论文信息 - Feedback-control modeling for cellualr response mechanisms based on a gene regulatory networks under radiotherapy

Feedback-control modeling for cellualr response mechanisms based on a gene regulatory networks under radiotherapy

In response to genome stresses, cell can trigger the self-defensive mechanisms by regulating the vital genes and their complicated signal pathways. To illustrate the celluar response in fighting against DNA damage under radiotherapy, a feedback-control model of P53 stress response networks is proposed at single cell level. The kinetics of Double Strand Breaks(DSBs) generation and repair, ARF and ATM activation, P53-MDM2 regulation, toxins degradation, as well as feedback-control to ion radiation (IR) dose are presented.

Zhihai Rong | Shihuang Shao | Jinpeng Qi

[1] Shihuang Shao,et al. Cellular responding DNA damage: An improved modeling of P53 gene regulatory networks under ion radiation (IR) , 2008, Appl. Math. Comput..

[2] Jinli Xie,et al. A mathematical model of P53 gene regulatory networks under radiotherapy , 2007, Biosystems.

[3] John Jeremy Rice,et al. A plausible model for the digital response of p53 to DNA damage. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[4] Yves Pommier,et al. Molecular interaction map of the p53 and Mdm2 logic elements, which control the Off-On switch of p53 in response to DNA damage. , 2005, Biochemical and biophysical research communications.

[5] J.-P. Qi,et al. A dynamic model for the p53 stress response networks under ion radiation , 2006, Amino Acids.

[6] Arnold Kristjuhan,et al. ARF and ATM/ATR cooperate in p53-mediated apoptosis upon oncogenic stress. , 2005, Biochemical and biophysical research communications.

[7] P J Slootweg,et al. P53 tumor suppressor gene mutations in laryngeal cancer and in recurrent disease following radiation therapy. , 2002, Oral oncology.

[8] M. Lindström,et al. Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts , 2003, Oncogene.