Photocontrol of Endogenous Glycine Receptors In Vivo.

[1]  P. Bregestovski,et al.  A photoswitchable GABA receptor channel blocker , 2019, British journal of pharmacology.

[2]  P. Bregestovski,et al.  Photopharmacology: A Brief Review Using the Control of Potassium Channels as an Example , 2019, Neuroscience and Behavioral Physiology.

[3]  Federico Comitani,et al.  Trans- Cis Proline Switches in a Pentameric Ligand-Gated Ion Channel: How They Are Affected by and How They Affect the Biomolecular Environment. , 2019, The journal of physical chemistry letters.

[4]  Kira E. Poskanzer,et al.  Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology , 2019, Proceedings of the National Academy of Sciences.

[5]  P. Bregestovski,et al.  Developmental Changes in the Inhibition of Glycinergic Synaptic Currents by Niflumic Acid in Hypoglossal Motoneurons , 2018, Front. Mol. Neurosci..

[6]  Ned S. Wingreen,et al.  Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome , 2018, Cell.

[7]  Rafael Yuste,et al.  Two-Photon Optogenetic Mapping of Excitatory Synaptic Connectivity and Strength , 2018, iScience.

[8]  Dirk Trauner,et al.  In Vivo Photopharmacology. , 2018, Chemical reviews.

[9]  Torsten Schwede,et al.  SWISS-MODEL: homology modelling of protein structures and complexes , 2018, Nucleic Acids Res..

[10]  C. Romanin,et al.  An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel , 2018, Nature Chemical Biology.

[11]  Dietmar Schmitz,et al.  Optogenetic Tools for Subcellular Applications in Neuroscience , 2017, Neuron.

[12]  E. Boyden,et al.  Temporally precise single-cell resolution optogenetics , 2017, Nature Neuroscience.

[13]  J. Changeux,et al.  Allosteric modulation as a unifying mechanism for receptor function and regulation , 2017, Diabetes, obesity & metabolism.

[14]  J. van Brederode,et al.  Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease , 2017, The Journal of Neuroscience.

[15]  M. Bear,et al.  Arbaclofen in fragile X syndrome: results of phase 3 trials , 2017, Journal of Neurodevelopmental Disorders.

[16]  Karl Deisseroth,et al.  Integration of optogenetics with complementary methodologies in systems neuroscience , 2017, Nature Reviews Neuroscience.

[17]  L. Aguayo,et al.  Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors , 2016, Molecular Pharmacology.

[18]  A. Díaz-Tahoces,et al.  Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches , 2016, Nature Communications.

[19]  T. Smart,et al.  Azogabazine; a photochromic antagonist of the GABAA receptor. , 2016, Organic & biomolecular chemistry.

[20]  Hiromi Hirata,et al.  Defects of the Glycinergic Synapse in Zebrafish , 2016, Front. Mol. Neurosci..

[21]  J. Hénin,et al.  Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors , 2016, PloS one.

[22]  R. Dutzler,et al.  Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels , 2016, PLoS biology.

[23]  Wolfgang Huber,et al.  An Optogenetic Method to Modulate Cell Contractility during Tissue Morphogenesis , 2015, Developmental cell.

[24]  P. Bregestovski,et al.  Selective potentiation of alpha 1 glycine receptors by ginkgolic acid , 2015, Front. Mol. Neurosci..

[25]  Mingzhi Zhang,et al.  Statistical Analysis of Zebrafish Locomotor Response , 2015, PloS one.

[26]  E. Gouaux,et al.  Glycine receptor mechanism elucidated by electron cryo-microscopy , 2015, Nature.

[27]  D. Trauner,et al.  Azobenzene-based inhibitors of human carbonic anhydrase II , 2015, Beilstein journal of organic chemistry.

[28]  T. Smart,et al.  The desensitization gate of inhibitory Cys-loop receptors , 2015, Nature Communications.

[29]  S. Devine,et al.  Brain feminization requires active repression of masculinization via DNA methylation , 2015, Nature Neuroscience.

