WNT signalling pathways as therapeutic targets in cancer , 2012, Nature Reviews Cancer.
[207] A. Chien,et al. Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers. , 2012, Gastroenterology.
[208] R. Hakem,et al. LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction. , 2013, Cell reports.
[209] N. Perrimon,et al. The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. , 1996, Genes & development.
[210] O. Olopade,et al. β-Catenin Is Required for the Tumorigenic Behavior of Triple-Negative Breast Cancer Cells , 2015, PloS one.
[211] C. Voermans,et al. Wnt signaling in normal and malignant hematopoiesis. , 2013, Cold Spring Harbor perspectives in biology.
[212] J. Rubin,et al. Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells , 2012, Journal of cellular physiology.
[213] G. Jönsson,et al. WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells , 2014, Molecular Cancer.