Correction: The Role of Compensatory Mutations in the Emergence of Drug Resistance

In PLoS Computational Biology, volume 2, issue 10: doi:10.1371/journal.pcbi.0020137 Equation 1 contained typographical errors in the first and last lines. The correct equation is as follows:

[1]  J. Koella,et al.  Epidemiological models for the spread of anti-malarial resistance , 2003, Malaria Journal.

[2]  B. Levin,et al.  Compensatory mutations, antibiotic resistance and the population genetics of adaptive evolution in bacteria. , 2000, Genetics.

[3]  Jeffrey P. Maskell,et al.  Multiple Mutations Modulate the Function of Dihydrofolate Reductase in Trimethoprim-ResistantStreptococcus pneumoniae , 2001, Antimicrobial Agents and Chemotherapy.

[4]  D. Andersson,et al.  Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolution. , 2004, Research in microbiology.

[5]  F. M. Stewart,et al.  The population genetics of antibiotic resistance. II: Analytic theory for sustained populations of bacteria in a community of hosts. , 1998, Theoretical population biology.

[6]  D. Gillespie Exact Stochastic Simulation of Coupled Chemical Reactions , 1977 .

[7]  M G Reynolds,et al.  Compensatory evolution in rifampin-resistant Escherichia coli. , 2000, Genetics.

[8]  Lars Liljas,et al.  Compensatory adaptation to the deleterious effect of antibiotic resistance in Salmonella typhimurium , 2002, Molecular microbiology.

[9]  B. Levin,et al.  Adaptation to the fitness costs of antibiotic resistance in Escherichia coli , 1997, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[10]  M. Lipsitch,et al.  The rise and fall of antimicrobial resistance. , 2001, Trends in microbiology.

[11]  E Massad,et al.  Modeling and simulating the evolution of resistance against antibiotics. , 1993, International journal of bio-medical computing.

[12]  Michael J. Jeger,et al.  Adaptation to the cost of resistance: a model of compensation, recombination, and selection in a haploid organism , 2005, Proceedings of the Royal Society B: Biological Sciences.

[13]  David L. Smith,et al.  Persistent colonization and the spread of antibiotic resistance in nosocomial pathogens: resistance is a regional problem. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[14]  S. Blower,et al.  Predicting and preventing the emergence of antiviral drug resistance in HSV-2 , 1998, Nature Medicine.

[15]  B. Levin,et al.  The biological cost of antibiotic resistance. , 1999, Current opinion in microbiology.

[16]  R. Anderson,et al.  Gonococcal infection, infertility, and population growth: II. The influence of heterogeneity in sexual behaviour. , 1992, IMA journal of mathematics applied in medicine and biology.

[17]  Rustom Antia,et al.  Within-Host Population Dynamics and the Evolution and Maintenance of Microparasite Virulence , 1994, The American Naturalist.

[18]  John W Tapsall,et al.  Antibiotic resistance in Neisseria gonorrhoeae. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[19]  B. Levin,et al.  Minimizing potential resistance: a population dynamics view. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[20]  J. Yorke,et al.  Gonorrhea Transmission Dynamics and Control , 1984 .

[21]  R. Anderson,et al.  The relationship between the volume of antimicrobial consumption in human communities and the frequency of resistance. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[22]  Neil M Ferguson,et al.  The epidemiological impact of antiretroviral use predicted by mathematical models: a review , 2005, Emerging themes in epidemiology.

[23]  Rustom Antia,et al.  Effects of Antiviral Usage on Transmission Dynamics of Herpes Simplex Virus Type 1 and on Antiviral Resistance: Predictions of Mathematical Models , 2000, Antimicrobial Agents and Chemotherapy.

[24]  A S Perelson,et al.  Emergence of drug resistance during an influenza epidemic: insights from a mathematical model. , 1998, The Journal of infectious diseases.

[25]  Rustom Antia,et al.  WITHIN‐HOST POPULATION DYNAMICS AND THE EVOLUTION OF MICROPARASITES IN A HETEROGENEOUS HOST POPULATION , 2002, Evolution; international journal of organic evolution.

[26]  D. Livermore,et al.  Minimising antibiotic resistance. , 2005, The Lancet. Infectious diseases.

