Helper Cell Function Critical Role of p38 and GATA3 in Natural

Kubo and Shigeo KoyasuKazuo Okamoto, Jinfang Zhu, Hiroshi Takayanagi, Masato Jun-ichi Furusawa, Kazuyo Moro, Yasutaka Motomura,http://www.jimmunol.org/content/191/4/1818doi: 10.4049/jimmunol.1300379July 2013;J Immunol€2013; 191:1818-1826; Prepublished online 12MaterialSupplementary9.DC1.htmlhttp://www.jimmunol.org/content/suppl/2013/07/12/jimmunol.130037Referenceshttp://www.jimmunol.org/content/191/4/1818.full#ref-list-1This article cites 50 articles, 18 of which you can access for free at: Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology is online at: Permissionshttp://www.aai.org/ji/copyright.htmlSubmit copyright permission requests at: Email Alertshttp://jimmunol.org/cgi/alerts/etocReceive free email-alerts when new articles cite this article. Sign up at: Erratahttp://www.jimmunol.org/content/193/3/1512.full.pdf or: An erratum has been published regarding this article. Please see next page

[1]  Douglas K. Miller,et al.  The Interleukin-1 Receptor-associated Kinase Is Degraded by Proteasomes following Its Phosphorylation* , 1997, The Journal of Biological Chemistry.

[2]  Anuradha Ray,et al.  Cyclic AMP Activates p38 Mitogen-Activated Protein Kinase in Th2 Cells: Phosphorylation of GATA-3 and Stimulation of Th2 Cytokine Gene Expression1 , 2000, The Journal of Immunology.

[3]  C. Allis,et al.  Translating the Histone Code , 2001, Science.

[4]  C. Allis,et al.  Histone methylation versus histone acetylation: new insights into epigenetic regulation. , 2001, Current opinion in cell biology.

[5]  Tsutomu Takeuchi,et al.  Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice , 2002, Nature Immunology.

[6]  K. Arai,et al.  Cutting Edge: The Differential Involvement of the N-Finger of GATA-3 in Chromatin Remodeling and Transactivation During Th2 Development , 2002, The Journal of Immunology.

[7]  Booki Min,et al.  Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses , 2004, Nature Immunology.

[8]  J Fernando Bazan,et al.  IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. , 2005, Immunity.

[9]  J. Chameau,et al.  News in Brief , 1979, Nature.

[10]  Ian M. Adcock,et al.  Regulation of Th2 Cytokine Genes by p38 MAPK-Mediated Phosphorylation of GATA-31 , 2007, The Journal of Immunology.

[11]  V. Papaioannou,et al.  Cre activity causes widespread apoptosis and lethal anemia during embryonic development , 2007, Genesis.

[12]  K. Rajewsky,et al.  Vagaries of conditional gene targeting , 2007, Nature Immunology.

[13]  P. Barnes,et al.  Role of GATA-3 in allergic diseases. , 2008, Current molecular medicine.

[14]  XuD HepworthMR LiewFY GrencisRK HumphreysNE.  IL-33, a potent inducer of adaptive immunity to intestinal nematodes. , 2008 .

[15]  Shinichiro Sawa,et al.  Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. , 2008, Immunity.

[16]  O. Hazeki,et al.  IRAK-4-dependent degradation of IRAK-1 is a negative feedback signal for TLR-mediated NF-kappaB activation. , 2007, Journal of biochemistry.

[17]  Florian Holsboer,et al.  Glucocorticoids inhibitGATA‐3 phosphorylation and activity in T cells , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[18]  Akira Niwa,et al.  Direct Hematological Toxicity and Illegitimate Chromosomal Recombination Caused by the Systemic Activation of CreERT21 , 2009, The Journal of Immunology.

[19]  Mark Coles,et al.  The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development , 2009, Nature Immunology.

[20]  Andreas Diefenbach,et al.  RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells , 2009, Nature Immunology.

