Application of Q-switch Alexandrite laser combined with fractional CO 2 laser in treating disseminated superficial actinic porokeratosis : report of two cases

As a subtype of porokeratosis, disseminated superficial actinic porokeratosis (DSAP) is an inherited autosomal dominant cutaneous dermal disorder of keratinization. Patients diagnosed with DSAP are characterized by multiple superficial lesions with a slightly elevated and sharply delineated ridge. Multiple therapies have been employed to treat DSAP. However, the clinical efficacy is relatively low. In this study, combined therapy of Q-switch Alexandrite laser and fractional CO2 laser was tentatively applied for the clinical treatment of DSAP. In this case report, two patients were pathologically diagnosed with DSAP by punch biopsy. They subsequently received Q-switch Alexandrite laser combined with fractional CO2 laser with the energy of 100-150 mJ at a pulse frequency of 2 Hz. The spot size was measured as 1.3 mm with a scan matrix of 2-7 and a density of 3. All patients were followed up for 3 to 8 months. Favorable cosmetic appearance was achieved. No recurrent DSAP was reported during follow-up.