Nanosurfer assay dissects β-cardiac myosin and cardiac myosin-binding protein C interactions

[1]  V. Galkin,et al.  Interaction of the C2 Ig-like Domain of Cardiac Myosin Binding Protein-C with F-actin. , 2021, Journal of molecular biology.

[2]  S. Sadayappan,et al.  The N terminus of myosin-binding protein C extends toward actin filaments in intact cardiac muscle , 2021, The Journal of general physiology.

[3]  Ashim Rai,et al.  Dynamic multimerization of Dab2–Myosin VI complexes regulates cargo processivity while minimizing cortical actin reorganization , 2020, The Journal of biological chemistry.

[4]  S. Harris.  Making waves: A proposed new role for myosin-binding protein C in regulating oscillatory contractions in vertebrate striated muscle , 2020, The Journal of general physiology.

[5]  M. Geeves,et al.  MyBP-C: one protein to govern them all , 2020, Journal of Muscle Research and Cell Motility.

[6]  J. Spudich,et al.  β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity , 2019, Nature Communications.

[7]  Brett A. Colson.  What a drag!: Skeletal myosin binding protein-C affects sarcomeric shortening , 2019, The Journal of general physiology.

[8]  D. Warshaw,et al.  Revealing the mechanism of how cardiac myosin-binding protein C N-terminal fragments sensitize thin filaments for myosin binding , 2019, Proceedings of the National Academy of Sciences.

[9]  J. Spudich,et al.  The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations , 2017, Nature Structural &Molecular Biology.

[10]  R. Sunahara,et al.  ER/K linked GPCR-G protein fusions systematically modulate second messenger response in cells , 2017, Scientific Reports.

[11]  K. Campbell,et al.  Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle* , 2017, The Journal of Biological Chemistry.

[12]  M. Tyska,et al.  Patterning protein complexes on DNA nanostructures using a GFP nanobody , 2016, Protein science : a publication of the Protein Society.

[13]  M. Irving,et al.  Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle , 2016, Nature Communications.

[14]  D. Warshaw,et al.  Phosphorylation and calcium antagonistically tune myosin-binding protein C’s structure and function , 2016, Proceedings of the National Academy of Sciences.

[15]  Vitold E. Galkin,et al.  C0 and C1 N-terminal Ig domains of myosin binding protein C exert different effects on thin filament activation , 2016, Proceedings of the National Academy of Sciences.

[16]  L. Carrier,et al.  Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology. , 2015, Gene.

[17]  Ann M Stock,et al.  Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity , 2015, Nature Communications.

[18]  Christian L. Vestergaard,et al.  Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules , 2015, Nature Communications.

[19]  J. Spudich,et al.  Mechanical coordination in motor ensembles revealed using engineered artificial myosin filaments. , 2015, Nature nanotechnology.

[20]  Yingying Liu,et al.  Omecamtiv Mecarbil modulates the kinetic and motile properties of porcine β-cardiac myosin. , 2015, Biochemistry.

[21]  S. Sadayappan,et al.  Orientation of myosin binding protein C in the cardiac muscle sarcomere determined by domain-specific immuno-EM. , 2015, Journal of molecular biology.

[22]  S. Harris,et al.  Effects of cardiac Myosin binding protein-C on actin motility are explained with a drag-activation-competition model. , 2015, Biophysical journal.

[23]  R. Moss,et al.  Cardiac MyBP-C regulates the rate and force of contraction in mammalian myocardium. , 2015, Circulation research.

[24]  E. Ostap,et al.  Inherent force-dependent properties of β-cardiac myosin contribute to the force-velocity relationship of cardiac muscle. , 2014, Biophysical journal.

[25]  S. Sivaramakrishnan,et al.  Harnessing the Unique Structural Properties of Isolated α-Helices* , 2014, The Journal of Biological Chemistry.

[26]  D. Warshaw,et al.  Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism , 2014, Proceedings of the National Academy of Sciences.

[27]  J. Shaffer,et al.  A Gain-of-Function Mutation in the M-domain of Cardiac Myosin-binding Protein-C Increases Binding to Actin* , 2013, The Journal of Biological Chemistry.

[28]  M. Bhuiyan,et al.  Determination of the critical residues responsible for cardiac myosin binding protein C's interactions. , 2012, Journal of molecular and cellular cardiology.

[29]  D. Warshaw,et al.  Molecular Mechanics of Cardiac Myosin-Binding Protein C in Native Thick Filaments , 2012, Science.