[21]  Qutayba Hamid,et al.  Increased Expression of IL-33 in Severe Asthma: Evidence of Expression by Airway Smooth Muscle Cells1 , 2009, The Journal of Immunology.

[22]  Bohan Wang,et al.  IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes. , 2009, Biochemical and biophysical research communications.

[23]  C. Dahinden,et al.  Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. , 2009, Blood.

[24]  Tak W. Mak,et al.  Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo , 2009, The Journal of experimental medicine.

[25]  Tsutomu Takeuchi,et al.  Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells , 2009, Nature.

[26]  D. E. Smith,et al.  IL‐33: a tissue derived cytokine pathway involved in allergic inflammation and asthma , 2010, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[27]  A. McKenzie,et al.  Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity , 2010, Nature.

[28]  David J. Erle,et al.  Systemically dispersed innate IL-13–expressing cells in type 2 immunity , 2010, Proceedings of the National Academy of Sciences.

[29]  Thomas Kamradt,et al.  The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells. , 2010, Blood.

[30]  Tsutomu Takeuchi,et al.  Natural helper cells: a new player in the innate immune response against helminth infection. , 2010, Advances in immunology.

[31]  茂呂 和世.  Innate production of T[H]2 cytokines by adipose tissue-associated c-Kit[+]Sca-1[+] lymphoid cells , 2010 .

[32]  Gérard Eberl,et al.  Lineage Relationship Analysis of RORγt+ Innate Lymphoid Cells , 2010, Science.

[33]  Yoichiro Iwakura,et al.  Review Functional Specialization of Interleukin-17 Family Members , 2022 .

[34]  Hiromasa Inoue,et al.  The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in TH2 cells , 2011, Nature Immunology.

[35]  David Artis,et al.  Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus , 2011, Nature Immunology.

[36]  Hergen Spits,et al.  Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161 , 2011, Nature Immunology.

[37]  Atsushi Hijikata,et al.  The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells , 2011, Nature Immunology.

[38]  Larry R. Pease,et al.  Lineage−Sca1+c-Kit−CD25+ Cells Are IL-33–Responsive Type 2 Innate Cells in the Mouse Bone Marrow , 2011, The Journal of Immunology.

[39]  Ya-Jen Chang,et al.  Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity , 2011, Nature Immunology.

[40]  Shoko Iwaki,et al.  Amplification of cytokine production through synergistic activation of NFAT and AP‐1 following stimulation of mast cells with antigen and IL‐33 , 2011, European journal of immunology.

[41]  Ci Xinxin,et al.  Florfenicol inhibits allergic airway inflammation in mice by p38 MAPK-mediated phosphorylation of GATA 3. , 2011, Clinical immunology.

[42]  David Artis,et al.  Cutting Edge: Natural Helper Cells Derive from Lymphoid Progenitors , 2011, The Journal of Immunology.

[43]  Freddy Radtke,et al.  Rorα is essential for nuocyte development , 2011, Nature Immunology.

[44]  Shigeo Koyasu,et al.  Role of Innate Lymphocytes in Infection and Inflammation , 2012, Front. Immun..

[45]  Kenji Nakanishi,et al.  Contribution of IL-33–activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice , 2012, Proceedings of the National Academy of Sciences.

[46]  R. Locksley,et al.  Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity , 2011, Nature Immunology.

[47]  David Voehringer,et al.  The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. , 2012, Immunity.

[48]  Hergen Spits,et al.  The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. , 2012, Immunity.

[49]  Fumio Takei,et al.  Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation. , 2012, Immunity.

[50]  Fumio Takei,et al.  Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. , 2012, Immunity.

[51]  Hiroshi Takayanagi,et al.  Critical Role of p38 and GATA3 in Natural Helper Cell Function , 2013, The Journal of Immunology.

[52]  Eric Vivier,et al.  Innate lymphoid cells — a proposal for uniform nomenclature , 2013, Nature Reviews Immunology.