[30]  P. Gorostiza,et al.  An allosteric modulator to control endogenous G protein-coupled receptors with light. , 2014, Nature chemical biology.

[31]  E. Isacoff,et al.  Tethered ligands reveal glutamate receptor desensitization depends on subunit occupancy , 2014, Nature chemical biology.

[32]  Alan D Kaye,et al.  Benzodiazepine pharmacology and central nervous system-mediated effects. , 2013, The Ochsner journal.

[33]  Vincenzo Carnevale,et al.  Exploring Volatile General Anesthetic Binding to a Closed Membrane-Bound Bacterial Voltage-Gated Sodium Channel via Computation , 2013, PLoS Comput. Biol..

[34]  P. Bregestovski,et al.  Calibration and functional analysis of three genetically encoded Cl−/pH sensors , 2013, Front. Mol. Neurosci..

[35]  D. Raines,et al.  Azo-propofols: photochromic potentiators of GABA(A) receptors. , 2012, Angewandte Chemie.

[36]  Marcus D. Hanwell,et al.  Avogadro: an advanced semantic chemical editor, visualization, and analysis platform , 2012, Journal of Cheminformatics.

[37]  M. Safo,et al.  Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5′-phosphate, GABA and anti-epileptic drugs , 2012, Disease Models & Mechanisms.

[38]  L. M. Lima,et al.  Synthesis, Biological Evaluation, and Structure–activity Relationship of Clonazepam, Meclonazepam, and 1,4‐Benzodiazepine Compounds with Schistosomicidal Activity , 2012, Chemical biology & drug design.

[39]  P. Moult,et al.  The Control of Locomotor Frequency by Excitation and Inhibition , 2012, The Journal of Neuroscience.

[40]  Chris de Graaf,et al.  Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands. , 2012, Nature chemical biology.

[41]  M. Richardson,et al.  Measuring thigmotaxis in larval zebrafish , 2012, Behavioural Brain Research.

[42]  G. Scharer,et al.  Prediction of long-term outcome in glycine encephalopathy: a clinical survey , 2012, Journal of Inherited Metabolic Disease.

[43]  Martin Lochner,et al.  High-affinity fluorescent ligands for the 5-HT3 receptor , 2012, Bioorganic & medicinal chemistry letters.

[44]  Feng Feng,et al.  ROBUST PHOTO-REGULATION OF GABAA RECEPTORS BY ALLOSTERIC MODULATION WITH A PROPOFOL ANALOG , 2012, Nature Communications.

[45]  Gonzalo Yevenes,et al.  Allosteric modulation of glycine receptors , 2011, British journal of pharmacology.

[46]  J Andrew McCammon,et al.  BINANA: a novel algorithm for ligand-binding characterization. , 2011, Journal of molecular graphics & modelling.

[47]  S. Sine,et al.  Functional Relationships between Agonist Binding Sites and Coupling Regions of Homomeric Cys-Loop Receptors , 2011, The Journal of Neuroscience.

[48]  H. Haas,et al.  Fragrant Dioxane Derivatives Identify β1-Subunit-containing GABAA Receptors* , 2010, The Journal of Biological Chemistry.

[49]  E. Levin,et al.  Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety , 2009, Pharmacology Biochemistry and Behavior.

[50]  C. Bouzat,et al.  Structural Basis of Activation of Cys-Loop Receptors: the Extracellular–Transmembrane Interface as a Coupling Region , 2009, Molecular Neurobiology.

[51]  A. Olson,et al.  AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading , 2009, J. Comput. Chem..

[52]  P. Schofield,et al.  Gating mechanisms in Cys-loop receptors , 2009, European Biophysics Journal.

[53]  Adriano B. L. Tort,et al.  Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin-positive interneurons , 2009, Proceedings of the National Academy of Sciences.

[54]  C. Cellai,et al.  Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents. , 2008, Bioorganic & medicinal chemistry letters.