[30]  D. Warshaw,et al.  The extent of cardiac myosin binding protein-C phosphorylation modulates actomyosin function in a graded manner , 2012, Journal of Muscle Research and Cell Motility.

[31]  M. Gautel,et al.  Structure, interactions and function of the N-terminus of cardiac myosin binding protein C (MyBP-C): who does what, with what, and to whom? , 2012, Journal of Muscle Research and Cell Motility.

[32]  P. Rosevear,et al.  Structural Insight into Unique Cardiac Myosin-binding Protein-C Motif , 2012, The Journal of Biological Chemistry.

[33]  J. Spudich,et al.  Systematic control of protein interaction using a modular ER/K α-helix linker , 2011, Proceedings of the National Academy of Sciences.

[34]  J. Squire,et al.  Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle , 2011, Proceedings of the National Academy of Sciences.

[35]  M. Gautel,et al.  Structure and Interactions of Myosin-binding Protein C Domain C0 , 2011, The Journal of Biological Chemistry.

[36]  S. Sadayappan,et al.  Phosphorylation and function of cardiac myosin binding protein-C in health and disease. , 2010, Journal of molecular and cellular cardiology.

[37]  J. Squire.  Muscle myosin filaments: cores, crowns and couplings , 2009, Biophysical Reviews.

[38]  J. Shaffer,et al.  The Myosin-binding Protein C Motif Binds to F-actin in a Phosphorylation-sensitive Manner* , 2009, Journal of Biological Chemistry.

[39]  R. Moss,et al.  Understanding the Organisation and Role of Myosin Binding Protein C in Normal Striated Muscle by Comparison with MyBP-C Knockout Cardiac Muscle , 2008, Journal of molecular biology.

[40]  M. Regnier,et al.  Myosin S2 is not required for effects of myosin binding protein‐C on motility , 2007, FEBS letters.

[41]  M. Regnier,et al.  Effects of the N-terminal Domains of Myosin Binding Protein-C in an in Vitro Motility Assay , 2006, Journal of Biological Chemistry.

[42]  R. Moss,et al.  Binding of Myosin Binding Protein-C to Myosin Subfragment S2 Affects Contractility Independent of a Tether Mechanism , 2004, Circulation research.

[43]  H. Watkins,et al.  Cardiac Myosin Binding Protein C: Its Role in Physiology and Disease , 2004, Circulation research.

[44]  C. Moncman,et al.  Mutations in the motor domain modulate myosin activity and myofibril organization , 2003, Journal of Cell Science.

[45]  M. Gautel,et al.  cAPK‐phosphorylation controls the interaction of the regulatory domain of cardiac myosin binding protein C with myosin‐S2 in an on‐off fashion , 1999, FEBS letters.

[46]  T. Mikawa,et al.  Isoform-specific Interaction of the Myosin-binding Proteins (MyBPs) with Skeletal and Cardiac Myosin Is a Property of the C-terminal Immunoglobulin Domain* , 1997, The Journal of Biological Chemistry.

[47]  J. Beckmann,et al.  Cardiac myosin binding protein–C gene splice acceptor site mutation is associated with familial hypertrophic cardiomyopathy , 1995, Nature Genetics.

[48]  J. Seidman,et al.  Mutations in the cardiac myosin binding protein–C gene on chromosome 11 cause familial hypertrophic cardiomyopathy , 1995, Nature Genetics.

[49]  I. Fraser,et al.  In Vitro Motility Analysis of Actin-Tropomyosin Regulation by Troponin and Calcium , 1995, The Journal of Biological Chemistry.

[50]  F. E. Weber,et al.  The major myosin-binding domain of skeletal muscle MyBP-C (C protein) resides in the COOH-terminal, immunoglobulin C2 motif , 1993, The Journal of cell biology.

[51]  R. Starr,et al.  A new protein of the thick filaments of vertebrate skeletal myofibrils. Extractions, purification and characterization. , 1973, Journal of molecular biology.

[52]  R. Starr,et al.  Polypeptide chains of intermediate molecular weight in myosin preparations , 1971, FEBS letters.

[53]  W. Lederer,et al.  Myosin-binding protein C corrects an intrinsic inhomogeneity in cardiac excitation-contraction coupling , 2015, Science Advances.

[54]  S. Sadayappan,et al.  Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain. , 2012, Journal of molecular and cellular cardiology.

[55]  J. Shaffer,et al.  Binding of the N-terminal fragment C0-C2 of cardiac MyBP-C to cardiac F-actin. , 2011, Journal of structural biology.

[56]  J. Spudich,et al.  Purification of muscle actin. , 1982, Methods in enzymology.