Frailty and the aging male

Frailty occurs in aging males for a variety of reasons. It is less common in males than females. Diseases which are particularly associated with frailty are diabetes mellitus, atherosclerosis, anemia and chronic obstructive pulmonary disease. Insulin resistance syndrome plays a pathogenetic role in the “fat-frail” syndrome. Sarcopenia occurs predominantly because of hormone deficiency and cytokine excess. Pain and anorexia are also associated with frailty. Stem cell research represents a potential promise for the treatment of frailty.

[1]  A. Seftel.  Testosterone Treatment Improves Body Composition and Sexual Function in Men With COPD, in a 6-Month Randomized Controlled Trial. , 2005, The Journal of urology.

[2]  I. Goldberg,et al.  Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[3]  R. Casaburi,et al.  Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease. , 2004, American journal of respiratory and critical care medicine.

[4]  R. Baumgartner,et al.  Cytokine-related aging process. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[5]  Alfred L Fisher,et al.  Of Worms and Women: Sarcopenia and its Role in Disability and Mortality , 2004, Journal of the American Geriatrics Society.

[6]  K. Chad,et al.  Effect of ceasing creatine supplementation while maintaining resistance training in older men. , 2004, Journal of aging and physical activity.

[7]  T. Braun,et al.  Myostatin mutation associated with gross muscle hypertrophy in a child. , 2004, The New England journal of medicine.

[8]  J. Gallagher.  The effects of calcitriol on falls and fractures and physical performance tests , 2004, The Journal of Steroid Biochemistry and Molecular Biology.

[9]  W. Ambrosius,et al.  Angiotensin-converting enzyme inhibition, body composition, and physical performance in aged rats. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[10]  S. M. Robinson,et al.  Triglycerides induce leptin resistance at the blood-brain barrier. , 2004, Diabetes.

[11]  Bess Dawson-Hughes,et al.  Effect of Vitamin D on falls: a meta-analysis. , 2004, JAMA.

[12]  Stephan von Haehling,et al.  Inflammatory mediators in chronic heart failure: an overview , 2004, Heart.

[13]  David R. Thomas.  Anemia and quality of life: unrecognized and undertreated. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[14]  L. Ferrucci,et al.  Inflammatory markers and physical performance in older persons: the InCHIANTI study. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[15]  S. Bandinelli,et al.  Hemoglobin levels and skeletal muscle: results from the InCHIANTI study. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[16]  L. Ferrucci,et al.  Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[17]  J. Morley.  The metabolic syndrome and aging. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[18]  J. Williamson,et al.  Patterns of disability related to diabetes mellitus in older women. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[19]  B. Johansson.  Functional and cellular effects of environmental enrichment after experimental brain infarcts. , 2004, Restorative neurology and neuroscience.

[20]  G. Yavuzer,et al.  Rehabilitation outcome of Turkish stroke patients: in a team approach setting , 2003, International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation.

[21]  K. Krishnan,et al.  Does antidepressant therapy improve cognition in elderly depressed patients? , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[22]  S. Bhasin.  Testosterone supplementation for aging-associated sarcopenia. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[23]  J. Morley,et al.  Invited review: Aging and energy balance. , 2003, Journal of applied physiology.

[24]  Matthew T. Haren,et al.  Oral testosterone supplementation increases muscle and decreases fat mass in healthy elderly males with low-normal gonadal status. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[25]  W. Banks,et al.  Memories are made of this: recent advances in understanding cognitive impairments and dementia. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[26]  D. Blazer.  Depression in late life: review and commentary. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[27]  J. Morley.  Anorexia and weight loss in older persons. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[28]  Douglas K. Miller,et al.  Editorial: Something about frailty. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[29]  D. Hall,et al.  Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans , 2002, Nature.

[30]  K. Chansky,et al.  Preoperative Supraphysiological Testosterone in Older Men Undergoing Knee Replacement Surgery , 2002, Journal of the American Geriatrics Society.

