tRNA gene number and codon usage in the C. elegans genome are co-adapted for optimal translation of highly expressed genes.

I warmly thank T.M. Lowe for providing me the results of his analyses of tRNA genes contents in C. elegans genome. I thank M. Gouy for his helpful comments and G. Marais for his suggestion about the relationship between the frequency of tRNA genes and dosage compensation on the X chromosome. This work was supported by the Centre National de la Recherche Scientifique.

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