Counterpoint: humans do not demonstrate selective brain cooling during hyperthermia.

Selective brain cooling is an attractive idea for protection of the central nervous system against fatigue ([17][1]) and potentially cellular damage. Several factors influence fatigue, but brain temperature appears to be of utmost importance for hyperthermia-induced fatigue during prolonged exercise

[1]  J. Shuhaiber,et al.  Antegrade or retrograde cerebral perfusion as an adjunct during hypothermic circulatory arrest for aortic arch surgery , 2007, Expert review of cardiovascular therapy.

[2]  S. Rubertsson,et al.  Noninvasive monitoring of brain temperature during mild hypothermia. , 2009, Magnetic resonance imaging.

[3]  Michel Cabanac,et al.  Tympanic temperature is a core temperature in humans , 1989 .

[4]  T. Nagasaka,et al.  Selective brain cooling in hyperthermia: the mechanisms and medical implications. , 1998, Medical hypotheses.

[5]  Michel Cabanac,et al.  Human Selective Brain Cooling , 1995 .

[6]  M. Cabanac,et al.  Natural selective cooling of the human brain: evidence of its occurrence and magnitude. , 1979, The Journal of physiology.

[7]  M E Raichle,et al.  Coupling between changes in human brain temperature and oxidative metabolism during prolonged visual stimulation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Lars Nybo,et al.  Hyperthermia and fatigue. , 2008, Journal of applied physiology.

[9]  L. Nybo.  CNS fatigue provoked by prolonged exercise in the heat. , 2010, Frontiers in bioscience.

[10]  S. Maloney,et al.  Adaptive heterothermy and selective brain cooling in arid-zone mammals. , 2002, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[11]  R. D. Hanson.  Respiratory heat loss at increased core temperature. , 1974, Journal of applied physiology.

[12]  C. Jessen.  Selective brain cooling in mammals and birds. , 2001, The Japanese journal of physiology.

[13]  S. Maloney,et al.  Absence of selective brain cooling in unrestrained baboons exposed to heat. , 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

[14]  Z. Mariak,et al.  The relationship between directly measured human cerebral and tympanic temperatures during changes in brain temperatures , 2004, European Journal of Applied Physiology and Occupational Physiology.

[15]  J Crezee,et al.  Temperature uniformity during hyperthermia: the impact of large vessels. , 1992, Physics in medicine and biology.

[16]  Z. Mariak,et al.  Direct cooling of the human brain by heat loss from the upper respiratory tract. , 1999, Journal of applied physiology.

[17]  J Pile-Spellman,et al.  Selective Brain Cooling with Endovascular Intracarotid Infusion of Cold Saline: A Pilot Feasibility Study , 2010, American Journal of Neuroradiology.

[18]  M Cabanac,et al.  Heat loss from the human head during exercise. , 1991, Journal of applied physiology.

[19]  Michel Cabanac,et al.  Selective brain cooling in humans: “fancy” or fact? , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[20]  G. Sung,et al.  A review of selective hypothermia in the management of traumatic brain injury. , 2008, Neurosurgical focus.

[21]  N. Lassen,et al.  Normal Average Value of Cerebral Blood Flow in Younger Adults is 50 ml/100 g/min , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[22]  T. Wieloch,et al.  A New Method of Selective, Rapid Cooling of the Brain: An Experimental Study , 2006, CardioVascular and Interventional Radiology.

[23]  N. Secher,et al.  Inadequate heat release from the human brain during prolonged exercise with hyperthermia , 2002, The Journal of physiology.

[24]  J Crezee,et al.  The theoretical and experimental evaluation of the heat balance in perfused tissue. , 1994, Physics in medicine and biology.