[31]  S. Forconi,et al.  C-reactive protein, physical disability, and prognosis in very old patients with ischemic stroke. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[32]  J. Morley.  A fall is a major event in the life of an older person. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[33]  A. Matsumoto.  Andropause: clinical implications of the decline in serum testosterone levels with aging in men. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[34]  J. Morley,et al.  Diabetes Mellitus in a Subgroup of Older Mexicans: Prevalence, Association with Cardiovascular Risk Factors, Functional and Cognitive Impairment, and Mortality , 2002, Journal of the American Geriatrics Society.

[35]  H. Perry,et al.  Something About Frailty , 2002 .

[36]  K. Chad,et al.  Creatine supplementation combined with resistance training in older men. , 2001, Medicine and science in sports and exercise.

[37]  S. W. Stevenson,et al.  Nonsteroidal anti-inflammatory therapy after eccentric exercise in healthy older individuals. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[38]  J. Morley,et al.  Utilizing pain assessment scales increases the frequency of diagnosing pain among elderly nursing home residents. , 2001, Journal of pain and symptom management.

[39]  Ronenn Roubenoff,et al.  From the Chicago MeetingsSarcopenia , 2001 .

[40]  L. Fried,et al.  Frailty in older adults: evidence for a phenotype. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[41]  Antonio Musarò,et al.  Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle , 2001, Nature Genetics.

[42]  J. Morley.  Editorial The Aging Athlete , 2000 .

[43]  J. Morley.  Diabetes mellitus: a major disease of older persons. , 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

[44]  M. Godschalk,et al.  Testosterone Improves Rehabilitation Outcomes in Ill Older Men , 2000, Journal of the American Geriatrics Society.

[45]  R. Baumgartner,et al.  Longitudinal changes in serum 25-hydroxyvitamin D in older people. , 1999, Metabolism: clinical and experimental.

[46]  P. Clarkson,et al.  Effects of 30 days of creatine ingestion in older men , 1999, European Journal of Applied Physiology and Occupational Physiology.

[47]  L. Lui,et al.  Reported and measured physical functioning in older inner-city diabetic African Americans. , 1999, The journals of gerontology. Series A, Biological sciences and medical sciences.

[48]  A. Sinclair.  Diabetes in the elderly: A perspective from the United Kingdom. , 1999, Clinics in geriatric medicine.

[49]  R. Baumgartner,et al.  Predictors of skeletal muscle mass in elderly men and women , 1999, Mechanisms of Ageing and Development.

[50]  D. Brooks,et al.  The influence of 6 months of oral anabolic steroids on body mass and respiratory muscles in undernourished COPD patients. , 1998, Chest.

[51]  J. Morley,et al.  Hospitalization and Mortality of Diabetes in Older Adults: A 3-year prospective study , 1998, Diabetes Care.

[52]  H. Magnussen,et al.  Testosterone levels in men with chronic obstructive pulmonary disease with or without glucocorticoid therapy. , 1998, The European respiratory journal.

[53]  H. Perry,et al.  Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. , 1997, The Journal of clinical endocrinology and metabolism.

[54]  P J Garry,et al.  Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. , 1997, Metabolism: clinical and experimental.

[55]  H. Perry,et al.  Effects of Testosterone Replacement Therapy in Old Hypogonadal Males: A Preliminary Study , 1993, Journal of the American Geriatrics Society.

[56]  L. Fitten,et al.  Depression: UCLA Geriatric Grand Rounds , 1989 .

[57]  W. Stanish,et al.  The aging athlete , 1989, The American journal of sports medicine.

[58]  J. Morley,et al.  Relationship between behavioral and motor responses of mature and old mice and cerebellar beta-adrenergic receptor density , 1988, Mechanisms of Ageing and Development.

[59]  J. Morley,et al.  Relationship of penile brachial pressure index to myocardial infarction and cerebrovascular accidents in older men. , 1988, The American journal of medicine.