[55]  G. Caliendo,et al.  Synthesis and pharmacological evaluation of peptide-mimetic protease-activated receptor-1 antagonists containing novel heterocyclic scaffolds. , 2008, Bioorganic & medicinal chemistry.

[56]  F. Kirchhoff,et al.  A Novel Glycine Receptor β Subunit Splice Variant Predicts an Unorthodox Transmembrane Topology , 2007, Journal of Biological Chemistry.

[57]  M. Parker,et al.  Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition , 2007, Journal of neurochemistry.

[58]  K. Schulten,et al.  Imaging the migration pathways for O2, CO, NO, and Xe inside myoglobin. , 2006, Biophysical journal.

[59]  P. Gharagozloo,et al.  Pharmacological characterisation of strychnine and brucine analogues at glycine and alpha7 nicotinic acetylcholine receptors. , 2006, European journal of pharmacology.

[60]  Henry A. Lester,et al.  Cis–trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel , 2005, Nature.

[61]  Hiromi Hirata,et al.  The Zebrafish shocked Gene Encodes a Glycine Transporter and Is Essential for the Function of Early Neural Circuits in the CNS , 2005, The Journal of Neuroscience.

[62]  Hiromi Hirata,et al.  Zebrafish bandoneon mutants display behavioral defects due to a mutation in the glycine receptor beta-subunit. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[63]  K. Rück-Braun,et al.  Efficient preparation of nitrosoarenes for the synthesis of azobenzenes. , 2005, The Journal of organic chemistry.

[64]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..

[65]  P. Bregestovski,et al.  A novel glycine receptor αZ1 subunit variant in the zebrafish brain , 2003, Neuroscience.

[66]  U. Rudolph,et al.  GABA(A) receptor subtypes: dissecting their pharmacological functions. , 2001, Trends in pharmacological sciences.

[67]  P. Bregestovski,et al.  Isolation and characterization of an alpha 2-type zebrafish glycine receptor subunit , 2001, Neuroscience.

[68]  D. Chesnoy-Marchais Potentiation of chloride responses to glycine by three 5‐HT3 antagonists in rat spinal neurones , 1996, British journal of pharmacology.

[69]  M. Denavit-Saubié,et al.  Inhibitions mediated by glycine and GABAA receptors shape the discharge pattern of bulbar respiratory neurons , 1996, Brain Research.

[70]  C. Kimmel,et al.  Stages of embryonic development of the zebrafish , 1995, Developmental dynamics : an official publication of the American Association of Anatomists.

[71]  M. Frisch,et al.  Ab Initio Calculation of Vibrational Absorption and Circular Dichroism Spectra Using Density Functional Force Fields , 1994 .

[72]  G. Yadid,et al.  Inhibitory effect of strychnine on acetylcholine receptor activation in bovine adrenal medullary chromaffin cells , 1994, British journal of pharmacology.

[73]  P. O'Connell,et al.  A missense mutation in the gene encoding the α1 subunit of the inhibitory glycine receptor in the spasmodic mouse , 1994, Nature Genetics.

[74]  O. Taleb,et al.  Expression of the human glycine receptor alpha 1 subunit in Xenopus oocytes: apparent affinities of agonists increase at high receptor density. , 1994, The EMBO journal.

[75]  P. Avner,et al.  Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant. , 1994, The Journal of biological chemistry.

[76]  E. Taylor,et al.  Conversion of a primary amino group into a nitroso group. Synthesis of nitroso-substituted heterocycles , 1982 .

[77]  Joseph Callaway,et al.  Inhomogeneous Electron Gas , 1973 .

[78]  L. Birkofer,et al.  C-Nitrosierungen über Silyl-Derivate , 1971 .

[79]  Yan Zhang,et al.  Glycine Receptor Drug Discovery. , 2017, Advances in pharmacology.

[80]  R C MacPhail,et al.  Locomotion in larval zebrafish: Influence of time of day, lighting and ethanol. , 2009, Neurotoxicology.

[81]  P. Schofield,et al.  Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel , 1997, The EMBO journal.