[27]  Herbert W. Hethcote,et al.  The Mathematics of Infectious Diseases , 2000, SIAM Rev..

[28]  M. Lipsitch,et al.  Antimicrobial Use and Antimicrobial Resistance: A Population Perspective , 2002, Emerging Infectious Diseases.

[29]  Neil M Ferguson,et al.  Modelling the Impact of Antiretroviral Use in Resource-Poor Settings , 2006, PLoS medicine.

[30]  Clifton E. Barry,et al.  Compensatory ahpC Gene Expression in Isoniazid-Resistant Mycobacterium tuberculosis , 1996, Science.

[31]  Martin A Nowak,et al.  Evolutionary dynamics of invasion and escape. , 2004, Journal of theoretical biology.

[32]  Carl T. Bergstrom,et al.  Ecological theory suggests that antimicrobial cycling will not reduce antimicrobial resistance in hospitals. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[33]  J. Sterne,et al.  Investigating ethnic inequalities in the incidence of sexually transmitted infections: mathematical modelling study , 2004, Sexually Transmitted Infections.

[34]  Kevin Burrage,et al.  Stochastic approaches for modelling in vivo reactions , 2004, Comput. Biol. Chem..

[35]  L. Cowen,et al.  Divergence in Fitness and Evolution of Drug Resistance in Experimental Populations of Candida albicans , 2001, Journal of bacteriology.

[36]  D. Andersson,et al.  Persistence of antibiotic resistant bacteria. , 2003, Current opinion in microbiology.

[37]  D. Andersson,et al.  Virulence of antibiotic-resistant Salmonella typhimurium. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[38]  Ted Cohen,et al.  Modeling epidemics of multidrug-resistant M. tuberculosis of heterogeneous fitness , 2004, Nature Medicine.

[39]  David L. Smith,et al.  Animal antibiotic use has an early but important impact on the emergence of antibiotic resistance in human commensal bacteria , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[40]  Hong Li,et al.  Efficient formulation of the stochastic simulation algorithm for chemically reacting systems. , 2004, The Journal of chemical physics.

[41]  O. Berg,et al.  Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance. , 2000, Science.

[42]  Carl T. Bergstrom,et al.  The epidemiology of antibiotic resistance in hospitals: paradoxes and prescriptions. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[43]  R. May,et al.  Infectious Diseases of Humans: Dynamics and Control , 1991, Annals of Internal Medicine.

[44]  J. Tapsall Antimicrobial resistance in Neisseria gonorrhoeae , 2001 .

[45]  W. Levine,et al.  The transmission dynamics of gonorrhoea: modelling the reported behaviour of infected patients from Newark, New Jersey. , 1999, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[46]  Rustom Antia,et al.  The role of evolution in the emergence of infectious diseases , 2003, Nature.

[47]  Tao Dong,et al.  Cross-reactive cytotoxic T lymphocytes against a HIV-1 p24 epitope in slow progressors with B*57 , 2002, AIDS.

[48]  F. M. Stewart,et al.  The population genetics of antibiotic resistance. , 1997, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[49]  S. Schrag,et al.  Reducing antibiotic resistance , 1996, Nature.

[50]  Susan Mallett,et al.  A population-dynamic model for evaluating the potential spread of drug-resistant influenza virus infections during community-based use of antivirals. , 2003, The Journal of antimicrobial chemotherapy.

[51]  S Bonhoeffer,et al.  Evaluating treatment protocols to prevent antibiotic resistance. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[52]  O. Berg,et al.  Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[53]  D. Andersson,et al.  Biological cost and compensatory evolution in fusidic acid‐resistant Staphylococcus aureus , 2001, Molecular microbiology.

[54]  S. Dancer,et al.  How antibiotics can make us sick: the less obvious adverse effects of antimicrobial chemotherapy. , 2004, The Lancet. Infectious diseases.

[55]  T. Chou,et al.  Modeling the emergence of the 'hot zones': tuberculosis and the amplification dynamics of drug resistance , 2004, Nature Medicine.

[56]  S. Levy,et al.  Antibacterial resistance worldwide: causes, challenges and responses , 2004, Nature Medicine.